{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:03:39Z","timestamp":1789736619284,"version":"4.0.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1016\/j.jhep.2006.09.007","type":"journal-article","created":{"date-parts":[[2006,10,24]],"date-time":"2006-10-24T17:57:34Z","timestamp":1161712654000},"page":"230-238","source":"Crossref","is-referenced-by-count":87,"title":["Prevention of severe toxic liver injury and oxidative stress in MCP-1-deficient mice"],"prefix":"10.1016","volume":"46","author":[{"given":"Elena","family":"Zamara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Galastri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Aleffi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Petrai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Aragno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Mastrocola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Novo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiana","family":"Bertolani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Milani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Vizzutti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Vercelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Pinzani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Laffi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"LaVilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Parola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Marra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2006.09.007_bib1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0168-8278(01)00142-8","article-title":"Oxidative stress-related molecules and liver fibrosis","volume":"35","author":"Parola","year":"2001","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2006.09.007_bib2","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1056\/NEJMra052723","article-title":"The many roles of chemokines and chemokine receptors in inflammation","volume":"354","author":"Charo","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2006.09.007_bib3","doi-asserted-by":"crossref","first-page":"d1899","DOI":"10.2741\/marra","article-title":"Chemokines in liver inflammation and fibrosis","volume":"7","author":"Marra","year":"2002","journal-title":"Front Biosci"},{"key":"10.1016\/j.jhep.2006.09.007_bib4","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1080\/mic.10.3-4.247.257","article-title":"Monocyte chemoattractant protein-1 (CCL2) in inflammatory disease and adaptive immunity: therapeutic opportunities and controversies","volume":"10","author":"Daly","year":"2003","journal-title":"Microcirculation"},{"key":"10.1016\/j.jhep.2006.09.007_bib5","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/hep.510290107","article-title":"Monocyte chemotactic protein-1 as a chemoattractant for human hepatic stellate cells","volume":"29","author":"Marra","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2006.09.007_bib6","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1189\/jlb.0903421","article-title":"MCP-1-dependent signaling in CCR2(-\/-) aortic smooth muscle cells","volume":"75","author":"Schecter","year":"2004","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jhep.2006.09.007_bib7","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1084\/jem.193.6.713","article-title":"Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis","volume":"193","author":"Huang","year":"2001","journal-title":"J Exp Med"},{"key":"10.1016\/j.jhep.2006.09.007_bib8","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0002-9440(10)63292-0","article-title":"Blockade of CCR2 ameliorates progressive fibrosis in kidney","volume":"165","author":"Kitagawa","year":"2004","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jhep.2006.09.007_bib9","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/S0002-9440(10)64995-4","article-title":"Exaggerated hepatic injury due to acetaminophen challenge in mice lacking C-C chemokine receptor 2","volume":"156","author":"Hogaboam","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jhep.2006.09.007_bib10","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.4049\/jimmunol.174.3.1549","article-title":"Monocyte chemoattractant protein-1 and CCR2 interactions are required for IFN-alpha\/beta-induced inflammatory responses and antiviral defense in liver","volume":"174","author":"Hokeness","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.jhep.2006.09.007_bib11","doi-asserted-by":"crossref","first-page":"6514","DOI":"10.1128\/IAI.73.10.6514-6522.2005","article-title":"The chemokine CCL2 is required for control of murine gastric Salmonella enterica infection","volume":"73","author":"Depaolo","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.jhep.2006.09.007_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj2220001","article-title":"Free radical mechanisms in tissue injury","volume":"222","author":"Slater","year":"1984","journal-title":"Biochem J"},{"key":"10.1016\/j.jhep.2006.09.007_bib13","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1093\/oxfordjournals.bmb.a072634","article-title":"Liver damage due to free radicals","volume":"49","author":"Poli","year":"1993","journal-title":"Br Med Bull"},{"key":"10.1016\/j.jhep.2006.09.007_bib14","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/path.1711660406","article-title":"Macrophage and perisinusoidal cell kinetics in acute liver injury","volume":"166","author":"Johnson","year":"1992","journal-title":"J Pathol"},{"key":"10.1016\/j.jhep.2006.09.007_bib15","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1084\/jem.187.4.601","article-title":"Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice","volume":"187","author":"Lu","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.jhep.2006.09.007_bib16","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1002\/hep.20965","article-title":"Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells","volume":"42","author":"Aleffi","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2006.09.007_bib17","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.2337\/diabetes.53.4.1082","article-title":"Oxidative stress impairs skeletal muscle repair in diabetic rats","volume":"53","author":"Aragno","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.jhep.2006.09.007_bib18","doi-asserted-by":"crossref","first-page":"5561","DOI":"10.1210\/en.2005-0712","article-title":"Up-regulation of advanced glycated products receptors in the brain of diabetic rats is prevented by antioxidant treatment","volume":"146","author":"Aragno","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.jhep.2006.09.007_bib19","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0168-8278(03)00480-X","article-title":"4-Hydroxynonenal as a selective pro-fibrogenic stimulus for activated human hepatic stellate cells","volume":"40","author":"Zamara","year":"2004","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2006.09.007_bib20","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/S0076-6879(94)33064-6","article-title":"Animal models and molecular markers for cerebral ischemia-reperfusion injury in brain","volume":"233","author":"Ravindranath","year":"1994","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.jhep.2006.09.007_bib21","doi-asserted-by":"crossref","first-page":"5252","DOI":"10.4049\/jimmunol.170.10.5252","article-title":"C-C chemokine ligand 2\/monocyte chemoattractant