{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:51:42Z","timestamp":1790603502074,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001646","name":"Robert Bosch Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["ES023438"],"award-info":[{"award-number":["ES023438"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD073070"],"award-info":[{"award-number":["HD073070"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK099232"],"award-info":[{"award-number":["DK099232"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23AA18399"],"award-info":[{"award-number":["K23AA18399"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HHSN276201200017C"],"award-info":[{"award-number":["HHSN276201200017C"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.jhep.2015.07.022","type":"journal-article","created":{"date-parts":[[2015,7,26]],"date-time":"2015-07-26T11:00:37Z","timestamp":1437908437000},"page":"44-52","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["Inflammatory regulation of steroid sulfatase: A novel mechanism to control estrogen homeostasis and inflammation in chronic liver disease"],"prefix":"10.1016","volume":"64","author":[{"given":"Mengxi","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich M.","family":"Zanger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad K.","family":"Mohammad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C.","family":"Cave","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilesh W.","family":"Gaikwad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha J.","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle W.","family":"Selcer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuhui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiujin","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2015.07.022_b0005","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1677\/joe.0.0460129","article-title":"Oestrogen metabolism in liver disease","volume":"46","author":"Adlercreutz","year":"1970","journal-title":"J Endocrinol"},{"key":"10.1016\/j.jhep.2015.07.022_b0010","first-page":"199","article-title":"Alcohol effects on hormone levels in normal postmenopausal women and in postmenopausal women with alcohol-induced cirrhosis","volume":"12","author":"Gavaler","year":"1995","journal-title":"Recent Dev Alcohol"},{"key":"10.1016\/j.jhep.2015.07.022_b0015","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1001\/archinte.1951.03810120063006","article-title":"The liver and estrogen metabolism; report of cases","volume":"88","author":"Long","year":"1951","journal-title":"AMA Arch Intern Med"},{"key":"10.1016\/j.jhep.2015.07.022_b0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/carcin\/19.1.1","article-title":"Functional role of estrogen metabolism in target cells: review and perspectives","volume":"19","author":"Zhu","year":"1998","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jhep.2015.07.022_b0025","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1096\/fasebj.11.4.9068609","article-title":"Enzymology of human cytosolic sulfotransferases","volume":"11","author":"Falany","year":"1997","journal-title":"FASEB J"},{"key":"10.1016\/j.jhep.2015.07.022_b0030","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1210\/endo-27-5-749","article-title":"Sex hormone changes associated with liver disease","volume":"27","author":"Glass","year":"1940","journal-title":"Endocrinology"},{"key":"10.1016\/j.jhep.2015.07.022_b0035","first-page":"447","article-title":"The influence of ethanol and liver disease on sex hormones and hepatic oestrogen receptors in women","volume":"40","author":"Becker","year":"1993","journal-title":"Dan Med Bull"},{"key":"10.1016\/j.jhep.2015.07.022_b0040","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S1043-2760(05)80018-9","article-title":"Steroid sulfation current concepts","volume":"4","author":"Hobkirk","year":"1993","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.jhep.2015.07.022_b0045","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1210\/er.2004-0003","article-title":"Steroid sulfatase: molecular biology, regulation, and inhibition","volume":"26","author":"Reed","year":"2005","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jhep.2015.07.022_b0050","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/BF00661898","article-title":"Clinical spectrum of steroid sulfatase deficiency: X-linked recessive ichthyosis, birth complications and cryptorchidism","volume":"140","author":"Traupe","year":"1983","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jhep.2015.07.022_b0055","first-page":"2288","article-title":"High expression of steroid sulfatase mRNA predicts poor prognosis in patients with estrogen receptor-positive breast cancer","volume":"9","author":"Miyoshi","year":"2003","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jhep.2015.07.022_b0060","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0039-128X(02)00016-8","article-title":"Regulation