{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T16:25:33Z","timestamp":1777825533926,"version":"3.51.4"},"reference-count":33,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":1019,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"National Health Service Blood and Transplant","award":["BS2003\/02"],"award-info":[{"award-number":["BS2003\/02"]}]},{"DOI":"10.13039\/100011234","name":"Bio-Rad","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100011234","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1016\/j.jhep.2010.04.034","type":"journal-article","created":{"date-parts":[[2010,7,2]],"date-time":"2010-07-02T08:24:10Z","timestamp":1278059050000},"page":"780-787","source":"Crossref","is-referenced-by-count":17,"title":["HBV reactivation after fludarabine chemotherapy identified on investigation of suspected transfusion-transmitted Hepatitis B virus"],"prefix":"10.1016","volume":"53","author":[{"given":"J.P.","family":"Power","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"El Chaar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Temple","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Spillane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Candotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.P.","family":"Allain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2010.04.034_bib1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/1096-9071(200011)62:3<299::AID-JMV1>3.0.CO;2-0","article-title":"Frequency of hepatitis B viral reactivation in cancer patients undergoing cytotoxic chemotherapy: a prospective study of 626 patients with identification of risk factors","volume":"62","author":"Yeo","year":"2000","journal-title":"J Med Virol"},{"key":"10.1016\/j.jhep.2010.04.034_bib2","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/j.1365-2141.2006.06465.x","article-title":"Screening, prevention and treatment of viral hepatitis B reactivation in patients with haematological malignancies","volume":"136","author":"Lalazar","year":"2007","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jhep.2010.04.034_bib3","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.1182\/blood-2005-03-1053","article-title":"Persistent B19 infection in immunocompetent individuals: implications for transfusion safety","volume":"106","author":"Lefr\u00e8re","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jhep.2010.04.034_bib4","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/nm1096-1104","article-title":"The hepatitis B virus persists for decades after patients\u2019 recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response","volume":"2","author":"Rehermann","year":"1996","journal-title":"Nat Med"},{"key":"10.1016\/j.jhep.2010.04.034_bib5","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0168-8278(97)80416-3","article-title":"De novo and apparent de novo hepatitis B virus infection after liver transplantation","volume":"26","author":"Roche","year":"1997","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2010.04.034_bib6","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/j.1365-2141.2006.06465.x","article-title":"Screening, prevention and treatment of viral hepatitis B reactivation in patients with haematological malignancies","volume":"136","author":"Lalazar","year":"2007","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jhep.2010.04.034_bib7","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1099\/vir.0.83347-0","article-title":"Molecular characterization of occult hepatitis B virus in genotype E-infected subjects","volume":"89","author":"Zahn","year":"2008","journal-title":"J Gen Virol"},{"key":"10.1016\/j.jhep.2010.04.034_bib8","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1046\/j.1365-2141.1999.01665.x","article-title":"Evidence that anti-HBc but not HBV DNA testing may prevent some HBV transmission by transfusion","volume":"107","author":"Allain","year":"1999","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jhep.2010.04.034_bib9","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1046\/j.1537-2995.2001.41091081.x","article-title":"HBV: amplified and back in the safety spotlight","volume":"41","author":"Kleinman","year":"2001","journal-title":"Transfusion"},{"key":"10.1016\/j.jhep.2010.04.034_bib10","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.tracli.2004.02.004","article-title":"Le groupe Agents Transmissibles par Transfusion de la Societe francaise de transfusion sanguine. Trends in residual risk of transfusion transmitted viral infections (HIV, HCV, HBV) in France between 1992 and 2002 and impact of nucleic acid testing","volume":"11","author":"Pillonel","year":"2004","journal-title":"Transfus Clin Biol"},{"key":"10.1016\/j.jhep.2010.04.034_bib11","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/j.1445-5994.2005.00926.x","article-title":"Residual risk of transfusion transmitted human immunodeficiency virus, hepatitis B virus, hepatitis C virus and human T lymphotrophic virus","volume":"35","author":"Seed","year":"2005","journal-title":"Intern Med J"},{"key":"10.1016\/j.jhep.2010.04.034_bib12","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1017\/S095026880000491X","article-title":"Prevalence of hepatitis B anti-core antibody in the republic of Ireland","volume":"125","author":"O\u2019Connel","year":"2000","journal-title":"Epidemiol Infect"},{"key":"10.1016\/j.jhep.2010.04.034_bib13","unstructured":"National Haemovigilance Office. Annual Report 2004, Dublin, Ireland; 2004."},{"key":"10.1016\/j.jhep.2010.04.034_bib14","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.jhep.2008.07.014","article-title":"Statements from the Taormina expert meeting on occult hepatitis B virus infection","volume":"49","author":"Raimondo","year":"2008","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2010.04.034_bib15","unstructured":"Serious Hazards of Transfusion (SHOT). Annual Report 2004, Manchester, UK; 2004."