{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T06:58:11Z","timestamp":1793084291004,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1016\/j.jhep.2010.07.031","type":"journal-article","created":{"date-parts":[[2010,9,23]],"date-time":"2010-09-23T08:36:04Z","timestamp":1285230964000},"page":"666-673","source":"Crossref","is-referenced-by-count":241,"title":["Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum"],"prefix":"10.1016","volume":"54","author":[{"given":"Ge","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Yao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huali","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Xi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2010.07.031_b0005","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1365-2036.2006.02742.x","article-title":"Updates in the pathogensis and therapy of hepatic sinusoidal obstruction syndrome","volume":"23","author":"Helmy","year":"2006","journal-title":"Aliment Pharm Ther"},{"key":"10.1016\/j.jhep.2010.07.031_b0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1081\/DMR-120028426","article-title":"Pyrrolizidine alkaloids-genotoxicity, metabolism enzymes, metabolic activation, and mechanisms","volume":"36","author":"Fu","year":"2004","journal-title":"Drug Metab Rev"},{"key":"10.1016\/j.jhep.2010.07.031_b0015","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/S0140-6736(01)00020-4","article-title":"Senecio disease or cirrhosis of the liver due to Senecio poisoning","volume":"2","author":"Willmot","year":"1920","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2010.07.031_b0020","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.3748\/wjg.v13.i10.1628","article-title":"Gynura root induces hepatic veno-occlusive disease: a case report and review of the literature","volume":"13","author":"Dai","year":"2007","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jhep.2010.07.031_b0025","unstructured":"International Program on Chemical Safety. Health and safety guide no. 26: pyrrolizidine alkaloids health and safety guide. Geneva (Switzerland): World Health Organization; 1989."},{"key":"10.1016\/j.jhep.2010.07.031_b0030","unstructured":"Medicines and Healthcare products Regulatory Agency. Public consultation: proposals to prohibit the sale, supply or importation of unlicensed medicinal products for internal use which contain Senecio species and proposals to amend three existing orders; 2007 [monograph on the Internet]."},{"key":"10.1016\/j.jhep.2010.07.031_b0035","unstructured":"U.S. Food and Drug Administration. FDA advises dietary supplement manufacturers to remove comfrey products from the market; 2001 [monograph on the Internet]."},{"key":"10.1016\/j.jhep.2010.07.031_b0040","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.aca.2007.10.021","article-title":"Quantitative analysis of total retronecine esters-type pyrrolizidine alkaloids in plant by high performance liquid chromatography","volume":"605","author":"Zhang","year":"2007","journal-title":"Anal Chim Acta"},{"key":"10.1016\/j.jhep.2010.07.031_b0045","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0021-9673(00)00896-7","article-title":"Simultaneous analysis of clivorine and its four microsomal metabolites by high-performance liquid chromatography","volume":"903","author":"Cui","year":"2000","journal-title":"J Chromatog A"},{"key":"10.1016\/j.jhep.2010.07.031_b0050","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1080\/00032710903060693","article-title":"Simultaneous determination of senecionine, senciphylline, and senecionine N-Oxide in Gynura segetum by RP-HPLC","volume":"42","author":"Yang","year":"2009","journal-title":"Anal Lett"},{"key":"10.1016\/j.jhep.2010.07.031_b0055","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/rcm.3398","article-title":"Identification of five hepatotoxic pyrrolizidine alkaloids in a commonly used traditional Chinese medicinal herb, Herba Senecionis scandentis (Qianliguang)","volume":"22","author":"Li","year":"2008","journal-title":"Rapid Commun Mass Spectrom"},{"key":"10.1016\/j.jhep.2010.07.031_b0060","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1002\/(SICI)1097-0231(19981030)12:20<1445::AID-RCM356>3.0.CO;2-G","article-title":"Determination of hepatotoxic pyrrolizidine alkaloids by on-line high performance liquid chromatography mass spectrometry with an electrospray interface","volume":"12","author":"Lin","year":"1998","journal-title":"Rapid Commun Mass Spectrom"},{"key":"10.1016\/j.jhep.2010.07.031_b0065","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/rcm.3862","article-title":"Simultaneous characterization of pyrrolizidine alkaloids and N-oxides in Gynura segetum by liquid chromatography\/ion trap mass