{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T14:48:34Z","timestamp":1784213314807,"version":"3.55.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.jhep.2015.08.026","type":"journal-article","created":{"date-parts":[[2015,8,31]],"date-time":"2015-08-31T16:19:27Z","timestamp":1441037967000},"page":"110-117","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"title":["Hic-5 deficiency attenuates the activation of hepatic stellate cells and liver fibrosis through upregulation of Smad7 in mice"],"prefix":"10.1016","volume":"64","author":[{"given":"Xiao-Feng","family":"Lei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenguang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo-ri","family":"Kim-Kaneyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomokatsu","family":"Omoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuro","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2015.08.026_b0005","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1056\/NEJMra035021","article-title":"Management of cirrhosis and ascites","volume":"350","author":"Gines","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2015.08.026_b0010","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1038\/ncomms3823","article-title":"Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology","volume":"4","author":"Mederacke","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhep.2015.08.026_b0015","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/physrev.00013.2007","article-title":"Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver","volume":"88","author":"Friedman","year":"2008","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jhep.2015.08.026_b0020","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1136\/gut.2005.088690","article-title":"Emerging insights into Transforming growth factor beta Smad signal in hepatic fibrogenesis","volume":"56","author":"Inagaki","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2015.08.026_b0025","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1053\/jhep.2001.25349","article-title":"The role of Smad3 in mediating mouse hepatic stellate cell activation","volume":"34","author":"Schnabl","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2015.08.026_b0030","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00441-011-1246-y","article-title":"TGF-beta in progression of liver disease","volume":"347","author":"Dooley","year":"2012","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.jhep.2015.08.026_b0035","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/39369","article-title":"Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling","volume":"389","author":"Nakao","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2015.08.026_b0040","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0016-5085(03)00666-8","article-title":"Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats","volume":"125","author":"Dooley","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2015.08.026_b0045","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1136\/gut.2005.085704","article-title":"Targeted and regulable expression of transgenes in hepatic stellate cells and myofibroblasts in culture and in vivo using an adenoviral Cre\/loxP system to antagonise hepatic fibrosis","volume":"56","author":"Kinoshita","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2015.08.026_b0050","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1097\/01.ASN.0000067632.04658.B8","article-title":"Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model","volume":"14","author":"Lan","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.jhep.2015.08.026_b0055","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1172\/JCI6094","article-title":"Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice","volume":"104","author":"Nakao","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2015.08.026_b0060","doi-asserted-by":"crossref","first-page":"26767","DOI":"10.1016\/S0021-9258(18)47085-8","article-title":"Characterization of the TGF beta 1-inducible hic-5 gene that encodes a putative novel zinc finger protein and its possible involvement in cellular senescence","volume":"269","author":"Shibanuma","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2015.08.026_b0065","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.bbrc.2008.09.051","article-title":"Hic-5, an adaptor protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo","volume":"376","author":"Kim-Kaneyama","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jhep.2015.08.026_b0070","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1091\/mbc.02-06-0099","article-title":"Hic-5 communicates between focal adhesions and the nucleus through oxidant-sensitive nuclear export signal","volume":"14","author":"Shibanuma","year":"2003","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.jhep.2015.08.026_b0075","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/S0006-291X(02)02644-X","article-title":"Transcriptional activation of the c-fos gene by a LIM protein, Hic-5","volume":"299","author":"Kim-Kaneyama","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jhep.2015.08.026_b0080","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/jcb.10754","article-title":"A LIM protein, Hic-5, functions as a potential coactivator for Sp1","volume":"91","author":"Shibanuma","year":"2004","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.jhep.2015.08.026_b0085","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1091\/mbc.11.6.2007","article-title":"Interaction of the tau2 transcriptional activation domain of glucocorticoid receptor with a novel steroid receptor coactivator, Hic-5, which localizes to both focal adhesions and the nuclear matrix","volume":"11","author":"Yang","year":"2000","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.jhep.2015.08.026_b0090","doi-asserted-by":"crossref","first-page":"6791","DOI":"10.1038\/onc.2008.291","article-title":"Smad7 is inactivated through a direct physical interaction with the LIM protein Hic-5\/ARA55","volume":"27","author":"Wang","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.jhep.2015.08.026_b0095","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.yjmcc.2010.09.024","article-title":"Hic-5 