{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:47:42Z","timestamp":1790732862705,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T00:00:00Z","timestamp":1497484800000},"content-version":"am","delay-in-days":349,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"regional ethics committee","award":["KEK-ZH-Nr. 2012-01 08"],"award-info":[{"award-number":["KEK-ZH-Nr. 2012-01 08"]}]},{"name":"Liver and Gastrointestinal Disease Foundation"},{"DOI":"10.13039\/501100006447","name":"Candoc Forschungskredit (University of Z\u00fcrich)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bridge to Academic Career (Swiss Surgical Society)"},{"name":"Association for Research in Surgery (Switzerland)"},{"name":"United European Gastroenterology Federation Research Prize 2011"},{"DOI":"10.13039\/501100006447","name":"Clinical Research Priority Program of the University Z\u00fcrich","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["S-87002-09-01"],"award-info":[{"award-number":["S-87002-09-01"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["CRSII3_141798\/1"],"award-info":[{"award-number":["CRSII3_141798\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.jhep.2016.02.040","type":"journal-article","created":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T21:09:36Z","timestamp":1457039376000},"page":"66-74","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"title":["Constitutive androstane receptor (Car)-driven regeneration protects liver from failure following tissue loss"],"prefix":"10.1016","volume":"65","author":[{"given":"Christoph","family":"Tschuor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Kachaylo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00ebrparim","family":"Limani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri A.","family":"Raptis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Linecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghua","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uli","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamile","family":"Grabliauskaite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achim","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amedeo","family":"Columbano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Graf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bostjan","family":"Humar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Alain","family":"Clavien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2016.02.040_b0005","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2012.08.043","article-title":"Liver failure after extended hepatectomy in mice is mediated by a p21-dependent barrier to liver regeneration","volume":"143","author":"Lehmann","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2016.02.040_b0010","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jss.2005.04.029","article-title":"A good model of hepatic failure after excessive hepatectomy in mice","volume":"127","author":"Makino","year":"2005","journal-title":"J Surg Res"},{"key":"10.1016\/j.jhep.2016.02.040_b0015","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/hep.23713","article-title":"What is critical for liver surgery and partial liver transplantation: size or quality?","volume":"52","author":"Clavien","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.02.040_b0020","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1056\/NEJMra065156","article-title":"Strategies for safer liver surgery and partial liver transplantation","volume":"356","author":"Clavien","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2016.02.040_b0025","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1097\/01.SLA.0000048976.11824.67","article-title":"Graft injury in relation to graft size in right lobe live donor liver transplantation: a study of hepatic sinusoidal injury in correlation with portal hemodynamics and intragraft gene expression","volume":"237","author":"Man","year":"2003","journal-title":"Ann Surg"},{"key":"10.1016\/j.jhep.2016.02.040_b0030","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/lt.22440","article-title":"Left lobe adult-to-adult living donor liver transplantation: Should portal inflow modulation be added?","volume":"18","author":"Ishizaki","year":"2012","journal-title":"Liver Transpl"},{"key":"10.1016\/j.jhep.2016.02.040_b0035","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/hep.510300215","article-title":"Ischemia impairs liver regeneration after major tissue loss in rodents: protective effects of interleukin-6","volume":"30","author":"Selzner","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.02.040_b0040","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1084\/jem.20040934","article-title":"RAGE limits regeneration after massive liver injury by coordinated suppression of TNF-alpha and NF-kappaB","volume":"201","author":"Cataldegirmen","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.jhep.2016.02.040_b0045","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/hep.21728","article-title":"Interleukin-6 inhibits oxidative injury and necrosis after extreme liver resection","volume":"46","author":"Jin","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.02.040_b0050","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1084\/jem.20131902","article-title":"Dissecting the complement pathway in hepatic injury and regeneration with a novel protective strategy","volume":"211","author":"Marshall","year":"2014","journal-title":"J Exp Med"},{"key":"10.1016\/j.jhep.2016.02.040_b0055","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1478-3231.2007.01628.x","article-title":"Rodent models of partial hepatectomies","volume":"28","author":"Martins","year":"2008","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2016.02.040_b0060","doi-asserted-by":"crossref","first-page":"4598","DOI":"10.1073\/pnas.0600499103","article-title":"Kupffer