spectrometry","volume":"23","author":"Qi","year":"2009","journal-title":"Rapid Commun Mass Spectrom"},{"key":"10.1016\/j.jhep.2010.07.031_b0070","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1365\/s10337-009-1149-1","article-title":"Sensitive determination of hepatotoxic pyrrolizidine alkaloids in Gynura segetum by micellar electrokinetic chromatography (MEKC)","volume":"70","author":"Qi","year":"2009","journal-title":"Chromatographia"},{"key":"10.1016\/j.jhep.2010.07.031_b0075","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1002\/mnfr.200800051","article-title":"Pyrrolizidine alkaloids in honey: risk analysis by gas chromatography\u2013mass spectrometry","volume":"52","author":"Kempf","year":"2008","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.jhep.2010.07.031_b0080","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1021\/tx030030q","article-title":"Metabolic formation of DHP-derived DNA adducts from a representative otonecine type pyrrolizidine alkaloid clivorine and the extract of Ligularia hodgsonnii Hook","volume":"17","author":"Xia","year":"2004","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.jhep.2010.07.031_b0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/s-0029-1185468","article-title":"Qianliguang (Senecio scadens) safety dilemma: dose is the key?","volume":"75","author":"Lin","year":"2009","journal-title":"Planta Med"},{"key":"10.1016\/j.jhep.2010.07.031_b0090","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/S0041-0101(98)00263-3","article-title":"The effects of pretreatment with glycyrrhizin and glycyrrhetinic acid on the retrorsine-induced hepatotoxicity in rats","volume":"37","author":"Lin","year":"1999","journal-title":"Toxicon"},{"key":"10.1016\/j.jhep.2010.07.031_b0095","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1021\/tx0340302","article-title":"Gender differences in microsomal metabolic activation of hepatotoxic clivorine in rat","volume":"16","author":"Lin","year":"2003","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.jhep.2010.07.031_b0100","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/S0090-9556(24)13677-X","article-title":"Characterization of rat liver microsomal metabolites of clivorine, a hepatotoxic otonecine-type pyrrolizidine alkaloid","volume":"28","author":"Lin","year":"2000","journal-title":"Drug Metab Disp"},{"key":"10.1016\/j.jhep.2010.07.031_b0105","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1124\/dmd.106.014100","article-title":"Deacetylclivorine: a gender-selective metabolite of clivorine formed in female Sprague\u2013Dawley rat liver microsomes","volume":"35","author":"Lin","year":"2007","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.jhep.2010.07.031_b0110","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1006\/taap.1995.1017","article-title":"Relationship between glutathione concentration and metabolism of pyrrolizidine alkaloid, monocrotaline, in the isolated, perfused liver","volume":"130","author":"Yan","year":"1995","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.jhep.2010.07.031_b0115","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/0895-4356(93)90101-6","article-title":"Causality assessment of adverse reactions to drugs-I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries","volume":"46","author":"Danan","year":"1993","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.jhep.2010.07.031_b0120","unstructured":"Health Department and National Chinese Medicine Management Office. Zhonghua Bencao. vol. 3. Shanghai: Shanghai Science and Technology Publishing House; 1999; p. 765\u20136."},{"key":"10.1016\/j.jhep.2010.07.031_b0125","first-page":"181","article-title":"Microsomal formation of a pyrrolic alcohol glutathione conjugate of clivorine, firm evidence for the formation of pyrrolic metabolite of an otonecine-type pyrrolizidine alkaloid","volume":"26","author":"Lin","year":"1998","journal-title":"Drug Metab Disp"},{"key":"10.1016\/j.jhep.2010.07.031_b0130","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1002\/mas.20094","article-title":"Time of flight mass spectrometry applied to the liquid chromatographic analysis of pesticides in water and food","volume":"25","author":"Lacorte","year":"2006","journal-title":"Mass Spectrom Rev"},{"key":"10.1016\/j.jhep.2010.07.031_b0135","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0140-6736(93)92984-2","article-title":"Rapidly progressive interstitial fibrosis in young women: association with slimming regimen including Chinese herbs","volume":"341","author":"Vanherwegham","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2010.07.031_b0140","first-page":"2402","article-title":"Clinical analysis of hepatic veno-occlusive disease induced