{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:07:41Z","timestamp":1791497261069,"version":"4.3.4"},"reference-count":28,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":1506,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1016\/j.jhep.2009.02.021","type":"journal-article","created":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T04:53:02Z","timestamp":1238561582000},"page":"1273-1277","source":"Crossref","is-referenced-by-count":47,"title":["Acute hepatitis caused by a natural lipid-lowering product: When \u201calternative\u201d medicine is no \u201calternative\u201d at all"],"prefix":"10.1016","volume":"50","author":[{"given":"Antonio","family":"Grieco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Miele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Pompili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Biolato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio M.","family":"Vecchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignazio","family":"Grattagliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Gasbarrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2009.02.021_bib1","doi-asserted-by":"crossref","unstructured":"Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults. Summary of the second report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation and treatment of high blood cholesterol in adults (Adult Treatment Panel II). JAMA 1993;269:3015\u201323.","DOI":"10.1001\/jama.1993.03500230097036"},{"key":"10.1016\/j.jhep.2009.02.021_bib2","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.cgh.2006.03.014","article-title":"Incidence of statin hepatotoxicity in patients with hepatitis C","volume":"4","author":"Khorashadi","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2009.02.021_bib3","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1592\/phco.24.6.584.34738","article-title":"Statins and liver toxicity: a meta-analysis","volume":"24","author":"de Denus","year":"2004","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.jhep.2009.02.021_bib4","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.clinthera.2006.01.005","article-title":"Statin-related adverse events: a meta-analysis","volume":"28","author":"Silva","year":"2006","journal-title":"Clin Ther"},{"key":"10.1016\/j.jhep.2009.02.021_bib5","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1161\/01.CIR.0000017634.00171.24","article-title":"Safety and tolerability of pravastatin in long-term clinical trials: prospective Pravastatin Pooling (PPP) Project","volume":"105","author":"Pfeffer","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jhep.2009.02.021_bib6","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1002\/hep.21848","volume":"46","author":"Lewis","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2009.02.021_bib7","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.jhep.2007.06.016","article-title":"Association between consumption of Herbalife nutritional supplements and acute hepatotoxicity","volume":"47","author":"Elinav","year":"2007","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2009.02.021_bib8","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.jhep.2007.06.014","article-title":"Herbal does not mean innocuous: ten cases of severe hepatotoxicity associated with dietary supplements from Herbalife products","volume":"47","author":"Schoepfer","year":"2007","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2009.02.021_bib9","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1097\/01.mcg.0000155132.42939.27","article-title":"Braised liver with herbs: the risks of naturopathic hepatoprotection","volume":"39","author":"Miele","year":"2005","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.jhep.2009.02.021_bib10","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1126\/science.1072891","article-title":"A natural product that lowers cholesterol as an antagonist ligand for FXR","volume":"296","author":"Urizar","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.jhep.2009.02.021_bib11","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1345\/aph.1D486","article-title":"Rhabdomyolysis caused by Commiphora mukul, a natural lipid-lowering agent","volume":"38","author":"Bianchi","year":"2004","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.jhep.2009.02.021_bib12","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0271-5317(97)00201-7","article-title":"Monascus purpureus (red yeast): a natural product that lowers blood cholesterol in animal models of hypercholesterolemia","volume":"18","author":"Zhu","year":"1998","journal-title":"Nutr Res"},{"key":"10.1016\/j.jhep.2009.02.021_bib13","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/ajcn\/69.2.231","article-title":"Cholesterol-lowering effects of a proprietary Chinese red-yeast-rice dietary supplement","volume":"69","author":"Heber","year":"1999","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jhep.2009.02.021_bib14","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1097\/00007890-200210270-00028","article-title":"Rhabdomyolysis due to red yeast rice (Monascus purpureus) in a renal transplant recipient","volume":"74","author":"Prasad","year":"2002","journal-title":"Transplantation"},{"key":"10.1016\/j.jhep.2009.02.021_bib15","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/ajcn\/69.2.175","article-title":"Dietary supplement or drug? The case of cholestin","volume":"69","author":"Havel","year":"1999","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jhep.2009.02.021_bib16","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.atherosclerosissup.2004.08.033","article-title":"The origin of the statins","volume":"5","author":"Endo","year":"2004","journal-title":"Atheroscler Suppl"},{"key":"10.1016\/j.jhep.2009.02.021_bib17","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.cld.2007.06.003","article-title":"Causality assessment of drug-induced hepatotoxicity: promises and pitfalls","volume":"11","author":"Shapiro","year":"2007","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.jhep.2009.02.021_bib18","doi-asserted-by":"crossref","first-page":"516","DOI":"10.7326\/0003-4819-149-7-200810070-00021","article-title":"Symptomatic hepatitis associated with the use of herbal red yeast rice","volume":"149","author":"Roselle","year":"2008","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jhep.2009.02.021_bib19","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1097\/00000441-200502000-00002","article-title":"Patients with elevated baseline liver enzymes do not have higher frequency of hepatotoxicity from lovastatin than those with normal baseline liver enzymes","volume":"329","author":"Vuppalanchi","year":"2005","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.jhep.2009.02.021_bib20","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1007\/BF02088142","article-title":"Acute hepatitis induced by HMG-CoA reductase inhibitor, lovastatin","volume":"39","author":"Grimbert","year":"1994","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jhep.2009.02.021_bib21","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/S0002-9149(02)02355-X","article-title":"The liver and lovastatin","volume":"89","author":"Tolman","year":"2002","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jhep.2009.02.021_bib22","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1191\/0961203303lu313cr","article-title":"Drug-induced lupus-like syndrome associated with severe autoimmune hepatitis","volume":"12","author":"Graziadei","year":"2003","journal-title":"Lupus"},{"key":"10.1016\/j.jhep.2009.02.021_bib23","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1097\/00042737-200308000-00014","article-title":"Autoimmune hepatitis revealed by atorvastatin","volume":"15","author":"Pelli","year":"2003","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2009.02.021_bib24","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1097\/00004836-200609000-00018","article-title":"Autoimmune hepatitis triggered by statins","volume":"40","author":"Alla","year":"2006","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.jhep.2009.02.021_bib25","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0168-8278(99)80297-9","article-title":"International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis","volume":"31","author":"Alvarez","year":"1999","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2009.02.021_bib26","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1001\/jama.300.8.915","article-title":"Lead, mercury, and arsenic in US- and Indian-manufactured Ayurvedic medicines sold over the internet","volume":"300","author":"Saper","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.jhep.2009.02.021_bib27","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1056\/NEJMoa021672","article-title":"Environmental lead exposure and progression of chronic renal diseases in patients without diabetes","volume":"348","author":"Lin","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2009.02.021_bib28","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1056\/NEJMoa022848","article-title":"Intellectual impairment in children with blood lead concentrations below 10 microg per deciliter","volume":"348","author":"Canfield","year":"2003","journal-title":"N Engl J Med"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827809001512?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827809001512?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,19]],"date-time":"2019-05-19T03:01:42Z","timestamp":1558234902000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827809001512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["S0168827809001512"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2009.02.021","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2009,6]]}}}