{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T13:59:52Z","timestamp":1761919192524},"reference-count":10,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1016\/j.jhep.2008.12.006","type":"journal-article","created":{"date-parts":[[2008,12,26]],"date-time":"2008-12-26T09:26:01Z","timestamp":1230283561000},"page":"633-635","source":"Crossref","is-referenced-by-count":10,"title":["When lightning strikes twice: The plot thickens for a dual role of the anion exchanger 2 (AE2\/SLC4A2) in the pathogenesis and treatment of primary biliary cirrhosis"],"prefix":"10.1016","volume":"50","author":[{"given":"Peter","family":"Fickert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Trauner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2008.12.006_bib1","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1056\/NEJM199810223391707","article-title":"Molecular pathogenesis of cholestasis","volume":"339","author":"Trauner","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2008.12.006_bib2","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1053\/j.gastro.2003.06.005","article-title":"Enterohepatic bile salt transporters in normal physiology and liver disease","volume":"126","author":"Kullak-Ublick","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2008.12.006_bib3","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1053\/j.gastro.2005.08.052","article-title":"Hepatocanalicular transport defects: pathophysiologic mechanisms of rare diseases","volume":"130","author":"Oude Elferink","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2008.12.006_bib4","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/0016-5085(93)90735-U","article-title":"Abnormal expression of anion exchanger genes in primary biliary cirrhosis","volume":"105","author":"Prieto","year":"1993","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2008.12.006_bib5","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/hep.510250104","article-title":"Decreased anion exchanger 2 immunoreactivity in the liver of patients with primary biliary cirrhosis","volume":"25","author":"Medina","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2008.12.006_bib6","first-page":"1422","article-title":"Anion exchanger immunoreactivity in human salivary glands in health and Sj\u00f6gren\u2019s syndrome","volume":"146","author":"Vazquez","year":"1995","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jhep.2008.12.006_bib7","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1053\/jhep.2002.33634","article-title":"Defective regulation of cholangiocyte Cl\u2212\/HCO3(\u2212) and Na+\/H+ exchanger activities in primary biliary cirrhosis","volume":"35","author":"Melero","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2008.12.006_bib8","first-page":"695","article-title":"Combination of ursodeoxycholic acid and glucocorticoids upregulates the AE2 alternate promoter in human liver cells","volume":"118","author":"Arenas","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2008.12.006_bib9","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1053\/j.gastro.2008.02.020","article-title":"Ae2a,b-deficient mice develop antimitochondrial antibodies and other features resembling primary biliary cirrhosis","volume":"134","author":"Salas","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2008.12.006_bib10","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.cld.2008.02.011","article-title":"Animal models of primary biliary cirrhosis","volume":"12","author":"Chuang","year":"2008","journal-title":"Clin Liver Dis"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827808008039?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827808008039?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,23]],"date-time":"2018-12-23T09:59:37Z","timestamp":1545559177000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827808008039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["S0168827808008039"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2008.12.006","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]}}}