{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T12:46:11Z","timestamp":1776775571581,"version":"3.51.2"},"reference-count":19,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2005,12]]},"DOI":"10.1016\/j.jhep.2005.06.006","type":"journal-article","created":{"date-parts":[[2005,7,12]],"date-time":"2005-07-12T20:06:18Z","timestamp":1121198778000},"page":"951-957","source":"Crossref","is-referenced-by-count":77,"title":["Persistent normalization of serum alanine aminotransferase levels improves the prognosis of type 1 autoimmune hepatitis"],"prefix":"10.1016","volume":"43","author":[{"given":"Yasuhiro","family":"Miyake","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Iwasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Terada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinjiro","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoichi","family":"Okamaoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Makino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruhiko","family":"Kobashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouichi","family":"Takaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohsaku","family":"Sakaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Shiratori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2005.06.006_bib1","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0168-8278(99)80297-9","article-title":"International Autoimmune Hepatitis Group report: review of criteria for diagnosis of autoimmune hepatitis","volume":"31","author":"Alvarez","year":"1999","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2005.06.006_bib2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/oxfordjournals.qjmed.a067264","article-title":"Controlled prospective trial of corticosteroid therapy in active chronic hepatitis","volume":"40","author":"Cook","year":"1971","journal-title":"Q J Med"},{"key":"10.1016\/j.jhep.2005.06.006_bib3","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0140-6736(73)92125-9","article-title":"Controlled trial of prednisone and azathioprine in active chronic hepatitis","volume":"1","author":"Murray-Lyon","year":"1973","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2005.06.006_bib4","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1136\/gut.16.11.876","article-title":"Prednisone for chronic active liver disease: dose titration, standard dose, and combination with azathioprine compared","volume":"16","author":"Summerskill","year":"1975","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2005.06.006_bib5","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/S0016-5085(19)33223-8","article-title":"Clinical, biochemical, and histological remission of severe chronic active liver disease: a controlled study of treatments and early prognosis","volume":"63","author":"Soloway","year":"1972","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2005.06.006_bib6","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1053\/gast.2001.24227","article-title":"Autoimmune hepatitis: clinical challenges","volume":"120","author":"Manns","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2005.06.006_bib7","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.jhep.2004.01.009","article-title":"Decreased fibrosis during corticosteroid therapy of autoimmune hepatitis","volume":"40","author":"Czaja","year":"2004","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2005.06.006_bib8","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1053\/gast.1996.v110.pm8608895","article-title":"Prognosis of histological cirrhosis in type 1 autoimmune hepatitis","volume":"110","author":"Roberts","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2005.06.006_bib9","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1053\/jhep.2002.31872","article-title":"Time-dependent Cox regression model is superior in prediction of prognosis in primary sclerosing cholangitis","volume":"35","author":"Boberg","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2005.06.006_bib10","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1016\/0016-5085(93)91086-W","article-title":"Updating prognosis in primary biliary cirrhosis using a time-dependent Cox regression model. PBC1 and PBC2 trial groups","volume":"105","author":"Christensen","year":"1993","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2005.06.006_bib11","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1002\/hep.1840190629","article-title":"Classification of chronic hepatitis: diagnosis, grading and staging","volume":"19","author":"Desmet","year":"1994","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2005.06.006_bib12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.0954-6820.1964.tb00549.x","article-title":"Correlation between histological findings and serum transaminase values in chronic disease of the liver","volume":"175","author":"Kallai","year":"1964","journal-title":"Acta Med Scand"},{"key":"10.1016\/j.jhep.2005.06.006_bib13","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/0016-5085(81)90126-8","article-title":"Laboratory assessment of severe chronic active liver disease during and after corticosteroid therapy: correlation of serum transaminase and gamma globulin levels with histologic features","volume":"80","author":"Czaja","year":"1981","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2005.06.006_bib14","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1111\/j.1572-0241.2004.30457.x","article-title":"Factors predicting relapse and poor outcome in type I autoimmune hepatitis: role of cirrhosis development, patterns of transaminases during remission and plasma cell activity in the liver biopsy","volume":"99","author":"Verma","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2005.06.006_bib15","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1053\/jhep.2002.32485","article-title":"Sustained remission after corticosteroid therapy for type 1 autoimmune hepatitis: a retrospective analysis","volume":"35","author":"Czaja","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2005.06.006_bib16","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1053\/jhep.2002.34944","article-title":"Diagnosis and treatment of autoimmune hepatitis","volume":"36","author":"Czaja","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2005.06.006_bib17","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/S0168-8278(94)80251-3","article-title":"The nature and prognostic implications of autoimmune hepatitis with an acute presentation","volume":"21","author":"Nikias","year":"1994","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2005.06.006_bib18","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/j.1440-1746.1998.tb00674.x","article-title":"Efficacy of ursodeoxycholic acid in Japanese patients with type 1 autoimmune hepatitis","volume":"13","author":"Nakamura","year":"1998","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2005.06.006_bib19","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1002\/hep.510300603","article-title":"Ursodeoxycholic acid as adjunctive therapy for problematic type 1 autoimmune hepatitis: a randomized placebo-controlled treatment trial","volume":"30","author":"Czaja","year":"1999","journal-title":"Hepatology"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827805004320?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827805004320?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T06:35:20Z","timestamp":1586327720000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827805004320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["S0168827805004320"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2005.06.006","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2005,12]]}}}