{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T08:30:45Z","timestamp":1793867445970,"version":"4.6.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["journal-of-hepatology.eu","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.jhep.2016.01.011","type":"journal-article","created":{"date-parts":[[2016,1,22]],"date-time":"2016-01-22T05:01:44Z","timestamp":1453438904000},"page":"1033-1040","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":131,"title":["Human liver chimeric mice as a new model of chronic hepatitis E virus infection and preclinical drug evaluation"],"prefix":"10.1016","volume":"64","author":[{"given":"Lena","family":"Allweiss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Gass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Giersch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Groth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine","family":"Kah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tassilo","family":"Volz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianna","family":"Rapp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Sch\u00f6bel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansgar W.","family":"Lohse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Polywka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Pischke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Herker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura","family":"Dandri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"L\u00fctgehetmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2016.01.011_b0005","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1099\/vir.0.068429-0","article-title":"Consensus proposals for classification of the family Hepeviridae","volume":"95","author":"Smith","year":"2014","journal-title":"J Gen Virol"},{"key":"10.1016\/j.jhep.2016.01.011_b0010","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1055\/s-0033-1338110","article-title":"Molecular virology of hepatitis E virus","volume":"33","author":"Holla","year":"2013","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jhep.2016.01.011_b0015","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1006\/viro.2001.1093","article-title":"Identification and characterization of the neutralization epitope(s) of the hepatitis E virus","volume":"288","author":"Meng","year":"2001","journal-title":"Virology"},{"key":"10.1016\/j.jhep.2016.01.011_b0020","doi-asserted-by":"crossref","first-page":"5637","DOI":"10.1128\/JVI.06711-11","article-title":"The PSAP motif within the ORF3 protein of an avian strain of the hepatitis E virus is not critical for viral infectivity in vivo but plays a role in virus release","volume":"86","author":"Kenney","year":"2012","journal-title":"J Virol"},{"key":"10.1016\/j.jhep.2016.01.011_b0025","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1099\/vir.0.025791-0","article-title":"A PSAP motif in the ORF3 protein of hepatitis E virus is necessary for virion release from infected cells","volume":"92","author":"Nagashima","year":"2011","journal-title":"J Gen Virol"},{"key":"10.1016\/j.jhep.2016.01.011_b0030","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.3201\/eid1808.120057","article-title":"Hepatitis E virus strains in rabbits and evidence of a closely related strain in humans, France","volume":"18","author":"Izopet","year":"2012","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.jhep.2016.01.011_b0035","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1016\/S0140-6736(14)61034-5","article-title":"Hepatitis E virus in blood components: a prevalence and transmission study in southeast England","volume":"384","author":"Hewitt","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2016.01.011_b0040","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1002\/hep.25505","article-title":"The global burden of hepatitis E virus genotypes 1 and 2 in 2005","volume":"55","author":"Rein","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.01.011_b0045","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1055\/s-0034-1399236","article-title":"Comparison of autochthonous and imported cases of hepatitis A or hepatitis E","volume":"53","author":"Hartl","year":"2015","journal-title":"Z Gastroenterol"},{"key":"10.1016\/j.jhep.2016.01.011_b0050","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1111\/jvh.12403","article-title":"Antiviral therapy in chronic hepatitis E: a systematic review","volume":"22","author":"Peters van Ton","year":"2015","journal-title":"J Viral Hepat"},{"key":"10.1016\/j.jhep.2016.01.011_b0055","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1056\/NEJMoa1215246","article-title":"Ribavirin for chronic hepatitis E virus infection in transplant recipients","volume":"370","author":"Kamar","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2016.01.011_b0060","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.vetmic.2009.03.017","article-title":"Hepatitis E virus: animal reservoirs and zoonotic risk","volume":"140","author":"Meng","year":"2010","journal-title":"Vet Microbiol"},{"key":"10.1016\/j.jhep.2016.01.011_b0065","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/ilar.42.2.161","article-title":"Animal models of hepatitis A and E","volume":"42","author":"Purcell","year":"2001","journal-title":"ILAR J"},{"key":"10.1016\/j.jhep.2016.01.011_b0070","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.jhep.2013.10.021","article-title":"Immune cell responses are not required to induce substantial hepatitis B virus antigen decline during pegylated interferon-alpha administration","volume":"60","author":"Allweiss","year":"2014","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2016.01.011_b0075","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/hep.24758","article-title":"Humanized chimeric uPA mouse model for the study of hepatitis B and D virus interactions and preclinical drug evaluation","volume":"55","author":"Lutgehetmann","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.01.011_b0080","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.jhep.2015.03.011","article-title":"Hepatitis Delta co-infection in humanized mice leads to pronounced induction of innate immune responses in comparison to HBV mono-infection","volume":"63","author":"Giersch","year":"2015","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2016.01.011_b0085","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1002\/hep.27159","article-title":"Binding of hepatitis B virus to its cellular receptor alters the expression profile of genes of bile acid metabolism","volume":"60","author":"Oehler","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.01.011_b0090","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.virusres.2006.01.013","article-title":"Hepatitis E virus genotyping