{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:46:17Z","timestamp":1791215177719,"version":"4.1.0"},"reference-count":88,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":958,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.jhep.2010.07.006","type":"journal-article","created":{"date-parts":[[2010,8,4]],"date-time":"2010-08-04T08:51:15Z","timestamp":1280911875000},"page":"1123-1134","source":"Crossref","is-referenced-by-count":342,"title":["Autophagy in liver diseases"],"prefix":"10.1016","volume":"53","author":[{"given":"Pierre-Emmanuel","family":"Rautou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdellah","family":"Mansouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Lebrec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Durand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Valla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Moreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2010.07.006_b0005","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nature06639","article-title":"Autophagy fights disease through cellular self-digestion","volume":"451","author":"Mizushima","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2010.07.006_b0010","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.cell.2010.04.009","article-title":"Mitochondria supply membranes for autophagosome biogenesis during starvation","volume":"141","author":"Hailey","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2010.07.006_b0015","doi-asserted-by":"crossref","first-page":"C776","DOI":"10.1152\/ajpcell.00507.2009","article-title":"Autophagy in health and disease. 1. Regulation and significance of autophagy: an overview","volume":"298","author":"Mehrpour","year":"2010","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.jhep.2010.07.006_b0020","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/nature09076","article-title":"Termination of autophagy and reformation of lysosomes regulated by mTOR","volume":"465","author":"Yu","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2010.07.006_b0025","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","article-title":"Autophagy in the pathogenesis of disease","volume":"132","author":"Levine","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2010.07.006_b0030","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ceb.2010.01.001","article-title":"The Beclin 1 interactome","volume":"22","author":"He","year":"2010","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.jhep.2010.07.006_b0035","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cell.2010.01.028","article-title":"Methods in mammalian autophagy research","volume":"140","author":"Mizushima","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2010.07.006_b0040","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1002\/hep.22146","article-title":"Autophagy in the liver","volume":"47","author":"Yin","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.07.006_b0045","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1038\/nature03029","article-title":"The role of autophagy during the early neonatal starvation period","volume":"432","author":"Kuma","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2010.07.006_b0050","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.prp.2006.04.001","article-title":"Glycogen autophagy in glucose homeostasis","volume":"202","author":"Kotoulas","year":"2006","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.jhep.2010.07.006_b0055","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0016-5085(03)01048-5","article-title":"Protective strategies against ischemic injury of the liver","volume":"125","author":"Selzner","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2010.07.006_b0060","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/270174a0","article-title":"Induction of autophagy by amino-acid deprivation in perfused rat liver","volume":"270","author":"Mortimore","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2010.07.006_b0065","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/BF02889111","article-title":"Inhibited autophagic degradation of cytoplasm during compensatory growth of liver cells after partial hepatectomy","volume":"30","author":"Pfeifer","year":"1979","journal-title":"Virchows Arch B Cell Pathol Incl Mol Pathol"},{"key":"10.1016\/j.jhep.2010.07.006_b0070","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/0022-4804(83)90108-7","article-title":"Limiting ischemic liver injury by interfering with lysosomal autophagy","volume":"34","author":"Schneider","year":"1983","journal-title":"J Surg Res"},{"key":"10.1016\/j.jhep.2010.07.006_b0075","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jss.2008.02.004","article-title":"Activation of peroxisome proliferator-activated receptor-gamma during hepatic ischemia is age-dependent","volume":"147","author":"Shin","year":"2008","journal-title":"J Surg Res"},{"key":"10.1016\/j.jhep.2010.07.006_b0080","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1002\/hep.22187","article-title":"Impaired autophagy: a mechanism of mitochondrial dysfunction in anoxic rat hepatocytes","volume":"47","author":"Kim","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.07.006_b0085","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/hep.23021","article-title":"Cisplatin prevents high mobility group box 1 release and is protective