of estrogen activity in human endometrium: effect of IL-1beta on steroid sulfatase activity in human endometrial stromal cells","volume":"67","author":"Matsuoka","year":"2002","journal-title":"Steroids"},{"key":"10.1016\/j.jhep.2015.07.022_b0065","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0960-0760(00)00177-1","article-title":"Regulation of steroid sulphatase expression and activity in breast cancer","volume":"75","author":"Newman","year":"2000","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.jhep.2015.07.022_b0070","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1053\/jhep.2001.21041","article-title":"Trends in survival of patients with hepatocellular carcinoma between 1977 and 1996 in the United States","volume":"33","author":"El-Serag","year":"2001","journal-title":"Hepatology (Baltimore, MD)"},{"key":"10.1016\/j.jhep.2015.07.022_b0075","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1210\/er.2007-0001","article-title":"The complex role of estrogens in inflammation","volume":"28","author":"Straub","year":"2007","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jhep.2015.07.022_b0080","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/tpj.2011.44","article-title":"Genomics of ADME gene expression: mapping expression quantitative trait loci relevant for absorption, distribution, metabolism and excretion of drugs in human liver","volume":"13","author":"Schroder","year":"2013","journal-title":"Pharmacogenomics J"},{"key":"10.1016\/j.jhep.2015.07.022_b0085","doi-asserted-by":"crossref","first-page":"4951","DOI":"10.1021\/ac400016e","article-title":"Ultra performance liquid chromatography-tandem mass spectrometry method for profiling of steroid metabolome in human tissue","volume":"85","author":"Gaikwad","year":"2013","journal-title":"Anal Chem"},{"key":"10.1016\/j.jhep.2015.07.022_b0090","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.steroids.2012.02.024","article-title":"Characterization of steroid sulfatase in the MC3T3-E1 mouse pre-osteoblastic cell line","volume":"77","author":"Selcer","year":"2012","journal-title":"Steroids"},{"key":"10.1016\/j.jhep.2015.07.022_b0095","doi-asserted-by":"crossref","first-page":"715","DOI":"10.2144\/000112014","article-title":"Two-step cross-linking method for identification of NF-kappaB gene network by chromatin immunoprecipitation","volume":"39","author":"Nowak","year":"2005","journal-title":"BioTechniques"},{"key":"10.1016\/j.jhep.2015.07.022_b0100","doi-asserted-by":"crossref","first-page":"D91","DOI":"10.1093\/nar\/gkh012","article-title":"JASPAR: an open-access database for eukaryotic transcription factor binding profiles","volume":"32","author":"Sandelin","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jhep.2015.07.022_b0105","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.jhep.2011.12.030","article-title":"C-reactive protein predicts short-term mortality in patients with cirrhosis","volume":"56","author":"Cervoni","year":"2012","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2015.07.022_b0110","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.yjmcc.2003.12.005","article-title":"Effect of C-reactive protein on chemokine expression in human aortic endothelial cells","volume":"36","author":"Devaraj","year":"2004","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jhep.2015.07.022_b0115","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1136\/gutjnl-2011-301146","article-title":"Transcriptome analysis identifies TNF superfamily receptors as potential therapeutic targets in alcoholic hepatitis","volume":"62","author":"Affo","year":"2013","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2015.07.022_b0120","first-page":"5635","article-title":"Alcohol stimulates estrogen receptor signaling in human breast cancer cell lines","volume":"60","author":"Fan","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.jhep.2015.07.022_b0125","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","article-title":"Defective LPS signaling in C3H\/HeJ and C57BL\/10ScCr mice: mutations in Tlr4 gene","volume":"282","author":"Poltorak","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.jhep.2015.07.022_b0130","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1582-4934.2004.tb00469.x","article-title":"Dissection of the multiple mechanisms of TNF-alpha-induced apoptosis in liver injury","volume":"8","author":"Ding","year":"2004","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.jhep.2015.07.022_b0135","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/j.cellsig.2008.03.001","article-title":"Phorbol ester-stimulated NF-kappaB-dependent transcription: roles for isoforms of novel protein kinase C","volume":"20","author":"Holden","year":"2008","journal-title":"Cell