{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T08:59:56Z","timestamp":1778317196368,"version":"3.51.4"},"reference-count":32,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.jhep.2013.05.008","type":"journal-article","created":{"date-parts":[[2013,5,13]],"date-time":"2013-05-13T19:30:57Z","timestamp":1368473457000},"page":"651-657","source":"Crossref","is-referenced-by-count":64,"title":["Evaluation of early cerebral metabolic, perfusion and microstructural changes in HCV-positive patients: A pilot study"],"prefix":"10.1016","volume":"59","author":[{"given":"Joanna","family":"Bladowska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Zimny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brygida","family":"Knysz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Ma\u0142yszczak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Ko\u0142towska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawe\u0142","family":"Szewczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"G\u0105siorowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha\u0142","family":"Furdal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek J.","family":"S\u0105siadek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2013.05.008_b0005","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.jhep.2011.09.015","article-title":"Effects of anti-viral therapy and HCV clearance on cerebral metabolism and cognition","volume":"56","author":"Byrnes","year":"2012","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2013.05.008_b0165","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jns.2011.08.025","article-title":"Hepatitis C virus co-infection increases neurocognitive impairment severity and risk of death in treated HIV\/AIDS","volume":"312","author":"Vivithanaporn","year":"2012","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.jhep.2013.05.008_b0015","doi-asserted-by":"crossref","first-page":"S140","DOI":"10.1097\/01.aids.0000192083.41561.00","article-title":"Emerging evidence of hepatitis C virus neuroinvasion","volume":"19","author":"Laskus","year":"2005","journal-title":"AIDS"},{"key":"10.1016\/j.jhep.2013.05.008_b0020","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1136\/gut.2009.199356","article-title":"Activation of brain macrophages\/microglia cells in hepatitis C infection","volume":"59","author":"Wilkinson","year":"2010","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2013.05.008_b0025","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.3748\/wjg.v17.i29.3369","article-title":"Neuropsychological alterations in hepatitis C infection: the role of inflammation","volume":"17","author":"Senzolo","year":"2011","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jhep.2013.05.008_b0030","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1128\/JVI.01890-08","article-title":"Hepatitis C virus neuroinvasion: identification of infected cells","volume":"83","author":"Wilkinson","year":"2009","journal-title":"J Virol"},{"key":"10.1016\/j.jhep.2013.05.008_b0035","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/00042737-200604000-00005","article-title":"Central nervous system changes in hepatitis C virus infection","volume":"18","author":"Forton","year":"2006","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2013.05.008_b0040","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s13311-010-0010-4","article-title":"The role of medical imaging in defining CNS abnormalities associated with HIV-infection and opportunistic infections","volume":"8","author":"Tate","year":"2011","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.jhep.2013.05.008_b0170","first-page":"5","article-title":"Usefulness of perfusion-weighted MR imaging in the differential diagnosis of Alzheimer\u2019s disease and mild cognitive impairment","volume":"16","author":"Zimny","year":"2010","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.jhep.2013.05.008_b0050","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1176\/jnp.2010.22.3.313","article-title":"White matter correlates of apathy in HIV-positive subjects: a diffusion tensor imaging study","volume":"22","author":"Hoare","year":"2010","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"10.1016\/j.jhep.2013.05.008_b0055","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.bandc.2009.03.005","article-title":"The Wisconsin card sorting test and the cognitive assessment of prefrontal executive functions: a critical update","volume":"71","author":"Nyhus","year":"2009","journal-title":"Brain Cogn"},{"key":"10.1016\/j.jhep.2013.05.008_b0060","series-title":"D2 test of attention","author":"Brickenkamp","year":"1998"},{"key":"10.1016\/j.jhep.2013.05.008_b0065","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/mrm.1910140311","article-title":"Functional cerebral imaging by susceptibility-contrast NMR","volume":"14","author":"Belliveau","year":"1990","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jhep.2013.05.008_b0070","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/BF00173036","article-title":"Choice of reference region in the quantification of single-photon emission tomography in primary degenerative dementia","volume":"21","author":"Talbot","year":"1994","journal-title":"Eur J Nucl Med"},{"key":"10.1016\/j.jhep.2013.05.008_b0075","first-page":"356","article-title":"Diffusion tensor imaging of cerebral white matter: a pictorial review of physics, fiber tract anatomy, and tumor imaging patterns","volume":"25","author":"Jellison","year":"2004","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.jhep.2013.05.008_b0080","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.jhep.2004.07.022","article-title":"Hepatitis