{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T17:51:31Z","timestamp":1781805091204,"version":"3.54.5"},"reference-count":49,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Research Grants Council of Hong Kong"},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2010CB945500"],"award-info":[{"award-number":["2010CB945500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2011CB504004"],"award-info":[{"award-number":["2011CB504004"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Area of Excellent Scheme","award":["AoE\/P-10-01"],"award-info":[{"award-number":["AoE\/P-10-01"]}]},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"crossref","award":["HL-51586"],"award-info":[{"award-number":["HL-51586"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.jhep.2010.05.034","type":"journal-article","created":{"date-parts":[[2010,8,5]],"date-time":"2010-08-05T08:58:43Z","timestamp":1280998723000},"page":"1108-1116","source":"Crossref","is-referenced-by-count":23,"title":["Rosiglitazone promotes fatty acyl CoA accumulation and excessive glycogen storage in livers of mice without adiponectin"],"prefix":"10.1016","volume":"53","author":[{"given":"Mingyan","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen S.L.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul K.H.","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Ming","family":"Che","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In-Kyu","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghai","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2010.05.034_b0005","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1517\/13543784.15.3.243","article-title":"Recent findings concerning thiazolidinediones in the treatment of diabetes","volume":"15","author":"Boden","year":"2006","journal-title":"Expert Opin Invest Drugs"},{"key":"10.1016\/j.jhep.2010.05.034_b0010","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1042\/BJ20071492","article-title":"Post-translational modifications of adiponectin: mechanisms and functional implications","volume":"409","author":"Wang","year":"2008","journal-title":"Biochem J"},{"key":"10.1016\/j.jhep.2010.05.034_b0015","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2174\/1568008033340090","article-title":"Dual roles of adiponectin\/Acrp30 in vivo as an anti-diabetic and anti-atherogenic adipokine","volume":"3","author":"Yamauchi","year":"2003","journal-title":"Curr Drug Targets Immune Endocr Metabol Disord"},{"key":"10.1016\/j.jhep.2010.05.034_b0020","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S1043-2760(01)00524-0","article-title":"ACRP30\/adiponectin: an adipokine regulating glucose and lipid metabolism","volume":"13","author":"Berg","year":"2002","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.jhep.2010.05.034_b0025","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1463-1326.2007.00755.x","article-title":"The effect of thiazolidinediones on adiponectin serum level: a meta-analysis","volume":"10","author":"Riera-Guardia","year":"2008","journal-title":"Diabetes Obes Metab"},{"key":"10.1016\/j.jhep.2010.05.034_b0030","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1111\/j.1463-1326.2008.00854.x","article-title":"Adiponectin and its response to thiazolidinediones are associated with insulin-mediated glucose metabolism in type 2 diabetic patients and their first-degree relatives","volume":"10","author":"Hulstrom","year":"2008","journal-title":"Diabetes Obes Metab"},{"key":"10.1016\/j.jhep.2010.05.034_b0035","doi-asserted-by":"crossref","first-page":"E767","DOI":"10.1152\/ajpendo.00378.2009","article-title":"Selective regulation of cellular and secreted multimeric adiponectin by antidiabetic therapies in humans","volume":"297","author":"Phillips","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jhep.2010.05.034_b0040","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.2337\/diabetes.51.10.2968","article-title":"The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects","volume":"51","author":"Yu","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.jhep.2010.05.034_b0045","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1172\/JCI200317797","article-title":"The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice","volume":"112","author":"Xu","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2010.05.034_b0050","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/S0002-9440(10)62476-5","article-title":"The roles of leptin and adiponectin: a novel paradigm in adipocytokine regulation of liver fibrosis and stellate cell biology","volume":"166","author":"Ding","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jhep.2010.05.034_b0055","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.jhep.2007.03.020","article-title":"Hypoadiponectinemia accelerates hepatic tumor formation in a nonalcoholic steatohepatitis mouse model","volume":"47","author":"Kamada","year":"2007","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2010.05.034_b0060","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.3748\/wjg.v12.i21.3352","article-title":"Adiponectin deficiency exacerbates lipopolysaccharide\/d-galactosamine-induced liver injury in mice","volume":"12","author":"Matsumoto","year":"2006","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jhep.2010.05.034_b0065","doi-asserted-by":"crossref","first-page":"G998","DOI":"10.1152\/ajpgi.00553.2005","article-title":"Adiponectin normalizes LPS-stimulated TNF-alpha production