{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:37:11Z","timestamp":1790753831280,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["journal-of-hepatology.eu","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.jhep.2014.10.021","type":"journal-article","created":{"date-parts":[[2014,10,18]],"date-time":"2014-10-18T15:30:35Z","timestamp":1413646235000},"page":"380-387","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Complete response of Ctnnb1-mutated tumours to \u03b2-catenin suppression by locked nucleic acid antisense in a mouse hepatocarcinogenesis model"],"prefix":"10.1016","volume":"62","author":[{"given":"Evan","family":"Delgado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohisa","family":"Okabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Preziosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacquelyn Olivia","family":"Russell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara Feliciano","family":"Alvarado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Oertel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari Nichole","family":"Nejak-Bowen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satdarshan P.S.","family":"Monga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2014.10.021_b0005","doi-asserted-by":"crossref","first-page":"7812","DOI":"10.1038\/sj.onc.1204982","article-title":"Selective pressure during tumour promotion by phenobarbital leads to clonal outgrowth of beta-catenin-mutated mouse liver tumours","volume":"20","author":"Aydinlik","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.jhep.2014.10.021_b0010","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.jhep.2006.11.017","article-title":"R-Etodolac decreases beta-catenin levels along with survival and proliferation of hepatoma cells","volume":"46","author":"Behari","year":"2007","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2014.10.021_b0015","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/toxsci\/kfr166","article-title":"Gender-specific interplay of signaling through beta-catenin and CAR in the regulation of xenobiotic-induced hepatocyte proliferation","volume":"123","author":"Braeuning","year":"2011","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.jhep.2014.10.021_b0020","doi-asserted-by":"crossref","first-page":"8293","DOI":"10.1038\/sj.onc.1206118","article-title":"New targets of beta-catenin signaling in the liver are involved in the glutamine metabolism","volume":"21","author":"Cadoret","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.jhep.2014.10.021_b0025","doi-asserted-by":"crossref","first-page":"G39","DOI":"10.1152\/ajpgi.00263.2007","article-title":"Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis","volume":"294","author":"Cheng","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"6","key":"10.1016\/j.jhep.2014.10.021_b0030","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/bjc.2014.425","article-title":"Glutamine depletion by crisantaspase hinders the growth of human hepatocellular carcinoma xenografts","volume":"111","author":"Chiu","year":"2014","journal-title":"Br J Cancer"},{"key":"10.1016\/j.jhep.2014.10.021_b0035","doi-asserted-by":"crossref","first-page":"8847","DOI":"10.1073\/pnas.95.15.8847","article-title":"Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas","volume":"95","author":"de La Coste","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"10.1016\/j.jhep.2014.10.021_b0040","doi-asserted-by":"crossref","first-page":"867","DOI":"10.2174\/15680096113139990081","article-title":"Beta-catenin knockdown in liver tumour cells by a cell permeable gamma guanidine-based peptide nucleic acid","volume":"13","author":"Delgado","year":"2013","journal-title":"Curr Cancer Drug Targets"},{"key":"10.1016\/j.jhep.2014.10.021_b0045","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1016\/j.ajpath.2014.04.002","article-title":"Identification and characterization of a novel small-molecule inhibitor of beta-catenin signaling","volume":"184","author":"Delgado","year":"2014","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jhep.2014.10.021_b0050","doi-asserted-by":"crossref","first-page":"9973","DOI":"10.1021\/bi025907j","article-title":"Implications of high-affinity hybridization by locked nucleic acid oligomers for inhibition of human telomerase","volume":"41","author":"Elayadi","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.jhep.2014.10.021_b0055","doi-asserted-by":"crossref","first-page":"12682","DOI":"10.1073\/pnas.0404875101","article-title":"A small molecule inhibitor of beta-catenin\/CREB-binding protein transcription [corrected]","volume":"101","author":"Emami","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2014.10.021_b0060","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nrc1934","article-title":"Hepatocellular carcinoma pathogenesis: from genes to environment","volume":"6","author":"Farazi","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.jhep.2014.10.021_b0065","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1002\/ijc.25516","article-title":"Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008","volume":"127","author":"Ferlay","year":"2010","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jhep.2014.10.021_b0070","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1093\/nar\/gkg185","article-title":"In vivo tumour growth inhibition and biodistribution studies of locked nucleic acid (LNA) antisense oligonucleotides","volume":"31","author":"Fluiter","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jhep.2014.10.021_b0075","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/j.1460-2075.1983.tb01464.x","article-title":"Heterogeneous distribution of glutamine synthetase among rat liver parenchymal cells in situ and in primary culture","volume":"2","author":"Gebhardt","year":"1983","journal-title":"EMBO J"},{"key":"10.1016\/j.jhep.2014.10.021_b0080","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1002\/hep.26924","article-title":"T-cell factor 4 and beta-catenin chromatin occupancies pattern zonal liver metabolism in mice","volume":"59","author":"Gougelet","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2014.10.021_b0085","doi-asserted-by":"crossref","first-page":"6318","DOI":"10.1128\/MCB.19.9.6318","article-title":"Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene","volume":"19","author":"Kawamoto","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jhep.2014.10.021_b0090","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1016\/S0960-894X(98)00366-7","article-title":"The first analogues of LNA (locked nucleic acids): phosphorothioate-LNA and 2\u2032-thio-LNA","volume":"8","author":"Kumar","year":"1998","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.jhep.2014.10.021_b0095","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.canlet.2013.09.020","article-title":"Beta-Catenin signaling in hepatocellular cancer: Implications in inflammation, fibrosis, and proliferation","volume":"343","author":"Lee","year":"2014","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jhep.2014.10.021_b0100","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1056\/NEJMoa0708857","article-title":"Sorafenib in advanced hepatocellular carcinoma","volume":"359","author":"Llovet","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2014.10.021_b0105","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/carcin\/bgh298","article-title":"A beta-catenin-dependent pathway regulates expression of cytochrome P450 isoforms in mouse liver tumours","volume":"26","author":"Loeppen","year":"2005","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jhep.2014.10.021_b0110","first-page":"5685","article-title":"Overexpression of glutamine synthetase is associated with beta-catenin-mutations in mouse liver tumours during promotion of hepatocarcinogenesis by phenobarbital","volume":"62","author":"Loeppen","year":"2002","journal-title":"Cancer Res"},{"key":"10.1016\/j.jhep.2014.10.021_b0115","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1038\/ncomms3218","article-title":"High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions","volume":"4","author":"Nault","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhep.2014.10.021_b0120","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.jhep.2013.08.019","article-title":"Genetics of hepatocellular carcinoma: the next generation","volume":"60","author":"Nault","year":"2014","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2014.10.021_b0125","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.semcancer.2010.12.010","article-title":"Beta-catenin signaling, liver regeneration and hepatocellular cancer: sorting the good from the bad","volume":"21","author":"Nejak-Bowen","year":"2011","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.jhep.2014.10.021_b0130","doi-asserted-by":"crossref","first-page":"e98817","DOI":"10.1371\/journal.pone.0098817","article-title":"Role of leukocyte cell-derived chemotaxin 2 as a biomarker in hepatocellular carcinoma","volume":"9","author":"Okabe","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jhep.2014.10.021_b0135","doi-asserted-by":"crossref","first-page":"5974","DOI":"10.1021\/ja012288d","article-title":"Locked nucleic acid (LNA) recognition of RNA: NMR solution structures of LNA:RNA hybrids","volume":"124","author":"Petersen","year":"2002","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.jhep.2014.10.021_b0140","first-page":"921","article-title":"Histology, bioenergetics and oxidative stress in mouse liver exposed to N-diethylnitrosamine","volume":"26","author":"Santos","year":"2012","journal-title":"In vivo"},{"key":"10.1016\/j.jhep.2014.10.021_b0145","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1093\/toxsci\/kfs018","article-title":"Quantitative analysis of the growth kinetics of