{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:37:08Z","timestamp":1792730228791,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["32003B-140776\/1"],"award-info":[{"award-number":["32003B-140776\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["3200B0-119090\/1"],"award-info":[{"award-number":["3200B0-119090\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.jhep.2012.10.004","type":"journal-article","created":{"date-parts":[[2012,10,11]],"date-time":"2012-10-11T00:03:24Z","timestamp":1349913804000},"page":"278-286","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":260,"title":["Protective mechanisms of end-ischemic cold machine perfusion in DCD liver grafts"],"prefix":"10.1016","volume":"58","author":[{"given":"Andrea","family":"Schlegel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier de","family":"Rougemont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Graf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Alain","family":"Clavien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Dutkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2012.10.004_b0005","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/TP.0b013e3181fed021","article-title":"Optimal time for hypothermic reconditioning of liver grafts by venous systemic oxygen persufflation in a large animal model","volume":"91","author":"Koetting","year":"2011","journal-title":"Transplantation"},{"key":"10.1016\/j.jhep.2012.10.004_b0010","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1111\/j.1600-6143.2011.03731.x","article-title":"Hypothermic reconditioning by gaseous oxygen improves survival after liver transplantation in the pig","volume":"11","author":"Minor","year":"2011","journal-title":"Am J Transplant"},{"key":"10.1016\/j.jhep.2012.10.004_b0015","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cryobiol.2012.03.010","article-title":"Hypothermic reconditioning by gaseous oxygen persufflation after cold storage of porcine kidneys","volume":"65","author":"Minor","year":"2012","journal-title":"Cryobiology"},{"key":"10.1016\/j.jhep.2012.10.004_b0020","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1097\/TP.0b013e3182492201","article-title":"Hypothermic reconditioning of porcine kidney grafts by short-term preimplantation machine perfusion","volume":"93","author":"Gallinat","year":"2012","journal-title":"Transplantation"},{"key":"10.1016\/j.jhep.2012.10.004_b0025","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1111\/j.1600-6143.2006.01264.x","article-title":"Rescue of the cold preserved rat liver by hypothermic oxygenated machine perfusion","volume":"6","author":"Dutkowski","year":"2006","journal-title":"Am J Transplant"},{"key":"10.1016\/j.jhep.2012.10.004_b0030","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1111\/j.1600-6143.2008.02165.x","article-title":"Machine perfusion for \u2018marginal\u2019 liver grafts","volume":"8","author":"Dutkowski","year":"2008","journal-title":"Am J Transplant"},{"key":"10.1016\/j.jhep.2012.10.004_b0035","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/j.1600-6143.2009.02932.x","article-title":"Hypothermic machine preservation in human liver transplantation: the first clinical series","volume":"10","author":"Guarrera","year":"2010","journal-title":"Am J Transplant"},{"key":"10.1016\/j.jhep.2012.10.004_b0040","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1097\/01.sla.0000247056.85590.6b","article-title":"Novel short-term hypothermic oxygenated perfusion (HOPE) system prevents injury in rat liver graft from non-heart beating donor","volume":"244","author":"Dutkowski","year":"2006","journal-title":"Ann Surg"},{"key":"10.1016\/j.jhep.2012.10.004_b0045","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1097\/SLA.0b013e3181bcb1ee","article-title":"One hour hypothermic oxygenated perfusion (HOPE) protects nonviable liver allografts donated after cardiac death","volume":"250","author":"de Rougemont","year":"2009","journal-title":"Ann Surg"},{"key":"10.1016\/j.jhep.2012.10.004_b0050","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1432-2277.2006.00433.x","article-title":"Determination of an adequate perfusion pressure for continuous dual vessel hypothermic machine perfusion of the rat liver","volume":"20","author":"t Hart","year":"2007","journal-title":"Transpl Int"},{"key":"10.1016\/j.jhep.2012.10.004_b0055","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1002\/lt.20510","article-title":"Oxygenation during hypothermic rat liver preservation: an in vitro slice study to demonstrate beneficial or toxic oxygenation effects","volume":"11","author":"t Hart","year":"2005","journal-title":"Liver Transpl"},{"key":"10.1016\/j.jhep.2012.10.004_b0060","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.trre.2011.10.006","article-title":"Current strategies to minimize hepatic ischemia\u2013reperfusion injury by targeting reactive oxygen species","volume":"26","author":"Jaeschke","year":"2012","journal-title":"Transplant Rev (Orlando)"},{"key":"10.1016\/j.jhep.2012.10.004_b0065","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/hep.21912","article-title":"Minocycline and N-methyl-4-isoleucine cyclosporin (NIM811) mitigate storage\/reperfusion injury after rat liver transplantation through suppression of the mitochondrial permeability transition","volume":"47","author":"Theruvath","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2012.10.004_b0070","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/MOT.0b013e328351083d","article-title":"Is extracorporeal hypothermic machine perfusion of the liver better than the \u2018good old icebox\u2019?","volume":"17","author":"Bae","year":"2012","journal-title":"Curr Opin Organ Transplant"},{"key":"10.1016\/j.jhep.2012.10.004_b0075","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/MOT.0b013e328351082a","article-title":"Extracorporeal machine liver perfusion: are we warming up?","volume":"17","author":"Hessheimer","year":"2012","journal-title":"Curr Opin Organ Transplant"},{"key":"10.1016\/j.jhep.2012.10.004_b0080","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1097\/SLA.0b013e3181bdd787","article-title":"Multifactorial biological modulation of warm ischemia reperfusion injury in liver transplantation from non-heart-beating donors eliminates primary nonfunction and reduces bile salt toxicity","volume":"250","author":"Monbaliu","year":"2009","journal-title":"Ann Surg"},{"key":"10.1016\/j.jhep.2012.10.004_b0085","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1089\/ars.2010.3356","article-title":"High-mobility group box 1, oxidative stress, and disease","volume":"14","author":"Tang","year":"2011","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jhep.2012.10.004_b0090","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cbi.2006.07.008","article-title":"Disruption of mitochondrial redox circuitry in oxidative stress","volume":"163","author":"Jones","year":"2006","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.jhep.2012.10.004_b0095","doi-asserted-by":"crossref","first-page":"7661","DOI":"10.4049\/jimmunol.175.11.7661","article-title":"Hepatic ischemia\/reperfusion injury involves functional TLR4 signaling in nonparenchymal cells","volume":"175","author":"Tsung","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.jhep.2012.10.004_b0100","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1097\/SLA.0b013e3181ffc256","article-title":"Machine perfusion versus cold storage for the preservation of kidneys donated after cardiac death: a multicenter, randomized, controlled trial","volume":"252","author":"Jochmans","year":"2010","journal-title":"Ann Surg"},{"key":"10.1016\/j.jhep.2012.10.004_b0105","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1056\/NEJMoa0802289","article-title":"Machine perfusion or cold storage in deceased-donor kidney transplantation","volume":"360","author":"Moers","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2012.10.004_b0110","first-page":"944","article-title":"Role of oxygen during hypothermic machine perfusion preservation of the liver","volume":"23","author":"Luer","year":"2010","journal-title":"Transpl Int"},{"key":"10.1016\/j.jhep.2012.10.004_b0115","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1093\/cvr\/cvq028","article-title":"Cyclosporine A-induced nitration of tyrosine 34 MnSOD in endothelial cells: role of mitochondrial superoxide","volume":"87","author":"Redondo-Horcajo","year":"2010","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jhep.2012.10.004_b0120","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/j.freeradbiomed.2012.01.013","article-title":"Mechanistic overview of reactive species-induced degradation of the endothelial glycocalyx during hepatic ischemia\/reperfusion injury","volume":"52","author":"van Golen","year":"2012","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jhep.2012.10.004_b0125","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1126\/science.1195491","article-title":"Intravascular danger signals guide neutrophils to sites of sterile inflammation","volume":"330","author":"McDonald","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.jhep.2012.10.004_b0130","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/path.2284","article-title":"Macrophage activation by endogenous danger signals","volume":"214","author":"Zhang","year":"2008","journal-title":"J Pathol"},{"key":"10.1016\/j.jhep.2012.10.004_b0135","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1097\/00007890-200102270-00003","article-title":"Extension of ischemic tolerance of porcine livers by cold preservation including postconditioning with gaseous oxygen","volume":"71","author":"Saad","year":"2001","journal-title":"Transplantation"},{"key":"10.1016\/j.jhep.2012.10.004_b0140","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1109\/TBME.2010.2065229","article-title":"From vascular corrosion cast to electrical analog model for the study of human liver hemodynamics and perfusion","volume":"58","author":"Debbaut","year":"2011","journal-title":"IEEE Trans Biomed Eng"},{"key":"10.1016\/j.jhep.2012.10.004_b0145","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/TP.0b013e31825774d7","article-title":"Hypothermic oxygenated machine perfusion in porcine donation after circulatory determination of death liver transplant","volume":"94","author":"Fondevila","year":"2012","journal-title":"Transplantation"},{"key":"10.1016\/j.jhep.2012.10.004_b0150","doi-asserted-by":"crossref","first-page":"119","DOI":"10.5301\/ijao.5000038","article-title":"Flow competition between hepatic arterial and portal venous flow during hypothermic machine perfusion preservation of porcine livers","volume":"35","author":"Monbaliu","year":"2012","journal-title":"Int J Artif Organs"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827812007702?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827812007702?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T17:10:01Z","timestamp":1781111401000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827812007702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S0168827812007702"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2012.10.004","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective mechanisms of end-ischemic cold machine perfusion in DCD liver grafts","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2012.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 European Association for the Study of the Liver. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}