by rat Kupffer cells after chronic ethanol feeding","volume":"290","author":"Thakur","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jhep.2010.05.034_b0070","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1074\/jbc.M505311200","article-title":"Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists","volume":"281","author":"Nawrocki","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2010.05.034_b0075","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1210\/jc.2003-031315","article-title":"Decreased plasma adiponectin concentrations are closely related to hepatic fat content and hepatic insulin resistance in pioglitazone-treated type 2 diabetic patients","volume":"89","author":"Bajaj","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl. 1","key":"10.1016\/j.jhep.2010.05.034_b0080","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1038\/sj.ijo.0802908","article-title":"Adiponectin: a relevant player in PPARgamma-agonist-mediated improvements in hepatic insulin sensitivity?","volume":"29","author":"Bouskila","year":"2005","journal-title":"Int J Obes (Lond)"},{"key":"10.1016\/j.jhep.2010.05.034_b0085","doi-asserted-by":"crossref","first-page":"12152","DOI":"10.1074\/jbc.M311113200","article-title":"Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity","volume":"279","author":"Pajvani","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2010.05.034_b0090","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1002\/hep.22444","article-title":"Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury","volume":"48","author":"Zhou","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.05.034_b0095","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1053\/j.gastro.2008.06.047","article-title":"Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis","volume":"135","author":"Aithal","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2010.05.034_b0100","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1097\/MCG.0b013e31818f4fc2","article-title":"Thiazolidinediones in NASH: Sustained Benefit After Drug Discontinuation?","volume":"43","author":"Argo","year":"2009","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.jhep.2010.05.034_b0105","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1056\/NEJMoa060326","article-title":"A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis","volume":"355","author":"Belfort","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2010.05.034_b0110","first-page":"836","article-title":"Pioglitazone trial for NASH: results show promise","volume":"132","author":"Lang","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2010.05.034_b0115","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/hep.20012","article-title":"A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis","volume":"39","author":"Promrat","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.05.034_b0120","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1053\/j.gastro.2008.03.078","article-title":"Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled fatty liver improvement with rosiglitazone therapy (FLIRT) Trial","volume":"135","author":"Ratziu","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2010.05.034_b0125","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jhep.2007.10.004","article-title":"Rosiglitazone: possible complications and treatment of non-alcoholic steatohepatitis (NASH)","volume":"48","author":"Henriksen","year":"2008","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2010.05.034_b0130","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1002\/hep.21813","article-title":"The effects of 48 weeks of rosiglitazone on hepatocyte mitochondria in human nonalcoholic steatohepatitis","volume":"46","author":"Caldwell","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.05.034_b0135","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1002\/hep.1840380427","article-title":"Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone","volume":"38","author":"Neuschwander-Tetri","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.05.034_b0140","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1097\/00004836-200205000-00021","article-title":"Rosiglitazone-induced granulomatous hepatitis","volume":"34","author":"Dhawan","year":"2002","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.jhep.2010.05.034_b0145","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/toxsci\/kfl180","article-title":"Troglitazone-induced hepatic necrosis in an animal model of silent genetic mitochondrial abnormalities","volume":"97","author":"Ong","year":"2007","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.jhep.2010.05.034_b0150","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.vph.2005.11.011","article-title":"Adverse hepatic and cardiac responses to rosiglitazone in a new mouse model of type 2 diabetes: relation to dysregulated phosphatidylcholine metabolism","volume":"45","author":"Pan","year":"2006","journal-title":"Vasc Pharmacol"},{"key":"10.1016\/j.jhep.2010.05.034_b0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-2952(01)00817-6","article-title":"Toxicological consequences of altered peroxisome proliferator-activated receptor gamma (PPARgamma) expression in the liver: insights from models of obesity and type 2 diabetes","volume":"63","author":"Boelsterli","year":"2002","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jhep.2010.05.034_b0160","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/hep.21687","article-title":"Effects