{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:46:30Z","timestamp":1791103590940,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1016\/j.jhep.2008.11.026","type":"journal-article","created":{"date-parts":[[2009,2,10]],"date-time":"2009-02-10T13:48:19Z","timestamp":1234273699000},"page":"909-917","source":"Crossref","is-referenced-by-count":24,"title":["Normoglycemia alone is insufficient to prevent long-term complications of hepatocellular adenoma in glycogen storage disease type Ib mice"],"prefix":"10.1016","volume":"51","author":[{"given":"Wai Han","family":"Yiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Jiunn","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Mead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew F.","family":"Starost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian C.","family":"Mansfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice Y.","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2008.11.026_bib1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2174\/1566524024605798","article-title":"Type I glycogen storage diseases: disorders of the glucose-6-phosphatase complex","volume":"2","author":"Chou","year":"2002","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.jhep.2008.11.026_bib2","series-title":"Membrane transporter diseases","first-page":"91","article-title":"Glucose-6-phosphate transporter: the key to glycogen storage disease type Ib","author":"Chou","year":"2003"},{"key":"10.1016\/j.jhep.2008.11.026_bib3","doi-asserted-by":"crossref","first-page":"47098","DOI":"10.1074\/jbc.M309472200","article-title":"Glucose-6-phosphate hydrolase, widely expressed outside the liver, can explain age-dependent resolution of hypoglycemia in glycogen storage disease type Ia","volume":"278","author":"Shieh","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2008.11.026_bib4","doi-asserted-by":"crossref","first-page":"12479","DOI":"10.1074\/jbc.M313271200","article-title":"Histidine-167 is the phosphate acceptor in glucose-6-phosphatase-\u03b2 forming a phosphohistidine-enzyme intermediate during catalysis","volume":"279","author":"Ghosh","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2008.11.026_bib5","doi-asserted-by":"crossref","first-page":"28794","DOI":"10.1074\/jbc.M604964200","article-title":"Bone-marrow derived cells require a functional glucose-6-phosphate transporter for normal myeloid functions","volume":"281","author":"Kim","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2008.11.026_bib6","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1172\/JCI30443","article-title":"Impaired neutrophil activity and increased susceptibility to bacterial infection in mice lacking glucose-6-phosphatase-beta","volume":"117","author":"Cheung","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2008.11.026_bib7","doi-asserted-by":"crossref","first-page":"5704","DOI":"10.1182\/blood-2007-12-129114","article-title":"Neutrophil stress and apoptosis underlie myeloid dysfunction in glycogen storage disease type Ib","volume":"111","author":"Kim","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.jhep.2008.11.026_bib8","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1007\/BF02072085","article-title":"Defective neutrophil and monocyte functions in glycogen storage disease type 1b: a literature review","volume":"152","author":"Gitzelmann","year":"1993","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jhep.2008.11.026_bib9","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1093\/hmg\/ddg263","article-title":"Impaired glucose homeostasis, neutrophil rafficking and function in mice lacking the glucose-6-phosphate transporter","volume":"12","author":"Chen","year":"2003","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jhep.2008.11.026_bib10","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1056\/NEJM197602192940805","article-title":"Continuous nocturnal intragastric feeding for management of type 1 glycogen-storage disease","volume":"294","author":"Greene","year":"1776","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2008.11.026_bib11","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1056\/NEJM198401193100306","article-title":"Cornstarch therapy in type I glycogen storage disease","volume":"310","author":"Chen","year":"1984","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2008.11.026_bib12","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/S0022-3476(05)80290-2","article-title":"Granulocyte and granulocyte-macrophage colony-stimulating factors for treatment of neutropenia in glycogen storage disease type Ib","volume":"119","author":"Schroten","year":"1991","journal-title":"J Pediatr"},{"key":"10.1016\/j.jhep.2008.11.026_bib13","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1056\/NEJM199206183262504","article-title":"Brief report: treatment of chronic inflammatory bowel disease in glycogen storage disease type Ib with colony-stimulating