Signal"},{"key":"10.1016\/j.jhep.2015.07.022_b0140","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1084\/jem.175.5.1181","article-title":"Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells","volume":"175","author":"Schreck","year":"1992","journal-title":"J Exp Med"},{"key":"10.1016\/j.jhep.2015.07.022_b0145","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0006-291X(03)01359-7","article-title":"Inhibition of 11 beta-hydroxysteroid dehydrogenase type 2 by dithiocarbamates","volume":"308","author":"Atanasov","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jhep.2015.07.022_b0150","first-page":"4146","article-title":"Tumor necrosis factor alpha regulates expression of the major histocompatibility complex class II-associated invariant chain by binding of an NF-kappa B-like factor to a promoter element","volume":"10","author":"Pessara","year":"1990","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jhep.2015.07.022_b0155","first-page":"3394","article-title":"In vivo inhibition of estrone sulfatase activity and growth of nitrosomethylurea-induced mammary tumors by 667 COUMATE","volume":"60","author":"Purohit","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.jhep.2015.07.022_b0160","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/S0026-895X(24)12085-8","article-title":"PS2 Gene expression in HepG2 cells: complex regulation through crosstalk between the estrogen receptor alpha, an estrogen-responsive element, and the activator protein 1 response element","volume":"61","author":"Barkhem","year":"2002","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.jhep.2015.07.022_b0165","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1515\/HMBCI.2010.025","article-title":"Estrogen regulation of X-box binding protein-1 and its role in estrogen induced growth of breast and endometrial cancer cells","volume":"2","author":"Sengupta","year":"2010","journal-title":"Horm Mol Biol Clin Investig"},{"key":"10.1016\/j.jhep.2015.07.022_b0170","doi-asserted-by":"crossref","first-page":"a000034","DOI":"10.1101\/cshperspect.a000034","article-title":"The NF-kappaB family of transcription factors and its regulation","volume":"1","author":"Oeckinghaus","year":"2009","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.jhep.2015.07.022_b0175","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0016-5085(76)80212-0","article-title":"Alcoholism: its effect on hypothalamic pituitary gonadal function","volume":"71","author":"Van Thiel","year":"1976","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2015.07.022_b0180","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1124\/dmd.114.060962","article-title":"A systematic comparison of the impact of inflammatory signaling on absorption, distribution, metabolism, and excretion gene expression and activity in primary human hepatocytes and HepaRG Cells","volume":"43","author":"Klein","year":"2015","journal-title":"Drug Metab and Dispos"},{"key":"10.1016\/j.jhep.2015.07.022_b0185","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/ng0596-83","article-title":"Cloning and expression of the mouse pseudoautosomal steroid sulphatase gene (Sts)","volume":"13","author":"Salido","year":"1996","journal-title":"Nat Genet"},{"key":"10.1016\/j.jhep.2015.07.022_b0190","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/0092-8674(88)90257-7","article-title":"The human X-linked steroid sulfatase gene and a Y-encoded pseudogene: evidence for an inversion of the Y chromosome during primate evolution","volume":"55","author":"Yen","year":"1988","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2015.07.022_b0195","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF02369901","article-title":"Characterization of the promoter region of human steroid sulfatase: a gene which escapes X inactivation","volume":"22","author":"Li","year":"1996","journal-title":"Somat Cell Mol Genet"},{"key":"10.1016\/j.jhep.2015.07.022_b0200","doi-asserted-by":"crossref","first-page":"615917","DOI":"10.1155\/2014\/615917","article-title":"Estrogen signaling in metabolic inflammation","volume":"2014","author":"Monteiro","year":"2014","journal-title":"Mediators Inflamm"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827815005139?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827815005139?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:53:44Z","timestamp":1777510424000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827815005139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S0168827815005139"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2015.07.022","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inflammatory regulation of steroid sulfatase: A novel mechanism to control estrogen homeostasis and inflammation in chronic liver disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2015.07.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}