{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T11:57:41Z","timestamp":1772366261402,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1016\/j.jhep.2005.07.007","type":"journal-article","created":{"date-parts":[[2005,7,28]],"date-time":"2005-07-28T16:00:22Z","timestamp":1122566422000},"page":"963-970","source":"Crossref","is-referenced-by-count":50,"title":["Microtubules are more stable and more highly acetylated in ethanol-treated hepatic cells"],"prefix":"10.1016","volume":"44","author":[{"given":"George T.","family":"Kannarkat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dean J.","family":"Tuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela L.","family":"Tuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Pt 4","key":"10.1016\/j.jhep.2005.07.007_bib1","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1242\/jcs.107.4.813","article-title":"An improved polarized rat hepatoma hybrid cell line. Generation and comparison with its hepatoma relatives and hepatocytes in vivo","volume":"107","author":"Shanks","year":"1994","journal-title":"J Cell Sci"},{"key":"10.1016\/j.jhep.2005.07.007_bib2","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1016\/j.bcp.2004.01.022","article-title":"WIF-B cells as a model for alcohol-induced hepatocyte injury","volume":"67","author":"Schaffert","year":"2004","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jhep.2005.07.007_bib3","first-page":"1073","article-title":"DNA damage, DNA repair, and alcohol toxicity\u2014a review","volume":"21","author":"Brooks","year":"1997","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.jhep.2005.07.007_bib4","doi-asserted-by":"crossref","first-page":"3758","DOI":"10.1073\/pnas.85.11.3758","article-title":"Nucleoside adducts are formed by cooperative reaction of acetaldehyde and alcohols: possible mechanism for the role of ethanol in carcinogenesis","volume":"85","author":"Fraenkel-Conrat","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jhep.2005.07.007_bib5","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1530-0277.1982.tb05000.x","article-title":"Acetaldehyde adducts of phospholipids","volume":"6","author":"Kenney","year":"1982","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.jhep.2005.07.007_bib6","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0165-1218(78)90103-9","article-title":"Acetaldehyde induces cross-links in DNA and causes sister-chromatid exchanges in human cells","volume":"58","author":"Ristow","year":"1978","journal-title":"Mutat Res"},{"key":"10.1016\/j.jhep.2005.07.007_bib7","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/S0022-2275(20)37711-7","article-title":"Acetaldehyde adducts and autoantibodies against VLDL and LDL in alcoholics","volume":"34","author":"Wehr","year":"1993","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jhep.2005.07.007_bib8","first-page":"5","article-title":"Covalent binding of acetaldehyde to hepatic proteins during ethanol oxidation","volume":"105","author":"Medina","year":"1985","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.jhep.2005.07.007_bib9","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/hep.1840060218","article-title":"Covalent binding of acetaldehyde selectively inhibits the catalytic activity of lysine-dependent enzymes","volume":"6","author":"Mauch","year":"1986","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2005.07.007_bib10","first-page":"103","article-title":"The binding of acetaldehyde to the active site of ribonuclease: alterations in catalytic activity and effects of phosphate","volume":"22","author":"Mauch","year":"1987","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.jhep.2005.07.007_bib11","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/j.1749-6632.1991.tb33920.x","article-title":"Acetaldehyde and microtubules","volume":"625","author":"Tuma","year":"1991","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.jhep.2005.07.007_bib12","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1172\/JCI110043","article-title":"Acetaldehyde adducts with hemoglobin","volume":"67","author":"Stevens","year":"1981","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2005.07.007_bib13","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/oxfordjournals.alcalc.a044914","article-title":"Covalent interactions of acetaldehyde with the actin\/microfilament system","volume":"24","author":"Xu","year":"1989","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.jhep.2005.07.007_bib14","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/0024-3205(89)90036-2","article-title":"Increased covalent binding of acetaldehyde to calmodulin in the presence of calcium","volume":"45","author":"Jennett","year":"1989","journal-title":"Life Sci"},{"key":"10.1016\/j.jhep.2005.07.007_bib15","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1749-6632.1987.tb48681.x","article-title":"The interaction of acetaldehyde with tubulin","volume":"492","author":"Tuma","year":"1987","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.jhep.2005.07.007_bib16","first-page":"271","article-title":"The chemistry of acetaldehyde\u2013protein adducts","volume":"1","author":"Tuma","year":"1991","journal-title":"Alcohol Alcohol Suppl"},{"key":"10.1016\/j.jhep.2005.07.007_bib17","first-page":"G757","article-title":"Ethanol-induced alterations of the microtubule cytoskeleton in hepatocytes","volume":"274","author":"Yoon","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jhep.2005.07.007_bib18","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1083\/jcb.123.6.1761","article-title":"WIF-B cells: an in vitro model for studies of hepatocyte polarity","volume":"123","author":"Ihrke","year":"1993","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jhep.2005.07.007_bib19","first-page":"197","article-title":"Liquid diet technique of ethanol administration: 1989 update","volume":"24","author":"Lieber","year":"1989","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.jhep.2005.07.007_bib20","first-page":"455","article-title":"Effects of ethanol on liver microtubules and Golgi apparatus. Possible role in altered hepatic secretion of plasma