},{"key":"10.1016\/j.jhep.2010.04.034_bib16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1423-0410.2006.00885.x","article-title":"Seven hundred and fifty-nine (759) chances to learn: a 3-year pilot project to analyse transfusion-related near-miss events in the Republic of Ireland","volume":"92","author":"Lundy","year":"2007","journal-title":"Vox Sang"},{"key":"10.1016\/j.jhep.2010.04.034_bib17","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jcv.2005.08.004","article-title":"Hepatitis B genotype and YMDD profiles in an untreated Irish population","volume":"35","author":"Horgan","year":"2006","journal-title":"J Clin Virol"},{"key":"10.1016\/j.jhep.2010.04.034_bib18","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1097\/00007890-199810150-00012","article-title":"Reactivation of hepatitis B after transplantation in patients with pre-existing anti-hepatitis B surface antigen antibodies: report on three cases and review of the literature","volume":"66","author":"Blanpain","year":"1998","journal-title":"Transplantation"},{"key":"10.1016\/j.jhep.2010.04.034_bib19","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1097\/00007890-199809150-00012","article-title":"Reverse seroconversion of hepatitis B after allogeneic bone marrow transplantation: a retrospective study of 37 patients with pretransplant anti-HBs and anti-HBc","volume":"66","author":"Dhedin","year":"1998","journal-title":"Transplantation"},{"key":"10.1016\/j.jhep.2010.04.034_bib20","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1053\/jhep.2003.50294","article-title":"HBV DNA persistence 10 years after liver transplantation despite successful anti-HBS passive immunoprophylaxis","volume":"38","author":"Roche","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.04.034_bib21","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1136\/gut.47.3.429","article-title":"Pathological and virological findings in patients with persistent hypertransaminasaemia of unknown aetiology","volume":"47","author":"Berasain","year":"2000","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2010.04.034_bib22","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/j.1365-2893.2006.00728.x","article-title":"Hepatitis B virus reactivation in patients receiving chemotherapy for malignancies: role of precore stop-codon and basic core promoter mutations","volume":"13","author":"Alexopoulou","year":"2006","journal-title":"J Viral Hep"},{"key":"10.1016\/j.jhep.2010.04.034_bib23","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.virusres.2003.10.007","article-title":"Hepatitis B virus (HBV) vaccine-induced escape mutants of HBV S gene among children from Qidong area, China","volume":"99","author":"Huang","year":"2004","journal-title":"Virus Res"},{"key":"10.1016\/j.jhep.2010.04.034_bib24","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1136\/gut.2003.034223","article-title":"Survey of hepatitis B surface variant infection in children 15 years after a nationwide vaccination programme in Taiwan","volume":"53","author":"Hsu","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2010.04.034_bib25","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.virol.2004.08.033","article-title":"Mutant hepatitis B virus surface antigens (HBsAg) are immunogenic but may have changed specificity","volume":"329","author":"Zheng","year":"2004","journal-title":"Virology"},{"key":"10.1016\/j.jhep.2010.04.034_bib26","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jcv.2006.10.006","article-title":"Reactivation of an occult hepatitis B virus escape mutant in an anti-HBs positive, anti-HBc negative lymphoma patient","volume":"38","author":"Awerkiew","year":"2007","journal-title":"J Clin Virol"},{"key":"10.1016\/j.jhep.2010.04.034_bib27","doi-asserted-by":"crossref","first-page":"7692","DOI":"10.1128\/JVI.72.9.7692-7696.1998","article-title":"Characterization of unusual escape variants of hepatitis B virus isolated from a hepatitis B surface antigen-negative subject","volume":"72","author":"Grethe","year":"1998","journal-title":"J Virol"},{"key":"10.1016\/j.jhep.2010.04.034_bib28","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1093\/infdis\/170.5.1300","article-title":"Molecular characterization of envelope antigenic variants of hepatitis B virus from Spain","volume":"170","author":"Wallace","year":"1994","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jhep.2010.04.034_bib29","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.jhep.2008.04.017","article-title":"Characterization of occult hepatitis B virus from blood donors carrying genotype A2 or genotype D strains","volume":"49","author":"Candotti","year":"2008","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2010.04.034_bib30","doi-asserted-by":"crossref","first-page":"4219","DOI":"10.3748\/wjg.v12.i26.4219","article-title":"Mutations in surface and polymerase gene of chronic hepatitis B patients with coexisting HBsAg and anti-HBs","volume":"12","author":"Lu","year":"2006","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jhep.2010.04.034_bib31","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.1200\/JCO.2001.19.16.3611","article-title":"Impact of therapy with chlorambucil, fludarabine, or fludarabine plus chlorambucil on infections in patients with chronic lymphocytic leukemia: intergroup study cancer and leukemia group B 9011","volume":"19","author":"Morrison","year":"2001","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jhep.2010.04.034_bib32","first-page":"1296","article-title":"Hep B virus reactivation after fludarabine based regimens for indolent non-Hodgkin\u2019s lymphomas: high prevalence of acquired viral genomic mutations","volume":"88","author":"Picardi","year":"2003","journal-title":"Haematologica"},{"key":"10.1016\/j.jhep.2010.04.034_bib33","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1046\/j.1423-0410.1998.7430133.x","article-title":"Review of counselling in a transfusion service: the London (UK) experience","volume":"74","author":"Miller","year":"1998","journal-title":"Vox Sang"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016882781000560X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016882781000560X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,6]],"date-time":"2020-06-06T11:21:39Z","timestamp":1591442499000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016882781000560X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S016882781000560X"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2010.04.034","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}