of rosiglitazone on the liver histology and mitochondrial function in ob\/ob mice","volume":"46","author":"Garcia-Ruiz","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.05.034_b0165","doi-asserted-by":"crossref","first-page":"34658","DOI":"10.1074\/jbc.C200362200","article-title":"Increased beta-oxidation but no insulin resistance or glucose intolerance in mice lacking adiponectin","volume":"277","author":"Ma","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2010.05.034_b0170","doi-asserted-by":"crossref","first-page":"16391","DOI":"10.1074\/jbc.M513907200","article-title":"Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex","volume":"281","author":"Wang","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2010.05.034_b0175","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1161\/01.RES.0000170075.73039.5b","article-title":"Effects of recombinant adenovirus-mediated uncoupling protein 2 overexpression on endothelial function and apoptosis","volume":"96","author":"Lee","year":"2005","journal-title":"Circ Res"},{"key":"10.1016\/j.jhep.2010.05.034_b0180","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2010.05.034_b0185","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0003-2697(92)90500-7","article-title":"A fast and versatile method for extraction and quantitation of long-chain acyl-CoA esters from tissue: content of individual long-chain acyl-CoA esters in various tissues from fed rat","volume":"207","author":"Rosendal","year":"1992","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jhep.2010.05.034_b0190","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1194\/jlr.D800001-JLR200","article-title":"Quantitation of fatty acyl-coenzyme As in mammalian cells by liquid chromatography-electrospray ionization tandem mass spectrometry","volume":"49","author":"Haynes","year":"2008","journal-title":"J Lipid Res"},{"issue":"Suppl.","key":"10.1016\/j.jhep.2010.05.034_b0195","doi-asserted-by":"crossref","first-page":"S186","DOI":"10.1046\/j.1440-1746.17.s1.10.x","article-title":"Non-alcoholic fatty liver disease","volume":"17","author":"Angulo","year":"2002","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2010.05.034_b0200","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/00365520601058395","article-title":"Pharmacological treatment of non-alcoholic steatohepatitis: the current evidence","volume":"42","author":"Diakou","year":"2007","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.jhep.2010.05.034_b0205","doi-asserted-by":"crossref","first-page":"121","DOI":"10.7326\/0003-4819-132-2-200001180-00006","article-title":"Hepatocellular injury in a patient receiving rosiglitazone. A case report","volume":"132","author":"Al-Salman","year":"2000","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jhep.2010.05.034_b0210","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/S0002-9343(01)00926-3","article-title":"Liver failure in a patient treated with long-term rosiglitazone therapy","volume":"111","author":"Gouda","year":"2001","journal-title":"Am J Med"},{"key":"10.1016\/j.jhep.2010.05.034_b0215","doi-asserted-by":"crossref","first-page":"G852","DOI":"10.1152\/ajpgi.00521.2005","article-title":"Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation","volume":"290","author":"Reddy","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jhep.2010.05.034_b0220","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1042\/bst0280177","article-title":"The mitochondrial trifunctional protein: centre of a beta-oxidation metabolon?","volume":"28","author":"Eaton","year":"2000","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.jhep.2010.05.034_b0225","first-page":"1","article-title":"Chronic, in vivo, PPARalpha activation prevents lipid overload in rat liver induced by high fat feeding","author":"Wierzbicki","year":"2009","journal-title":"Adv Med Sci"},{"key":"10.1016\/j.jhep.2010.05.034_b0230","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cmet.2005.06.002","article-title":"Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3","volume":"2","author":"Brand","year":"2005","journal-title":"Cell Metab"},{"key":"10.1016\/j.jhep.2010.05.034_b0235","doi-asserted-by":"crossref","first-page":"11462","DOI":"10.1158\/0008-5472.CAN-06-1969","article-title":"Adiponectin modulates the glycogen synthase kinase-3beta\/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice","volume":"66","author":"Wang","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.jhep.2010.05.034_b0240","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1074\/jbc.M806538200","article-title":"LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling","volume":"284","author":"Terrand","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2010.05.034_b0245","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.cca.2008.10.009","article-title":"Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone","volume":"400","author":"Ruano","year":"2009","journal-title":"Clin Chim Acta"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827810006902?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827810006902?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T15:47:09Z","timestamp":1635954429000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827810006902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0168827810006902"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2010.05.034","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}