{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:16:53Z","timestamp":1791040613088,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1016\/j.jhep.2007.11.022","type":"journal-article","created":{"date-parts":[[2008,1,17]],"date-time":"2008-01-17T12:39:57Z","timestamp":1200573597000},"page":"721-727","source":"Crossref","is-referenced-by-count":151,"title":["Effect of sustained virological response to treatment on the incidence of abnormal glucose values in chronic hepatitis C"],"prefix":"10.1016","volume":"48","author":[{"given":"Manuel","family":"Romero-G\u00f3mez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conrado M.","family":"Fern\u00e1ndez-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal J.","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mois\u00e9s","family":"Diago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n","family":"Planas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricard","family":"Sol\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"Pons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Salmer\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Barcena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Carmona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Dur\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2007.11.022_bib1","doi-asserted-by":"crossref","first-page":"7075","DOI":"10.3748\/wjg.v12.i44.7075","article-title":"Hepatitis C and insulin resistance","volume":"12","author":"Romero-G\u00f3mez","year":"2006","journal-title":"WJG"},{"key":"10.1016\/j.jhep.2007.11.022_bib2","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.2337\/dc05-2509","article-title":"Proinflammatory cytokines, insulin resistance, and insulin secretion in chronic hepatitis C patients: a case-control study","volume":"295","author":"Lecube","year":"2006","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jhep.2007.11.022_bib3","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1053\/j.gastro.2003.11.056","article-title":"Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance","volume":"126","author":"Shintani","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2007.11.022_bib4","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1053\/j.gastro.2004.12.049","article-title":"Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients","volume":"128","author":"Romero-Gomez","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2007.11.022_bib5","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.2337\/dc05-1995","article-title":"Glucose abnormalities in patients with hepatitis C virus infection: epidemiology and pathogenesis","volume":"29","author":"Lecube","year":"2006","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jhep.2007.11.022_bib6","doi-asserted-by":"crossref","first-page":"592","DOI":"10.7326\/0003-4819-133-8-200010170-00009","article-title":"Prevalence of type 2 diabetes mellitus among persons with hepatitis C virus infection in the United States","volume":"133","author":"Mehta","year":"2000","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jhep.2007.11.022_bib7","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1111\/j.1572-0241.2003.08728.x","article-title":"Tumor necrosis factor-alpha-induced insulin resistance may mediate the hepatitis C virus-diabetes association","volume":"98","author":"Knobler","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2007.11.022_bib8","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/S0002-9440(10)63408-6","article-title":"Hepatitis C virus down-regulates insulin receptor substrates 1 and 2 through up-regulation of suppressor of cytokine signaling 3","volume":"165","author":"Kawaguchi","year":"2004","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jhep.2007.11.022_bib9","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1053\/jhep.2003.50291","article-title":"Hepatitis C infection and incident type 2 diabetes","volume":"38","author":"Mehta","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2007.11.022_bib10","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.2337\/dc06-0456","article-title":"Sustained virological response correlates with reduction in the incidence of glucose abnormalities in patients with chronic hepatitis C virus infection","volume":"29","author":"Simo","year":"2006","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jhep.2007.11.022_bib11","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/j.1572-0241.2006.01038.x","article-title":"Clearance of HCV improves insulin resistance, beta-cell function, and hepatic expression of insulin receptor substrate 1 and 2","volume":"102","author":"Kawaguchi","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2007.11.022_bib12","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1093\/aje\/kwg259","article-title":"Community-based study of hepatitis C virus infection and type 2 diabetes: an association affected by age and hepatitis severity status","volume":"158","author":"Wang","year":"2003","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jhep.2007.11.022_bib13","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1053\/j.gastro.2003.08.032","article-title":"Insulin resistance is associated with chronic hepatitis C and virus infection fibrosis progression","volume":"125","author":"Hui","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2007.11.022_bib14","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1002\/hep.21634","article-title":"The hepatitis C virus core protein of genotypes 3a and 1b downregulates insulin receptor substrate 1 through genotype-specific mechanisms","volume":"45","author":"Pazienza","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2007.11.022_bib15","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0168-8278(01)00143-X","article-title":"Risk factors for diabetes mellitus and early insulin resistance in chronic hepatitis C","volume":"35","author":"Petit","year":"2001","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2007.11.022_bib16","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/hep.1840140117","article-title":"Relationship between insulin sensitivity, insulin secretion and glucose tolerance in cirrhosis","volume":"14","author":"Kruszynska","year":"1991","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2007.11.022_bib17","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jhep.2004.03.020","article-title":"Insulin resistance and insulin secretion in chronic hepatitis C virus infection","volume":"41","author":"Narita","year":"2004","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2007.11.022_bib18","doi-asserted-by":"crossref","unstructured":"Diagnosis and classification of diabetes mellitus. Diabetes Care 2005;28:S37\u2013S42.","DOI":"10.2337\/diacare.28.suppl_1.S37"},{"key":"10.1016\/j.jhep.2007.11.022_bib19","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jacc.2006.03.043","volume":"48","author":"Kim","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jhep.2007.11.022_bib20","doi-asserted-by":"crossref","first-page":"813","DOI":"10.7326\/0003-4819-142-10-200505170-00006","article-title":"Impaired fasting glucose and cardiovascular outcomes in postmenopausal women with coronary artery disease","volume":"142","author":"Kanaya","year":"2005","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jhep.2007.11.022_bib21","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1007\/s00125-006-0189-4","article-title":"The threshold for diagnosing impaired fasting glucose: a position statement by the European Diabetes Epidemiology Group (EDEG)","volume":"49","author":"Forouhi","year":"2006","journal-title":"Diabetologia"},{"key":"10.1016\/j.jhep.2007.11.022_bib22","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1111\/j.1572-0241.2003.07450.x","article-title":"Serum leptin levels correlate with hepatic steatosis in chronic hepatitis C","volume":"98","author":"Romero-Gomez","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2007.11.022_bib23","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.2337\/diacare.27.5.1171","article-title":"High prevalence of glucose abnormalities in patients with hepatitis C virus infection: a multivariate analysis considering the liver injury","volume":"27","author":"Lecube","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jhep.2007.11.022_bib24","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1572-0241.2005.40429.x","article-title":"Chronic hepatitis C and type II diabetes mellitus: a prospective cross-sectional study","volume":"100","author":"Zein","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2007.11.022_bib25","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1136\/bmj.308.6940.1323","article-title":"Comparison of tests for glycated haemoglobin and fasting and two hour plasma glucose concentrations as diagnostic methods for diabetes","volume":"308","author":"McCance","year":"1994","journal-title":"BMJ"},{"key":"10.1016\/j.jhep.2007.11.022_bib26","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1046\/j.1464-5491.2002.00835.x","article-title":"Impaired glucose tolerance and impaired fasting glycaemia: the current status on definition and intervention","volume":"19","author":"Unwin","year":"2002","journal-title":"Diabetes Med"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016882780800010X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016882780800010X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T23:33:53Z","timestamp":1630539233000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016882780800010X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["S016882780800010X"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2007.11.022","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2008,5]]}}}