{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:37:43Z","timestamp":1791268663194,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.jhep.2011.03.022","type":"journal-article","created":{"date-parts":[[2011,5,22]],"date-time":"2011-05-22T17:36:12Z","timestamp":1306085772000},"page":"26-33","source":"Crossref","is-referenced-by-count":137,"title":["Protective role of IL-33\/ST2 axis in Con A-induced hepatitis"],"prefix":"10.1016","volume":"56","author":[{"given":"Vladislav","family":"Volarevic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Mitrovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marija","family":"Milovanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivanka","family":"Zelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Nikolic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slobodanka","family":"Mitrovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"Pejnovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nebojsa","family":"Arsenijevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miodrag L.","family":"Lukic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2011.03.022_b0005","doi-asserted-by":"crossref","first-page":"3712","DOI":"10.4049\/jimmunol.0901221","article-title":"Inflammatory regulation by TLR3 in acute hepatitis","volume":"183","author":"Xiao","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.jhep.2011.03.022_b0010","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1248\/bpb.32.1215","article-title":"Hepatoprotective effect of syringic acid and vanillic acid on concanavalin a-induced liver injury","volume":"32","author":"Itoh","year":"2009","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.jhep.2011.03.022_b0015","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.jhep.2005.08.019","article-title":"Up-regulation of the anti-inflammatory adipokine adiponectin in acute liver failure in mice","volume":"44","author":"Wolf","year":"2006","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2011.03.022_b0020","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.jhep.2005.06.022","article-title":"Transgenic overexpression of interleukin-8 in mouse liver protects against galactosamine\/endotoxin toxicity","volume":"44","author":"Hanson","year":"2006","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2011.03.022_b0025","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1172\/JCI115836","article-title":"A T cell-dependent experimental liver injury in mice inducible by concanavalin A","volume":"90","author":"Tiegs","year":"1992","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2011.03.022_b0030","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1046\/j.1440-1711.1998.00779.x","article-title":"IL-6, IFN-gamma and TNF-alpha production by liver-associated T cells and acute liver injury in rats administered concanavalin A","volume":"76","author":"Cao","year":"1998","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.jhep.2011.03.022_b0035","first-page":"190","article-title":"Concanavalin A-induced T-cell-mediated hepatic injury in mice: the role of tumor necrosis factor","volume":"21","author":"Gantner","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2011.03.022_b0040","first-page":"1608","article-title":"Critical involvement of interferon gamma in the pathogenesis of T-cell activation-associated hepatitis and regulatory mechanisms of interleukin-6 for the manifestations of hepatitis","volume":"23","author":"Mizuhara","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2011.03.022_b0045","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1189\/jlb.72.2.262","article-title":"Concanavalin-A-induced liver injury is severely impaired in mice deficient in P-selectin","volume":"72","author":"Massaguer","year":"2002","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jhep.2011.03.022_b0050","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1053\/gast.1996.v111.pm8690213","article-title":"Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A","volume":"111","author":"K\u00fcsters","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2011.03.022_b0055","doi-asserted-by":"crossref","first-page":"5498","DOI":"10.1073\/pnas.040566697","article-title":"Critical contribution of liver natural killer T cells to a murine model of hepatitis","volume":"97","author":"Takeda","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jhep.2011.03.022_b0060","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.jhep.2005.08.015","article-title":"Poly I:C prevents T cell-mediated hepatitis via an NK-dependent mechanism","volume":"44","author":"Wang","year":"2006","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2011.03.022_b0065","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.immuni.2005.09.015","article-title":"IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines","volume":"23","author":"Schmitz","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.jhep.2011.03.022_b0070","doi-asserted-by":"crossref","first-page":"6633","DOI":"10.4049\/jimmunol.166.11.6633","article-title":"A novel pathway regulating lipopolysaccharide-induced shock by ST2\/T1 via inhibition of Toll-like receptor 4 expression","volume":"166","author":"Sweet","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.jhep.2011.03.022_b0075","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0014-5793(89)81679-5","article-title":"A putative protein of a growth specific cDNA from BALB\/c-3T3 cells is highly similar to the extracellular portion of mouse interleukin 1 receptor","volume":"258","author":"Tominaga","year":"1989","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jhep.2011.03.022_b0080","doi-asserted-by":"crossref","first-page":"26369","DOI":"10.1074\/jbc.M704916200","article-title":"Soluble ST2 blocks IL-33 signaling in allergic airway inflammation","volume":"282","author":"Hayakawa","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2011.03.022_b0085","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1006\/bbrc.2001.5090","article-title":"Identification of human ST2 protein in the sera of patients with autoimmune diseases","volume":"284","author":"Kuroiwa","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jhep.2011.03.022_b0090","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1002\/art.24305","article-title":"Inhibition of interleukin-33 signaling attenuates the severity of experimental arthritis","volume":"60","author":"Palmer","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jhep.2011.03.022_b0095","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nri2692","article-title":"Disease-associated functions of IL-33: the new kid in the IL-1 family","volume":"10","author":"Liew","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jhep.2011.03.022_b0100","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.immuni.2009.06.011","article-title":"IL-33 raises alarm","volume":"31","author":"Lamkanfi","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.jhep.2011.03.022_b0105","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1084\/jem.187.5.787","article-title":"Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T