{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:00:35Z","timestamp":1790114435199,"version":"4.0.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NIH","award":["AA002666"],"award-info":[{"award-number":["AA002666"]}]},{"name":"NIH","award":["AA008169"],"award-info":[{"award-number":["AA008169"]}]},{"name":"NIH","award":["AA011431"],"award-info":[{"award-number":["AA011431"]}]},{"name":"NIH","award":["AA012908"],"award-info":[{"award-number":["AA012908"]}]},{"name":"NIH","award":["AA11290"],"award-info":[{"award-number":["AA11290"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.jhep.2010.08.007","type":"journal-article","created":{"date-parts":[[2010,9,7]],"date-time":"2010-09-07T08:31:30Z","timestamp":1283848290000},"page":"164-172","source":"Crossref","is-referenced-by-count":103,"title":["Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease"],"prefix":"10.1016","volume":"54","author":[{"given":"Zoltan","family":"Derdak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles H.","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine A.","family":"Villegas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas M.","family":"Mark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne M.","family":"de la Monte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack R.","family":"Wands","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2010.08.007_b0005","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s00535-007-2075-3","article-title":"Conceptual importance of identifying alcoholic liver disease as a lifestyle disease","volume":"42","author":"Tsukamoto","year":"2007","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.jhep.2010.08.007_b0010","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1055\/s-2006-960170","article-title":"Genetics of alcoholic liver disease and nonalcoholic fatty liver disease","volume":"27","author":"Wilfred de Alwis","year":"2007","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jhep.2010.08.007_b0015","doi-asserted-by":"crossref","first-page":"e477","DOI":"10.1111\/j.1440-1746.2008.05339.x","article-title":"Insulin resistance in experimental alcohol-induced liver disease","volume":"23","author":"de la Monte","year":"2008","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2010.08.007_b0020","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1053\/jhep.2003.50368","article-title":"Potential role of PTEN phosphatase in ethanol-impaired survival signaling in the liver","volume":"38","author":"Yeon","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.08.007_b0025","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S1097-2765(01)00323-9","article-title":"Regulation of PTEN transcription by p53","volume":"8","author":"Stambolic","year":"2001","journal-title":"Mol Cell"},{"key":"10.1016\/j.jhep.2010.08.007_b0030","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.bbrc.2004.09.213","article-title":"Abrogation of hepatocyte apoptosis and early appearance of liver dysplasia in ethanol-fed p53-deficient mice","volume":"325","author":"Pani","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jhep.2010.08.007_b0035","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.bbrc.2008.06.006","article-title":"Alcohol alters hepatic FoxO1, p53, and mitochondrial SIRT5 deacetylation function","volume":"373","author":"Lieber","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jhep.2010.08.007_b0040","doi-asserted-by":"crossref","first-page":"3872","DOI":"10.1038\/sj.onc.1205513","article-title":"A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis","volume":"21","author":"Trinei","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.jhep.2010.08.007_b0045","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.biocel.2008.10.011","article-title":"The p53-p66shc-Manganese Superoxide Dismutase (MnSOD) network: a mitochondrial intrigue to generate reactive oxygen species","volume":"41","author":"Pani","year":"2009","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.jhep.2010.08.007_b0050","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.jhep.2009.01.021","article-title":"PPARdelta agonist attenuates alcohol-induced hepatic insulin resistance and improves liver injury and repair","volume":"50","author":"Pang","year":"2009","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2010.08.007_b0055","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/0003-2697(89)90646-5","article-title":"An endpoint enzymatic assay for fructose 2,6-bisphosphate performed in 96-well plates","volume":"178","author":"Bruni","year":"1989","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jhep.2010.08.007_b0060","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1210\/endo.130.1.1727716","article-title":"Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output","volume":"130","author":"Lang","year":"1992","journal-title":"Endocrinology"},{"key":"10.1016\/j.jhep.2010.08.007_b0065","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/hep.21310","article-title":"Lack of UCP2 reduces Fas-mediated liver injury in ob\/ob mice and reveals importance of cell-specific UCP2 expression","volume":"44","author":"Fulop","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.08.007_b0070","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1158\/0008-5472.CAN-08-0053","article-title":"The mitochondrial uncoupling protein-2 promotes chemoresistance in cancer cells","volume":"68","author":"Derdak","year":"2008","journal-title":"Cancer Res"},{"key":"10.1016\/j.jhep.2010.08.007_b0075","doi-asserted-by":"crossref","first-page":"4502","DOI":"10.1093\/nar\/29.21.4502","article-title":"Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: