{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T18:53:44Z","timestamp":1773428024651,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1016\/j.jhep.2006.06.016","type":"journal-article","created":{"date-parts":[[2006,7,30]],"date-time":"2006-07-30T06:01:00Z","timestamp":1154239260000},"page":"825-835","source":"Crossref","is-referenced-by-count":38,"title":["Secretin receptors in the human liver: Expression in biliary tract and cholangiocarcinoma, but not in hepatocytes or hepatocellular carcinoma"],"prefix":"10.1016","volume":"45","author":[{"given":"Meike","family":"K\u00f6rner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory M.","family":"Hayes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Rehmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"Scholz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertram","family":"Wiedenmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence J.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Claude","family":"Reubi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2006.06.016_bib1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1210\/er.2002-0007","article-title":"Peptide receptors as molecular targets for cancer diagnosis and therapy","volume":"24","author":"Reubi","year":"2003","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jhep.2006.06.016_bib2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.7326\/0003-4819-125-1-199607010-00005","article-title":"Somatostatin receptor scintigraphy: its sensitivity compared with that of other imaging methods in detecting primary and metastatic gastrinomas","volume":"125","author":"Gibril","year":"1996","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jhep.2006.06.016_bib3","first-page":"610","article-title":"Tumor response and clinical benefit in neuroendocrine tumors after 7.4 GBq (90)Y-DOTATOC","volume":"43","author":"Waldherr","year":"2002","journal-title":"J Nucl Med"},{"key":"10.1016\/j.jhep.2006.06.016_bib4","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1200\/JCO.2005.08.066","article-title":"Radiolabeled somatostatin analog [177Lu-DOTA0,Tyr3]octreotate in patients with endocrine gastroenteropancreatic tumors","volume":"23","author":"Kwekkeboom","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jhep.2006.06.016_bib5","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1159\/000049160","article-title":"Established clinical use of octreotide and lanreotide in oncology","volume":"47","author":"Oberg","year":"2001","journal-title":"Chemotherapy"},{"key":"10.1016\/j.jhep.2006.06.016_bib6","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1002\/j.1460-2075.1991.tb07686.x","article-title":"Molecular cloning and expression of a cDNA encoding the secretin receptor","volume":"10","author":"Ishihara","year":"1991","journal-title":"EMBO J"},{"key":"10.1016\/j.jhep.2006.06.016_bib7","doi-asserted-by":"crossref","unstructured":"Harmar AJ. Family-B G-protein-coupled receptors. Genome Biol 2001; 2:reviews3013.1-3013.10.","DOI":"10.1186\/gb-2001-2-12-reviews3013"},{"key":"10.1016\/j.jhep.2006.06.016_bib8","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S0002-9440(10)61186-8","article-title":"Secretin receptors in normal and diseased human pancreas: marked reduction of receptor binding in ductal neoplasia","volume":"167","author":"K\u00f6rner","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jhep.2006.06.016_bib9","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1007\/s00535-003-1235-3","article-title":"Secretin, 100 years later","volume":"38","author":"Chey","year":"2003","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.jhep.2006.06.016_bib10","first-page":"195","article-title":"Gastrin release from antral G cells stimulated with secretin","volume":"87","author":"Hattori","year":"1992","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2006.06.016_bib11","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1038\/bjc.1997.251","article-title":"Expression of receptors for gut peptides in human pancreatic adenocarcinoma and tumour-free pancreas","volume":"75","author":"Tang","year":"1997","journal-title":"Br J Cancer"},{"key":"10.1016\/j.jhep.2006.06.016_bib12","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1136\/gut.40.2.267","article-title":"Expression of peptide receptors in human endocrine tumours of the pancreas","volume":"40","author":"Tang","year":"1997","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2006.06.016_bib13","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1172\/JCI107817","article-title":"Canalicular bile secretion in man. Studies utilizing the biliary clearance of (14C)mannitol","volume":"54","author":"Boyer","year":"1974","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2006.06.016_bib14","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1136\/gut.15.4.273","article-title":"Secretion of water and electrolytes into the duodenum in normal subjects and in patients with cirrhosis: the response to secretin and pancreozymin","volume":"15","author":"Turnberg","year":"1974","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2006.06.016_bib15","doi-asserted-by":"crossref","first-page":"697","DOI":"10.3109\/00365527209180980","article-title":"Choleresis induced by secretin: distinctly increased response in cirrhotics","volume":"7","author":"Bode","year":"1972","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.jhep.2006.06.016_bib16","first-page":"G1064","article-title":"Large