{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T09:34:29Z","timestamp":1793266469871,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Bonfor-Stiftung","award":["O-107.0084"],"award-info":[{"award-number":["O-107.0084"]}]},{"name":"Bonfor-Stiftung","award":["O-107.0103"],"award-info":[{"award-number":["O-107.0103"]}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["SFB TRR57 P18"],"award-info":[{"award-number":["SFB TRR57 P18"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Swiss National Foundation for Scientific Research","award":["320000-117725"],"award-info":[{"award-number":["320000-117725"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1016\/j.jhep.2010.04.025","type":"journal-article","created":{"date-parts":[[2010,6,21]],"date-time":"2010-06-21T01:02:27Z","timestamp":1277082147000},"page":"702-712","source":"Crossref","is-referenced-by-count":206,"title":["Atorvastatin attenuates hepatic fibrosis in rats after bile duct ligation via decreased turnover of hepatic stellate cells"],"prefix":"10.1016","volume":"53","author":[{"given":"Jonel","family":"Trebicka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hennenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarete","family":"Odenthal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khanwali","family":"Shir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Granzow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabelle","family":"Vogt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Peter","family":"Dienes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Lammert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrg","family":"Reichen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Heller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilman","family":"Sauerbruch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2010.04.025_bib1","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.jhep.2007.01.020","article-title":"Simvastatin treatment improves liver sinusoidal endothelial dysfunction in CCl(4) cirrhotic rats","volume":"46","author":"Abraldes","year":"2007","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2010.04.025_bib2","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.1478-3231.2008.01682.x","article-title":"Atorvastatin induces apoptosis by a caspase-9-dependent pathway: an in vitro study on activated rat hepatic stellate cells","volume":"28","author":"Aprigliano","year":"2008","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2010.04.025_bib3","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2010.04.025_bib4","first-page":"332","article-title":"Pharmacological intervention in renal fibrosis and vascular sclerosis","volume":"14","author":"Becker","year":"2001","journal-title":"J Nephrol"},{"key":"10.1016\/j.jhep.2010.04.025_bib5","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/S0090-9556(24)15242-7","article-title":"Metabolism and excretion of atorvastatin in rats and dogs","volume":"27","author":"Black","year":"1999","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.jhep.2010.04.025_bib6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF00496631","article-title":"Comparative evaluation of immunohistochemistry and enzyme histochemistry for granulocyte visualization in formalin-fixed and paraffin-embedded liver and lung biopsies","volume":"77","author":"Dinges","year":"1983","journal-title":"Histochemistry"},{"key":"10.1016\/j.jhep.2010.04.025_bib7","series-title":"Semin Liver Dis","first-page":"307","article-title":"The hepatic stellate cell","author":"Friedman","year":"2001"},{"key":"10.1016\/j.jhep.2010.04.025_bib8","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","article-title":"Mechanisms of hepatic fibrogenesis","volume":"134","author":"Friedman","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2010.04.025_bib9","doi-asserted-by":"crossref","first-page":"G1695","DOI":"10.1152\/ajpgi.00209.2006","article-title":"Measurement of liver collagen synthesis by heavy water labeling: effects of profibrotic toxicants and antifibrotic interventions","volume":"292","author":"Gardner","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jhep.2010.04.025_bib10","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.2353\/ajpath.2007.060882","article-title":"Rosuvastatin treatment prevents progressive kidney inflammation and fibrosis in stroke-prone rats","volume":"170","author":"Gianella","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jhep.2010.04.025_bib11","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1582-4934.2006.tb00292.x","article-title":"Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-\u03b2 as major players and therapeutic targets","volume":"10","author":"Gressner","year":"2006","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.jhep.2010.04.025_bib12","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/hep.1840070308","article-title":"The evolution of changes in quantitative liver function tests in a rat model of biliary cirrhosis: correlation with morphometric measurement of hepatocyte mass","volume":"7","author":"Gross","year":"1987","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.04.025_bib13","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1053\/gast.2002.37069","article-title":"Genome-wide analysis of hepatic fibrosis in inbred mice identifies the susceptibility locus Hfib1 on chromosome 15","volume":"123","author":"Hillebrandt","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2010.04.025_bib14","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-2697(81)90261-X","article-title":"A simple method to determine nanogram levels of 4-hydroxyproline in biological tissues","volume":"112","author":"Jamall","year":"1981","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jhep.2010.04.025_bib15","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0168-8278(99)80168-8","article-title":"Role of Rho small GTP binding protein in the regulation of actin cytoskeleton in hepatic stellate