in a murine model of hepatic ischemia\/reperfusion injury","volume":"50","author":"Cardinal","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.07.006_b0090","doi-asserted-by":"crossref","first-page":"351","DOI":"10.4161\/auto.5.3.7650","article-title":"Participation of autophagy in the initiation of graft dysfunction after rat liver transplantation","volume":"5","author":"Gotoh","year":"2009","journal-title":"Autophagy"},{"key":"10.1016\/j.jhep.2010.07.006_b0095","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1679\/aohc.68.71","article-title":"Participation of autophagy in the degeneration process of rat hepatocytes after transplantation following prolonged cold preservation","volume":"68","author":"Lu","year":"2005","journal-title":"Arch Histol Cytol"},{"key":"10.1016\/j.jhep.2010.07.006_b0100","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1002\/lt.21751","article-title":"Impaired autophagic clearance after cold preservation of fatty livers correlates with tissue necrosis upon reperfusion and is reversed by hypothermic reconditioning","volume":"15","author":"Minor","year":"2009","journal-title":"Liver Transpl"},{"key":"10.1016\/j.jhep.2010.07.006_b0105","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.jhep.2009.06.028","article-title":"Concurrent induction of necrosis, apoptosis, and autophagy in ischemic preconditioned human livers formerly treated by chemotherapy","volume":"51","author":"Domart","year":"2009","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2010.07.006_b0110","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.3748\/wjg.v10.i17.2580","article-title":"Ischemic preconditioning protects liver from hepatectomy under hepatic inflow occlusion for hepatocellular carcinoma patients with cirrhosis","volume":"10","author":"Li","year":"2004","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jhep.2010.07.006_b0115","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1097\/01.sla.0000098620.27623.7d","article-title":"A prospective randomized study in 100 consecutive patients undergoing major liver resection with versus without ischemic preconditioning","volume":"238","author":"Clavien","year":"2003","journal-title":"Ann Surg"},{"key":"10.1016\/j.jhep.2010.07.006_b0120","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/nm.1851","article-title":"Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function","volume":"14","author":"Zhang","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.jhep.2010.07.006_b0125","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/S0046-8177(88)80149-7","article-title":"Response of human hepatocyte lysosomes to postmortem anoxia","volume":"19","author":"Yu","year":"1988","journal-title":"Hum Pathol"},{"key":"10.1016\/j.jhep.2010.07.006_b0130","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.chom.2009.05.016","article-title":"Autophagy, immunity, and microbial adaptations","volume":"5","author":"Deretic","year":"2009","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jhep.2010.07.006_b0135","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1128\/JVI.02093-07","article-title":"Hepatitis C virus genotype 1a growth and induction of autophagy","volume":"82","author":"Ait-Goughoulte","year":"2008","journal-title":"J Virol"},{"key":"10.1016\/j.jhep.2010.07.006_b0140","doi-asserted-by":"crossref","first-page":"14046","DOI":"10.1073\/pnas.0907344106","article-title":"The autophagy machinery is required to initiate hepatitis C virus replication","volume":"106","author":"Dreux","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jhep.2010.07.006_b0145","first-page":"943A","article-title":"In vivo evidence of altered hepatocyte autophagic response in livers from patients with chronic Hepatitis C virus infection","volume":"50","author":"Rautou","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.07.006_b0150","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1002\/hep.22464","article-title":"Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein response","volume":"48","author":"Sir","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.07.006_b0155","article-title":"Inhibition of hepatitis C virus replication by chloroquine targeting virus-associated autophagy","author":"Mizui","year":"2009","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.jhep.2010.07.006_b0160","doi-asserted-by":"crossref","DOI":"10.4161\/auto.5.7.9243","article-title":"Knockdown of autophagy-related gene decreases the production of infectious hepatitis C virus particles","volume":"5","author":"Tanida","year":"2009","journal-title":"Autophagy"},{"key":"10.1016\/j.jhep.2010.07.006_b0165","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1073\/pnas.012485299","article-title":"Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway","volume":"99","author":"Talloczy","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jhep.2010.07.006_b0170","doi-asserted-by":"crossref","first-page":"24","DOI":"10.4161\/auto.2176","article-title":"PKR-dependent autophagic degradation of herpes simplex virus type 1","volume":"2","author":"Talloczy","year":"2006","journal-title":"Autophagy"},{"key":"10.1016\/j.jhep.2010.07.006_b0175","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1073\/pnas.0911373107","article-title":"The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication","volume":"107","author":"Sir","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jhep.2010.07.006_b0180","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/hep.22581","article-title":"Hepatitis