{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T19:45:14Z","timestamp":1793389514120,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T00:00:00Z","timestamp":1445299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Oxford NIHR Biomedical Research Centre"}],"content-domain":{"domain":["journal-of-hepatology.eu","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.jhep.2015.10.009","type":"journal-article","created":{"date-parts":[[2015,11,10]],"date-time":"2015-11-10T20:18:39Z","timestamp":1447186719000},"page":"308-315","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":201,"title":["Multiparametric magnetic resonance imaging predicts clinical outcomes in patients with chronic liver disease"],"prefix":"10.1016","volume":"64","author":[{"given":"Michael","family":"Pavlides","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajarshi","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Sellwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine J.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Robson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan C.","family":"Booth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Collier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Neubauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor","family":"Barnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2015.10.009_b0005","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1136\/gutjnl-2011-300342","article-title":"Prevalence of non-alcoholic fatty liver disease and advanced fibrosis in Hong Kong Chinese: a population study using proton-magnetic resonance spectroscopy and transient elastography","volume":"61","author":"Wong","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2015.10.009_b0010","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1053\/j.gastro.2010.09.038","article-title":"Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study","volume":"140","author":"Williams","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2015.10.009_b0015","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S1473-3099(05)70216-4","article-title":"Global epidemiology of hepatitis C virus infection","volume":"5","author":"Shepard","year":"2005","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jhep.2015.10.009_b0020","first-page":"533","article-title":"EASL International Consensus Conference on Hepatitis B. 13\u201314 September, 2002: Geneva, Switzerland. Consensus statement (short version)","volume":"38","year":"2003","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2015.10.009_b0025","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jhep.2005.10.013","article-title":"Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies","volume":"44","author":"D\u2019Amico","year":"2006","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2015.10.009_b0030","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0168-8278(96)80234-0","article-title":"Intra-observer and inter-observer variation in the histopathological assessment of chronic viral hepatitis","volume":"25","author":"Goldin","year":"1996","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2015.10.009_b0035","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/gastro\/got006","article-title":"Wedge and needle liver biopsies show discordant histopathology in morbidly obese patients undergoing Roux-en-Y gastric bypass surgery","volume":"1","author":"Rawlins","year":"2013","journal-title":"Gastroenterol Rep"},{"key":"10.1016\/j.jhep.2015.10.009_b0040","doi-asserted-by":"crossref","first-page":"e3857","DOI":"10.1371\/journal.pone.0003857","article-title":"Concordance in a world without a gold standard: a new non-invasive methodology for improving accuracy of fibrosis markers","volume":"3","author":"Poynard","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.jhep.2015.10.009_b0045","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1053\/j.gastro.2004.08.052","article-title":"Serum markers detect the presence of liver fibrosis: a cohort study","volume":"127","author":"Rosenberg","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2015.10.009_b0050","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1136\/gut.2009.203166","article-title":"Enhanced liver fibrosis test can predict clinical outcomes in patients with chronic liver disease","volume":"59","author":"Parkes","year":"2010","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2015.10.009_b0055","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1007\/s00330-013-3046-0","article-title":"Non-invasive evaluation of liver fibrosis: a comparison of ultrasound-based transient elastography and MR elastography in patients with viral hepatitis B and C","volume":"24","author":"Bohte","year":"2014","journal-title":"Eur Radiol"},{"key":"10.1016\/j.jhep.2015.10.009_b0060","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.cgh.2014.09.046","article-title":"Diagnostic performance of magnetic resonance elastography in staging liver fibrosis: a systematic review and meta-analysis of individual participant data","volume":"13","author":"Singh","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2015.10.009_b0065","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.jhep.2011.01.051","article-title":"Liver stiffness accurately predicts portal hypertension related complications in patients with chronic liver disease: a prospective study","volume":"55","author":"Robic","year":"2011","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2015.10.009_b0070","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.jhep.2014.04.044","article-title":"Non-invasive assessment of liver fibrosis with impulse elastography: comparison of Supersonic Shear Imaging with ARFI and FibroScan(R)","volume":"61","author":"Cassinotto","year":"2014","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2015.10.009_b0075","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.jhep.2013.12.016","article-title":"Role of magnetic resonance elastography in compensated and decompensated liver disease","volume":"60","author":"Asrani","year":"2014","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2015.10.009_b0080","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/hep.23425","article-title":"Pitfalls of liver stiffness measurement: a 5-year prospective study of 13,369 examinations","volume":"51","author":"Castera","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2015.10.009_b0085","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.cgh.2014.07.037","article-title":"Significant variations in elastometry measurements made within short-term in patients with chronic liver diseases","volume":"13","author":"Nascimbeni","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2015.10.009_b0090","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.mri.2014.10.003","article-title":"Comparison of the diagnostic accuracies of magnetic resonance elastography and transient elastography for hepatic fibrosis","volume":"33","author":"Ichikawa","year":"2015","journal-title":"Magn Reson