{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:33:33Z","timestamp":1792035213704,"version":"4.4.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.jhep.2010.05.030","type":"journal-article","created":{"date-parts":[[2010,8,4]],"date-time":"2010-08-04T08:51:15Z","timestamp":1280911875000},"page":"1117-1122","source":"Crossref","is-referenced-by-count":105,"title":["Enteral nutrition with or without N-acetylcysteine in the treatment of severe acute alcoholic hepatitis: A randomized multicenter controlled trial"],"prefix":"10.1016","volume":"53","author":[{"given":"Christophe","family":"Moreno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Langlet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Hittelet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Lasser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Degr\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Evrard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Colle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Lemmers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Devi\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Le Moine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2010.05.030_b0005","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1055\/s-2007-1007350","article-title":"Treatment of alcoholic liver disease","volume":"13","author":"Mezey","year":"1993","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jhep.2010.05.030_b0010","doi-asserted-by":"crossref","unstructured":"Alcoholic liver disease: morphological manifestations. Review by an international group. Lancet 1981;1:707\u2013711.","DOI":"10.1016\/S0140-6736(81)91984-X"},{"key":"10.1016\/j.jhep.2010.05.030_b0015","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0016-5085(78)90790-4","article-title":"Treatment of acute alcoholic hepatitis with encephalopathy. Comparison of prednisolone with caloric supplements","volume":"74","author":"Lesesne","year":"1978","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2010.05.030_b0020","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/0016-5085(80)90867-7","article-title":"Double-blind controlled trial of prednisolone therapy in patients with severe acute alcoholic hepatitis and spontaneous encephalopathy","volume":"78","author":"Depew","year":"1980","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2010.05.030_b0025","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1056\/NEJM199202203260802","article-title":"A randomized trial of prednisolone in patients with severe alcoholic hepatitis","volume":"326","author":"Ramond","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2010.05.030_b0030","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/j.1365-2036.2004.01881.x","article-title":"Review article: current management of alcoholic liver disease","volume":"19","author":"Tome","year":"2004","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jhep.2010.05.030_b0035","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/S0168-8278(01)00289-6","article-title":"Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis (AH): individual data analysis of the last three randomized placebo controlled double blind trials of corticosteroids in severe AH","volume":"36","author":"Mathurin","year":"2002","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2010.05.030_b0040","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1002\/hep.20957","article-title":"Alcohol and oxidative liver injury","volume":"43","author":"Dey","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.05.030_b0045","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0741-8329(87)90003-6","article-title":"S-Adenosyl-l-methionine: its effect on aminolevulinate dehydratase and glutathione in acute ethanol intoxication","volume":"4","author":"Paredes","year":"1987","journal-title":"Alcohol"},{"key":"10.1016\/j.jhep.2010.05.030_b0050","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1172\/JCI113063","article-title":"Effect of chronic ethanol feeding on rat hepatocytic glutathione. Compartmentation, efflux, and response to incubation with ethanol","volume":"80","author":"Fernandez-Checa","year":"1987","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2010.05.030_b0055","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1172\/JCI114008","article-title":"Effect of chronic ethanol feeding on rat hepatocytic glutathione. Relationship of cytosolic glutathione to efflux and mitochondrial sequestration","volume":"83","author":"Fernandez-Checa","year":"1989","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2010.05.030_b0060","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/0008-8749(92)90205-4","article-title":"N-Acetylcysteine and glutathione as inhibitors of tumor necrosis factor production","volume":"140","author":"Peristeris","year":"1992","journal-title":"Cell Immunol"},{"key":"10.1016\/j.jhep.2010.05.030_b0065","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1007\/s10495-006-0090-0","article-title":"N-Acetyl-cysteine protects liver from apoptotic death in an animal model of fulminant hepatic failure","volume":"11","author":"San-Miguel","year":"2006","journal-title":"Apoptosis"},{"key":"10.1016\/j.jhep.2010.05.030_b0070","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1177\/0115426506021003245","article-title":"Nutrition in alcoholic liver disease","volume":"21","author":"DiCecco","year":"2006","journal-title":"Nutr Clin Pract"},{"key":"10.1016\/j.jhep.2010.05.030_b0075","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1053\/jhep.2000.8627","article-title":"Short- and long-term outcome of severe alcohol-induced hepatitis treated with steroids or enteral nutrition: a multicenter randomized trial","volume":"32","author":"Cabr\u00e9","year":"2000","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.05.030_b0080","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/hep.510230122","article-title":"Definition and diagnostic criteria of refractory ascites and hepatorenal syndrome in cirrhosis. International Ascites Club","volume":"23","author":"Arroyo","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.05.030_b0085","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1096\/fj.00-0650rev","article-title":"Current concepts in the pathogenesis of alcoholic liver injury","volume":"15","author":"Tsukamoto","year":"2001","journal-title":"FASEB J"},{"key":"10.1016\/j.jhep.2010.05.030_b0090","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1053\/gast.2003.50087","article-title":"Oxidants and antioxidants in alcohol-induced liver disease","volume":"124","author":"Arteel","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2010.05.030_b0095","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/S0891-5849(01)00741-9","article-title":"Introduction-serial review: alcohol, oxidative stress and cell injury","volume":"31","author":"Cederbaum","year":"2001","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jhep.2010.05.030_b0100","doi-asserted-by":"crossref","first-page":"S272","DOI":"10.1111\/j.1440-1746.1997.tb00510.x","article-title":"Pathogenesis of alcoholic liver disease with particular emphasis on oxidative stress","volume":"12","author":"Ishii","year":"1997","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2010.05.030_b0105","first-page":"1436","article-title":"Role