factors","volume":"326","author":"Roe","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2008.11.026_bib14","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1007\/BF02072092","article-title":"Glycogen storage disease I and hepatocellular tumours","volume":"52","author":"Bianchi","year":"1993","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jhep.2008.11.026_bib15","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1097\/00005176-199703000-00008","article-title":"Hepatocellular adenomas in glycogen storage disease type I and III: a series of 43 patients and review of the literature","volume":"24","author":"Labrune","year":"1997","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jhep.2008.11.026_bib16","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1007\/BF02679993","article-title":"Glycogen storage disease type I: pathophysiology of liver adenomas","volume":"161","author":"Lee","year":"2002","journal-title":"Eur J Pediatr"},{"issue":"Suppl 1","key":"10.1016\/j.jhep.2008.11.026_bib17","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1007\/BF02679990","article-title":"Glycogen storage disease type I: diagnosis, management, clinical course and outcome. Results of the European Study on Glycogen Storage Disease Type I (ESGSD I)","volume":"161","author":"Rake","year":"2002","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jhep.2008.11.026_bib18","doi-asserted-by":"crossref","first-page":"13865","DOI":"10.1074\/jbc.274.20.13865","article-title":"Transmembrane topology of human Glucose-6-phosphate transporter","volume":"274","author":"Pan","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2008.11.026_bib19","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/sj.gt.3302869","article-title":"Glucose-6-phosphate transporter gene therapy corrects metabolic and myeloid abnormalities in glycogen storage disease type Ib mice","volume":"14","author":"Yiu","year":"2007","journal-title":"Gene Ther"},{"key":"10.1016\/j.jhep.2008.11.026_bib20","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0169-409X(00)00125-3","article-title":"Adenovirus-mediated gene transfer to liver","volume":"46","author":"Wilson","year":"2001","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.jhep.2008.11.026_bib21","doi-asserted-by":"crossref","first-page":"11854","DOI":"10.1073\/pnas.182412299","article-title":"Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy","volume":"99","author":"Gao","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jhep.2008.11.026_bib22","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1128\/JVI.78.6.3110-3122.2004","article-title":"Rapid uncoating of vector genomes is the key to efficient liver transduction with pseudotyped adeno-associated virus vectors","volume":"78","author":"Thomas","year":"2004","journal-title":"J Virol"},{"key":"10.1016\/j.jhep.2008.11.026_bib23","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1089\/104303401300042500","article-title":"CMV-beta-actin promoter directs higher expression from an adeno-associated viral vector in the liver than the cytomegalovirus or elongation factor 1 alpha promoter and results in therapeutic levels of human factor X in mice","volume":"12","author":"Xu","year":"2001","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.jhep.2008.11.026_bib24","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1089\/hum.1998.9.18-2745","article-title":"Novel tools for production and purification of recombinant adenoassociated virus vectors","volume":"10","author":"Grimm","year":"1998","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.jhep.2008.11.026_bib25","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0076-6879(00)16760-6","article-title":"Production and purification of recombinant adeno-associated virus","volume":"316","author":"Hauswirth","year":"2000","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.jhep.2008.11.026_bib26","doi-asserted-by":"crossref","first-page":"6969","DOI":"10.1128\/JVI.75.15.6969-6976.2001","article-title":"Extrachromosomal recombinant adeno-associated virus vector genomes are primarily responsible for stable liver transduction in vivo","volume":"75","author":"Nakai","year":"2001","journal-title":"J Virol"},{"key":"10.1016\/j.jhep.2008.11.026_bib27","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/mt.2008.72","article-title":"Gene delivery to the juvenile mouse liver using AAV2\/8 vectors","volume":"16","author":"Cunningham","year":"2008","journal-title":"Mol Ther"},{"key":"10.1016\/j.jhep.2008.11.026_bib28","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.ymthe.2005.05.016","article-title":"Efficient hepatic delivery and expression from a recombinant adeno-associated virus 8 pseudotyped \u03b11-antitrypsin vector","volume":"12","author":"Conlon","year":"2005","journal-title":"Mol Ther"},{"key":"10.1016\/j.jhep.2008.11.026_bib29","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1128\/JVI.79.1.214-224.2005","article-title":"Unrestricted