{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:21:44Z","timestamp":1790392904795,"version":"4.1.0"},"reference-count":71,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["journal-of-hepatology.eu","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.jhep.2016.04.010","type":"journal-article","created":{"date-parts":[[2016,8,6]],"date-time":"2016-08-06T03:22:24Z","timestamp":1470453744000},"page":"560-569","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":78,"title":["Nocturnal hypoxia-induced oxidative stress promotes progression of pediatric non-alcoholic fatty liver disease"],"prefix":"10.1016","volume":"65","author":[{"given":"Shikha S.","family":"Sundaram","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Halbower","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxing","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Robbins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelley E.","family":"Capocelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Klawitter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin T.","family":"Shearn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald J.","family":"Sokol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2016.04.010_b0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1055\/s-2001-12925","article-title":"Nonalcoholic steatohepatitis: definition and pathology","volume":"21","author":"Brunt","year":"2001","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jhep.2016.04.010_b0010","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1542\/peds.2006-1212","article-title":"Prevalence of fatty liver in children and adolescents","volume":"118","author":"Schwimmer","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.jhep.2016.04.010_b0015","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1056\/NEJMra011775","article-title":"Nonalcoholic fatty liver disease","volume":"346","author":"Angulo","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2016.04.010_b0020","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1042\/CS20030285","article-title":"Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients","volume":"106","author":"Videla","year":"2004","journal-title":"Clin Sci"},{"key":"10.1016\/j.jhep.2016.04.010_b0025","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.cca.2011.04.013","article-title":"The role of oxidative stress in non-alcoholic steatohepatitis","volume":"412","author":"Koek","year":"2011","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jhep.2016.04.010_b0030","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/00004836-199706000-00013","article-title":"Hypoxic hepatitis caused by severe hypoxemia from obstructive sleep apnea","volume":"24","author":"Henrion","year":"1997","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.jhep.2016.04.010_b0035","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1016\/0016-5085(95)90659-2","article-title":"Ischemic hepatitis due to obstructive sleep apnea","volume":"109","author":"Mathurin","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2016.04.010_b0040","doi-asserted-by":"crossref","first-page":"G871","DOI":"10.1152\/ajpgi.00145.2007","article-title":"Chronic intermittent hypoxia causes hepatitis in a mouse model of diet-induced fatty liver","volume":"293","author":"Savransky","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jhep.2016.04.010_b0045","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1038\/oby.2011.240","article-title":"Intermittent hypoxia exacerbates metabolic effects of diet-induced obesity","volume":"19","author":"Drager","year":"2011","journal-title":"Obesity"},{"key":"10.1016\/j.jhep.2016.04.010_b0050","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1164\/rccm.200804-608OC","article-title":"Obstructive sleep apnea, insulin resistance, and steatohepatitis in severe obesity","volume":"179","author":"Polotsky","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jhep.2016.04.010_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpeds.2013.10.072","article-title":"Obstructive sleep apnea and hypoxemia are associated with advanced liver histology in pediatric nonalcoholic fatty liver disease","volume":"164","author":"Sundaram","year":"2014","journal-title":"J Pediatr"},{"key":"10.1016\/j.jhep.2016.04.010_b0060","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1164\/rccm.201307-1339OC","article-title":"Obstructive sleep apnea syndrome affects liver histology and inflammatory cell activation in pediatric nonalcoholic fatty liver disease, regardless of obesity\/insulin resistance","volume":"189","author":"Nobili","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jhep.2016.04.010_b0065","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1053\/j.gastro.2012.04.001","article-title":"The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology","volume":"142","author":"Chalasani","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2016.04.010_b0070","first-page":"1","article-title":"CDC