of lipid peroxidation in the pathogenesis of the ethanol-induced fatty liver","volume":"26","author":"Di Luzio","year":"1967","journal-title":"Fed Proc"},{"key":"10.1016\/j.jhep.2010.05.030_b0110","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1172\/JCI117306","article-title":"Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes","volume":"94","author":"Garcia-Ruiz","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2010.05.030_b0115","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/S0016-5085(98)70034-4","article-title":"Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor","volume":"115","author":"Colell","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2010.05.030_b0120","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1016\/S0022-3565(25)13125-X","article-title":"Medium chain triglycerides and vitamin E reduce the severity of established experimental alcoholic liver disease","volume":"277","author":"Nanji","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jhep.2010.05.030_b0125","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/hep.510310219","article-title":"The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat","volume":"31","author":"Iimuro","year":"2000","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.05.030_b0130","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1053\/gast.2001.23253","article-title":"Delivery of the Cu\/Zn superoxide dismutase gene with adenovirus reduces early alcohol-induced liver injury in rats","volume":"120","author":"Wheeler","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2010.05.030_b0135","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.jhep.2005.11.039","article-title":"Antioxidants versus corticosteroids in the treatment of severe alcoholic hepatitis \u2013 a randomized clinical trial","volume":"44","author":"Phillips","year":"2006","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2010.05.030_b0140","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0168-8278(03)00476-8","article-title":"A randomized placebo controlled trial of vitamin E for alcoholic hepatitis","volume":"40","author":"Mezey","year":"2004","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2010.05.030_b0145","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jhep.2007.03.027","article-title":"A randomized trial of antioxidant therapy alone or with corticosteroids in acute alcoholic hepatitis","volume":"47","author":"Stewart","year":"2007","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2010.05.030_b0150","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1002\/hep.1840100529","article-title":"Animal models for alcoholic liver disease","volume":"10","author":"French","year":"1989","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.05.030_b0155","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1002\/hep.21138","article-title":"Differential liver sensitization to toll-like receptor pathways in mice with alcoholic fatty liver","volume":"43","author":"Gustot","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.05.030_b0160","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/978-1-4757-0632-1_27","article-title":"Alcoholic liver injury: experimental models in rats and baboons","volume":"59","author":"Lieber","year":"1975","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jhep.2010.05.030_b0165","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1002\/hep.20206","article-title":"Foie-Alcool group of the Association Fran\u00e7aise pour l\u2019Etude du Foie. A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis","volume":"39","author":"Naveau","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.05.030_b0170","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1053\/j.gastro.2008.08.057","article-title":"A randomized, double-blinded, placebo-controlled multicenter trial of etanercept in the treatment of alcoholic hepatitis","volume":"135","author":"Boetticher","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2010.05.030_b0175","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/S0168-8278(02)00230-1","article-title":"Combination of steroids with infliximab or placebo in severe alcoholic hepatitis: a randomized controlled pilot study","volume":"37","author":"Spahr","year":"2002","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2010.05.030_b0180","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/hep.1840090302","article-title":"Increased tumor necrosis factor production by monocytes in alcoholic hepatitis","volume":"9","author":"McClain","year":"1989","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.05.030_b0185","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/S0016-5085(99)70354-9","article-title":"Essential role of tumor necrosis alpha in alcohol-induced liver injury in mice","volume":"117","author":"Yin","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2010.05.030_b0190","first-page":"699","article-title":"Transport of reduced glutathione in hepatic mitochondria and mitoplasts from ethanol-treated rats: effect of membrane physical properties and S-adenosyl-l-methionine","volume":"26","author":"Colell","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.05.030_b0195","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1053\/jhep.2003.09038","article-title":"Early change in bilirubin levels is an important prognostic factor in severe alcoholic hepatitis treated with prednisolone","volume":"38","author":"Mathurin","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.05.030_b0200","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S0140-6736(05)74933-3","article-title":"Improvement in renal function in hepatorenal syndrome with N-acetylcysteine","volume":"353","author":"Holt","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2010.05.030_b0205","doi-asserted-by":"crossref","first-page":"A38","DOI":"10.1016\/S0168-8278(08)60040-9","article-title":"Treatment of severe acute alcoholic hepatitis (AAH) with corticoids plus N-acetyl cysteine (C-NAC) versus corticoids (C): planed interim analysis of a multicentre, controlled, randomized trial","volume":"48","author":"Nguyen-Khac","year":"2008","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2010.05.030_b0210","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1053\/gast.2000.20189","article-title":"Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial","volume":"119","author":"Akriviadis","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2010.05.030_b0215","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1002\/hep.21607","article-title":"The Lille model: a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids","volume":"45","author":"Louvet","year":"2007","journal-title":"Hepatology"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827810006835?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827810006835?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T19:56:06Z","timestamp":1740340566000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827810006835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0168827810006835"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2010.05.030","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}