hepatocyte transduction with adeno-associated virus serotype 8 vectors in mice","volume":"79","author":"Nakai","year":"2005","journal-title":"J Virol"},{"key":"10.1016\/j.jhep.2008.11.026_bib30","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.ymthe.2006.01.014","article-title":"Adeno-associated virus vector serotypes mediate sustained correction of bilirubin UDP glucuronosyltransferase deficiency in rats","volume":"13","author":"Seppen","year":"2006","journal-title":"Mol Ther"},{"key":"10.1016\/j.jhep.2008.11.026_bib31","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1146\/annurev.immunol.25.022106.141538","article-title":"Ontogeny of the hematopoietic system","volume":"25","author":"Cumano","year":"2007","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jhep.2008.11.026_bib32","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.immuni.2007.06.004","article-title":"Myeloid lineage commitment from the hematopoietic stem cell","volume":"26","author":"Iwasaki","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.jhep.2008.11.026_bib33","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1089\/hum.2007.143","article-title":"Recombinant self-complementary adeno-associated virus serotype vector-mediated hematopoietic stem cell transduction and lineage-restricted, long-term transgene expression in a murine serial bone marrow transplantation model","volume":"19","author":"Maina","year":"2008","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.jhep.2008.11.026_bib34","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.molmed.2007.12.003","article-title":"Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis","volume":"14","author":"Marra","year":"2008","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.jhep.2008.11.026_bib35","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF00910722","article-title":"Studies of glycogen-induced inflammation of mice. Dynamics of inflammatory responses and influence of antiinflammatory drugs and protease inhibitors","volume":"6","author":"Yamashita","year":"1982","journal-title":"Inflammation"},{"key":"10.1016\/j.jhep.2008.11.026_bib36","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s000110050326","article-title":"Cytokine and adhesion molecule requirements for neutrophil recruitment during glycogen-induced peritonitis","volume":"47","author":"Mulligan","year":"1998","journal-title":"Inflamm Res"},{"key":"10.1016\/j.jhep.2008.11.026_bib37","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/hep.21068","article-title":"Genotype-phenotype correlation in hepatocellular adenoma: new classification and relationship with HCC","volume":"43","author":"Zucman-Rossi","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2008.11.026_bib38","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1002\/hep.21743","article-title":"Hepatocellular adenoma subtype classification using molecular markers and immunohistochemistry","volume":"46","author":"Bioulac-Sage","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2008.11.026_bib39","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/00000478-198806000-00008","article-title":"Adenomas in glycogen storage disease type 1. Two cases with unusual histologic features","volume":"12","author":"Poe","year":"1988","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.jhep.2008.11.026_bib40","doi-asserted-by":"crossref","first-page":"e402","DOI":"10.5858\/2003-127-e402-HAIGSD","article-title":"Hepatic adenomatosis in glycogen storage disease type Ia: report of a case with unusual histology","volume":"127","author":"Volmar","year":"2003","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.jhep.2008.11.026_bib41","first-page":"17","article-title":"Adeno-associated viral vectors as gene delivery vehicles","volume":"6","author":"Carter","year":"2000","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.jhep.2008.11.026_bib42","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/sj.gt.3302233","article-title":"Gene therapy progress and prospects: recombinant adeno-associated virus (rAAV) vectors","volume":"11","author":"Flotte","year":"2004","journal-title":"Gene Ther"},{"key":"10.1016\/j.jhep.2008.11.026_bib43","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1126\/science.1142658","article-title":"AAV vector integration sites in mouse hepatocellular carcinoma","volume":"317","author":"Donsante","year":"2007","journal-title":"Science"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827809000099?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827809000099?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T12:52:45Z","timestamp":1633092765000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827809000099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S0168827809000099"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2008.11.026","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2009,11]]}}}