{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:29:22Z","timestamp":1789615762285,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003074","name":"Agencia Nacional of Promoci\u00f3n cient\u00edfica y Tecnol\u00f3gica (ANPCYT, Argentina)","doi-asserted-by":"crossref","award":["PICT2006-0517"],"award-info":[{"award-number":["PICT2006-0517"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional of Promoci\u00f3n cient\u00edfica y Tecnol\u00f3gica (ANPCYT, Argentina)","doi-asserted-by":"crossref","award":["PICT2005-38237"],"award-info":[{"award-number":["PICT2005-38237"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional of Promoci\u00f3n cient\u00edfica y Tecnol\u00f3gica (ANPCYT, Argentina)","doi-asserted-by":"crossref","award":["PICT2007-0139"],"award-info":[{"award-number":["PICT2007-0139"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1016\/j.jhep.2010.02.028","type":"journal-article","created":{"date-parts":[[2010,4,22]],"date-time":"2010-04-22T08:46:03Z","timestamp":1271925963000},"page":"145-154","source":"Crossref","is-referenced-by-count":34,"title":["Brucella-infected hepatocytes mediate potentially tissue-damaging immune responses"],"prefix":"10.1016","volume":"53","author":[{"given":"M. Victoria","family":"Delpino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Barrionuevo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Scian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A","family":"Fossati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo C.","family":"Baldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2010.02.028_bib1","series-title":"Madkour\u2019s Brucellosis","first-page":"150","article-title":"Gastrointestinal brucellosis","author":"Madkour","year":"2001"},{"key":"10.1016\/j.jhep.2010.02.028_bib2","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1056\/NEJMra050570","article-title":"Brucellosis","volume":"352","author":"Pappas","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2010.02.028_bib3","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cgh.2006.08.010","article-title":"The liver in brucellosis","volume":"5","author":"Akritidis","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2010.02.028_bib4","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1146\/annurev.immunol.021908.132629","article-title":"The liver as a lymphoid organ","volume":"27","author":"Crispe","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jhep.2010.02.028_bib5","doi-asserted-by":"crossref","first-page":"5185","DOI":"10.1128\/IAI.00622-06","article-title":"Autocrine role for interleukin-8 in Bartonella henselae-induced angiogenesis","volume":"74","author":"McCord","year":"2006","journal-title":"Infect Immun"},{"key":"10.1016\/j.jhep.2010.02.028_bib6","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1590\/S0036-46652005000200003","article-title":"Rat hepatocyte invasion by Listeria monocytogenes and analysis of TNF-alpha role in apoptosis","volume":"47","author":"Santos","year":"2005","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"10.1016\/j.jhep.2010.02.028_bib7","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.4049\/jimmunol.144.7.2609","article-title":"Cytokine-induced gene expression of a neutrophil chemotactic factor\/IL-8 in human hepatocytes","volume":"144","author":"Thornton","year":"1990","journal-title":"J Immunol"},{"key":"10.1016\/j.jhep.2010.02.028_bib8","doi-asserted-by":"crossref","first-page":"G583","DOI":"10.1152\/ajpgi.00422.2005","article-title":"Mechanisms of liver injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways","volume":"290","author":"Schwabe","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jhep.2010.02.028_bib9","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1111\/j.1478-3231.2008.01775.x","article-title":"Contribution of hepatic stellate cells and matrix metalloproteinase 9 in acute liver failure","volume":"28","author":"Yan","year":"2008","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2010.02.028_bib10","doi-asserted-by":"crossref","first-page":"S88","DOI":"10.1111\/j.1440-1746.2006.04586.x","article-title":"Matrix metalloproteinases, the pros and cons, in liver fibrosis","volume":"21","author":"Han","year":"2006","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2010.02.028_bib11","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/ncprheum0727","article-title":"Reappraising metalloproteinases in rheumatoid arthritis and osteoarthritis: destruction or repair?","volume":"4","author":"Murphy","year":"2008","journal-title":"Nat Clin Pract Rheumatol"},{"key":"10.1016\/j.jhep.2010.02.028_bib12","doi-asserted-by":"crossref","first-page":"4635","DOI":"10.4049\/jimmunol.173.7.4635","article-title":"Lipoproteins, not lipopolysaccharide, are the key mediators of the proinflammatory response elicited by heat-killed Brucella abortus","volume":"173","author":"Giambartolomei","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.jhep.2010.02.028_bib13","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1006\/abio.1994.1186","article-title":"Quantitative zymography: detection of picogram quantities of gelatinases","volume":"218","author":"Kleiner","year":"1994","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jhep.2010.02.028_bib14","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1365-2958.2004.04017.x","article-title":"Adaptation of the Brucellae to their intracellular niche","volume":"52","author":"Roop","year":"2004","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.jhep.2010.02.028_bib15","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1046\/j.1462-5822.2001.00102.x","article-title":"Essential role of the VirB machinery in the maturation of the Brucella abortus-containing