B virus X protein sensitizes cells to starvation-induced autophagy via up-regulation of beclin 1 expression","volume":"49","author":"Tang","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.07.006_b0185","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1093\/intimm\/dxq050","article-title":"Endothelial cells are damaged by autophagic induction before hepatocytes in Con A-induced acute hepatitis","volume":"22","author":"Yang","year":"2010","journal-title":"Int Immunol"},{"key":"10.1016\/j.jhep.2010.07.006_b0190","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/hep.21509","article-title":"Concanavalin A induces autophagy in hepatoma cells and has a therapeutic effect in a murine in situ hepatoma model","volume":"45","author":"Chang","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.07.006_b0195","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1177\/039463200802100406","article-title":"Autophagy induction in T cell-independent acute hepatitis induced by concanavalin A in SCID\/NOD mice","volume":"21","author":"Chang","year":"2008","journal-title":"Int J Immunopathol Pharmacol"},{"key":"10.1016\/j.jhep.2010.07.006_b0200","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/labinvest.2009.129","article-title":"The protective role of pregnane X receptor in lipopolysaccharide\/d-galactosamine-induced acute liver injury","volume":"90","author":"Wang","year":"2010","journal-title":"Lab Invest"},{"key":"10.1016\/j.jhep.2010.07.006_b0205","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1053\/j.gastro.2008.05.055","article-title":"Acute liver cell damage in patients with anorexia nervosa: a possible role of starvation-induced hepatocyte autophagy","volume":"135","author":"Rautou","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2010.07.006_b0210","article-title":"Hypoxia-induced autophagy: cell death or cell survival?","author":"Mazure","year":"2009","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.jhep.2010.07.006_b0215","doi-asserted-by":"crossref","first-page":"275","DOI":"10.4161\/auto.3915","article-title":"Mitophagy: the life-or-death dichotomy includes yeast","volume":"3","author":"Abeliovich","year":"2007","journal-title":"Autophagy"},{"key":"10.1016\/j.jhep.2010.07.006_b0220","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/cdd.2008.103","article-title":"Autophagic disposal of the aggregation-prone protein that causes liver inflammation and carcinogenesis in alpha-1-antitrypsin deficiency","volume":"16","author":"Perlmutter","year":"2009","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jhep.2010.07.006_b0225","doi-asserted-by":"crossref","first-page":"G961","DOI":"10.1152\/ajpgi.2000.279.5.G961","article-title":"Retention of mutant alpha(1)-antitrypsin Z in endoplasmic reticulum is associated with an autophagic response","volume":"279","author":"Teckman","year":"2000","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jhep.2010.07.006_b0230","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.1074\/jbc.M509409200","article-title":"Intracellular inclusions containing mutant alpha1-antitrypsin Z are propagated in the absence of autophagic activity","volume":"281","author":"Kamimoto","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2010.07.006_b0235","doi-asserted-by":"crossref","first-page":"G851","DOI":"10.1152\/ajpgi.00175.2003","article-title":"Mitochondrial autophagy and injury in the liver in alpha 1-antitrypsin deficiency","volume":"286","author":"Teckman","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jhep.2010.07.006_b0240","doi-asserted-by":"crossref","first-page":"27769","DOI":"10.1074\/jbc.M704330200","article-title":"Regulator of G Signaling 16 is a marker for the distinct endoplasmic reticulum stress state associated with aggregated mutant alpha1-antitrypsin Z in the classical form of alpha1-antitrypsin deficiency","volume":"282","author":"Hidvegi","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2010.07.006_b0245","doi-asserted-by":"crossref","first-page":"393","DOI":"10.4161\/auto.4256","article-title":"The heterotrimeric G protein G(i3) regulates hepatic autophagy downstream of the insulin receptor","volume":"3","author":"Gohla","year":"2007","journal-title":"Autophagy"},{"key":"10.1016\/j.jhep.2010.07.006_b0250","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1002\/hep.21822","article-title":"Alpha-1-antitrypsin mutant Z protein content in individual hepatocytes correlates with cell death in a mouse model","volume":"46","author":"Lindblad","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.07.006_b0255","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1126\/science.1190354","article-title":"An autophagy-enhancing drug promotes degradation of mutant {alpha}1-antitrypsin z and reduces hepatic fibrosis","volume":"329","author":"Hidvegi","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.jhep.2010.07.006_b0260","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1258\/ebm.2010.009297","article-title":"Rapamycin reduces intrahepatic alpha-1-antitrypsin mutant Z protein polymers and liver injury in a mouse model","volume":"235","author":"Kaushal","year":"2010","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.jhep.2010.07.006_b0265","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1056\/NEJMra0805786","article-title":"Alcoholic