by Sedum aizoon","volume":"33","author":"Wu","year":"2008","journal-title":"China J Chin Mater Med"},{"key":"10.1016\/j.jhep.2010.07.031_b0145","first-page":"593","article-title":"Sonogaphic characteristics of hepatic veno-occlusive disease","volume":"10","author":"Ma","year":"2008","journal-title":"Zhejiang Clin Med J"},{"key":"10.1016\/j.jhep.2010.07.031_b0150","first-page":"107","article-title":"Clinical and pathological diagnosis of hepatic veno-occlusive disease","volume":"11","author":"Liu","year":"2008","journal-title":"J Clin Hepatol"},{"key":"10.1016\/j.jhep.2010.07.031_b0155","first-page":"90","article-title":"Treatment of hepatic veno-occlusive disease induced by overdose of Gynura segetum","volume":"14","author":"Zhang","year":"2009","journal-title":"Zhejiang J Trauma"},{"key":"10.1016\/j.jhep.2010.07.031_b0160","first-page":"412","article-title":"Treatment of 8 cases of hepatic veno-occlusive disease induced by Tusanqi","volume":"18","author":"Huang","year":"2009","journal-title":"Mod J Integr Trad Chin West Med"},{"key":"10.1016\/j.jhep.2010.07.031_b0165","first-page":"26","article-title":"The diagnosis and treatment of hepatic veno-occlusive disease induced by Gynura root","volume":"20","author":"Huang","year":"2008","journal-title":"Chin J Clin Gastroenterol"},{"key":"10.1016\/j.jhep.2010.07.031_b0170","first-page":"251","article-title":"A case report of wrong diagnosis of hepatic veno-occlusive disease and review of the literature","volume":"17","author":"Li","year":"2007","journal-title":"Chin J Integr Trad West Med Liver Dis"},{"key":"10.1016\/j.jhep.2010.07.031_b0175","first-page":"319","article-title":"Two cases of hepatic veno-occlusive disease induced by Tusanqi","volume":"22","author":"Li","year":"2006","journal-title":"Chin J Clin Hepatol"},{"key":"10.1016\/j.jhep.2010.07.031_b0180","first-page":"513","article-title":"Two cases of veno-occlusive disease and review","volume":"17","author":"Pang","year":"2008","journal-title":"Chin J Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2010.07.031_b0185","first-page":"394","article-title":"Two cases of hepatic veno-occlusive disease induced by Tusanqi","volume":"13","author":"Chen","year":"2005","journal-title":"Chin J Hepatol"},{"key":"10.1016\/j.jhep.2010.07.031_b0190","first-page":"344","article-title":"A case report of acute liver damage induced by Jusanqi","volume":"10","author":"Yan","year":"2005","journal-title":"Chin Hepatol"},{"key":"10.1016\/j.jhep.2010.07.031_b0195","unstructured":"Li JP, Hu MH, Jin HH, Dai T, Zhu LF. Treatment of hepatic veno-occlusive disease by orthotopic liver transplantation. Chin J Hepatobil Surg 2001;7:cover 2."},{"key":"10.1016\/j.jhep.2010.07.031_b0200","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.ejim.2007.03.006","article-title":"Hepatic veno-occlusive disease associated with the use of Gynura segetum","volume":"18","author":"Chen","year":"2007","journal-title":"Europ J Intern Med"},{"key":"10.1016\/j.jhep.2010.07.031_b0205","first-page":"191","article-title":"Alkaloids of Gynura segetum (Lour.) Merr","volume":"25","author":"Yuan","year":"1990","journal-title":"Acta Pharm Sin"},{"key":"10.1016\/j.jhep.2010.07.031_b0210","unstructured":"Jiangsu New Medicinal College. Dictionary of Chinese Herbal Medicine. Shanghai: People\u2019s Publishing House; 1977."},{"key":"10.1016\/j.jhep.2010.07.031_b0215","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/0003-2697(70)90478-1","article-title":"Estimation of metabolites of pyrrolizidine alkaloids in animal tissues","volume":"38","author":"Mattocks","year":"1970","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jhep.2010.07.031_b0220","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/00007691-200006000-00011","article-title":"Clinical and analytical aspects of pyrrolizidine poisoning caused by South African traditional medicines","volume":"22","author":"Steenkamp","year":"2000","journal-title":"Ther Drug Monit"},{"key":"10.1016\/j.jhep.2010.07.031_b0225","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1159\/000070799","article-title":"Veno-occlusive disease in a fetus caused by pyrrolizidine alkaloids of food origin","volume":"18","author":"Rasenack","year":"2003","journal-title":"Fetal Diagn Ther"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827810008238?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827810008238?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:31:01Z","timestamp":1740529861000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827810008238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S0168827810008238"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2010.07.031","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4]]}}}