{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:22:14Z","timestamp":1791177734887,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.jhep.2012.11.019","type":"journal-article","created":{"date-parts":[[2012,11,22]],"date-time":"2012-11-22T10:02:39Z","timestamp":1353578559000},"page":"509-521","source":"Crossref","is-referenced-by-count":59,"title":["The added value of quality of life (QoL) for prognosis of overall survival in patients with palliative hepatocellular carcinoma"],"prefix":"10.1016","volume":"58","author":[{"given":"Momar","family":"Diouf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Filleron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"Barbare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo\u00efc","family":"Fin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Picard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Bouch\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laetitia","family":"Dahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Paoletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Bonnetain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2012.11.019_b0005","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/ijc.1440","article-title":"Estimating the world cancer burden: Globocan 2000","volume":"94","author":"Parkin","year":"2001","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jhep.2012.11.019_b0010","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S1089-3261(05)70107-0","article-title":"Hepatocellular cancer. A century of progress","volume":"4","author":"Kew","year":"2000","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.jhep.2012.11.019_b0015","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1056\/NEJMoa0708857","article-title":"Sorafenib in advanced hepatocellular carcinoma","volume":"359","author":"Llovet","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2012.11.019_b0020","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1016\/S0140-6736(02)08649-X","article-title":"Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial","volume":"359","author":"Llovet","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2012.11.019_b0025","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.ejca.2008.01.004","article-title":"Multicentre randomised phase III trial comparing tamoxifen alone or with transarterial lipiodol chemoembolisation for unresectable hepatocellular carcinoma in cirrhotic patients","volume":"44","author":"Doffo\u00ebl","year":"2008","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jhep.2012.11.019_b0030","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1002\/1097-0142(19850815)56:4<918::AID-CNCR2820560437>3.0.CO;2-E","article-title":"Natural history of hepatocellular carcinoma and prognosis in relation to treatment. Study of 850 patients","volume":"56","author":"Okuda","year":"1985","journal-title":"Cancer"},{"key":"10.1016\/j.jhep.2012.11.019_b0035","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1002\/hep.510280322","article-title":"A new prognostic system for hepatocellular carcinoma: a retrospective study of 435 patients: The Cancer of the Liver Italian Program (CLIP) investigators","volume":"28","author":"The Cancer of Liver Italian Program Investigators","year":"1998","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2012.11.019_b0040","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1053\/he.2000.5628","article-title":"Prospective validation of the CLIP score: a new prognostic system for patients with cirrhosis and hepatocellular carcinoma","volume":"31","author":"The Cancer of Liver Italian Program Investigators","year":"2000","journal-title":"J Hepatol (Baltimore, Md.)"},{"key":"10.1016\/j.jhep.2012.11.019_b0045","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1055\/s-2007-1007122","article-title":"Prognosis of hepatocellular carcinoma: the BCLC staging classification","volume":"19","author":"Llovet","year":"1999","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jhep.2012.11.019_b0050","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0168-8278(99)80173-1","article-title":"A new prognostic classification for predicting survival in patients with hepatocellular carcinoma. Groupe d\u2019Etude et de Traitement du Carcinome Hepatocellulaire","volume":"31","author":"Chevret","year":"1999","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2012.11.019_b0055","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1093\/annonc\/mdn030","article-title":"Prognosis of advanced hepatocellular carcinoma: comparison of three staging systems in two French clinical trials","volume":"19","author":"Collette","year":"2008","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jhep.2012.11.019_b0060","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jhep.2010.06.015","article-title":"Development and validation of a new prognostic score of death for patients with hepatocellular carcinoma in palliative setting","volume":"54","author":"Tournoux-Facon","year":"2011","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2012.11.019_b0065","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4","article-title":"Tutorial in biostatistics. Multivariable prognostic models issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors","volume":"15","author":"Harrell","year":"1996","journal-title":"Statist Med"},{"key":"10.1016\/j.jhep.2012.11.019_b0070","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1002\/sim.1486","article-title":"Predictive accuracy and explained variation","volume":"22","author":"Schemper","year":"2003","journal-title":"Statist Med"},{"key":"10.1016\/j.jhep.2012.11.019_b0075","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S1470-2045(09)70200-1","article-title":"Baseline quality of life as a prognostic indicator of survival: a meta-analysis of individual patient data from EORTC clinical trials","volume":"10","author":"Quinten","year":"2009","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jhep.2012.11.019_b0080","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1093\/annonc\/mdl065","article-title":"Quality of life is predictive of survival in patients with unresectable hepatocellular carcinoma","volume":"17","author":"Yeo","year":"2006","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jhep.2012.11.019_b0085","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s11136-008-9365-y","article-title":"Quality of life as a prognostic factor of overall survival in patients with advanced hepatocellular carcinoma: results from two French clinical trials","volume":"17","author":"Bonnetain","year":"2008","journal-title":"Qual Life Res"},{"key":"10.1016\/j.jhep.2012.11.019_b0090","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1016\/j.ejca.2009.02.018","article-title":"Treatment