growth charts: United States","author":"Kuczmarski","year":"2000","journal-title":"Advance data"},{"key":"10.1016\/j.jhep.2016.04.010_b0075","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1111\/j.1572-0241.1999.01377.x","article-title":"Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions","volume":"94","author":"Brunt","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2016.04.010_b0080","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.04.010_b0085","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/hep.20842","article-title":"Histopathology of pediatric nonalcoholic fatty liver disease","volume":"42","author":"Schwimmer","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.04.010_b0090","first-page":"49","article-title":"Markers of activated inflammatory cells correlate with severity of liver damage in children with nonalcoholic fatty liver disease","volume":"30","author":"De Vito","year":"2012","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.jhep.2016.04.010_b0095","doi-asserted-by":"crossref","first-page":"15449","DOI":"10.1074\/jbc.M113.543942","article-title":"Identification of 5\u2019 AMP-activated kinase as a target of reactive aldehydes during chronic ingestion of high concentrations of ethanol","volume":"289","author":"Shearn","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2016.04.010_b0100","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.freeradbiomed.2013.07.011","article-title":"Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis","volume":"65","author":"Shearn","year":"2013","journal-title":"Free Radical Biol Med"},{"key":"10.1016\/j.jhep.2016.04.010_b0105","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0168-8278(02)00073-9","article-title":"In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases","volume":"37","author":"Seki","year":"2002","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2016.04.010_b0110","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1378\/chest.06-2827","article-title":"Childhood obstructive sleep-disordered breathing: a clinical update and discussion of technological innovations and challenges","volume":"132","author":"Halbower","year":"2007","journal-title":"Chest"},{"key":"10.1016\/j.jhep.2016.04.010_b0115","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1542\/peds.2005-1067","article-title":"Polysomnographic characteristics in normal preschool and early school-aged children","volume":"117","author":"Montgomery-Downs","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.jhep.2016.04.010_b0120","doi-asserted-by":"crossref","first-page":"597","DOI":"10.5664\/jcsm.2172","article-title":"Rules for scoring respiratory events in sleep: update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events. Deliberations of the Sleep Apnea Definitions Task Force of the American Academy of Sleep Medicine","volume":"8","author":"Berry","year":"2012","journal-title":"J Clin Sleep Med"},{"key":"10.1016\/j.jhep.2016.04.010_b0125","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.jhep.2016.04.010_b0130","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1373\/clinchem.2006.078972","article-title":"HPLC-atmospheric pressure chemical ionization MS\/MS for quantification of 15\u2013F2t-isoprostane in human urine and plasma","volume":"53","author":"Haschke","year":"2007","journal-title":"Clin Chem"},{"key":"10.1016\/j.jhep.2016.04.010_b0135","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/rcm.4871","article-title":"Quantification of 15\u2013F2t-isoprostane in human plasma and urine: results from enzyme-linked immunoassay and liquid chromatography\/tandem mass spectrometry cannot be compared","volume":"25","author":"Klawitter","year":"2011","journal-title":"Rapid Commun Mass Spectrom"},{"key":"10.1016\/j.jhep.2016.04.010_b0140","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1096\/fj.04-2330rev","article-title":"Isoprostanes: markers and mediators of oxidative stress","volume":"18","author":"Montuschi","year":"2004","journal-title":"FASEB J"},{"key":"10.1016\/j.jhep.2016.04.010_b0145","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0022-3476(99)70059-4","article-title":"Prospective, long-term study of fat-soluble vitamin status in children with cystic fibrosis identified by newborn screen","volume":"135","author":"Feranchak","year":"1999","journal-title":"J Pediatr"},{"key":"10.1016\/j.jhep.2016.04.010_b0150","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1006\/abbi.2000.1829","article-title":"Mitochondrial adaptations to obesity-related oxidant stress","volume":"378","author":"Yang","year":"2000","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.jhep.2016.04.010_b0155","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/S0016-5085(96)70028-8","article-title":"Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation","volume":"111","author":"Weltman","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2016.04.010_b0160","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1111\/j.1572-0241.2004.30159.x","article-title":"Systemic