{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T03:44:13Z","timestamp":1789703053225,"version":"4.0.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.jhep.2012.04.035","type":"journal-article","created":{"date-parts":[[2012,5,24]],"date-time":"2012-05-24T21:06:19Z","timestamp":1337893579000},"page":"549-555","source":"Crossref","is-referenced-by-count":104,"title":["Molecular MR imaging of liver fibrosis: A feasibility study using rat and mouse models"],"prefix":"10.1016","volume":"57","author":[{"given":"Miloslav","family":"Polasek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan C.","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritika","family":"Uppal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel T.","family":"Sch\u00fchle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamu K.","family":"Alford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galen S.","family":"Loving","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suguru","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Y.","family":"Lauwers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander R.","family":"Guimaraes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth K.","family":"Tanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Caravan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2012.04.035_b0005","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1172\/JCI30542","article-title":"Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ","volume":"117","author":"Iredale","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2012.04.035_b0010","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","article-title":"Mechanisms of hepatic fibrogenesis","volume":"134","author":"Friedman","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2012.04.035_b0015","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2012.04.035_b0020","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1053\/jhep.2003.50320","article-title":"Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C","volume":"38","author":"Hui","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2012.04.035_b0025","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1053\/jhep.2002.33324","article-title":"Survival, liver failure, and hepatocellular carcinoma in obesity-related cryptogenic cirrhosis","volume":"35","author":"Ratziu","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2012.04.035_b0030","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/hep.21347","article-title":"Global challenges in liver disease","volume":"44","author":"Williams","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2012.04.035_b0035","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S1386-6532(05)00384-7","article-title":"Worldwide epidemiology of HBV infection, disease burden, and vaccine prevention","volume":"34","author":"Lavanchy","year":"2005","journal-title":"J Clin Virol"},{"key":"10.1016\/j.jhep.2012.04.035_b0040","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1111\/j.1572-0241.2006.00469.x","article-title":"Introduction to chronic hepatitis B infection","volume":"101","author":"Wright","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2012.04.035_b0045","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.cld.2006.08.022","article-title":"Reversal of fibrosis: no longer a pipe dream?","volume":"10","author":"Fallowfield","year":"2006","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.jhep.2012.04.035_b0050","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1053\/j.gastro.2008.03.001","article-title":"Diagnosis and quantitation of fibrosis","volume":"134","author":"Manning","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2012.04.035_b0055","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1053\/j.gastro.2005.03.084","article-title":"Sampling variability of liver biopsy in nonalcoholic fatty liver disease","volume":"128","author":"Ratziu","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2012.04.035_b0060","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1111\/j.1572-0241.2004.30110.x","article-title":"Evaluation of liver fibrosis: a concise review","volume":"99","author":"Afdhal","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2012.04.035_b0065","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1111\/j.1478-3231.2008.01691.x","article-title":"Utilization rates, complications and costs of percutaneous liver biopsy: a population-based study including 4275 biopsies","volume":"28","author":"Myers","year":"2008","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2012.04.035_b0070","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3748\/wjg.v5.i4.301","article-title":"Liver biopsy: complications and risk factors","volume":"5","author":"Thampanitchawong","year":"1999","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jhep.2012.04.035_b0075","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.gtc.2011.06.010","article-title":"Noninvasive tools to assess hepatic fibrosis: ready for prime time?","volume":"40","author":"Schmeltzer","year":"2011","journal-title":"Gastroenterol Clin North Am"},{"key":"10.1016\/j.jhep.2012.04.035_b0080","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/hep.24013","article-title":"Noninvasive assessment of liver fibrosis","volume":"53","author":"Martinez","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2012.04.035_b0085","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/MOG.0b013e328343e9a3","article-title":"Noninvasive tools to assess liver disease","volume":"27","author":"Clark","year":"2011","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.jhep.2012.04.035_b0090","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1471-230X-11-91","article-title":"Non-Invasive markers for hepatic fibrosis","volume":"11","author":"Baranova","year":"2011","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.jhep.2012.04.035_b0095","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1097\/MCG.0b013e3181e12c39","article-title":"Ultrasound-based hepatic elastography: origins, limitations, and applications","volume":"44","author":"Cohen","year":"2010","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.jhep.2012.04.035_b0100","doi-asserted-by":"crossref","first-page":"4791","DOI":"10.3748\/wjg.v13.i36.4791","article-title":"Transient elastography for the assessment of chronic liver disease: ready for the clinic?","volume":"13","author":"Cobbold","year":"2007","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jhep.2012.04.035_b0105","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1053\/j.gastro.2007.11.053","article-title":"Noninvasive assessment of liver fibrosis and portal hypertension with transient elastography","volume":"134","author":"Rockey","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2012.04.035_b0110","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1053\/j.gastro.2008.01.034","article-title":"Performance