{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T18:00:33Z","timestamp":1776276033513,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Key Clinical Project"},{"name":"National Sciences and Technology Major Project of China","award":["2012ZX10002-017"],"award-info":[{"award-number":["2012ZX10002-017"]}]},{"name":"Science Fund for Outstanding Young Scholars of Sichuan University","award":["2013SCU04B11"],"award-info":[{"award-number":["2013SCU04B11"]}]}],"content-domain":{"domain":["journal-of-hepatology.eu","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.jhep.2015.08.036","type":"journal-article","created":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T21:46:48Z","timestamp":1442612808000},"page":"342-351","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Loss of Gs\u03b1 impairs liver regeneration through a defect in the crosstalk between cAMP and growth factor signaling"],"prefix":"10.1016","volume":"64","author":[{"given":"Changli","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xufeng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maling","family":"Gou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongjie","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keting","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Bu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujun","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2015.08.036_b0005","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1002\/hep.20969","article-title":"Liver regeneration","volume":"43","author":"Fausto","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2015.08.036_b0010","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0968-0004(92)90005-T","article-title":"G proteins","volume":"17","author":"Hepler","year":"1992","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.jhep.2015.08.036_b0015","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/dnares\/7.2.111","article-title":"Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes","volume":"7","author":"Hurowitz","year":"2000","journal-title":"DNA Res"},{"key":"10.1016\/j.jhep.2015.08.036_b0020","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1534\/genetics.105.040584","article-title":"The heterotrimeric G-protein GanB(alpha)-SfaD(beta)-GpgA(gamma) is a carbon source sensor involved in early cAMP-dependent germination in Aspergillusnidulans","volume":"171","author":"Lafon","year":"2005","journal-title":"Genetics"},{"key":"10.1016\/j.jhep.2015.08.036_b0025","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1073\/pnas.0609033103","article-title":"CAMP activation of PKA defines an ancient signaling mechanism","volume":"104","author":"Das","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2015.08.036_b0030","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1172\/JCI24196","article-title":"Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gs alpha deficiency","volume":"115","author":"Chen","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2015.08.036_b0035","doi-asserted-by":"crossref","first-page":"19601","DOI":"10.1073\/pnas.0704796104","article-title":"Beta cell-specific deficiency of the stimulatory G protein alpha-subunit Gs alpha leads to reduced beta cell mass and insulin-deficient diabetes","volume":"104","author":"Xie","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2015.08.036_b0040","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1593\/neo.06796","article-title":"GNAS1T393C polymorphism is associated with clinical course in patients with intrahepatic cholangiocarcinoma","volume":"9","author":"Schmitz","year":"2007","journal-title":"Neoplasia"},{"key":"10.1016\/j.jhep.2015.08.036_b0045","doi-asserted-by":"crossref","first-page":"E97","DOI":"10.1210\/jc.2013-1823","article-title":"Hepatobiliary and pancreatic neoplasms in patients with McCune-Albright syndrome","volume":"99","author":"Gaujoux","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jhep.2015.08.036_b0050","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/srep00161","article-title":"Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas","volume":"1","author":"Furukawa","year":"2011","journal-title":"Sci Rep"},{"key":"10.1016\/j.jhep.2015.08.036_b0055","doi-asserted-by":"crossref","first-page":"e81706","DOI":"10.1371\/journal.pone.0081706","article-title":"GNAS and KRAS mutations are common in intraductal papillary neoplasms of the bile duct","volume":"8","author":"Sasaki","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jhep.2015.08.036_b0060","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jhep.2011.07.018","article-title":"GNAS-activating mutations define a rare subgroup of inflammatory liver tumors characterized by STAT3 activation","volume":"56","author":"Nault","year":"2012","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2015.08.036_b0065","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1002\/hep.26542","article-title":"Loss of histone deacetylases 1 and 2 in hepatocytes impairs murine liver regeneration through Ki67 depletion","volume":"58","author":"Xia","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2015.08.036_b0070","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.4161\/cc.8.17.9465","article-title":"Cdk2 plays a critical role in hepatocyte cell cycle progression and survival in the setting of cyclin D1 expression in vivo","volume":"8","author":"Hanse","year":"2009","journal-title":"Cell Cycle"},{"key":"10.1016\/j.jhep.2015.08.036_b0075","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1053\/j.gastro.2009.05.003","article-title":"Aberrant cell cycle progression and endoreplication in regenerating livers of mice that lack a single E-type cyclin","volume":"137","author":"Nevzorova","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2015.08.036_b0080","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1002\/hep.26584","article-title":"Concurrent deletion of cyclin E1 and cyclin-dependent kinase 2 in hepatocytes inhibits DNA replication andliver regeneration in mice","volume":"59","author":"Hu","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2015.08.036_b0085","doi-asserted-by":"crossref","first-page":"10608","DOI":"10.1073\/pnas.0403412101","article-title":"Met provides essential signals for liver regeneration","volume":"101","author":"Borowiak","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2015.08.036_b0090","doi-asserted-by":"crossref","first-page":"17081","DOI":"10.1073\/pnas.0704126104","article-title":"The EGF receptor is required for efficient liver regeneration","volume":"104","author":"Natarajan","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2015.08.036_b0095","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0764-4469(01)01356-7","article-title":"Phosphorylation