{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:19:17Z","timestamp":1791109157239,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.jhep.2012.04.019","type":"journal-article","created":{"date-parts":[[2012,5,22]],"date-time":"2012-05-22T02:26:51Z","timestamp":1337653611000},"page":"499-507","source":"Crossref","is-referenced-by-count":21,"title":["Hepatitis C virus (HCV) protein expression enhances hepatic fibrosis in HCV transgenic mice exposed to a fibrogenic agent"],"prefix":"10.1016","volume":"57","author":[{"given":"Philippe","family":"Chouteau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Defer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Florimond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Cald\u00e9raro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Higgs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurore","family":"Gaudin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"M\u00e9rour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Dhumeaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Lerat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel","family":"Pawlotsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2012.04.019_b0005","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1053\/gast.2002.31001","article-title":"Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus","volume":"122","author":"Lerat","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2012.04.019_b0010","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1053\/j.gastro.2003.12.005","article-title":"Impaired clearance of virus-infected hepatocytes in transgenic mice expressing the hepatitis C virus polyprotein","volume":"126","author":"Disson","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2012.04.019_b0015","doi-asserted-by":"crossref","first-page":"33466","DOI":"10.1074\/jbc.M109.019810","article-title":"Hepatitis C virus proteins induce lipogenesis and defective triglyceride secretion in transgenic mice","volume":"284","author":"Lerat","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2012.04.019_b0020","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1053\/j.gastro.2007.10.011","article-title":"Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription","volume":"134","author":"Nishina","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2012.04.019_b0025","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1002\/hep.23169","article-title":"Calpain activation by hepatitis C virus proteins inhibits the extrinsic apoptotic signaling pathway","volume":"50","author":"Simonin","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2012.04.019_b0030","doi-asserted-by":"crossref","first-page":"4901","DOI":"10.1158\/0008-5472.CAN-09-4554","article-title":"Downregulation of Gadd45beta expression by hepatitis C virus leads to defective cell cycle arrest","volume":"70","author":"Higgs","year":"2010","journal-title":"Cancer Res"},{"key":"10.1016\/j.jhep.2012.04.019_b0035","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/hep.1840040307","article-title":"Purified rat liver fat-storing cells in culture divide and contain collagen","volume":"4","author":"De Leeuw","year":"1984","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2012.04.019_b0040","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/ncpgasthep0055","article-title":"Mechanisms of disease: mechanisms of hepatic fibrosis and therapeutic implications","volume":"1","author":"Friedman","year":"2004","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2012.04.019_b0045","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0003-2697(87)90673-7","article-title":"Isolation and culture of hepatic lipocytes, Kupffer cells, and sinusoidal endothelial cells by density gradient centrifugation with Stractan","volume":"161","author":"Friedman","year":"1987","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jhep.2012.04.019_b0050","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.1073\/pnas.73.10.3719","article-title":"Vitamin A-containing lipocytes and formation of type III collagen in liver injury","volume":"73","author":"Kent","year":"1976","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2012.04.019_b0055","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1053\/j.gastro.2009.07.050","article-title":"Visualizing hepatitis C virus infections in human liver by two-photon microscopy","volume":"137","author":"Liang","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2012.04.019_b0060","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1002\/hep.20130","article-title":"Nomenclature of the finer branches of the biliary tree: canals, ductules, and ductular reactions in human livers","volume":"39","author":"Roskams","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2012.04.019_b0065","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1053\/j.gastro.2004.09.076","article-title":"Relation between hepatocyte G1 arrest, impaired hepatic regeneration, and fibrosis in chronic hepatitis C virus infection","volume":"128","author":"Marshall","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2012.04.019_b0070","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1023\/A:1011977923941","article-title":"P21WAF1\/CTP1 expression and hepatitis virus type","volume":"46","author":"Wagayama","year":"2001","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jhep.2012.04.019_b0075","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1053\/jhep.2003.50371","article-title":"Sympathetic nervous system inhibition increases hepatic progenitors and reduces liver injury","volume":"38","author":"Oben","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2012.04.019_b0080","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1053\/jhep.2001.28457","article-title":"Transforming growth factor beta and the liver","volume":"34","author":"Bissell","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2012.04.019_b0085","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/hep.20082","article-title":"Oval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease","volume":"39","author":"Yang","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2012.04.019_b0090","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0168-8278(98)80065-2","article-title":"Hepatic OV-6 expression in human liver disease and rat experiments: evidence for hepatic progenitor cells in man","volume":"29","author":"Roskams","year":"1998","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2012.04.019_b0095","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1017\/S1462399409000994","article-title":"Cholangiocyte proliferation and liver fibrosis","volume":"11","author":"Glaser","year":"2009","journal-title":"Expert Rev Mol Med"},{"key":"10.1016\/j.jhep.2012.04.019_b0100","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0168-8278(99)80169-X","article-title":"Expression of platelet-derived growth factor in newly formed cholangiocytes during experimental biliary fibrosis in