{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:57:49Z","timestamp":1790337469507,"version":"4.1.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Duke Hepatology Clinic Database and Biorepository"},{"name":"Diane Uzarski"},{"name":"Crystal Cates"},{"name":"Chris Delionbach"},{"name":"Melissa Austin"},{"name":"Arlene Hughes"},{"name":"Michael Mosteller"},{"name":"David H Murdock Institute for Business and Culture"},{"DOI":"10.13039\/100006510","name":"Duke University","doi-asserted-by":"crossref","award":["1 UL1 RR024128-01"],"award-info":[{"award-number":["1 UL1 RR024128-01"]}],"id":[{"id":"10.13039\/100006510","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Dr. Robert Califf, Principal Investigator"},{"DOI":"10.13039\/100006513","name":"Duke Clinical Research Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006513","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Richard B"},{"name":"Boebel Family Fund"},{"name":"National Health and Medical Research Council of Australia"},{"DOI":"10.13039\/501100001202","name":"Gastroenterology Society of Australia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001202","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1016\/j.jhep.2011.03.015","type":"journal-article","created":{"date-parts":[[2011,4,20]],"date-time":"2011-04-20T02:05:12Z","timestamp":1303265112000},"page":"1195-1200","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":67,"title":["Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C"],"prefix":"10.1016","volume":"55","author":[{"given":"Hans L.","family":"Tillmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyur","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Muir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia D.","family":"Guy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine H.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang Qian","family":"Lao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen D.","family":"Gardner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"McHutchison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette J.","family":"McCarthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2011.03.015_b0005","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nature08309","article-title":"Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance","volume":"461","author":"Ge","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2011.03.015_b0010","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2010.10.004","article-title":"Thio CL.IL28B and the control of hepatitis C virus infection","author":"Balagopal","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2011.03.015_b0015","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1002\/hep.23592","article-title":"Interferon lambda genotype and low serum LDL cholesterol levels in patients with chronic hepatitis C infection","volume":"51","author":"Li","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2011.03.015_b0020","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1053\/j.gastro.2009.12.003","article-title":"Farglitazar lacks antifibrotic activity in patients with chronic hepatitis C infection","volume":"138","author":"McHutchison","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2011.03.015_b0025","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1479-5876-5-33","article-title":"Serum proteomic analysis focused on fibrosis in patients with hepatitis C virus infection","volume":"5","author":"White","year":"2007","journal-title":"J Transl Med"},{"key":"10.1016\/j.jhep.2011.03.015_b0030","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1111\/j.1572-0241.1999.01377.x","article-title":"Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions","volume":"94","author":"Brunt","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2011.03.015_b0035","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1053\/j.gastro.2010.07.005","article-title":"A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice","volume":"139","author":"Tillmann","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2011.03.015_b0040","article-title":"Importance of IL28B gene polymorphisms in hepatitis C virus genotype 2 and 3 infected patients","author":"Sarrazin","year":"2010","journal-title":"J Hepatol"},{"issue":"8","key":"10.1016\/j.jhep.2011.03.015_b0045","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.3851\/IMP1689","article-title":"Screening for IL28B gene variants identifies predictors of hepatitis C therapy success","volume":"15","author":"Doehring","year":"2010","journal-title":"Antivir Ther"},{"key":"10.1016\/j.jhep.2011.03.015_b0050","doi-asserted-by":"crossref","DOI":"10.1099\/vir.0.029124-0","article-title":"IL-28B predicts response to chronic hepatitis C therapy -fine-mapping and replication study in Asian populations","author":"Ochi","year":"2011","journal-title":"J Gen Virol."},{"key":"10.1016\/j.jhep.2011.03.015_b0055","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0016-5085(93)90432-C","article-title":"Pathological diagnosis of chronic hepatitis C: a multicenter comparative study with chronic hepatitis B. The hepatitis interventional therapy group","volume":"104","author":"Lefkowitch","year":"1993","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2011.03.015_b0060","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/hep.1840150403","article-title":"The histological features of chronic hepatitis C and autoimmune chronic hepatitis: a comparative analysis","volume":"15","author":"Bach","year":"1992","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2011.03.015_b0065","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1161\/01.ATV.2.1.68","article-title":"Effect of interferon on plasma lipoproteins and on the activity of postheparin plasma lipases","volume":"2","author":"Ehnholm","year":"1982","journal-title":"Arteriosclerosis"},{"key":"10.1016\/j.jhep.2011.03.015_b0070","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1002\/hep.510250632","article-title":"Interferon alpha induces disorder of lipid metabolism by lowering postheparin lipases and cholesteryl ester transfer protein activities in patients with chronic hepatitis C","volume":"25","author":"Shinohara","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2011.03.015_b0075","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1046\/j.1365-2036.2000.00792.x","article-title":"Effects of interferon-beta on plasma lipid and lipoprotein composition and post-heparin lipase activities in patients with chronic hepatitis C","volume":"14","author":"Andrade","year":"2000","journal-title":"Aliment Pharmacol Ther"},{"issue":"9","key":"10.1016\/j.jhep.2011.03.015_b0080","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1161\/01.ATV.12.9.1053","article-title":"The effect of interferon on the metabolism of LDLs","volume":"12","author":"Schectman","year":"1992","journal-title":"Arterioscler Thromb"},{"key":"10.1016\/j.jhep.2011.03.015_b0085","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1128\/JVI.01156-09","article-title":"Modulation of hepatitis C virus RNA abundance and the isoprenoid biosynthesis pathway by microRNA miR-122 involves distinct mechanisms","volume":"84","author":"Sarnow","year":"2010","journal-title":"J Virol"},{"key":"10.1016\/j.jhep.2011.03.015_b0090","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.tem.2009.05.007","article-title":"Meta-regulation: microRNA regulation of glucose and lipid metabolism","volume":"20","author":"Lynn","year":"2009","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.jhep.2011.03.015_b0095","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cmet.2006.01.005","article-title":"MiR-122 regulation of lipid metabolism revealed by in vivo antisense targeting","volume":"3","author":"Esau","year":"2006","journal-title":"Cell Metab"},{"key":"10.1016\/j.jhep.2011.03.015_b0100","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1872-034X.2009.00607.x","article-title":"A predictive model of response to peginterferon ribavirin in chronic hepatitis C using classification and regression tree analysis","volume":"40","author":"Kurosaki","year":"2010","journal-title":"Hepatol Res"},{"key":"10.1016\/j.jhep.2011.03.015_b0105","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1177\/135965350901400501","article-title":"Time course of insulin resistance during antiviral therapy in non-diabetic, non-cirrhotic patients with genotype 1 HCV infection","volume":"14","author":"Petta","year":"2009","journal-title":"Antivir Ther"},{"key":"10.1016\/j.jhep.2011.03.015_b0110","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1053\/j.gastro.2010.06.062","article-title":"Randomized trial of albinterferon alfa-2b for the treatment of patients with chronic hepatitis C virus genotype 2 or 3","volume":"139","author":"Nelson","year":"2010","journal-title":"Gastroenterology"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827811002893?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827811002893?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T19:32:24Z","timestamp":1759174344000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827811002893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S0168827811002893"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2011.03.015","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2011.03.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}