analysis by laser-capture microdissection","volume":"29","author":"Cao","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jhep.2010.08.007_b0080","doi-asserted-by":"crossref","first-page":"29342","DOI":"10.1074\/jbc.M202411200","article-title":"Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP)","volume":"277","author":"You","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2010.08.007_b0085","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1053\/j.gastro.2004.09.049","article-title":"The role of AMP-activated protein kinase in the action of ethanol in the liver","volume":"127","author":"You","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2010.08.007_b0090","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/ncb1111","article-title":"SREBPs suppress IRS-2-mediated insulin signalling in the liver","volume":"6","author":"Ide","year":"2004","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jhep.2010.08.007_b0095","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S1097-2765(05)00010-9","article-title":"Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob\/ob mice","volume":"6","author":"Shimomura","year":"2000","journal-title":"Mol Cell"},{"key":"10.1016\/j.jhep.2010.08.007_b0100","doi-asserted-by":"crossref","first-page":"S99","DOI":"10.1002\/hep.20973","article-title":"Nonalcoholic fatty liver disease: from steatosis to cirrhosis","volume":"43","author":"Farrell","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.08.007_b0105","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1365-2036.2008.03710.x","article-title":"Review article: current management of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis","volume":"28","author":"Younossi","year":"2008","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jhep.2010.08.007_b0110","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/BF00763099","article-title":"Molecular basis of mitochondrial DNA disease","volume":"26","author":"Brown","year":"1994","journal-title":"J Bioenergy Biomembr"},{"key":"10.1016\/j.jhep.2010.08.007_b0115","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1056\/NEJM199509073331007","article-title":"Seminars in medicine of the Beth Israel Hospital, Boston. Mitochondrial DNA and disease","volume":"333","author":"Johns","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2010.08.007_b0120","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1038\/nm1001-1111","article-title":"Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells","volume":"7","author":"Hwang","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.jhep.2010.08.007_b0125","doi-asserted-by":"crossref","first-page":"26591","DOI":"10.1074\/jbc.M109.022491","article-title":"JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis","volume":"284","author":"Cazanave","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2010.08.007_b0130","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1002\/hep.21904","article-title":"Acute ethanol exposure inhibits insulin signaling in the liver","volume":"46","author":"He","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2010.08.007_b0135","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1126\/science.1126863","article-title":"P53 regulates mitochondrial respiration","volume":"312","author":"Matoba","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.jhep.2010.08.007_b0140","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1074\/jbc.M807821200","article-title":"Structural and biochemical studies of TIGAR (TP53-induced glycolysis and apoptosis regulator)","volume":"284","author":"Li","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2010.08.007_b0145","doi-asserted-by":"crossref","first-page":"E536","DOI":"10.1152\/ajpendo.00126.2006","article-title":"Perturbation of glucose flux in the liver by decreasing F26P2 levels causes hepatic insulin resistance and hyperglycemia","volume":"291","author":"Wu","year":"2006","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jhep.2010.08.007_b0150","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1111\/j.1530-0277.2007.00452.x","article-title":"Chronic ethanol-induced insulin resistance is associated with macrophage infiltration into adipose tissue and altered expression of adipocytokines","volume":"31","author":"Kang","year":"2007","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.jhep.2010.08.007_b0155","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1055\/s-2001-12929","article-title":"Mitochondria in steatohepatitis","volume":"21","author":"Pessayre","year":"2001","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jhep.2010.08.007_b0160","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cell.2006.05.036","article-title":"TIGAR, a p53-inducible regulator of glycolysis and apoptosis","volume":"126","author":"Bensaad","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2010.08.007_b0165","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1126\/science.7678183","article-title":"Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance","volume":"259","author":"Hotamisligil","year":"1993","journal-title":"Science"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827810007786?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827810007786?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T00:39:27Z","timestamp":1559608767000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827810007786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S0168827810007786"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2010.08.007","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}