deficiency enhances mechanosensitive apoptosis and modulates vascular remodeling","volume":"50","author":"Kim-Kaneyama","year":"2011","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jhep.2015.08.026_b0100","doi-asserted-by":"crossref","first-page":"e000747","DOI":"10.1161\/JAHA.113.000747","article-title":"Identification of Hic-5 as a novel scaffold for the MKK4\/p54 JNK pathway in the development of abdominal aortic aneurysms","volume":"3","author":"Lei","year":"2014","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jhep.2015.08.026_b0105","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1038\/jid.2008.90","article-title":"Hic-5 promotes the hypertrophic scar myofibroblast phenotype by regulating the TGF-beta1 autocrine loop","volume":"128","author":"Dabiri","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jhep.2015.08.026_b0110","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/ki.2009.417","article-title":"Upregulation of Hic-5 in glomerulosclerosis and its regulation of mesangial cell apoptosis","volume":"77","author":"Hornigold","year":"2010","journal-title":"Kidney Int"},{"key":"10.1016\/j.jhep.2015.08.026_b0115","doi-asserted-by":"crossref","first-page":"e59","DOI":"10.1159\/000335780","article-title":"Glomerular expression of hydrogen peroxide-inducible clone-5 in human and rat progressive mesangial proliferative glomerulonephritis","volume":"120","author":"Suga","year":"2012","journal-title":"Nephron Exp Nephrol"},{"key":"10.1016\/j.jhep.2015.08.026_b0120","first-page":"2710","article-title":"Seven steps to stellate cells","volume":"51","author":"Maschmeyer","year":"2011","journal-title":"J Vis Exp"},{"key":"10.1016\/j.jhep.2015.08.026_b0125","doi-asserted-by":"crossref","first-page":"16289","DOI":"10.1074\/jbc.M600711200","article-title":"Transcriptional profiling reveals novel markers of liver fibrogenesis: gremlin and insulin-like growth factor-binding proteins","volume":"281","author":"Boers","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2015.08.026_b0130","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/hep.25650","article-title":"Comparative proteomic analysis of rat hepatic stellate cell activation: a comprehensive view and suppressed immune response","volume":"56","author":"Ji","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2015.08.026_b0135","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1083\/jcb.201108143","article-title":"Hic-5 promotes invadopodia formation and invasion during TGF-beta-induced epithelial-mesenchymal transition","volume":"197","author":"Pignatelli","year":"2012","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jhep.2015.08.026_b0140","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/labinvest.2013.42","article-title":"Inhibition of collagen I accumulation reduces glomerulosclerosis by a Hic-5-dependent mechanism in experimental diabetic nephropathy","volume":"93","author":"Hornigold","year":"2013","journal-title":"Lab Invest"},{"key":"10.1016\/j.jhep.2015.08.026_b0145","doi-asserted-by":"crossref","first-page":"d793","DOI":"10.2741\/gressner","article-title":"Roles of TGF-beta in hepatic fibrosis","volume":"7","author":"Gressner","year":"2002","journal-title":"Front Biosci"},{"key":"10.1016\/j.jhep.2015.08.026_b0150","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1055\/s-2005-858989","article-title":"TGF-beta\/Smad signaling in the injured liver","volume":"44","author":"Breitkopf","year":"2006","journal-title":"Z Gastroenterol"},{"key":"10.1016\/j.jhep.2015.08.026_b0155","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1053\/j.gastro.2005.03.088","article-title":"Cell type-specific intervention of transforming growth factor beta\/Smad signaling suppresses collagen gene expression and hepatic fibrosis in mice","volume":"129","author":"Inagaki","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2015.08.026_b0160","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1006\/bbrc.2001.4811","article-title":"Expression of Smads during in vitro transdifferentiation of hepatic stellate cells to myofibroblasts","volume":"283","author":"Dooley","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jhep.2015.08.026_b0165","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2015.08.026_b0170","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1172\/JCI18212","article-title":"NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis","volume":"112","author":"Bataller","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2015.08.026_b0175","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0168-8278(01)00142-8","article-title":"Oxidative stress-related molecules and liver fibrosis","volume":"35","author":"Parola","year":"2001","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2015.08.026_b0180","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/S0016-5085(00)70368-4","article-title":"Angiotensin II induces contraction and proliferation of human hepatic stellate cells","volume":"118","author":"Bataller","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2015.08.026_b0185","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1002\/hep.510290346","article-title":"Transforming growth factor beta1 induces the expression of alpha1(I) procollagen mRNA by a hydrogen peroxide-C\/EBPbeta-dependent mechanism in rat hepatic stellate cells","volume":"29","author":"Garcia-Trevijano","year":"1999","journal-title":"Hepatology"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016882781500598X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016882781500598X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T12:25:00Z","timestamp":1656246300000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016882781500598X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S016882781500598X"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2015.08.026","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hic-5 deficiency attenuates the activation of hepatic stellate cells and liver fibrosis through upregulation of Smad7 in mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2015.08.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}