{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:49:17Z","timestamp":1790632157872,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["journal-of-hepatology.eu","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.jhep.2015.08.024","type":"journal-article","created":{"date-parts":[[2015,8,31]],"date-time":"2015-08-31T12:18:43Z","timestamp":1441023523000},"page":"427-432","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Central obesity is associated with non-cirrhotic portal vein thrombosis"],"prefix":"10.1016","volume":"64","author":[{"given":"Christophe","family":"Bureau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Laurent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Ang\u00e8le","family":"Robic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Christol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maeva","family":"Guillaume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Bernard","family":"Ruidavets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Ferrieres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Marie","family":"P\u00e9ron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Pierre","family":"Vinel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2015.08.024_b0005","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1056\/NEJMra010076","article-title":"Mesenteric venous thrombosis","volume":"345","author":"Kumar","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2015.08.024_b0010","doi-asserted-by":"crossref","first-page":"S224","DOI":"10.1046\/j.1440-1746.17.s3.4.x","article-title":"Spectrum of portal vein thrombosis in the West","volume":"17","author":"Valla","year":"2002","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2015.08.024_b0015","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.jhep.2013.08.013","article-title":"Non-cirrhotic portal hypertension \u2013 Diagnosis and management","volume":"60","author":"Khanna","year":"2014","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2015.08.024_b0020","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1471-230X-7-34","article-title":"Portal vein thrombosis; risk factors, clinical presentation and treatment","volume":"7","author":"Sogaard","year":"2007","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.jhep.2015.08.024_b0025","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/hep.23259","article-title":"Acute portal vein thrombosis unrelated to cirrhosis: a prospective multicenter follow-up study","volume":"51","author":"Plessier","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2015.08.024_b0030","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1136\/gut.49.5.720","article-title":"Extrahepatic portal vein thrombosis: aetiology and determinants of survival","volume":"49","author":"Janssen","year":"2001","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2015.08.024_b0035","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1002\/hep.22772","article-title":"Vascular disorders of the liver","volume":"49","author":"DeLeve","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2015.08.024_b0040","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1002\/hep.510310307","article-title":"Cause of portal or hepatic venous thrombosis in adults: the role of multiple concurrent factors","volume":"31","author":"Denninger","year":"2000","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2015.08.024_b0045","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jhep.2014.08.032","article-title":"Role of calreticulin mutations in the etiological diagnosis of splanchnic vein thrombosis","volume":"62","author":"Turon","year":"2015","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2015.08.024_b0050","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S0140-6736(14)60460-8","article-title":"Global, regional, and national prevalence of overweight and obesity in children and adults during 1980\u20132013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"384","author":"Ng","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2015.08.024_b0055","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.diabet.2007.08.001","article-title":"A review of the metabolic syndrome","volume":"33","author":"Balkau","year":"2007","journal-title":"Diabetes Metab"},{"key":"10.1016\/j.jhep.2015.08.024_b0060","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ahj.2004.07.012","article-title":"Metabolic syndrome: evaluation of pathological and therapeutic outcomes","volume":"149","author":"Miranda","year":"2005","journal-title":"Am Heart J"},{"key":"10.1016\/j.jhep.2015.08.024_b0065","doi-asserted-by":"crossref","first-page":"374","DOI":"10.3324\/haematol.10828","article-title":"Venous thromboembolism\u2013a manifestation of the metabolic syndrome","volume":"92","author":"Ay","year":"2007","journal-title":"Haematologica"},{"key":"10.1016\/j.jhep.2015.08.024_b0070","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1161\/CIRCULATIONAHA.107.709204","article-title":"Cardiovascular risk factors and venous thromboembolism: a meta-analysis","volume":"117","author":"Ageno","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jhep.2015.08.024_b0075","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1161\/CIRCULATIONAHA.109.921460","article-title":"Risk factors for venous thromboembolism: results from the Copenhagen City Heart Study","volume":"121","author":"Holst","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jhep.2015.08.024_b0080","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.amjmed.2005.03.012","article-title":"Obesity as a risk factor in venous thromboembolism","volume":"118","author":"Stein","year":"2005","journal-title":"Am J Med"},{"key":"10.1016\/j.jhep.2015.08.024_b0085","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1055\/s-0037-1613379","article-title":"Obesity: risk of venous thrombosis and the interaction with coagulation factor levels and oral contraceptive use","volume":"89","author":"Abdollahi","year":"2003","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jhep.2015.08.024_b0090","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1161\/ATVBAHA.109.188920","article-title":"Anthropometric measures of obesity and risk of venous thromboembolism: the Tromso study","volume":"30","author":"Borch","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jhep.2015.08.024_b0095","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1161\/CIRCULATIONAHA.109.863241","article-title":"Anthropometry, body fat, and venous thromboembolism: a Danish follow-up study","volume":"120","author":"Severinsen","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jhep.2015.08.024_b0100","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/j.1538-7836.2009.03295.x","article-title":"Metabolic syndrome and risk of venous thromboembolism: Longitudinal Investigation of Thromboembolism