chemically induced mouse liver tumours by magnetic resonance imaging","volume":"126","author":"Schmid","year":"2012","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.jhep.2014.10.021_b0150","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/bjc.2014.275","article-title":"Genetic ablation of beta-catenin inhibits the proliferative phenotype of mouse liver adenomas","volume":"111","author":"Singh","year":"2014","journal-title":"Br J Cancer"},{"key":"10.1016\/j.jhep.2014.10.021_b0155","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.semcancer.2008.01.004","article-title":"The utility of LNA in microRNA-based cancer diagnostics and therapeutics","volume":"18","author":"Stenvang","year":"2008","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.jhep.2014.10.021_b0160","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1053\/j.gastro.2006.08.042","article-title":"Conditional deletion of beta-catenin reveals its role in liver growth and regeneration","volume":"131","author":"Tan","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2014.10.021_b0165","doi-asserted-by":"crossref","first-page":"929","DOI":"10.2174\/156800911797264725","article-title":"L-Asparaginase and inhibitors of glutamine synthetase disclose glutamine addiction of beta-catenin-mutated human hepatocellular carcinoma cells","volume":"11","author":"Tardito","year":"2011","journal-title":"Curr Cancer Drug Targets"},{"key":"10.1016\/j.jhep.2014.10.021_b0170","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.jhep.2010.07.020","article-title":"Pegylated interferon alpha targets Wnt signaling by inducing nuclear export of beta-catenin","volume":"54","author":"Thompson","year":"2011","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2014.10.021_b0175","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1002\/ijc.28798","article-title":"Ha-ras and beta-catenin oncoproteins orchestrate metabolic programs in mouse liver tumours","volume":"135","author":"Unterberger","year":"2014","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jhep.2014.10.021_b0180","doi-asserted-by":"crossref","first-page":"5633","DOI":"10.1073\/pnas.97.10.5633","article-title":"Potent and nontoxic antisense oligonucleotides containing locked nucleic acids","volume":"97","author":"Wahlestedt","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2014.10.021_b0185","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1002\/ijc.24810","article-title":"Small molecule antagonists of Tcf4\/beta-catenin complex inhibit the growth of HCC cells in vitro and in vivo","volume":"126","author":"Wei","year":"2010","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jhep.2014.10.021_b0190","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/j.jhep.2011.03.014","article-title":"Hepatocyte gamma-catenin compensates for conditionally deleted beta-catenin at adherens junctions","volume":"55","author":"Wickline","year":"2011","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2014.10.021_b0195","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1593\/neo.122098","article-title":"Gamma-Catenin at adherens junctions: mechanism and biologic implications in hepatocellular cancer after beta-catenin knockdown","volume":"15","author":"Wickline","year":"2013","journal-title":"Neoplasia"},{"key":"10.1016\/j.jhep.2014.10.021_b0200","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.tibs.2010.05.003","article-title":"Glutamine addiction: a new therapeutic target in cancer","volume":"35","author":"Wise","year":"2010","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.jhep.2014.10.021_b0205","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nrgastro.2010.100","article-title":"Hepatocellular carcinoma: a global view","volume":"7","author":"Yang","year":"2010","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2014.10.021_b0210","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1593\/neo.07469","article-title":"SiRNA-mediated beta-catenin knockdown in human hepatoma cells results in decreased growth and survival","volume":"9","author":"Zeng","year":"2007","journal-title":"Neoplasia"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016882781400782X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016882781400782X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T02:50:45Z","timestamp":1717469445000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016882781400782X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S016882781400782X"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2014.10.021","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Complete response of Ctnnb1-mutated tumours to \u03b2-catenin suppression by locked nucleic acid antisense in a mouse hepatocarcinogenesis model","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2014.10.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2014.11.021","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}