Imaging"},{"key":"10.1016\/j.jhep.2015.10.009_b0095","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1016\/S0140-6736(14)61838-9","article-title":"Addressing liver disease in the UK: a blueprint for attaining excellence in health care and reducing premature mortality from lifestyle issues of excess consumption of alcohol, obesity, and viral hepatitis","volume":"384","author":"Williams","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2015.10.009_b0100","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/hep.27720","article-title":"Strategies and endpoints of antifibrotic drug trials","volume":"62","author":"Torok","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2015.10.009_b0105","doi-asserted-by":"crossref","first-page":"307","DOI":"10.4103\/0975-7406.72130","article-title":"Food and drug administration\u2019s critical path initiative and innovations in drug development paradigm: challenges, progress, and controversies","volume":"2","author":"Mahajan","year":"2010","journal-title":"J Pharm Bioallied Sci"},{"key":"10.1016\/j.jhep.2015.10.009_b0110","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jhep.2013.09.002","article-title":"Multiparametric magnetic resonance for the non-invasive diagnosis of liver disease","volume":"60","author":"Banerjee","year":"2014","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2015.10.009_b0115","unstructured":"Tunnicliffe E, Robson M, Banerjee R. Medical Imaging. Application number PCT\/GB2014\/050815; 2014."},{"key":"10.1016\/j.jhep.2015.10.009_b0120","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/0168-8278(95)80226-6","article-title":"Histological grading and staging of chronic hepatitis","volume":"22","author":"Ishak","year":"1995","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2015.10.009_b0125","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1007\/s00330-012-2378-5","article-title":"MR relaxometry of the liver: significant elevation of T1 relaxation time in patients with liver cirrhosis","volume":"22","author":"Heye","year":"2012","journal-title":"Eur Radiol"},{"key":"10.1016\/j.jhep.2015.10.009_b0130","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/jmri.23620","article-title":"Quantitative evaluation of liver cirrhosis using T1 relaxation time with 3tesla MRI before and after oxygen inhalation","volume":"36","author":"Kim","year":"2012","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.jhep.2015.10.009_b0135","doi-asserted-by":"crossref","DOI":"10.1038\/srep05621","article-title":"MRI-based estimation of liver function: Gd-EOB-DTPA-enhanced T1 relaxometry of 3T vs. the MELD score","volume":"4","author":"Haimerl","year":"2014","journal-title":"Sci Rep"},{"key":"10.1016\/j.jhep.2015.10.009_b0140","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1532-429X-12-69","article-title":"Shortened Modified Look-Locker Inversion recovery (ShMOLLI) for clinical myocardial T1-mapping at 1.5 and 3 T within a 9 heartbeat breathhold","volume":"12","author":"Piechnik","year":"2010","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1016\/j.jhep.2015.10.009_b0145","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1136\/gut.46.2.277","article-title":"Liver iron is predictive of death in alcoholic cirrhosis: a multivariate study of 229 consecutive patients with alcoholic and\/or hepatitis C virus cirrhosis: a prospective follow up study","volume":"46","author":"Ganne-Carrie","year":"2000","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2015.10.009_b0150","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1053\/j.gastro.2009.11.013","article-title":"HFE genotype, parenchymal iron accumulation, and liver fibrosis in patients with nonalcoholic fatty liver disease","volume":"138","author":"Valenti","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2015.10.009_b0155","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1002\/hep.22865","article-title":"Evolution of hepatic steatosis in patients with advanced hepatitis C: results from the hepatitis C antiviral long-term treatment against cirrhosis (HALT-C) trial","volume":"49","author":"Lok","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2015.10.009_b0160","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.jhep.2013.04.027","article-title":"A systematic review of follow-up biopsies reveals disease progression in patients with non-alcoholic fatty liver","volume":"59","author":"Pais","year":"2013","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2015.10.009_b0165","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1136\/gut.52.2.288","article-title":"Worsening of steatosis is an independent factor of fibrosis progression in untreated patients with chronic hepatitis C and paired liver biopsies","volume":"52","author":"Castera","year":"2003","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2015.10.009_b0170","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/hep.27212","article-title":"Increased risk of cirrhosis and its decompensation in chronic hepatitis C patients with new-onset diabetes: a nationwide cohort study","volume":"60","author":"Huang","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2015.10.009_b0175","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1046\/j.1463-1326.2003.00256.x","article-title":"The impact of diabetes and obesity on liver histology in patients with hepatitis C","volume":"5","author":"Friedenberg","year":"2003","journal-title":"Diabetes Obes Metab"},{"key":"10.1016\/j.jhep.2015.10.009_b0180","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1136\/jcp.2003.009357","article-title":"Steatosis and fibrosis in patients with chronic hepatitis C","volume":"57","author":"Wyatt","year":"2004","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.jhep.2015.10.009_b0185","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1002\/jmri.22066","article-title":"Repeatability of magnetic resonance elastography for quantification of hepatic stiffness","volume":"31","author":"Hines","year":"2010","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.jhep.2015.10.009_b0190","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1002\/hep.27647","article-title":"Ezetimibe for the treatment of nonalcoholic steatohepatitis: assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial)","volume":"61","author":"Loomba","year":"2015","journal-title":"Hepatology"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827815006807?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827815006807?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T10:59:06Z","timestamp":1748689146000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827815006807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S0168827815006807"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2015.10.009","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multiparametric magnetic resonance imaging predicts clinical outcomes in patients with chronic liver disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2015.10.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}