C virus infection affects the brain\u2014evidence from psychometric studies and magnetic resonance spectroscopy","volume":"41","author":"Weissenborn","year":"2004","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2013.05.008_b0085","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/hep.20635","article-title":"Prevalence and significance of neurocognitive dysfunction in hepatitis C in the absence of correlated risk factors","volume":"41","author":"McAndrews","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2013.05.008_b0090","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jhep.2008.03.022","article-title":"Cerebral immune activation in chronic hepatitis C infection: a magnetic resonance spectroscopy study","volume":"49","author":"Forton","year":"2008","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2013.05.008_b0095","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.ejrad.2012.11.029","article-title":"Evaluation of metabolic changes within the normal appearing gray and white matters in neurologically asymptomatic HIV-1-positive and HCV-positive patients: magnetic resonance spectroscopy and immunologic correlation","volume":"82","author":"Bladowska","year":"2013","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.jhep.2013.05.008_b0100","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S0730-725X(00)00173-9","article-title":"Magnetic resonance spectroscopy of the brain in neurologically asymptomatic HIV-infected patients","volume":"18","author":"Suwanwela","year":"2000","journal-title":"Magn Reson Imaging"},{"key":"10.1016\/j.jhep.2013.05.008_b0105","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.nic.2007.12.006","article-title":"Imaging of topographic viral CNS infections","volume":"18","author":"Rumboldt","year":"2008","journal-title":"Neuroimaging Clin N Am"},{"key":"10.1016\/j.jhep.2013.05.008_b0110","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/BF03165008","article-title":"Luxury perfusion phenomenon in acute herpes simplex virus encephalitis","volume":"9","author":"Tanaka","year":"1995","journal-title":"Ann Nucl Med"},{"key":"10.1016\/j.jhep.2013.05.008_b0115","first-page":"1041","article-title":"Hyperperfusion and early technetium-99m-HMPAO SPECT appearance of central nervous system toxoplasmosis","volume":"35","author":"Catafau","year":"1994","journal-title":"J Nucl Med"},{"key":"10.1016\/j.jhep.2013.05.008_b0120","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1001\/archneur.60.6.877","article-title":"Cerebellitis in an adult with abnormal magnetic resonance findings prior to the onset of ataxia","volume":"60","author":"Gruis","year":"2003","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jhep.2013.05.008_b0125","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1148\/radiol.2281010683","article-title":"Human immunodeficiency virus 1-associated minor motor disorders: perfusion-weighted MR imaging and 1H MR spectroscopy","volume":"228","author":"Wenserski","year":"2003","journal-title":"Radiology"},{"key":"10.1016\/j.jhep.2013.05.008_b0130","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1001\/archneur.57.11.1601","article-title":"Potential time course of human immunodeficiency virus type 1-associated minor motor deficits: electrophysiologic and positron emission tomography findings","volume":"57","author":"von Giesen","year":"2000","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jhep.2013.05.008_b0135","first-page":"2275","article-title":"Diffusion-tensor imaging of the brain in human immunodeficiency virus-positive patients","volume":"26","author":"Thurnher","year":"2005","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.jhep.2013.05.008_b0140","first-page":"656","article-title":"Diffusion alterations in corpus callosum of patients with HIV","volume":"27","author":"Wu","year":"2005","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.jhep.2013.05.008_b0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1750-3639.1996.tb00775.x","article-title":"Neuropathology of early HIV-1 infection","volume":"6","author":"Gray","year":"1996","journal-title":"Brain Pathol"},{"key":"10.1016\/j.jhep.2013.05.008_b0150","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0925-4927(00)00082-2","article-title":"White matter abnormalities in HIV-1 infection: a diffusion tensor imaging study","volume":"106","author":"Pomara","year":"2001","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.jhep.2013.05.008_b0155","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1177\/197140091202500304","article-title":"Quantitative evaluation of changes in the selected white matter tracts using diffusion tensor imaging in patients with Alzheimer\u2019s disease and mild cognitive impairment","volume":"25","author":"Zimny","year":"2012","journal-title":"Neuroradiol J"},{"key":"10.1016\/j.jhep.2013.05.008_b0160","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1136\/jnnp.72.6.742","article-title":"White matter damage in Alzheimer\u2019s disease assessed in vivo using diffusion tensor magnetic resonance imaging","volume":"72","author":"Bozzali","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827813003346?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827813003346?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T02:22:41Z","timestamp":1539656561000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827813003346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S0168827813003346"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2013.05.008","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]}}}