{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T05:59:34Z","timestamp":1769147974560,"version":"3.49.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1016\/j.jhep.2007.08.012","type":"journal-article","created":{"date-parts":[[2007,11,13]],"date-time":"2007-11-13T12:22:34Z","timestamp":1194956554000},"page":"61-67","source":"Crossref","is-referenced-by-count":47,"title":["Presence of bacterial-DNA in cirrhosis identifies a subgroup of patients with marked inflammatory response not related to endotoxin"],"prefix":"10.1016","volume":"48","author":[{"given":"Jos\u00e9 M.","family":"Gonz\u00e1lez-Navajas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Bellot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rub\u00e9n","family":"Franc\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Zapater","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"Garc\u00eda-Pag\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Pascual","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"P\u00e9rez-Mateo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Bosch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Such","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2007.08.012_bib1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1086\/514940","article-title":"Spontaneous bacterial peritonitis","volume":"27","author":"Such","year":"1998","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jhep.2007.08.012_bib2","first-page":"217","article-title":"Bacterial translocation from the gastrointestinal tract","volume":"23","author":"Berg","year":"1992","journal-title":"J Med"},{"key":"10.1016\/j.jhep.2007.08.012_bib3","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1053\/jhep.2003.50038","article-title":"Increased lipopolysaccharide binding protein in cirrhotic patients with marked immune and hemodynamic derangement","volume":"37","author":"Albillos","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2007.08.012_bib4","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1053\/jhep.2002.33715","article-title":"Detection and identification of bacterial DNA in patients with cirrhosis and culture-negative, nonneutrocytic ascites","volume":"36","author":"Such","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2007.08.012_bib5","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/hep.21286","article-title":"The detection of bacterial DNA in blood of rats with CCl(4)-induced cirrhosis with ascites represents episodes of bacterial translocation","volume":"44","author":"Guarner","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2007.08.012_bib6","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0168-8278(00)00013-1","article-title":"Bacterial translocation of enteric organisms in patients with cirrhosis","volume":"34","author":"Cirera","year":"2001","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2007.08.012_bib7","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1053\/jhep.2002.30082","article-title":"Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis","volume":"35","author":"Fernandez","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2007.08.012_bib8","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/hep.20055","article-title":"A sequential study of serum bacterial DNA in patients with advanced cirrhosis and ascites","volume":"39","author":"Frances","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2007.08.012_bib9","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1136\/gut.2003.027425","article-title":"Bacterial DNA activates cell mediated immune response and nitric oxide overproduction in peritoneal macrophages from patients with cirrhosis and ascites","volume":"53","author":"Frances","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2007.08.012_bib10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/00042737-200501000-00010","article-title":"Intracellular cytokine expression in peritoneal monocyte\/macrophages obtained from patients with cirrhosis and presence of bacterial DNA","volume":"17","author":"Frances","year":"2005","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2007.08.012_bib11","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1001\/jama.273.2.117","article-title":"The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study","volume":"273","author":"Rangel-Frausto","year":"1995","journal-title":"JAMA"},{"key":"10.1016\/j.jhep.2007.08.012_bib12","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1476-5381.1992.tb14365.x","article-title":"Dependence of the metabolism of nitric oxide (NO) in healthy human whole blood on the oxygenation of its red cell haemoglobin","volume":"106","author":"Wennmalm","year":"1992","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jhep.2007.08.012_bib13","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1002\/hep.1840180520","article-title":"Increased serum nitrite and nitrate levels in patients with cirrhosis: relationship to endotoxemia","volume":"18","author":"Guarner","year":"1993","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2007.08.012_bib14","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1084\/jem.179.1.269","article-title":"Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14","volume":"179","author":"Hailman","year":"1994","journal-title":"J Exp Med"},{"key":"10.1016\/j.jhep.2007.08.012_bib15","doi-asserted-by":"crossref","first-page":"4100","DOI":"10.1074\/jbc.271.8.4100","article-title":"Catalytic properties of lipopolysaccharide (LPS) binding protein. Transfer of LPS to soluble CD14","volume":"271","author":"Yu","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2007.08.012_bib16","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/39622","article-title":"Lipopolysaccharide-binding protein is required to combat a murine Gram-negative bacterial infection","volume":"389","author":"Jack","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2007.08.012_bib17","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.4049\/jimmunol.167.5.2759","article-title":"Critical role of lipopolysaccharide-binding protein and CD14 in immune responses against Gram-negative bacteria","volume":"167","author":"Le Roy","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.jhep.2007.08.012_bib18","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0952-7915(99)00046-1","article-title":"Tlr4: central component of the sole mammalian LPS sensor","volume":"12","author":"Beutler","year":"2000","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jhep.2007.08.012_bib19","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/35047123","article-title":"A Toll-like receptor recognizes bacterial DNA","volume":"408","author":"Hemmi","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2007.08.012_bib20","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S1074-7613(01)00144-3","article-title":"Toll meets bacterial CpG-DNA","volume":"14","author":"Wagner","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.jhep.2007.08.012_bib21","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1128\/IAI.62.7.2715-2721.1994","article-title":"Gram-positive cell walls stimulate synthesis of tumor necrosis factor alpha and interleukin-6 by human monocytes","volume":"62","author":"Heumann","year":"1994","journal-title":"Infect Immun"},{"key":"10.1016\/j.jhep.2007.08.012_bib22","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1007\/s10875-007-9090-2","article-title":"Bacterial DNA induces the complement system activation in serum and ascitic fluid from patients with advanced cirrhosis","volume":"27","author":"Frances","year":"2007","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jhep.2007.08.012_bib23","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1006\/cimm.1999.1572","article-title":"Immunostimulatory DNA pre-priming: a novel approach for prolonged Th1-biased immunity","volume":"198","author":"Kobayashi","year":"1999","journal-title":"Cell Immunol"},{"key":"10.1016\/j.jhep.2007.08.012_bib24","first-page":"G1281","article-title":"NOX, a novel nitric oxide scavenger, reduces bacterial translocation in rats after endotoxin challenge","volume":"277","author":"Dickinson","year":"1999","journal-title":"Am J Physiol"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827807005594?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827807005594?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T01:42:13Z","timestamp":1588038133000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827807005594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S0168827807005594"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2007.08.012","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}