but not small intrahepatic bile ducts are involved in secretin-regulated ductal bile secretion","volume":"272","author":"Alpini","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jhep.2006.06.016_bib17","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1172\/JCI116705","article-title":"Effect of secretion on intracellular pH regulation in isolated rat bile duct epithelial cells","volume":"92","author":"Alvaro","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2006.06.016_bib18","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/0016-5085(92)90183-Y","article-title":"Localization and characterization of secretin binding sites expressed by rat bile duct epithelium","volume":"102","author":"Farouk","year":"1992","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2006.06.016_bib19","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1053\/gast.1996.v110.pm8613073","article-title":"Morphological, molecular, and functional heterogeneity of cholangiocytes from normal rat liver","volume":"110","author":"Alpini","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2006.06.016_bib20","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.amjsurg.2004.01.007","article-title":"Outcomes after resection of cholangiocellular carcinoma","volume":"187","author":"Huang","year":"2004","journal-title":"Am J Surg"},{"key":"10.1016\/j.jhep.2006.06.016_bib21","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/S0959-8049(97)10166-6","article-title":"The role of chemotherapy and radiation in the management of biliary cancer: a review of the literature","volume":"34","author":"Hejna","year":"1998","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jhep.2006.06.016_bib22","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1056\/NEJM199910283411807","article-title":"Biliary tract cancers","volume":"341","author":"de Groen","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2006.06.016_bib23","series-title":"World Health Organization classification of tumours. Pathology and genetics of tumours of the digestive system","author":"Hamilton","year":"2000"},{"key":"10.1016\/j.jhep.2006.06.016_bib24","first-page":"G1437","article-title":"Cellular distribution of secretin receptor expression in rat pancreas","volume":"275","author":"Ulrich","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jhep.2006.06.016_bib25","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/S0016-5085(98)70491-3","article-title":"Secretin and vasoactive intestinal peptide receptors: members of a unique family of G protein-coupled receptors","volume":"114","author":"Ulrich","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2006.06.016_bib26","first-page":"467","article-title":"Molecular cloning and expression of a human secretin receptor","volume":"47","author":"Patel","year":"1995","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.jhep.2006.06.016_bib27","first-page":"397","article-title":"Morphometric and immunohistochemical characterization of human liver regeneration","volume":"147","author":"Rubin","year":"1995","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jhep.2006.06.016_bib28","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1097\/01.pas.0000174013.14569.90","article-title":"Value of immunohistochemistry for somatostatin receptor subtype sst2A in cancer tissues: lessons from the comparison of anti-sst2A antibodies with somatostatin receptor autoradiography","volume":"29","author":"K\u00f6rner","year":"2005","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.jhep.2006.06.016_bib29","first-page":"5223","article-title":"Silencing of secretin receptor function by dimerization with a misspliced variant secretin receptor in ductal pancreatic adenocarcinoma","volume":"62","author":"Ding","year":"2002","journal-title":"Cancer Res"},{"key":"10.1016\/j.jhep.2006.06.016_bib30","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/(SICI)1097-0029(19970915)38:6<552::AID-JEMT2>3.0.CO;2-H","article-title":"Microstructure and development of the normal and pathologic biliary tract in humans, including blood supply","volume":"38","author":"Nakanuma","year":"1997","journal-title":"Microsc Res Tech"},{"key":"10.1016\/j.jhep.2006.06.016_bib31","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1002\/hep.20130","article-title":"Nomenclature of the finer branches of the biliary tree: canals, ductules, and ductular reactions in human livers","volume":"39","author":"Roskams","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2006.06.016_bib32","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1006\/bbrc.1995.1268","article-title":"Molecular cloning and functional expression of a human pancreatic secretin receptor","volume":"207","author":"Jiang","year":"1995","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jhep.2006.06.016_bib33","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1053\/gast.2002.31039","article-title":"Dominant negative action of an abnormal secretin receptor arising from mRNA missplicing in a gastrinoma","volume":"122","author":"Ding","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2006.06.016_bib34","first-page":"3105","article-title":"Vasoactive intestinal peptide\/pituitary adenylate cyclase-activating peptide receptor subtypes in human tumors and their tissues of