{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:47:54Z","timestamp":1782514074122,"version":"3.54.5"},"reference-count":29,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2005,10,1]],"date-time":"2005-10-01T00:00:00Z","timestamp":1128124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2005,10]]},"DOI":"10.1016\/j.jhep.2005.04.007","type":"journal-article","created":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T13:39:29Z","timestamp":1117633169000},"page":"590-598","source":"Crossref","is-referenced-by-count":148,"title":["Outcome in a hepatitis C (genotype 1b) single source outbreak in Germany\u2014a 25-year multicenter study"],"prefix":"10.1016","volume":"43","author":[{"given":"Manfred","family":"Wiese","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Gr\u00fcngreiff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"G\u00fcthoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lafrenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute","family":"Oesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiner","family":"Porst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2005.04.007_bib1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1177\/0091270003258669","article-title":"Global burden of disease for hepatitis C","volume":"44","author":"Global Burden of Hepatitis C Working Group","year":"2004","journal-title":"J Clin Pharmacol"},{"key":"10.1016\/j.jhep.2005.04.007_bib2","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/S0168-8278(99)80154-8","article-title":"EASL international consensus conference on hepatitis C","volume":"30","year":"1999","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2005.04.007_bib3","doi-asserted-by":"crossref","unstructured":"National institutes of health consensus development conference panel statement: management of hepatitis C: 2002\u2014June 10\u201312, 2002. Hepatology 2002; 36: S3\u2013S20.","DOI":"10.1002\/hep.1840360703"},{"key":"10.1016\/j.jhep.2005.04.007_bib4","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.3949\/ccjm.70.Suppl_4.S2","article-title":"The epidemiology and natural history of hepatitis C infection","volume":"70","author":"Zein","year":"2003","journal-title":"Cleve Clin J Med"},{"key":"10.1016\/j.jhep.2005.04.007_bib5","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1046\/j.1440-1746.2002.02730.x","article-title":"Is the severe liver disease a common outcome for people with chronic hepatitis C?","volume":"17","author":"Dore","year":"2002","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2005.04.007_bib6","doi-asserted-by":"crossref","first-page":"21S","DOI":"10.1002\/hep.510260704","article-title":"Natural History of Hepatitis C","volume":"26","author":"Seeff","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2005.04.007_bib7","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1002\/hep.1840360706","article-title":"Natural history of chronic hepatitis C","volume":"36","author":"Seeff","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2005.04.007_bib8","unstructured":"Bericht der Staatlichen Hygiene-Inspektion vom 26. November 1979, Ministerium f\u00fcr Gesundheitswesen der DDR. In: Deutsche Bundestag; Bundesdrucksache 13\/2732 vom 24.10.1995. Bonn: Bundesanzeiger Verlagsgesellschaft mbH; 1995."},{"key":"10.1016\/j.jhep.2005.04.007_bib9","first-page":"759","article-title":"Zum gegenw\u00e4rtigen Erkenntnisstand bei Non-A-Non-B Hepatitis (NANBH)\u2014Eigene Ergebnisse zu Klinik und Epidemiologie","volume":"43","author":"Wiese","year":"1988","journal-title":"Z Klin Med"},{"key":"10.1016\/j.jhep.2005.04.007_bib10","unstructured":"Wiese M. NonA-nonB-hepatitis. Virushepatitis C. Stuttgart: Fischer; 1991."},{"key":"10.1016\/j.jhep.2005.04.007_bib11","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1053\/jhep.2000.8169","article-title":"Low frequency of cirrhosis in a hepatitis C (Genotype 1b) single-source outbreak in Germany: A 20-year multicenter study","volume":"32","author":"Wiese","year":"2000","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2005.04.007_bib12","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/BF01311170","article-title":"Sequence variability in the env-encoding region of hepatitis C virus isolated from patients infected during a single source outbreak","volume":"137","author":"H\u00f6hne","year":"1994","journal-title":"Arch Virol"},{"key":"10.1016\/j.jhep.2005.04.007_bib13","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1056\/NEJM199904223401602","article-title":"Clinical outcomes after hepatitis C infection from contaminated anti-D immune globulin","volume":"340","author":"Kenny-Walsh","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2005.04.007_bib14","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0140-6736(95)91993-7","article-title":"Molecular epidemiology of an outbreak of infection with hepatitis C virus in recipients of anti-D immunoglobulin","volume":"345","author":"Power","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2005.04.007_bib15","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1046\/j.1365-2559.1997.5530803.x","article-title":"Hepatitis