hepatitis","volume":"360","author":"Lucey","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2010.07.006_b0270","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1042\/bj2730149","article-title":"Inhibition of proteolysis in the liver by chronic ethanol feeding","volume":"273","author":"Poso","year":"1991","journal-title":"Biochem J"},{"key":"10.1016\/j.jhep.2010.07.006_b0275","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1530-0277.1989.tb00283.x","article-title":"Effect of chronic ethanol administration on protein catabolism in rat liver","volume":"13","author":"Donohue","year":"1989","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.jhep.2010.07.006_b0280","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1126\/science.1198096","article-title":"Alcoholic hepatomegaly: accumulation of protein in the liver","volume":"190","author":"Baraona","year":"1975","journal-title":"Science"},{"key":"10.1016\/j.jhep.2010.07.006_b0285","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00795-009-0476-5","article-title":"Autophagy is involved in the elimination of intracellular inclusions, Mallory-Denk bodies, in hepatocytes","volume":"43","author":"Harada","year":"2010","journal-title":"Med Mol Morphol"},{"key":"10.1016\/j.jhep.2010.07.006_b0290","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1016\/j.yexcr.2007.04.024","article-title":"From Mallory to Mallory-Denk bodies: what, how and why?","volume":"313","author":"Zatloukal","year":"2007","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.jhep.2010.07.006_b0295","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1002\/hep.22294","article-title":"Autophagy activation by rapamycin eliminates mouse Mallory-Denk bodies and blocks their proteasome inhibitor-mediated formation","volume":"47","author":"Harada","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.07.006_b0300","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1083\/jcb.200412022","article-title":"Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice","volume":"169","author":"Komatsu","year":"2005","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jhep.2010.07.006_b0305","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1111\/j.1530-0277.2007.00354.x","article-title":"Embryonic cerebral cortical progenitors are resistant to apoptosis, but increase expression of suicide receptor DISC-complex genes and suppress autophagy following ethanol exposure","volume":"31","author":"Prock","year":"2007","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.jhep.2010.07.006_b0310","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.3748\/wjg.15.1178","article-title":"Autophagy and ethanol-induced liver injury","volume":"15","author":"Donohue","year":"2009","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jhep.2010.07.006_b0315","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/jcp.1041520304","article-title":"Cytoskeletal elements are required for the formation and maturation of autophagic vacuoles","volume":"152","author":"Aplin","year":"1992","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jhep.2010.07.006_b0320","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1600-0854.2005.00368.x","article-title":"Microtubules facilitate autophagosome formation and fusion of autophagosomes with endosomes","volume":"7","author":"Kochl","year":"2006","journal-title":"Traffic"},{"key":"10.1016\/j.jhep.2010.07.006_b0325","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/S0016-5085(97)70014-3","article-title":"Vesicle movement in rat hepatocytes is reduced by ethanol exposure: alterations in microtubule-based motor enzymes","volume":"113","author":"Torok","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2010.07.006_b0330","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1053\/j.gastro.2004.09.049","article-title":"The role of AMP-activated protein kinase in the action of ethanol in the liver","volume":"127","author":"You","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2010.07.006_b0335","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/ncb2021","article-title":"The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1","volume":"12","author":"Komatsu","year":"2010","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jhep.2010.07.006_b0340","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/nature07976","article-title":"Autophagy regulates lipid metabolism","volume":"458","author":"Singh","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2010.07.006_b0345","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/4581118a","article-title":"Cell biology: another way to get rid of fat","volume":"458","author":"Zechner","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2010.07.006_b0350","doi-asserted-by":"crossref","first-page":"C973","DOI":"10.1152\/ajpcell.00527.2009","article-title":"Autophagy in health and disease: 2. Regulation of lipid metabolism and storage by autophagy: pathophysiological implications","volume":"298","author":"Czaja","year":"2010","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.jhep.2010.07.006_b0355","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.cmet.2010.04.005","article-title":"Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance","volume":"11","author":"Yang","year":"2010","journal-title":"Cell