based on full-length genome and partial genomic regions","volume":"120","author":"Zhai","year":"2006","journal-title":"Virus Res"},{"key":"10.1016\/j.jhep.2016.01.011_b0095","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1086\/592757","article-title":"Molecular epidemiology and interferon susceptibility of the natural recombinant hepatitis C virus strain RF1_2k\/1b","volume":"198","author":"Kurbanov","year":"2008","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jhep.2016.01.011_b0100","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jviromet.2012.07.027","article-title":"Minor groove binder modification of widely used TaqMan probe for hepatitis E virus reduces risk of false negative real-time PCR results","volume":"186","author":"Garson","year":"2012","journal-title":"J Virol Methods"},{"key":"10.1016\/j.jhep.2016.01.011_b0105","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1128\/JVI.80.5.2418-2428.2006","article-title":"Association between hepatitis C virus and very-low-density lipoprotein (VLDL)\/LDL analyzed in iodixanol density gradients","volume":"80","author":"Nielsen","year":"2006","journal-title":"J Virol"},{"key":"10.1016\/j.jhep.2016.01.011_b0110","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1128\/JCM.02002-09","article-title":"Hepatitis E Virus (HEV) strains in serum samples can replicate efficiently in cultured cells despite the coexistence of HEV antibodies: characterization of HEV virions in blood circulation","volume":"48","author":"Takahashi","year":"2010","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jhep.2016.01.011_b0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0132503","article-title":"Hepatitis E Virus Produced from Cell Culture Has a Lipid Envelope","volume":"10","author":"Qi","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jhep.2016.01.011_b0120","doi-asserted-by":"crossref","first-page":"11264","DOI":"10.1128\/JVI.01205-10","article-title":"Pathogenesis of hepatitis E virus and hepatitis C virus in chimpanzees: similarities and differences","volume":"84","author":"Yu","year":"2010","journal-title":"J Virol"},{"key":"10.1016\/j.jhep.2016.01.011_b0125","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/jmv.1890420306","article-title":"Detection of the negative strand of hepatitis E virus RNA in the livers of experimentally infected rhesus monkeys: evidence for viral replication","volume":"42","author":"Nanda","year":"1994","journal-title":"J Med Virol"},{"key":"10.1016\/j.jhep.2016.01.011_b0130","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1007\/s007050050384","article-title":"Experimental infection of pigs with the newly identified swine hepatitis E virus (swine HEV), but not with human strains of HEV","volume":"143","author":"Meng","year":"1998","journal-title":"Arch Virol"},{"key":"10.1016\/j.jhep.2016.01.011_b0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009160","article-title":"Experimental infection of rabbits with rabbit and genotypes 1 and 4 hepatitis E viruses","volume":"5","author":"Ma","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jhep.2016.01.011_b0140","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/ilar\/ilu007","article-title":"Naturally occurring animal models of human hepatitis E virus infection","volume":"55","author":"Yugo","year":"2014","journal-title":"ILAR J"},{"key":"10.1016\/j.jhep.2016.01.011_b0145","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1053\/jhep.2001.23314","article-title":"Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus","volume":"33","author":"Dandri","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.01.011_b0150","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/90968","article-title":"Hepatitis C virus replication in mice with chimeric human livers","volume":"7","author":"Mercer","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.jhep.2016.01.011_b0155","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nbt1389","article-title":"Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein","volume":"26","author":"Petersen","year":"2008","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jhep.2016.01.011_b0160","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nbt.3179","article-title":"Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody","volume":"33","author":"Mailly","year":"2015","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jhep.2016.01.011_b0165","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/hep.25651","article-title":"Severe necroinflammatory reaction caused by natural killer cell-mediated Fas\/Fas ligand interaction and dendritic cells in human hepatocyte chimeric mouse","volume":"56","author":"Okazaki","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.01.011_b0170","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1007\/s00705-008-0179-6","article-title":"Monoclonal antibodies raised against the ORF3 protein of hepatitis E virus (HEV) can capture HEV particles in culture supernatant and serum but not those in feces","volume":"153","author":"Takahashi","year":"2008","journal-title":"Arch Virol"},{"key":"10.1016\/j.jhep.2016.01.011_b0175","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1365-3148.2006.00652.x","article-title":"Transfusion-transmitted hepatitis E in a \u2019nonhyperendemic\u2019 country","volume":"16","author":"Boxall","year":"2006","journal-title":"Transfus Med"},{"key":"10.1016\/j.jhep.2016.01.011_b0180","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1111\/j.1537-2995.2008.01722.x","article-title":"A case of transfusion-transmitted hepatitis E caused by blood from a donor infected with hepatitis E virus via zoonotic food-borne route","volume":"48","author":"Matsubayashi","year":"2008","journal-title":"Transfusion"},{"key":"10.1016\/j.jhep.2016.01.011_b0185","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1055\/s-0033-1338118","article-title":"Immunopathogenesis of hepatitis E virus infection","volume":"33","author":"Wedemeyer","year":"2013","journal-title":"Semin Liver Dis"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827816000179?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827816000179?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T01:57:59Z","timestamp":1537063079000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827816000179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["S0168827816000179"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2016.01.011","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human liver chimeric mice as a new model of chronic hepatitis E virus infection and preclinical drug evaluation","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2016.01.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2016.02.015","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}