C virus liver disease in women infected with contaminated anti-D immunoglobulin","volume":"30","author":"Sheehan","year":"1997","journal-title":"Histopathology"},{"key":"10.1016\/j.jhep.2005.04.007_bib16","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/00042737-199701000-00018","article-title":"Jaundice at onset signifies a good prognosis in anti-D-associated HCV infection","volume":"9","author":"Sachithanandan","year":"1997","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2005.04.007_bib17","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1136\/gut.49.3.423","article-title":"The natural course of hepatitis C infection after 22 years in a unique homogenous cohort: spontaneous viral clearance and chronic HCV infection","volume":"49","author":"Barrett","year":"2001","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2005.04.007_bib18","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/S0016-5085(02)80326-2","article-title":"Whomsoever ignores the natural history of the hepatitis C virus is doomed to treat it","volume":"122","author":"Zucker","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2005.04.007_bib19","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/0168-8278(95)80226-6","article-title":"Histological grading and staging of chronic hepatitis","volume":"22","author":"Ishak","year":"1995","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2005.04.007_bib20","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1053\/jhep.2001.27831","article-title":"Estimating progression to cirrhosis in chronic hepatitis C virus infection","volume":"34","author":"Freeman","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2005.04.007_bib21","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1053\/jhep.2001.21905","article-title":"Long-term mortality and morbidity of transfusion-associated non-A, non-B and type C hepatitis: a National Heart, Lung and Blood Institute collaborative study","volume":"33","author":"Seeff","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2005.04.007_bib22","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1002\/hep.1840140603","article-title":"Long-term clinical and histopathological follow-up of chronic posttransfusion hepatitis","volume":"14","author":"DiBisceglie","year":"1991","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2005.04.007_bib23","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0168-8278(05)80657-9","article-title":"Long-term follow-up of non-A, non-B (type C) posttransfusion hepatitis","volume":"16","author":"Tremolada","year":"1992","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2005.04.007_bib24","doi-asserted-by":"crossref","first-page":"110","DOI":"10.7326\/0003-4819-119-2-199307150-00003","article-title":"Non-A, non-B posttransfusion hepatitis: looking back into the second decade","volume":"119","author":"Koretz","year":"1993","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jhep.2005.04.007_bib25","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1600-0676.1993.tb00644.x","article-title":"Outcome of acute asymptomatic non-A, non-B hepatitis: a thirteen year follow-up study of hepatitis C virus markers","volume":"13","author":"Mattson","year":"1993","journal-title":"Liver"},{"key":"10.1016\/j.jhep.2005.04.007_bib26","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1002\/hep.20221","article-title":"Whom? When? How? Another piece of evidence for early treatment of acute hepatitis C","volume":"39","author":"Wedemeyer","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2005.04.007_bib27","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.jhep.2004.01.012","volume":"40","author":"Shiffman","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2005.04.007_bib28","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0270-9139(03)80149-0","article-title":"International, multicenter, randomized, controlled study for the treatment of patients with chronic hepatitis C and persistently normal ALT levels with peginterferon alpha-2a (40KD) (PEGASYS) and ribavirin (COPEGUS)","volume":"38","author":"Zeuzem","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2005.04.007_bib29","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0140-6736(96)07642-8","article-title":"Natural history of liver fibrosis progression in patients with chronic hepatitis C","volume":"349","author":"Poynard","year":"1997","journal-title":"Lancet"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016882780500317X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016882780500317X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,26]],"date-time":"2019-01-26T04:59:45Z","timestamp":1548478785000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016882780500317X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,10]]}},"alternative-id":["S016882780500317X"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2005.04.007","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2005,10]]}}}