cells","volume":"187","author":"Xu","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.jhep.2011.03.022_b0110","doi-asserted-by":"crossref","first-page":"4866","DOI":"10.4049\/jimmunol.161.9.4866","article-title":"The IL-1 receptor-related T1 antigen is expressed on immature and mature mast cells and on fetal blood mast cell progenitors","volume":"161","author":"Moritz","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.jhep.2011.03.022_b0115","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0006-291X(02)02578-0","article-title":"ST2 protein induced by inflammatory stimuli can modulate acute lung inflammation","volume":"299","author":"Oshikawa","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jhep.2011.03.022_b0120","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1002\/j.1460-2075.1994.tb06367.x","article-title":"Alternative promoter usage of the Fos-responsive gene Fit-1 generates mRNA isoforms coding for either secreted or membrane-bound proteins related to the IL-1 receptor","volume":"13","author":"Bergers","year":"1994","journal-title":"EMBO J"},{"key":"10.1016\/j.jhep.2011.03.022_b0125","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1084\/jem.191.6.1069","article-title":"T1\/ST2-deficient mice demonstrate the importance of T1\/ST2 in developing primary T helper cell type 2 responses","volume":"191","author":"Townsend","year":"2000","journal-title":"J Exp Med"},{"key":"10.1016\/j.jhep.2011.03.022_b0130","first-page":"45","article-title":"The new semi-quantitative method for determination of liver damage after Concanavalin A administration","volume":"11","author":"Volarevic","year":"2010","journal-title":"Ser J Exp Clin Res"},{"key":"10.1016\/j.jhep.2011.03.022_b0135","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1365-2249.2008.03815.x","article-title":"Isolation of murine intrahepatic immune cells employing a modified procedure for mechanical disruption and functional characterization of the B, T and natural killer T cells obtained","volume":"155","author":"Blom","year":"2008","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jhep.2011.03.022_b0140","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1189\/jlb.0905527","article-title":"l-Selectin and intercellular adhesion molecule-1 regulate the development of Concanavalin A-induced liver injury","volume":"79","author":"Kawasuji","year":"2006","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jhep.2011.03.022_b0145","doi-asserted-by":"crossref","first-page":"7473","DOI":"10.4049\/jimmunol.181.11.7473","article-title":"Requirement of IL-17RA in Con A induced hepatitis and negative regulation of IL-17 production in mouse T cells","volume":"181","author":"Nagata","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.jhep.2011.03.022_b0150","doi-asserted-by":"crossref","first-page":"3278","DOI":"10.4049\/jimmunol.0803417","article-title":"End-organ damage in a mouse model of fulminant liver inflammation requires CD4+ T cell production of IFN-\u03b3 but is independent of Fas","volume":"182","author":"Robinson","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.jhep.2011.03.022_b0155","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.4049\/jimmunol.159.3.1418","article-title":"Suppression of concanavalin A-induced hepatitis in IFN-\u03b3\u2212\/\u2212 mice, but not in TNF-\u03b1\u2212\/\u2212 mice. role for IFN-\u03b3 in activating apoptosis of hepatocytes","volume":"159","author":"Tagawa","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.jhep.2011.03.022_b0160","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1067\/mai.2002.123233","article-title":"IFN-gamma secretion by CD8T cells inhibits allergen-induced airway eosinophilia but not late airway responses","volume":"109","author":"Suzuki","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jhep.2011.03.022_b0165","first-page":"241","article-title":"The roles of innate immune cells in liver injury and regeneration","volume":"4","author":"Dong","year":"2007","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.jhep.2011.03.022_b0170","doi-asserted-by":"crossref","first-page":"5498","DOI":"10.1073\/pnas.040566697","article-title":"Critical contribution of liver natural killer T cells to a murine model of hepatitis","volume":"97","author":"Takeda","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jhep.2011.03.022_b0175","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.immuni.2007.07.023","article-title":"Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation","volume":"27","author":"Zenewicz","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.jhep.2011.03.022_b0180","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.2353\/ajpath.2010.100028","article-title":"Protective role of interleukin-17 in murine NKT cell-driven acute experimental hepatitis","volume":"177","author":"Wondimu","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jhep.2011.03.022_b0185","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/hep.21498","article-title":"IL-10, regulatory T cells, and Kupffer cells mediate tolerance in concanavalin A-induced liver injury in mice","volume":"45","author":"Erhardt","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2011.03.022_b0190","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1093\/intimm\/dxn060","article-title":"IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK cells","volume":"20","author":"Smithgall","year":"2008","journal-title":"Int Immunol"},{"key":"10.1016\/j.jhep.2011.03.022_b0195","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1002\/eji.200838575","article-title":"The pro-Th2 cytokine IL-33 directly interacts with invariant NKT and NK cells to induce IFN-gamma production","volume":"39","author":"Bourgeois","year":"2009","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jhep.2011.03.022_b0200","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1161\/CIRCHEARTFAILURE.109.873240","article-title":"Interleukin-33 prevents apoptosis and improves survival after experimental myocardial infarction through ST2 signaling","volume":"2","author":"Seki","year":"2009","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jhep.2011.03.022_b0205","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.immuni.2009.05.007","article-title":"Suppression of Interleukin-33 bioactivity through proteolysis by apoptotic caspases","volume":"31","author":"Luthi","year":"2009","journal-title":"Immunity"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827811003680?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827811003680?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T23:33:42Z","timestamp":1686094422000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827811003680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S0168827811003680"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2011.03.022","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}