rats","volume":"31","author":"Grappone","year":"1999","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2012.04.019_b0105","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s004180050126","article-title":"Heterogeneity of liver cells expressing procollagen types I and IV in vivo","volume":"107","author":"Herbst","year":"1997","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.jhep.2012.04.019_b0110","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0016-5085(95)90019-5","article-title":"Growth factor and procollagen type I gene expression in human liver disease","volume":"108","author":"Malizia","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2012.04.019_b0115","first-page":"59","article-title":"Cellular localization of type I, III and IV procollagen gene transcripts in normal and fibrotic human liver","volume":"137","author":"Milani","year":"1990","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jhep.2012.04.019_b0120","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1002\/hep.510300425","article-title":"Expression of connective tissue growth factor in experimental rat and human liver fibrosis","volume":"30","author":"Paradis","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2012.04.019_b0125","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1053\/gast.1996.v110.pm8566602","article-title":"Endothelin 1 is overexpressed in human cirrhotic liver and exerts multiple effects on activated hepatic stellate cells","volume":"110","author":"Pinzani","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2012.04.019_b0130","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0002-9440(10)65595-2","article-title":"Contribution of hepatic parenchymal and nonparenchymal cells to hepatic fibrogenesis in biliary atresia","volume":"153","author":"Ramm","year":"1998","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jhep.2012.04.019_b0135","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/S0002-9440(10)64074-6","article-title":"Proliferating bile duct epithelial cells are a major source of connective tissue growth factor in rat biliary fibrosis","volume":"158","author":"Sedlaczek","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jhep.2012.04.019_b0140","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1055\/s-0030-1255354","article-title":"Macrophages: master regulators of inflammation and fibrosis","volume":"30","author":"Wynn","year":"2010","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jhep.2012.04.019_b0145","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/hep.20650","article-title":"Fibrosis correlates with a ductular reaction in hepatitis C: roles of impaired replication, progenitor cells and steatosis","volume":"41","author":"Clouston","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2012.04.019_b0150","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/713611034","article-title":"Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model","volume":"33","author":"Weber","year":"2003","journal-title":"Critical Rev Toxicol"},{"key":"10.1016\/j.jhep.2012.04.019_b0155","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.1172\/JCI41732","article-title":"Antagonism of the chemokine CCl5 ameliorates experimental liver fibrosis in mice","volume":"120","author":"Berres","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2012.04.019_b0160","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1053\/j.gastro.2007.05.012","article-title":"Progressive fibrosis in nonalcoholic steatohepatitis: association with altered regeneration and a ductular reaction","volume":"133","author":"Richardson","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2012.04.019_b0165","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1755-1536-1-5","article-title":"Redox mechanisms in hepatic chronic wound healing and fibrogenesis","volume":"1","author":"Novo","year":"2008","journal-title":"Fibrogenesis Tissue Repair"},{"key":"10.1016\/j.jhep.2012.04.019_b0170","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1002\/prca.201000049","article-title":"Hepatitis C virus-induced oxidative stress and mitochondrial dysfunction: a focus on recent advances in proteomics","volume":"4","author":"Simula","year":"2010","journal-title":"Proteomics Clin Appl"},{"key":"10.1016\/j.jhep.2012.04.019_b0175","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1053\/j.gastro.2005.03.089","article-title":"Hepatitis C virus-replicating hepatocytes induce fibrogenic activation of hepatic stellate cells","volume":"129","author":"Schulze-Krebs","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2012.04.019_b0180","doi-asserted-by":"crossref","first-page":"9599","DOI":"10.1073\/pnas.171311298","article-title":"Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B","volume":"98","author":"Gong","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2012.04.019_b0185","first-page":"4365","article-title":"Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis","volume":"61","author":"Moriya","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.jhep.2012.04.019_b0190","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0163-7258(93)90074-N","article-title":"Tissue inhibitor of metalloproteinases (TIMP, aka EPA): structure, control of expression and biological functions","volume":"59","author":"Denhardt","year":"1993","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jhep.2012.04.019_b0195","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1002\/hep.22701","article-title":"P75 neurotrophin receptor signaling regulates hepatic myofibroblast proliferation and apoptosis in recovery from rodent liver fibrosis","volume":"49","author":"Kendall","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2012.04.019_b0200","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1002\/hep.510280320","article-title":"Expression of cyclin-dependent kinase inhibitor p21 in human liver","volume":"28","author":"Crary","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2012.04.019_b0205","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0002-9440(10)65299-6","article-title":"Oval cell numbers in human chronic liver diseases are directly related to disease severity","volume":"154","author":"Lowes","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jhep.2012.04.019_b0210","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jhep.2006.08.015","article-title":"Attenuated liver progenitor (oval) cell and fibrogenic responses to the choline deficient, ethionine supplemented diet in the BALB\/c inbred strain of mice","volume":"46","author":"Knight","year":"2007","journal-title":"J Hepatol"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827812003418?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827812003418?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T09:55:44Z","timestamp":1542966944000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827812003418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0168827812003418"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2012.04.019","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}