{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T12:35:30Z","timestamp":1769690130652,"version":"3.49.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.jhep.2012.06.017","type":"journal-article","created":{"date-parts":[[2012,6,21]],"date-time":"2012-06-21T18:25:32Z","timestamp":1340303132000},"page":"995-1003","source":"Crossref","is-referenced-by-count":30,"title":["Liver specific deletion of CYLDexon7\/8 induces severe biliary damage, fibrosis and increases hepatocarcinogenesis in mice"],"prefix":"10.1016","volume":"57","author":[{"given":"Toni","family":"Urbanik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina Johanna","family":"Boger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Longerich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Becker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl Roland","family":"Ehrenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"H\u00f6velmeyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Schuchmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"J\u00e4ger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ari","family":"Waisman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus Alexander","family":"W\u00f6rns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Schulze-Bergkamen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2012.06.017_b0005","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1042\/BST0370937","article-title":"The emerging complexity of protein ubiquitination","volume":"37","author":"Komander","year":"2009","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.jhep.2012.06.017_b0010","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/nature01803","article-title":"CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members","volume":"424","author":"Trompouki","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2012.06.017_b0180","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/cdd.2009.43","article-title":"CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes","volume":"17","author":"Sun","year":"2010","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jhep.2012.06.017_b0020","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.cell.2006.03.041","article-title":"Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling","volume":"125","author":"Massoumi","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2012.06.017_b0025","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1172\/JCI28746","article-title":"Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice","volume":"116","author":"Zhang","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2012.06.017_b0030","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1084\/jem.20070318","article-title":"Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD","volume":"204","author":"Hovelmeyer","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.jhep.2012.06.017_b0035","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/carcin\/bgl081","article-title":"Reduced expression of CYLD in human colon and hepatocellular carcinomas","volume":"28","author":"Hellerbrand","year":"2007","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jhep.2012.06.017_b0040","first-page":"121","article-title":"Down-regulation of CYLD as a trigger for NF-kappaB activation and a mechanism of apoptotic resistance in hepatocellular carcinoma cells","volume":"38","author":"Urbanik","year":"2010","journal-title":"Int J Oncol"},{"key":"10.1016\/j.jhep.2012.06.017_b0045","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/hep.22664","article-title":"Knockout of myeloid cell leukemia-1 induces liver damage and increases apoptosis susceptibility of murine hepatocytes","volume":"49","author":"Vick","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2012.06.017_b0050","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/hep.20396","article-title":"Genetic manipulations utilizing albumin and alpha-fetoprotein promoter\/enhancers affect both hepatocytes and oval cells","volume":"40","author":"Matthews","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2012.06.017_b0055","doi-asserted-by":"crossref","first-page":"3818","DOI":"10.1038\/sj.onc.1209558","article-title":"Liver stem cells and their implication in hepatocellular and cholangiocarcinoma","volume":"25","author":"Roskams","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.jhep.2012.06.017_b0060","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1158\/1535-7163.MCT-08-0238","article-title":"SN52, a novel nuclear factor-kappaB inhibitor, blocks nuclear import of RelB:p52 dimer and sensitizes prostate cancer cells to ionizing radiation","volume":"7","author":"Xu","year":"2008","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.jhep.2012.06.017_b0065","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1053\/gast.1996.v111.pm8698195","article-title":"Effects of ursodeoxycholate and cholate feeding on liver disease in FVB mice with a disrupted mdr2 P-glycoprotein gene","volume":"111","author":"Van Nieuwkerk","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2012.06.017_b0070","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nature02924","article-title":"NF-kappaB functions as a tumour promoter in inflammation-associated cancer","volume":"431","author":"Pikarsky","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2012.06.017_b0185","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1002\/hep.24175","article-title":"Transcription factor Fra-1 induces cholangitis and liver fibrosis","volume":"53","author":"Kireva","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2012.06.017_b0080","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1002\/hep.21802","article-title":"Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis","volume":"46","author":"Elsharkawy","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2012.06.017_b0085","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00441-011-1246-y","article-title":"TGF-beta in progression of liver disease","volume":"347","author":"Dooley","year":"2012","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.jhep.2012.06.017_b0090","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/nm1377","article-title":"A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells","volume":"12","author":"Lee","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.jhep.2012.06.017_b0095","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00428-011-1048-3","article-title":"Ductal plates in hepatic ductular reactions. Hypothesis and implications. I. Types of ductular reaction reconsidered","volume":"458","author":"Desmet","year":"2011","journal-title":"Virchows Arch"},{"key":"10.1016\/j.jhep.2012.06.017_b0100","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/hep.22480","article-title":"Notch signaling in bile duct development: new insights raise new questions","volume":"48","author":"Lemaigre","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2012.06.017_b0190","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s00534-010-0365-2","article-title":"Immunohistochemical study of hepatocyte, cholangiocyte and stem cell markers of hepatocellular carcinoma","volume":"18","author":"Shibuya","year":"2011","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"10.1016\/j.jhep.2012.06.017_b0110","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ccr.2006.12.016","article-title":"Deletion of NEMO\/IKK[gamma] in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma","volume":"11","author":"Luedde","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jhep.2012.06.017_b0115","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.gde.2008.01.020","article-title":"NF-kappaB and cancer-identifying targets and mechanisms","volume":"18","author":"Naugler","year":"2008","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/j.jhep.2012.06.017_b0195","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/ni.2060","article-title":"Inflammation meets cancer, with NF-kappaB as the matchmaker","volume":"12","author":"Ben-Neriah","year":"2011","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jhep.2012.06.017_b0125","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/0092-8674(95)90070-5","article-title":"The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation","volume":"81","author":"Hsu","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2012.06.017_b0130","doi-asserted-by":"crossref","first-page":"3688","DOI":"10.1074\/jbc.M610271200","article-title":"Specificity of TRAF3 in its negative regulation of the noncanonical NF-kappa B pathway","volume":"282","author":"He","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2012.06.017_b0200","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nri2998","article-title":"Expanding TRAF function: TRAF3 as a tri-faced immune regulator","volume":"11","author":"Hacker","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jhep.2012.06.017_b0205","doi-asserted-by":"crossref","first-page":"373","DOI":"10.18632\/oncotarget.170","article-title":"Mouse models of hepatocarcinogenesis: what can we learn for the prevention of human hepatocellular carcinoma?","volume":"1","author":"Vucur","year":"2010","journal-title":"Oncotarget"},{"key":"10.1016\/j.jhep.2012.06.017_b0210","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.3748\/wjg.v16.i11.1344","article-title":"Alcohol, nutrition and liver cancer: role of Toll-like receptor signaling","volume":"16","author":"French","year":"2010","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jhep.2012.06.017_b0215","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1038\/ncb2362","article-title":"Caspase 8 inhibits programmed necrosis by processing CYLD","volume":"13","author":"O\u2019Donnell","year":"2011","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jhep.2012.06.017_b0155","doi-asserted-by":"crossref","first-page":"5891","DOI":"10.1182\/blood-2008-08-175489","article-title":"Naturally occurring short splice variant of CYLD positively regulates dendritic cell function","volume":"113","author":"Srokowski","year":"2009","journal-title":"Blood"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827812004436?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827812004436?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T16:50:32Z","timestamp":1542905432000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827812004436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S0168827812004436"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2012.06.017","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}