protein-1 directly inhibits NKT cell IL-4 production and is hepatoprotective in T cell-mediated hepatitis in the mouse","volume":"170","author":"Ajuebor","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.jhep.2006.09.007_bib22","doi-asserted-by":"crossref","first-page":"12053","DOI":"10.1073\/pnas.94.22.12053","article-title":"Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2","volume":"94","author":"Kuziel","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jhep.2006.09.007_bib23","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1172\/JCI119475","article-title":"MCP-1 protects mice in lethal endotoxemia","volume":"99","author":"Zisman","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2006.09.007_bib24","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1172\/JCI200420126","article-title":"Experimental arthritis in CC chemokine receptor 2-null mice closely mimics severe human rheumatoid arthritis","volume":"113","author":"Quinones","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2006.09.007_bib25","doi-asserted-by":"crossref","first-page":"G765","DOI":"10.1152\/ajpgi.00308.2005","article-title":"Secretion of MCP-1\/CCL2 by bile duct epithelia induces myofibroblastic transdifferentiation of portal fibroblasts","volume":"290","author":"Kruglov","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jhep.2006.09.007_bib26","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1172\/JCI119798","article-title":"Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice","volume":"100","author":"Boring","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2006.09.007_bib27","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/35006097","article-title":"Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1","volume":"404","author":"Gu","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2006.09.007_bib28","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.virol.2004.09.006","article-title":"Differential roles of CCL2 and CCR2 in host defense to coronavirus infection","volume":"329","author":"Held","year":"2004","journal-title":"Virology"},{"key":"10.1016\/j.jhep.2006.09.007_bib29","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/ncpgasthep0055","article-title":"Mechanisms of disease: mechanisms of hepatic fibrosis and therapeutic implications","volume":"1","author":"Friedman","year":"2004","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2006.09.007_bib30","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1053\/j.gastro.2004.10.005","article-title":"Suppression of macrophage infiltration inhibits activation of hepatic stellate cells and liver fibrogenesis in rats","volume":"128","author":"Imamura","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2006.09.007_bib31","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1136\/gut.2005.068593","article-title":"Renaming cytokines: MCP-1, major chemokine in pancreatitis","volume":"54","author":"Marra","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2006.09.007_bib32","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S1097-2765(00)80139-2","article-title":"Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice","volume":"2","author":"Gu","year":"1998","journal-title":"Mol Cell"},{"key":"10.1016\/j.jhep.2006.09.007_bib33","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1084\/jem.190.12.1813","article-title":"Monocyte chemoattractant protein 1-dependent leukocytic infiltrates are responsible for autoimmune disease in MRL-Fas(lpr) mice","volume":"190","author":"Tesch","year":"1999","journal-title":"J Exp Med"},{"key":"10.1016\/j.jhep.2006.09.007_bib34","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1002\/path.1362","article-title":"Impaired hepatic granuloma formation in mice deficient in C-C chemokine receptor 2","volume":"200","author":"Jinnouchi","year":"2003","journal-title":"J Pathol"},{"key":"10.1016\/j.jhep.2006.09.007_bib35","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/hep.510250218","article-title":"Neutrophil-derived superoxide anion induces lipid peroxidation and stimulates collagen synthesis in human hepatic stellate cells: role of nitric oxide","volume":"25","author":"Casini","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2006.09.007_bib36","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/toxsci\/65.2.166","article-title":"Mechanisms of hepatotoxicity","volume":"65","author":"Jaeschke","year":"2002","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.jhep.2006.09.007_bib37","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0014-5793(85)80790-0","article-title":"Carbon tetrachloride induced lipid peroxidation is dependent on an ethanol-inducible form of rabbit liver microsomal cytochrome P450","volume":"183","author":"Johansson","year":"1985","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jhep.2006.09.007_bib38","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1152\/physrev.1997.77.2.517","article-title":"Cytochrome P4502E1: its physiological and pathological role","volume":"77","author":"Lieber","year":"1997","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jhep.2006.09.007_bib39","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/713611034","article-title":"Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model","volume":"33","author":"Weber","year":"2003","journal-title":"Crit Rev Toxicol"},{"key":"10.1016\/j.jhep.2006.09.007_bib40","first-page":"66","article-title":"Expression of monocyte chemotactic protein-1 precedes monocyte recruitment in a rat model of acute liver injury, and is modulated by vitamin E","volume":"47","author":"Marra","year":"1999","journal-title":"J Investig Med"},{"key":"10.1016\/j.jhep.2006.09.007_bib41","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/jlb.55.1.120","article-title":"Monocyte chemoattractant protein 1 (MCP-1) expression occurs in toxic rat liver injury and human liver disease","volume":"55","author":"Czaja","year":"1994","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jhep.2006.09.007_bib42","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1172\/JCI116753","article-title":"Cultured human liver fat-storing cells produce monocyte chemotactic protein-1. Regulation by proinflammatory cytokines","volume":"92","author":"Marra","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2006.09.007_bib43","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1053\/gast.1996.v110.pm8964413","article-title":"Regulation of monocyte chemoattractant protein 1 by cytokines and oxygen free radicals in rat hepatic fat storing cells","volume":"110","author":"Xu","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2006.09.007_bib44","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.tox.2005.10.012","article-title":"The course of CCl4 induced hepatotoxicity is altered in mGST 4-4 null (-\/-) mice","volume":"218","author":"Dwivedi","year":"2006","journal-title":"Toxicology"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827806005538?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827806005538?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T00:04:25Z","timestamp":1555891465000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827806005538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S0168827806005538"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2006.09.007","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]}}}