proteins","volume":"41","author":"Matsuda","year":"1979","journal-title":"Lab Invest"},{"key":"10.1016\/j.jhep.2005.07.007_bib21","first-page":"G111","article-title":"Protection against ethanol injury by prostaglandin in a human intestinal cell line: role of microtubules","volume":"274","author":"Banan","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jhep.2005.07.007_bib22","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/nrm1260","article-title":"Post-translational modifications regulate microtubule function","volume":"4","author":"Westermann","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jhep.2005.07.007_bib23","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1083\/jcb.103.1.13","article-title":"Cytoplasmic microtubules containing acetylated alpha-tubulin in Chlamydomonas reinhardtii: spatial arrangement and properties","volume":"103","author":"LeDizet","year":"1986","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jhep.2005.07.007_bib24","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1083\/jcb.104.2.289","article-title":"Microtubules containing acetylated alpha-tubulin in mammalian cells in culture","volume":"104","author":"Piperno","year":"1987","journal-title":"J Cell Biol"},{"issue":"Pt 1","key":"10.1016\/j.jhep.2005.07.007_bib25","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1242\/jcs.92.1.57","article-title":"Microtubules are acetylated in domains that turn over slowly","volume":"92","author":"Webster","year":"1989","journal-title":"J Cell Sci"},{"key":"10.1016\/j.jhep.2005.07.007_bib26","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1093\/emboj\/19.6.1176","article-title":"Acetylation: a regulatory modification to rival phosphorylation?","volume":"19","author":"Kouzarides","year":"2000","journal-title":"Eur Mol Biol Org J"},{"key":"10.1016\/j.jhep.2005.07.007_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/gb-2002-3-5-reviews0006","article-title":"The diversity of acetylated proteins","volume":"3","author":"Polevoda","year":"2002","journal-title":"Genome Biol"},{"key":"10.1016\/j.jhep.2005.07.007_bib28","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/417455a","article-title":"HDAC6 is a microtubule-associated deacetylase","volume":"417","author":"Hubbert","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2005.07.007_bib29","doi-asserted-by":"crossref","first-page":"6820","DOI":"10.1093\/emboj\/cdf682","article-title":"In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation","volume":"21","author":"Matsuyama","year":"2002","journal-title":"Eur Mol Biol Org J"},{"key":"10.1016\/j.jhep.2005.07.007_bib30","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S1097-2765(03)00038-8","article-title":"The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase","volume":"11","author":"North","year":"2003","journal-title":"Mol Cell"},{"key":"10.1016\/j.jhep.2005.07.007_bib31","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1093\/emboj\/cdg115","article-title":"HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo","volume":"22","author":"Zhang","year":"2003","journal-title":"Eur Mol Biol Org J"},{"key":"10.1016\/j.jhep.2005.07.007_bib32","doi-asserted-by":"crossref","first-page":"4868","DOI":"10.1073\/pnas.96.9.4868","article-title":"Three proteins define a class of human histone deacetylases related to yeast Hda1p","volume":"96","author":"Grozinger","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"issue":"Pt 5","key":"10.1016\/j.jhep.2005.07.007_bib33","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1242\/jcs.107.5.1321","article-title":"A possible role for stable microtubules in intracellular transport from the endoplasmic reticulum to the Golgi apparatus","volume":"107","author":"Mizuno","year":"1994","journal-title":"J Cell Sci"},{"key":"10.1016\/j.jhep.2005.07.007_bib34","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1083\/jcb.142.1.153","article-title":"Functional specialization of stable and dynamic microtubules in protein traffic in WIF-B cells","volume":"142","author":"Pous","year":"1998","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jhep.2005.07.007_bib35","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/oxfordjournals.alcalc.a044986","article-title":"Effects of ethanol on hepatic protein trafficking: impairment of receptor-mediated endocytosis","volume":"25","author":"Tuma","year":"1990","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.jhep.2005.07.007_bib36","first-page":"297","article-title":"Effects of alcohol on hepatic protein metabolism and trafficking","volume":"1","author":"Tuma","year":"1991","journal-title":"Alcohol Alcohol Suppl"},{"key":"10.1016\/j.jhep.2005.07.007_bib37","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1055\/s-2008-1040529","article-title":"Effects of ethanol on protein trafficking in the liver","volume":"8","author":"Tuma","year":"1988","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jhep.2005.07.007_bib38","doi-asserted-by":"crossref","first-page":"9797","DOI":"10.1074\/jbc.273.16.9797","article-title":"Kinesin is a candidate for cross-bridging microtubules and intermediate filaments. Selective binding of kinesin to detyrosinated tubulin and vimentin","volume":"273","author":"Liao","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2005.07.007_bib39","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/0003-9861(87)90420-6","article-title":"Covalent binding of acetaldehyde to tubulin: evidence for preferential binding to the alpha-chain","volume":"256","author":"Jennett","year":"1987","journal-title":"Arch Biochem Biophys"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827805004939?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827805004939?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T00:15:27Z","timestamp":1626221727000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827805004939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["S0168827805004939"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2005.07.007","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1029784.347588","asserted-by":"object"}]},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}