{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:46:00Z","timestamp":1787316360451,"version":"build-2736575974"},"reference-count":42,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.jhep.2013.07.021","type":"journal-article","created":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T22:33:07Z","timestamp":1374186787000},"page":"1285-1291","source":"Crossref","is-referenced-by-count":75,"title":["Common genetic variants regulating ADD3 gene expression alter biliary atresia risk"],"prefix":"10.1016","volume":"59","author":[{"given":"Guo","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara Sze-Man","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily Hoi-Man","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William Wai-Chun","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man-Ting","family":"So","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruizhong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elly Sau-Wai","family":"Ngan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent Chi-Hang","family":"Lui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick Ho-Yu","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivy Hau-Yee","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juncheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiakang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan-Zhao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfa","family":"Tou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuming","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin Kin-Wai","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenny","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul F.","family":"O\u2032Reilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth Kak-Yuen","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pak-Chung","family":"Sham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey S.","family":"Cherny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Kwong-Hang","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Merc\u00e8","family":"Garcia-Barcel\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2013.07.021_b0010","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S0140-6736(05)72221-2","article-title":"Surgery for biliary atresia","volume":"355","author":"Lloyd","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2013.07.021_b0015","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1002\/hep.22182","article-title":"Universal screening for biliary atresia using an infant stool color card in Taiwan","volume":"47","author":"Hsiao","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2013.07.021_b0020","first-page":"646","article-title":"Biliary atresia in french polynesia. Retrospective study of 10years","volume":"1","author":"Vic","year":"1994","journal-title":"Arch Pediatr"},{"key":"10.1016\/j.jhep.2013.07.021_b0025","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1097\/MPG.0b013e318282a913","article-title":"International incidence and outcomes of biliary atresia: a systematic review of population-based studies","volume":"56","author":"Jimenez-Rivera","year":"2013","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jhep.2013.07.021_b0030","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/hep.20549","article-title":"A challenge on the use of the words embryonic and perinatal in the context of biliary atresia","volume":"41","author":"Davenport","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2013.07.021_b0035","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1093\/infdis\/174.1.8","article-title":"Detection of group C rotavirus in infants with extrahepatic biliary atresia","volume":"174","author":"Riepenhoff-Talty","year":"1996","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jhep.2013.07.021_b0040","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1056\/NEJM198208193070806","article-title":"Biliary atresia and reovirus type 3 infection","volume":"307","author":"Morecki","year":"1982","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2013.07.021_b0045","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s100240010045","article-title":"Cytomegalovirus and human herpesvirus 6, but not human papillomavirus, are present in neonatal giant cell hepatitis and extrahepatic biliary atresia","volume":"3","author":"Domiati-Saad","year":"2000","journal-title":"Pediatr Dev Pathol"},{"key":"10.1016\/j.jhep.2013.07.021_b0050","first-page":"113","article-title":"Considerations of the pathogenesis of neonatal hepatitis, biliary atresia and choledochal cyst\u2013the concept of infantile obstructive cholangiopathy","volume":"6","author":"Landing","year":"1974","journal-title":"Prog Pediatr Surg"},{"key":"10.1016\/j.jhep.2013.07.021_b0055","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1097\/00005176-199811000-00007","article-title":"Presence of human papillomavirus in extrahepatic biliary atresia","volume":"27","author":"Drut","year":"1998","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jhep.2013.07.021_b0060","doi-asserted-by":"crossref","first-page":"F451","DOI":"10.1136\/adc.2009.159780","article-title":"Epidemiology of biliary atresia in England and Wales (1999\u20132006)","volume":"94","author":"Livesey","year":"2009","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.jhep.2013.07.021_b0065","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1751-0813.1990.tb07385.x","article-title":"Congenital biliary atresia and jaundice in lambs and calves","volume":"67","author":"Harper","year":"1990","journal-title":"Aust Vet J"},{"key":"10.1016\/j.jhep.2013.07.021_b0070","unstructured":"Kristin Lorent, Kyung A. Koo, Weilong Gong, Steve Whittaker, John R. Porter, Rebecca Wells. Michael pack isolation and identification of a plant toxin that induces biliary atresia in livestock and zebrafish. In: The 63rd annual meeting of American Association for the Study of Liver Diseases, Boston, Massachusetts, USA; 2012."},{"key":"10.1016\/j.jhep.2013.07.021_b0075","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1053\/j.sempedsurg.2012.05.002","article-title":"Biliary atresia: the animal models","volume":"21","author":"Petersen","year":"2012","journal-title":"Semin Pediatr Surg"},{"key":"10.1016\/j.jhep.2013.07.021_b0080","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1053\/j.gastro.2010.09.020","article-title":"Viruses and autoantibodies in biliary atresia","volume":"139","author":"Selmi","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2013.07.021_b0085","first-page":"67","article-title":"Extrahepatic biliary atresia and twinning","volume":"24","author":"Silveira","year":"1991","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.jhep.2013.07.021_b0090","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/0022-3468(91)90613-X","article-title":"Familial biliary atresia in three siblings including twins","volume":"26","author":"Smith","year":"1991","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jhep.2013.07.021_b0095","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1002\/ajmg.a.33332","article-title":"Genomic alterations in biliary atresia suggest region of potential disease susceptibility