of advanced hepatocellular carcinoma with long-acting octreotide: a phase III multicentre, randomised, double blind placebo-controlled study","volume":"45","author":"Barbare","year":"2009","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jhep.2012.11.019_b0095","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","article-title":"The European Organization for Research and Treatment of Cancer QLQ-C30. A quality-of-life instrument for use in international clinical trials in oncology.","volume":"Inst. 85","author":"Aaronson","year":"1993","journal-title":"J Natl Cancer"},{"key":"10.1016\/j.jhep.2012.11.019_b0100","series-title":"On behalf of the EORTC quality of life group: the EORTC QLQ-C30 scoring manual","author":"Fayers","year":"2001"},{"key":"10.1016\/j.jhep.2012.11.019_b0105","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/bjs.1800600817","article-title":"Transection of the oesophagus for bleeding oesophageal varices","volume":"60","author":"Pugh","year":"1973","journal-title":"Br J Surg"},{"key":"10.1016\/j.jhep.2012.11.019_b0110","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/sim.4085","article-title":"Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers","volume":"2011","author":"Pencina","year":"2011","journal-title":"Statist Med"},{"key":"10.1016\/j.jhep.2012.11.019_b0115","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1002\/(SICI)1097-0258(19990330)18:6<681::AID-SIM71>3.0.CO;2-R","article-title":"Multiple imputation of missing blood pressure covariates in survival analysis","volume":"18","author":"Van Buuren","year":"1999","journal-title":"Statist Med"},{"key":"10.1016\/j.jhep.2012.11.019_b0120","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0895-4356(02)00539-5","article-title":"Developing a prognostic model in presence of missing data: an ovarian cancer study","volume":"56","author":"Clark","year":"2003","journal-title":"J Clin Epidemio"},{"key":"10.1016\/j.jhep.2012.11.019_b0125","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1093\/aje\/kwh101","article-title":"Limitations of the odds ratio in gauging the performance of a diagnostic, prognostic, or screening marker","volume":"159","author":"Pepe","year":"2004","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jhep.2012.11.019_b0130","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1161\/CIRCULATIONAHA.106.672402","article-title":"Use and misuse of the receiver operating characteristic curve in risk prediction","volume":"115","author":"Cook","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jhep.2012.11.019_b0135","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/S0959-8049(99)00192-6","article-title":"What has been learned from measuring health-related quality of life in clinical oncology?","volume":"35","author":"Osoba","year":"1999","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jhep.2012.11.019_b0140","doi-asserted-by":"crossref","DOI":"10.1586\/14737167.8.2.179","article-title":"Prognostic factor analysis of health-related quality of life data in cancer: statistical methodological evaluation","author":"Mauer","year":"2008","journal-title":"Expert Rev Pharmacoecon Outcomes Res"},{"key":"10.1016\/j.jhep.2012.11.019_b0145","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/sim.2331","article-title":"Dichotomizing continuous predictors in multiple regression: a bad idea","volume":"25","author":"Royston","year":"2006","journal-title":"Stat Med"},{"key":"10.1016\/j.jhep.2012.11.019_b0150","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1093\/annonc\/mdf034","article-title":"Clinical determinants of survival in patients with 5-fluorouracil-based treatment for metastatic colorectal cancer: results of a multivariate analysis of 3825 patients","volume":"13","author":"K\u00f6hne","year":"2002","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jhep.2012.11.019_b0155","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1634\/theoncologist.2011-0039","article-title":"Simplified prognostic model in patients with oxaliplatin-based or irinoecan-based first-line chemotherapy for metastatic colorectal cancer: a GERCOR study","volume":"16","author":"Chibaudel","year":"2011","journal-title":"The Oncologist"},{"key":"10.1016\/j.jhep.2012.11.019_b0160","first-page":"1258","article-title":"Follicular lymphoma international prognostic index","volume":"104","author":"Solal-C\u00e9ligny","year":"2004","journal-title":"Am Soc Hematol"},{"key":"10.1016\/j.jhep.2012.11.019_b0165","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/(SICI)1097-0258(20000115)19:1<113::AID-SIM245>3.0.CO;2-O","article-title":"Categorizing a prognostic variable: review of methods, code for easy implementation and application to decision-making about cancer treatments","volume":"19","author":"Mazumdar","year":"2000","journal-title":"Statist Med"},{"key":"10.1016\/j.jhep.2012.11.019_b0170","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1002\/(SICI)1097-0258(19961030)15:20<2203::AID-SIM357>3.0.CO;2-G","article-title":"A simulation study of cross-validation for selecting an optimal cutpoint in univariate survival analysis","volume":"15","author":"Faraggi","year":"1996","journal-title":"Statist Med"},{"key":"10.1016\/j.jhep.2012.11.019_b0175","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2288-10-7","article-title":"Comparison of techniques for handling missing covariate data within prognostic modelling studies: a simulation study","volume":"10","author":"Marshall","year":"2010","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.jhep.2012.11.019_b0180","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1136\/bmj.b375","article-title":"Prognosis and prognostic research: what, why, and how?","volume":"338","author":"Moons","year":"2009","journal-title":"Br Med J"},{"key":"10.1016\/j.jhep.2012.11.019_b0185","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1016\/j.ejca.2004.06.033","article-title":"Development of a questionnaire module to supplement the EORTC QLQ-C30 to assess quality of life in patients with hepatocellular carcinoma, the EORTC QLQ-HCC18","volume":"40","author":"Blazeby","year":"2004","journal-title":"Eur J Cancer"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827812008884?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827812008884?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,21]],"date-time":"2018-10-21T06:54:23Z","timestamp":1540104863000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827812008884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S0168827812008884"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2012.11.019","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}