Metab"},{"key":"10.1016\/j.jhep.2010.07.006_b0360","doi-asserted-by":"crossref","first-page":"31484","DOI":"10.1074\/jbc.M109.033936","article-title":"Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibition of FoxO1-dependent expression of key autophagy genes by insulin","volume":"284","author":"Liu","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2010.07.006_b0365","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.cmet.2010.05.006","article-title":"Autophagy: a potential link between obesity and insulin resistance","volume":"11","author":"Codogno","year":"2010","journal-title":"Cell Metab"},{"key":"10.1016\/j.jhep.2010.07.006_b0370","doi-asserted-by":"crossref","first-page":"285","DOI":"10.4161\/auto.3930","article-title":"ER-phagy: selective autophagy of the endoplasmic reticulum","volume":"3","author":"Bernales","year":"2007","journal-title":"Autophagy"},{"key":"10.1016\/j.jhep.2010.07.006_b0375","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.cell.2010.02.034","article-title":"Endoplasmic reticulum stress and the inflammatory basis of metabolic disease","volume":"140","author":"Hotamisligil","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2010.07.006_b0380","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1126\/science.1103160","article-title":"Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes","volume":"306","author":"Ozcan","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.jhep.2010.07.006_b0385","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/j.bbamcr.2009.01.006","article-title":"Anti- and pro-tumor functions of autophagy","volume":"1793","author":"Morselli","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jhep.2010.07.006_b0390","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/nrc2254","article-title":"Role of autophagy in cancer","volume":"7","author":"Mathew","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.jhep.2010.07.006_b0395","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1172\/JCI20039","article-title":"Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene","volume":"112","author":"Qu","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2010.07.006_b0400","doi-asserted-by":"crossref","first-page":"9167","DOI":"10.1158\/0008-5472.CAN-08-1573","article-title":"Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma","volume":"68","author":"Ding","year":"2008","journal-title":"Cancer Res"},{"key":"10.1016\/j.jhep.2010.07.006_b0405","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1111\/j.1349-7006.2009.01113.x","article-title":"HAb18G\/CD147 inhibits starvation-induced autophagy in human hepatoma cell SMMC7721 with an involvement of Beclin 1 down-regulation","volume":"100","author":"Gou","year":"2009","journal-title":"Cancer Sci"},{"key":"10.1016\/j.jhep.2010.07.006_b0410","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1002\/hep.23597","article-title":"Roles of hypoxia-inducible factor-1alpha (HIF-1alpha) versus HIF-2alpha in the survival of hepatocellular tumor spheroids","volume":"51","author":"Menrad","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.07.006_b0415","doi-asserted-by":"crossref","first-page":"9348","DOI":"10.1158\/0008-5472.CAN-08-1642","article-title":"OSU-03012, a novel celecoxib derivative, induces reactive oxygen species-related autophagy in hepatocellular carcinoma","volume":"68","author":"Gao","year":"2008","journal-title":"Cancer Res"},{"key":"10.1016\/j.jhep.2010.07.006_b0420","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bcp.2009.03.013","article-title":"Down-regulation of the HGF\/MET autocrine loop induced by celecoxib and mediated by P-gp in MDR-positive human hepatocellular carcinoma cell line","volume":"78","author":"Mazzanti","year":"2009","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jhep.2010.07.006_b0425","article-title":"Sirolimus-based immunosuppression is associated with increased survival after liver transplantation for hepatocellular carcinoma","author":"Toso","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.07.006_b0430","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/cr.2010.82","article-title":"Overview of macroautophagy regulation in mammalian cells","volume":"20","author":"Mehrpour","year":"2010","journal-title":"Cell Res"},{"key":"10.1016\/j.jhep.2010.07.006_b0435","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.cmet.2009.02.002","article-title":"A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance","volume":"9","author":"Newgard","year":"2009","journal-title":"Cell Metab"},{"key":"10.1016\/j.jhep.2010.07.006_b0440","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/nrd2272","article-title":"Potential therapeutic applications of autophagy","volume":"6","author":"Rubinsztein","year":"2007","journal-title":"Nat Rev Drug Discov"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827810006938?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827810006938?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T15:46:06Z","timestamp":1685720766000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827810006938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":88,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0168827810006938"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2010.07.006","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}