in 2q37.3","volume":"152","author":"Leyva-Vega","year":"2010","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.jhep.2013.07.021_b0100","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1093\/hmg\/ddq196","article-title":"Genome-wide association study identifies a susceptibility locus for biliary atresia on 10q24.2","volume":"19","author":"Garcia-Barcelo","year":"2010","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jhep.2013.07.021_b0105","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1053\/j.gastro.2013.01.022","article-title":"Evidence from human and zebrafish that GPC1 is a biliary atresia susceptibility gene","volume":"144","author":"Cui","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2013.07.021_b0110","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1111\/j.1872-034X.2011.00870.x","article-title":"Association of X-prolyl aminopeptidase 1 rs17095355 polymorphism with biliary atresia in Thai children","volume":"41","author":"Kaewkiattiyot","year":"2011","journal-title":"Hepatol Res"},{"key":"10.1016\/j.jhep.2013.07.021_b0115","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/nature09534","article-title":"A map of human genome variation from population-scale sequencing","volume":"467","author":"Genomes Project","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2013.07.021_b0120","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1002\/hep.22229","article-title":"Temporal-spatial activation of apoptosis and epithelial injury in murine experimental biliary atresia","volume":"47","author":"Erickson","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2013.07.021_b0125","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/gepi.20032","article-title":"Use of unphased multilocus genotype data in indirect association studies","volume":"27","author":"Clayton","year":"2004","journal-title":"Genet Epidemiol"},{"key":"10.1016\/j.jhep.2013.07.021_b0130","doi-asserted-by":"crossref","first-page":"11763","DOI":"10.1073\/pnas.95.20.11763","article-title":"Genetic relationship of populations in China","volume":"95","author":"Chu","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2013.07.021_b0135","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/01621459.1961.10482090","article-title":"Multiple comparisons among means","volume":"56","author":"Dunn","year":"1961","journal-title":"J Am Stat Assoc"},{"key":"10.1016\/j.jhep.2013.07.021_b0140","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jhep.2013.07.021_b0145","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1093\/nar\/gkr1257","article-title":"A comprehensive framework for prioritizing variants in exome sequencing studies of Mendelian diseases","volume":"40","author":"Li","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jhep.2013.07.021_b0150","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nature02168","article-title":"Int HapMap project","volume":"426","author":"International HapMap C","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2013.07.021_b0155","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nrg1596","article-title":"The Human Genome Diversity Project: past, present and future","volume":"6","author":"Cavalli-Sforza","year":"2005","journal-title":"Nature Rev Genet"},{"key":"10.1016\/j.jhep.2013.07.021_b0160","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/1471-2148-9-221","article-title":"SNP@Evolution: a hierarchical database of positive selection on the human genome","volume":"9","author":"Cheng","year":"2009","journal-title":"BMC Evol Biol"},{"key":"10.1016\/j.jhep.2013.07.021_b0165","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1101\/gr.631202","article-title":"Interrogating a high-density SNP map for signatures of natural selection","volume":"12","author":"Akey","year":"2002","journal-title":"Genome Res"},{"key":"10.1016\/j.jhep.2013.07.021_b0170","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1101\/gr.4326505","article-title":"Genomic regions exhibiting positive selection identified from dense genotype data","volume":"15","author":"Carlson","year":"2005","journal-title":"Genome Res"},{"key":"10.1016\/j.jhep.2013.07.021_b0175","doi-asserted-by":"crossref","first-page":"e1000294","DOI":"10.1371\/journal.pbio.1000294","article-title":"Rare variants create synthetic genome-wide associations","volume":"8","author":"Dickson","year":"2010","journal-title":"PLoS Biol"},{"key":"10.1016\/j.jhep.2013.07.021_b0180","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nrg1522","article-title":"Genome-wide association studies: theoretical and practical concerns","volume":"6","author":"Wang","year":"2005","journal-title":"Nature Rev Genet"},{"key":"10.1016\/j.jhep.2013.07.021_b0185","doi-asserted-by":"crossref","first-page":"e1001046","DOI":"10.1371\/journal.pbio.1001046","article-title":"A user\u2019s guide to the encyclopedia of DNA elements (ENCODE)","volume":"9","author":"Consortium","year":"2011","journal-title":"PLoS Biol"},{"key":"10.1016\/j.jhep.2013.07.021_b0190","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1161\/CIRCULATIONAHA.108.809970","article-title":"Evolutionary genetics of coronary heart disease","volume":"119","author":"Ding","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jhep.2013.07.021_b0195","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/1471-2148-12-114","article-title":"Colon cancer associated genes exhibit signatures of positive selection at functionally significant positions","volume":"12","author":"Morgan","year":"2012","journal-title":"BMC Evol Biol"},{"key":"10.1016\/j.jhep.2013.07.021_b0200","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1242\/dev.050526","article-title":"The miR-143-adducin3 pathway is essential for cardiac chamber morphogenesis","volume":"137","author":"Deacon","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.jhep.2013.07.021_b0205","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0140-6736(05)63430-7","article-title":"Polymorphism of alpha-adducin and hypertension","volume":"350","author":"Iwai","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2013.07.021_b0210","doi-asserted-by":"crossref","first-page":"3506","DOI":"10.1091\/mbc.E10-03-0259","article-title":"Adducins regulate remodeling of apical junctions in human epithelial cells","volume":"21","author":"Naydenov","year":"2010","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.jhep.2013.07.021_b0215","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1091\/mbc.E07-08-0818","article-title":"Adducin promotes micrometer-scale organization of beta2-spectrin in lateral membranes of bronchial epithelial cells","volume":"19","author":"Abdi","year":"2008","journal-title":"Mol Biol Cell"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827813005321?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827813005321?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T17:40:01Z","timestamp":1563471601000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827813005321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S0168827813005321"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2013.07.021","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]}}}