Etiology","volume":"7","author":"Steffen","year":"2009","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jhep.2015.08.024_b0105","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/1471-230X-12-114","article-title":"Obesity is an independent risk factor for pre-transplant portal vein thrombosis in liver recipients","volume":"12","author":"Ayala","year":"2012","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.jhep.2015.08.024_b0110","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.acvd.2009.02.002","article-title":"Trends in plasma lipids, lipoproteins and dyslipidaemias in French adults, 1996\u20132007","volume":"102","author":"Ferri\u00e8res","year":"2009","journal-title":"Arch Cardiovasc Dis"},{"key":"10.1016\/j.jhep.2015.08.024_b0115","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","article-title":"Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III)","volume":"285","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.jhep.2015.08.024_b0120","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.diii.2013.04.006","article-title":"Quantification of the visceral and subcutaneous fat by computed tomography: interobserver correlation of a single slice technique","volume":"94","author":"Sottier","year":"2013","journal-title":"Diagn Interv Imaging"},{"key":"10.1016\/j.jhep.2015.08.024_b0125","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1001\/jama.1997.03540320044033","article-title":"A prospective study of risk factors for pulmonary embolism in women","volume":"277","author":"Goldhaber","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.jhep.2015.08.024_b0130","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1111\/liv.12386","article-title":"Type 2 diabetes mellitus as a risk factor for intestinal resection in patients with superior mesenteric vein thrombosis","volume":"34","author":"Elkrief","year":"2014","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2015.08.024_b0135","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1056\/NEJM198512193132501","article-title":"Increased plasma levels of a rapid inhibitor of tissue plasminogen activator in young survivors of myocardial infarction","volume":"313","author":"Hamsten","year":"1985","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2015.08.024_b0140","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0140-6736(87)93050-9","article-title":"Plasminogen activator inhibitor in plasma: risk factor for recurrent myocardial infarction","volume":"2","author":"Hamsten","year":"1987","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2015.08.024_b0145","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1182\/blood-2010-02-267740","article-title":"Venous thrombosis risk associated with plasma hypofibrinolysis is explained by elevated plasma levels of TAFI and PAI-1","volume":"116","author":"Meltzer","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jhep.2015.08.024_b0150","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1160\/TH06-12-0745","article-title":"Association between the plasminogen activator inhibitor-1 4G\/5G polymorphism and venous thrombosis. A meta-analysis","volume":"97","author":"Tsantes","year":"2007","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jhep.2015.08.024_b0155","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1023\/A:1011955018052","article-title":"Plasminogen activator inhibitor type-1 (part one): basic mechanisms, regulation, and role for thromboembolic disease","volume":"11","author":"Huber","year":"2001","journal-title":"J Thromb Thrombolysis"},{"key":"10.1016\/j.jhep.2015.08.024_b0160","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0753-3322(00)88103-2","article-title":"Plasma plasminogen activator inhibitor 1, insulin resistance and android obesity","volume":"53","author":"Bastard","year":"1999","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jhep.2015.08.024_b0165","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1111\/j.1464-5491.2005.01646.x","article-title":"Non-alcoholic hepatic steatosis and its relation to increased plasma biomarkers of inflammation and endothelial dysfunction in non-diabetic men. Role of visceral adipose tissue","volume":"22","author":"Targher","year":"2005","journal-title":"Diabet Med"},{"key":"10.1016\/j.jhep.2015.08.024_b0170","doi-asserted-by":"crossref","first-page":"635","DOI":"10.2174\/13816128113199990021","article-title":"Mechanisms linking leptin to arterial and venous thrombosis: potential pharmacological targets","volume":"20","author":"Sch\u00e4fer","year":"2014","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.jhep.2015.08.024_b0175","first-page":"717480","article-title":"Thrombophilic genetic factors PAI-1, MTHFRC677T, V Leiden 506Q, and prothrombin 20210a in noncirrhotic portal vein thrombosis and Budd-Chiari syndrome in a caucasian population","volume":"2013","author":"D\u2019Amico","year":"2013","journal-title":"Int J Vasc Med"},{"key":"10.1016\/j.jhep.2015.08.024_b0180","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1182\/blood-2009-03-211557","article-title":"Impaired fibrinolysis as a risk factor for Budd-Chiari syndrome","volume":"115","author":"Hoekstra","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jhep.2015.08.024_b0185","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jhep.2014.03.013","article-title":"Procoagulant imbalance in patients with non-alcoholic fatty liver disease","volume":"61","author":"Tripodi","year":"2014","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2015.08.024_b0190","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1478-3231.2010.02375.x","article-title":"Increased coagulation factor VIII, IX, XI and XII activities in non-alcoholic fatty liver disease","volume":"31","author":"Kotronen","year":"2011","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2015.08.024_b0195","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1056\/NEJMra0912063","article-title":"Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease","volume":"363","author":"Targher","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2015.08.024_b0200","article-title":"Prothrombotic factors in histologically proven NAFLD and NASH","author":"Verrijken","year":"2013","journal-title":"Hepatology"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827815005966?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827815005966?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T20:38:32Z","timestamp":1556311112000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827815005966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S0168827815005966"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2015.08.024","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Central obesity is associated with non-cirrhotic portal vein thrombosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2015.08.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}