origin","volume":"60","author":"Reubi","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.jhep.2006.06.016_bib35","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1172\/JCI111713","article-title":"Glucagon receptor of human liver. Studies of its molecular weight and binding properties, and its ability to activate hepatic adenylyl cyclase of non-obese and obese subjects","volume":"75","author":"Livingston","year":"1985","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2006.06.016_bib36","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1002\/hep.1840190613","article-title":"Immunohistochemical detection of chloride\/bicarbonate anion exchangers in human liver","volume":"19","author":"Mart\u00ednez-Ans\u00f3","year":"1994","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2006.06.016_bib37","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jchemneu.2003.07.003","article-title":"Functional autoradiography of neuropeptide Y Y1 and Y2 receptor subtypes in rat brain using agonist stimulated [35S]GTPgammaS binding","volume":"26","author":"Shaw","year":"2003","journal-title":"J Chem Neuroanat"},{"key":"10.1016\/j.jhep.2006.06.016_bib38","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1136\/gut.11.2.126","article-title":"Bile salt secretion in cirrhosis of the liver","volume":"11","author":"Turnberg","year":"1970","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2006.06.016_bib39","first-page":"G922","article-title":"Upregulation of secretin receptor gene expression in rat cholangiocytes after bile duct ligation","volume":"266","author":"Alpini","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jhep.2006.06.016_bib40","first-page":"G289","article-title":"Molecular and functional heterogeneity of cholangiocytes from rat liver after bile duct ligation","volume":"272","author":"Alpini","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jhep.2006.06.016_bib41","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/0016-5085(89)91503-5","article-title":"Effect of secretin on bile formation in rats with cirrhosis of the liver: structure-function relationship","volume":"97","author":"Knuchel","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2006.06.016_bib42","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1172\/JCI113355","article-title":"Biliary physiology in rats with bile ductular cell hyperplasia. Evidence for a secretory function of proliferated bile ductules","volume":"81","author":"Alpini","year":"1988","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2006.06.016_bib43","first-page":"G527","article-title":"Secretin stimulates bile ductular secretory activity through the cAMP system","volume":"263","author":"Lenzen","year":"1992","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jhep.2006.06.016_bib44","first-page":"313","article-title":"An increase of choleresis in secondary biliary cirrhosis in rats is caused by bile duct secretion","volume":"14","author":"Taillandier","year":"1990","journal-title":"Gastroenterol Clin Biol"},{"key":"10.1016\/j.jhep.2006.06.016_bib45","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/0016-5085(89)90510-6","article-title":"Mechanism for increase of gastrin release by secretin in Zollinger-Ellison syndrome","volume":"96","author":"Chiba","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2006.06.016_bib46","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1016\/0016-5085(90)91105-F","article-title":"Growth effects of regulatory peptides on human pancreatic cancer lines PANC-1 and MIA PaCa-2","volume":"98","author":"Liehr","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2006.06.016_bib47","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1385\/ENDO:9:2:171","article-title":"Growth effects of regulatory peptides and intracellular signaling routes in human pancreatic cancer cell lines","volume":"9","author":"Douziech","year":"1998","journal-title":"Endocrine"},{"key":"10.1016\/j.jhep.2006.06.016_bib48","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/hep.20537","article-title":"Cholangiocarcinoma: molecular targeting strategies for chemoprevention and therapy","volume":"41","author":"Sirica","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2006.06.016_bib49","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1080\/003655202753416911","article-title":"Absence of therapeutic efficacy of the somatostatin analogue lanreotide in advanced primary hepatic cholangiocellular cancer and adenocarcinoma of the gallbladder despite in vivo somatostatin-receptor expression","volume":"37","author":"Fiebiger","year":"2002","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.jhep.2006.06.016_bib50","first-page":"1841","article-title":"Tumor response after [(90)Y-DOTA(0),Tyr(3)]octreotide radionuclide therapy in a transplantable rat tumor model is dependent on tumor size","volume":"42","author":"de Jong","year":"2001","journal-title":"J Nucl Med"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827806003898?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827806003898?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,20]],"date-time":"2019-04-20T11:30:15Z","timestamp":1555759815000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827806003898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["S0168827806003898"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2006.06.016","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}