of transient elastography for the staging of liver fibrosis: a meta-analysis","volume":"134","author":"Friedrich-Rust","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2012.04.035_b0115","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/ca.21006","article-title":"Magnetic resonance elastography: a review","volume":"23","author":"Mariappan","year":"2010","journal-title":"Clin Anat"},{"key":"10.1016\/j.jhep.2012.04.035_b0120","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1148\/radiol.2402050606","article-title":"MR elastography of the liver: preliminary results","volume":"240","author":"Rouviere","year":"2006","journal-title":"Radiology"},{"key":"10.1016\/j.jhep.2012.04.035_b0125","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1053\/j.gastro.2008.03.076","article-title":"Magnetic resonance elastography for the noninvasive staging of liver fibrosis","volume":"135","author":"Huwart","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2012.04.035_b0130","doi-asserted-by":"crossref","first-page":"553","DOI":"10.2214\/AJR.10.4580","article-title":"Assessment of chronic hepatitis and fibrosis: comparison of MR elastography and diffusion-weighted imaging","volume":"196","author":"Wang","year":"2011","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.jhep.2012.04.035_b0135","doi-asserted-by":"crossref","first-page":"8171","DOI":"10.1002\/anie.200700700","article-title":"Collagen-targeted MRI contrast agent for molecular imaging of fibrosis","volume":"46","author":"Caravan","year":"2007","journal-title":"Angewandte Chemie-International Edition"},{"key":"10.1016\/j.jhep.2012.04.035_b0140","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1148\/radiol.2473070975","article-title":"Postinfarction myocardial scarring in mice. Molecular MR imaging with use of a collagen-targeting contrast agent","volume":"247","author":"Helm","year":"2008","journal-title":"Radiology"},{"key":"10.1016\/j.jhep.2012.04.035_b0145","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1097\/01.rli.0000184756.66360.d3","article-title":"Comparison of magnetic properties of MRI contrast media solutions at different magnetic field strengths","volume":"40","author":"Rohrer","year":"2005","journal-title":"Invest Radiol"},{"key":"10.1016\/j.jhep.2012.04.035_b0150","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/0168-8278(95)80226-6","article-title":"Histological grading and staging of chronic hepatitis","volume":"22","author":"Ishak","year":"1995","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2012.04.035_b0155","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S1570-0232(03)00248-4","article-title":"Liquid chromatographic determination of hydroxyproline in tissue samples","volume":"791","author":"Hutson","year":"2003","journal-title":"Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences"},{"key":"10.1016\/j.jhep.2012.04.035_b0160","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1097\/00004424-199506000-00008","article-title":"Biodistribution of radiolabeled, formulated gadopentetate, gadoteridol, gadoterate, and gadodiamide in mice and rats","volume":"30","author":"Tweedle","year":"1995","journal-title":"Invest Radiol"},{"key":"10.1016\/j.jhep.2012.04.035_b0165","doi-asserted-by":"crossref","first-page":"14","DOI":"10.2214\/AJR.09.2601","article-title":"Advanced MRI methods for assessment of chronic liver disease","volume":"193","author":"Taouli","year":"2009","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.jhep.2012.04.035_b0170","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/hep.21972","article-title":"Magnetic resonance imaging of hepatic fibrosis: emerging clinical applications","volume":"47","author":"Talwalkar","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2012.04.035_b0175","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1148\/radiol.2473070605","article-title":"Induced hepatic fibrosis in rats: hepatic steatosis, macromolecule content, perfusion parameters, and their correlations\u2013preliminary MR imaging in rats","volume":"247","author":"Kim","year":"2008","journal-title":"Radiology"},{"key":"10.1016\/j.jhep.2012.04.035_b0180","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1148\/radiol.09090021","article-title":"Diffusion-weighted MR imaging of the liver","volume":"254","author":"Taouli","year":"2010","journal-title":"Radiology"},{"key":"10.1016\/j.jhep.2012.04.035_b0185","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1148\/radiol.10100853","article-title":"Evaluation of the mean and entropy of apparent diffusion coefficient values in chronic hepatitis C: correlation with pathologic fibrosis stage and inflammatory activity grade","volume":"258","author":"Fujimoto","year":"2011","journal-title":"Radiology"},{"key":"10.1016\/j.jhep.2012.04.035_b0190","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1148\/radiol.2392050505","article-title":"Liver fibrosis: noninvasive diagnosis with double contrast material-enhanced MR imaging","volume":"239","author":"Aguirre","year":"2006","journal-title":"Radiology"},{"key":"10.1016\/j.jhep.2012.04.035_b0195","doi-asserted-by":"crossref","first-page":"e311","DOI":"10.1016\/j.ejrad.2011.01.020","article-title":"Gd-EOB-DTPA-enhanced MR imaging: evaluation of hepatic enhancement effects in normal and cirrhotic livers","volume":"80","author":"Tamada","year":"2011","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.jhep.2012.04.035_b0200","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1148\/radiol.10100621","article-title":"Staging hepatic fibrosis: comparison of gadoxetate disodium-enhanced and diffusion-weighted MR imaging\u2013preliminary observations","volume":"259","author":"Watanabe","year":"2011","journal-title":"Radiology"},{"key":"10.1016\/j.jhep.2012.04.035_b0205","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/jmri.22580","article-title":"Quantitative assessment of liver fat with magnetic resonance imaging and spectroscopy","volume":"34","author":"Reeder","year":"2011","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.jhep.2012.04.035_b0210","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.mri.2009.10.005","article-title":"Diet and gastrointestinal signal on T1-weighted magnetic resonance imaging of mice","volume":"28","author":"Kiryu","year":"2010","journal-title":"Magn Reson Imaging"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827812003650?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827812003650?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T06:22:58Z","timestamp":1542954178000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827812003650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0168827812003650"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2012.04.035","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}