cell-dependent TNF-alpha signaling mediates injury in the arterialized small-for-size liver transplantation in the mouse","volume":"103","author":"Tian","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2016.02.040_b0065","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/35038112","article-title":"The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism","volume":"407","author":"Wei","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2016.02.040_b0070","doi-asserted-by":"crossref","first-page":"4156","DOI":"10.1073\/pnas.0630614100","article-title":"Induction of bilirubin clearance by the constitutive androstane receptor (CAR)","volume":"100","author":"Huang","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2016.02.040_b0075","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/sj.onc.1200891","article-title":"Increased expression of c-fos, c-jun and LRF-1 is not required for in vivo priming of hepatocytes by the mitogen TCPOBOP","volume":"14","author":"Columbano","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/j.jhep.2016.02.040_b0080","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1126\/science.1121435","article-title":"Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration","volume":"312","author":"Huang","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.jhep.2016.02.040_b0085","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1053\/jlts.2003.50170","article-title":"Arterialized partial orthotopic liver transplantation in the mouse: a new model and evaluation of the critical liver mass","volume":"9","author":"Tian","year":"2003","journal-title":"Liver Transpl"},{"key":"10.1016\/j.jhep.2016.02.040_b0090","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1038\/nprot.2010.111","article-title":"Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies","volume":"5","author":"de Graaf","year":"2010","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jhep.2016.02.040_b0095","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1002\/hep.22475","article-title":"C-Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia","volume":"48","author":"Blanco-Bose","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.02.040_b0100","doi-asserted-by":"crossref","first-page":"16881","DOI":"10.1073\/pnas.252570299","article-title":"The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration","volume":"99","author":"Wang","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2016.02.040_b0105","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1128\/MCB.20.9.2951-2958.2000","article-title":"The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR","volume":"20","author":"Tzameli","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jhep.2016.02.040_b0110","doi-asserted-by":"crossref","first-page":"15122","DOI":"10.1074\/jbc.M001215200","article-title":"Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands","volume":"275","author":"Moore","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2016.02.040_b0115","doi-asserted-by":"crossref","first-page":"17277","DOI":"10.1074\/jbc.M300138200","article-title":"Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes","volume":"278","author":"Maglich","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2016.02.040_b0120","doi-asserted-by":"crossref","first-page":"396","DOI":"10.4161\/cc.10.3.14709","article-title":"Multiple faces of FoxM1 transcription factor: lessons from transgenic mouse models","volume":"10","author":"Kalin","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1016\/j.jhep.2016.02.040_b0125","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ydbio.2013.10.012","article-title":"The human constitutive androstane receptor promotes the differentiation and maturation of hepatic-like cells","volume":"384","author":"Chen","year":"2013","journal-title":"Dev Biol"},{"key":"10.1016\/j.jhep.2016.02.040_b0130","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/sj.bjc.6606064","article-title":"Constitutive androstane receptor agonist CITCO inhibits growth and expansion of brain tumour stem cells","volume":"104","author":"Chakraborty","year":"2011","journal-title":"Br J Cancer"},{"key":"10.1016\/j.jhep.2016.02.040_b0135","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1093\/carcin\/13.10.1893","volume":"13","author":"Diwan","year":"1992","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jhep.2016.02.040_b0140","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1210\/me.2004-0520","article-title":"Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor","volume":"19","author":"Huang","year":"2005","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.jhep.2016.02.040_b0145","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00228-002-0429-6","article-title":"Cancer incidence among patients using antiepileptic drugs: a long-term follow-up of 28,000 patients","volume":"58","author":"Lamminpaa","year":"2002","journal-title":"Eur J Clin Pharmacol"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016882781630006X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016882781630006X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T11:11:29Z","timestamp":1689765089000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016882781630006X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S016882781630006X"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2016.02.040","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Constitutive androstane receptor (Car)-driven regeneration protects liver from failure following tissue loss","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2016.02.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}