by PKA of a site unique to B-Raf kinase","volume":"324","author":"K\u00f6nig","year":"2001","journal-title":"C R Acad Sci III"},{"key":"10.1016\/j.jhep.2015.08.036_b0100","doi-asserted-by":"crossref","first-page":"6413","DOI":"10.4049\/jimmunol.1001829","article-title":"The role of the transcription factorCREBin immune function","volume":"185","author":"Wen","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.jhep.2015.08.036_b0105","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1007\/s12031-013-0226-y","article-title":"Neuroprotective effects of 3,6\u2032-disinapoyl sucrose through increased BDNF levels and CREB phosphorylation via the CaMKII and ERK1\/2 pathway","volume":"53","author":"Hu","year":"2014","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.jhep.2015.08.036_b0110","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1093\/nar\/26.1.362","article-title":"Databases on transcriptional regulation: TRANSFAC: TRRD and COMPEL","volume":"26","author":"Heinemeyer","year":"1998","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jhep.2015.08.036_b0115","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1046\/j.1523-1755.1999.00705.x","article-title":"Regulation of the G1\/S transition phase in mesangial cells by E2F1","volume":"56","author":"Inoshita","year":"1999","journal-title":"Kidney Int"},{"key":"10.1016\/j.jhep.2015.08.036_b0120","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1242\/jcs.01189","article-title":"The Rb network","volume":"117","author":"DeGregori","year":"2004","journal-title":"J Cell Sci"},{"key":"10.1016\/j.jhep.2015.08.036_b0125","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.cell.2014.11.050","article-title":"Long-term culture of genome-stable bipotent stem cells from adult human liver","volume":"160","author":"Huch","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2015.08.036_b0130","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1053\/j.gastro.2014.03.025","article-title":"Molecular changes leading to gastric cancer: a suggestion from rare-type gastric tumors with GNAS mutations","volume":"146","author":"Ikuta","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2015.08.036_b0135","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.ajpath.2011.05.029","article-title":"Activation of the inactive hepatocyte through histone acetylation: a mechanism for functional compensation after massive loss of hepatocyte","volume":"179","author":"Shi","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jhep.2015.08.036_b0140","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/S0168-8278(99)80320-1","article-title":"Liver regeneration in response to partial hepatectomy in rats treated with retrorsine: a kinetic study","volume":"31","author":"Laconi","year":"1999","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2015.08.036_b0145","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1080\/07435808609035434","article-title":"Paradoxical effects of glucose feeding on liver regeneration and survival after partial hepatectomy","volume":"12","author":"Caruana","year":"1986","journal-title":"Endocr Res"},{"key":"10.1016\/j.jhep.2015.08.036_b0150","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/0092-8674(89)90013-5","article-title":"Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine133","volume":"59","author":"Gonzalez","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2015.08.036_b0155","doi-asserted-by":"crossref","first-page":"e1251","DOI":"10.1038\/cddis.2014.229","article-title":"Sulfur dioxide inhibits vascular smooth muscle cell proliferation via suppressing the Erk\/MAP kinase pathway mediated by cAMP\/PKA signaling","volume":"5","author":"Liu","year":"2014","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jhep.2015.08.036_b0160","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.2337\/db05-1618","article-title":"ERK1\/2 control phosphorylation and protein level of cAMP-responsive element-binding protein: a key role in glucose-mediated pancreatic beta-cell survival","volume":"55","author":"Costes","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.jhep.2015.08.036_b0165","doi-asserted-by":"crossref","first-page":"7487","DOI":"10.1128\/MCB.18.12.7487","article-title":"Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation","volume":"18","author":"Wang","year":"1998","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jhep.2015.08.036_b0170","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/mrd.1080420418","article-title":"Interactions between Ras and Raf: key regulatory proteins in cellular transformation","volume":"42","author":"Marshall","year":"1995","journal-title":"Mol Reprod Dev"},{"key":"10.1016\/j.jhep.2015.08.036_b0175","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1083\/jcb.132.6.1133","article-title":"Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF\/SF, EGF, and TGF-\u03b1 in a chemically defined (HGM) medium","volume":"132","author":"Block","year":"1996","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jhep.2015.08.036_b0180","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/hep.1840160224","article-title":"Small cell colonies appear in the primary culture of adult rat hepatocytes in the presence of nicotinamide and epidermal growth factor","volume":"16","author":"Mitaka","year":"1992","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2015.08.036_b0185","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/369418a0","article-title":"Ras-dependent activation of MAP kinase pathway mediated by G-protein \u03b2\u03b3 subunits","volume":"369","author":"Crespo","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2015.08.036_b0190","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1128\/MCB.22.10.3237-3246.2002","article-title":"Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259","volume":"22","author":"Dhillon","year":"2002","journal-title":"Mol Cell Biol"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827815006200?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827815006200?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T20:38:44Z","timestamp":1556311124000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827815006200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S0168827815006200"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2015.08.036","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of Gs\u03b1 impairs liver regeneration through a defect in the crosstalk between cAMP and growth factor signaling","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2015.08.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}