vacuole","volume":"3","author":"Comerci","year":"2001","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.jhep.2010.02.028_bib16","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1128\/IAI.00203-08","article-title":"Inactivation of the type IV secretion system reduces the Th1 polarization of the immune response to Brucella abortus infection","volume":"76","author":"Rol\u00e1n","year":"2008","journal-title":"Infect Immun"},{"key":"10.1016\/j.jhep.2010.02.028_bib17","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0168-8278(05)80216-8","article-title":"Immune modulation of adhesion molecules ICAM-1 (CD54) and LFA-3 (CD58) in human hepatocyte cell lines","volume":"17","author":"Kvale","year":"1993","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2010.02.028_bib18","doi-asserted-by":"crossref","first-page":"G408","DOI":"10.1152\/ajpgi.1997.272.3.G408","article-title":"CD18 integrin and CD54-dependent neutrophil adhesion to cytokine-stimulated human hepatocytes","volume":"272","author":"Nagendra","year":"1997","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jhep.2010.02.028_bib19","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/S0168-8278(96)80237-6","article-title":"Intercellular adhesion molecule-1 (ICAM-1; CD54) expression in human hepatocytic cells depends on protein kinase C","volume":"25","author":"Kvale","year":"1996","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2010.02.028_bib20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0741-8329(02)00200-8","article-title":"Neutrophil-mediated tissue injury in alcoholic hepatitis","volume":"27","author":"Jaeschke","year":"2002","journal-title":"Alcohol"},{"key":"10.1016\/j.jhep.2010.02.028_bib21","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1111\/j.1478-3231.2006.01327.x","article-title":"Role of neutrophils in acute inflammatory liver injury","volume":"26","author":"Jaeschke","year":"2006","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2010.02.028_bib22","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1002\/hep.22763","article-title":"Chemokines in the immunopathogenesis of hepatitis C infection","volume":"49","author":"Heydtmann","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.02.028_bib23","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1136\/jcp.20.3.267","article-title":"Histological findings in human brucellosis","volume":"20","author":"Hunt","year":"1967","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.jhep.2010.02.028_bib24","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0732-8893(01)00344-3","article-title":"Chronic hepatosplenic abscesses in Brucellosis. Clinico-therapeutic features and molecular diagnostic approach","volume":"42","author":"Colmenero","year":"2002","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.jhep.2010.02.028_bib25","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.micinf.2009.04.010","article-title":"Brucella abortus activates human neutrophils","volume":"11","author":"Zwerdling","year":"2009","journal-title":"Microbes Infect"},{"key":"10.1016\/j.jhep.2010.02.028_bib26","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1182\/blood.V76.10.2117.2117","article-title":"The amino-terminal 29- and 72-kD fragments of fibronectin mediate selective monocyte recruitment","volume":"76","author":"Lohr","year":"1990","journal-title":"Blood"},{"key":"10.1016\/j.jhep.2010.02.028_bib27","doi-asserted-by":"crossref","first-page":"644","DOI":"10.2460\/ajvr.2004.65.644","article-title":"Pathologic changes associated with brucellosis experimentally induced by aerosol exposure in rhesus macaques (Macaca mulatta)","volume":"65","author":"Mense","year":"2004","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.jhep.2010.02.028_bib28","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/hep.510280324","article-title":"Parenchymal cell apoptosis as a signal for sinusoidal sequestration and transendothelial migration of neutrophils in murine models of endotoxin and Fas-antibody-induced liver injury","volume":"28","author":"Lawson","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.02.028_bib29","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1128\/IAI.68.1.342-351.2000","article-title":"In vitro Brucella suis infection prevents the programmed cell death of human monocytic cells","volume":"68","author":"Gross","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.jhep.2010.02.028_bib30","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/hep.21922","article-title":"Metalloproteinase-9 deficiency protects against hepatic ischemia\/reperfusion injury","volume":"47","author":"Hamada","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.02.028_bib31","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1189\/jlb.0103015","article-title":"Smooth and rough lipopolysaccharide phenotypes of Brucella induce different intracellular trafficking and cytokine\/chemokine release in human monocytes","volume":"74","author":"Rittig","year":"2003","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jhep.2010.02.028_bib32","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1128\/IAI.01259-08","article-title":"Proinflammatory response of human osteoblastic cell lines and osteoblast\u2013monocyte interaction upon infection with Brucella spp.","volume":"77","author":"Delpino","year":"2009","journal-title":"Infect Immun"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827810002631?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827810002631?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T21:46:10Z","timestamp":1685569570000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827810002631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S0168827810002631"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2010.02.028","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}