cells","volume":"31","author":"Kato","year":"1999","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2010.04.025_bib16","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/abbi.1999.1625","article-title":"TGF-\u03b21 stimulation of fibronectin transcription in cultured human lung fibroblasts requires active geranylgeranyl transferase I, phosphatidylcholine-specific phospholipase C, protein kinase C-delta, and p38, but not erk1\/erk2","volume":"374","author":"Kucich","year":"2000","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.jhep.2010.04.025_bib17","doi-asserted-by":"crossref","first-page":"21926","DOI":"10.1074\/jbc.274.31.21926","article-title":"3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1)","volume":"274","author":"Laufs","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2010.04.025_bib18","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1002\/hep.22753","article-title":"Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential","volume":"49","author":"Moles","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.04.025_bib19","doi-asserted-by":"crossref","first-page":"G147","DOI":"10.1152\/ajpgi.00462.2007","article-title":"Atorvastatin attenuates angiotensin II-induced inflammatory actions in the liver","volume":"296","author":"Moreno","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jhep.2010.04.025_bib20","doi-asserted-by":"crossref","first-page":"165","DOI":"10.7888\/juoeh.26.165","article-title":"Pitavastatin enhances the anti-fibrogenesis effects of candesartan, an angiotensin II receptor blocker, on CCl4-induced liver fibrosis in rats","volume":"26","author":"Nie","year":"2004","journal-title":"J UOEH"},{"key":"10.1016\/j.jhep.2010.04.025_bib21","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/S0168-8278(97)80473-4","article-title":"Effects of simvastatin, pentoxifylline and spironolactone on hepatic fibrosis and portal hypertension in rats with bile duct ligation","volume":"26","author":"Oberti","year":"1997","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2010.04.025_bib22","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.mam.2007.09.002","article-title":"Myofibroblast \u2013 like cells and liver fibrogenesis: emerging concepts in a rapidly moving scenario","volume":"29","author":"Parola","year":"2008","journal-title":"Mol Aspects Med"},{"key":"10.1016\/j.jhep.2010.04.025_bib23","doi-asserted-by":"crossref","first-page":"d1720","DOI":"10.2741\/pinzani","article-title":"PDGF and signal transduction in hepatic stellate cells","volume":"7","author":"Pinzani","year":"2002","journal-title":"Front Biosci"},{"key":"10.1016\/j.jhep.2010.04.025_bib24","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/S0168-8278(03)00051-5","article-title":"Effect of HMG-CoA reductase inhibitors on proliferation and protein synthesis by rat hepatic stellate cells","volume":"38","author":"Rombouts","year":"2003","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2010.04.025_bib25","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1002\/1529-0131(200007)43:7<1624::AID-ANR28>3.0.CO;2-E","article-title":"Inhibition of type I collagen gene expression in normal and systemic sclerosis fibroblasts by a specific inhibitor of geranylgeranyl transferase I","volume":"43","author":"Rosenbloom","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jhep.2010.04.025_bib26","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1478-3231.2008.01902.x","article-title":"Hepatocyte expression of angiotensin II type 1 receptor is downregulated in advanced human liver fibrosis","volume":"29","author":"Schulte","year":"2009","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2010.04.025_bib27","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1159\/000007494","article-title":"Hepatic fibrosis \u2013 therapeutic strategies","volume":"59","author":"Schuppan","year":"1998","journal-title":"Digestion"},{"key":"10.1016\/j.jhep.2010.04.025_bib28","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/hep.21673","article-title":"Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA\/Rho-kinase and activation of endothelial nitric oxide synthase","volume":"46","author":"Trebicka","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.04.025_bib29","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1002\/hep.22170","article-title":"Hemodynamic effects of urotensin II and its specific receptor antagonist palosuran in cirrhotic rats","volume":"47","author":"Trebicka","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.04.025_bib30","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1161\/01.HYP.37.6.1450","article-title":"HMG-CoA reductase inhibitors improve endothelial dysfunction in normocholesterolemic hypertension via reduced production of reactive oxygen species","volume":"37","author":"Wassmann","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.jhep.2010.04.025_bib31","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0168-8278(01)00177-5","article-title":"Dynamic change of cells expressing MMP-2 mRNA and MT1-MMP mRNA in the recovery from liver fibrosis in the rat","volume":"35","author":"Watanabe","year":"2001","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2010.04.025_bib32","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1165\/rcmb.2004-0127OC","article-title":"Simvastatin inhibits growth factor expression and modulates profibrogenic markers in lung fibroblasts","volume":"32","author":"Watts","year":"2005","journal-title":"Am J Respir Cell Mol Biol"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827810005416?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827810005416?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T02:58:00Z","timestamp":1740193080000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827810005416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S0168827810005416"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2010.04.025","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}