levels of lipid peroxidation and its metabolic and dietary correlates in patients with nonalcoholic steatohepatitis","volume":"99","author":"Chalasani","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2016.04.010_b0165","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/S0168-8278(01)00192-1","article-title":"Non-alcoholic fatty liver disease in an area of southern Italy: main clinical, histological, and pathophysiological aspects","volume":"35","author":"Loguercio","year":"2001","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2016.04.010_b0170","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3892\/ijmm_00000487","article-title":"Oxidative stress parameters in paediatric non-alcoholic fatty liver disease","volume":"26","author":"Nobili","year":"2010","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.jhep.2016.04.010_b0175","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1007\/s10620-014-3031-8","article-title":"OxNASH score correlates with histologic features and severity of nonalcoholic fatty liver disease","volume":"59","author":"Alkhouri","year":"2014","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jhep.2016.04.010_b0180","doi-asserted-by":"crossref","first-page":"869","DOI":"10.3109\/10715762.2013.837577","article-title":"Involvement of free radicals and oxidative stress in NAFLD\/NASH","volume":"47","author":"Sumida","year":"2013","journal-title":"Free Radical Res"},{"key":"10.1016\/j.jhep.2016.04.010_b0185","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/hep.1840160225","article-title":"Increased 4-hydroxynonenal levels in experimental alcoholic liver disease: association of lipid peroxidation with liver fibrogenesis","volume":"16","author":"Kamimura","year":"1992","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.04.010_b0190","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0022-2143(99)90022-7","article-title":"Hepatic lipid peroxidation in hereditary hemochromatosis and alcoholic liver injury","volume":"133","author":"Niemela","year":"1999","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.jhep.2016.04.010_b0195","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/hep.510260118","article-title":"In situ detection of lipid peroxidation by-products in chronic liver diseases","volume":"26","author":"Paradis","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.04.010_b0200","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0002-9343(00)00481-2","article-title":"Phagocytes and oxidative stress","volume":"109","author":"Babior","year":"2000","journal-title":"Am J Med"},{"key":"10.1016\/j.jhep.2016.04.010_b0205","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1056\/NEJM198501173120305","article-title":"Oxygen-derived free radicals in postischemic tissue injury","volume":"312","author":"McCord","year":"1985","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2016.04.010_b0210","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1152\/japplphysiol.01291.2006","article-title":"Effects of intermittent hypoxia on oxidative stress-induced myocardial damage in mice","volume":"102","author":"Park","year":"2007","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.jhep.2016.04.010_b0215","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s11325-010-0370-3","article-title":"An experimental research on chronic intermittent hypoxia leading to liver injury","volume":"15","author":"Feng","year":"2011","journal-title":"Sleep Breath"},{"key":"10.1016\/j.jhep.2016.04.010_b0220","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.3390\/ijms16023323","article-title":"Reduction of oxidative stress attenuates lipoapoptosis exacerbated by hypoxia in human hepatocytes","volume":"16","author":"Hwang","year":"2015","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jhep.2016.04.010_b0225","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.freeradbiomed.2013.08.180","article-title":"The effects of intermittent hypoxia on redox status, NF-kappaB activation, and plasma lipid levels are dependent on the lowest oxygen saturation","volume":"65","author":"Quintero","year":"2013","journal-title":"Free Radical Biol Med"},{"key":"10.1016\/j.jhep.2016.04.010_b0230","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00011-014-0778-5","article-title":"Antioxidants inhibit the inflammatory and apoptotic processes in an intermittent hypoxia model of sleep apnea","volume":"64","author":"da Rosa","year":"2015","journal-title":"Inflamm Res"},{"key":"10.1016\/j.jhep.2016.04.010_b0235","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1136\/thoraxjnl-2015-206782","article-title":"Altered gut-liver axis and hepatic adiponectin expression in OSAS: novel mediators of liver injury in paediatric non-alcoholic fatty liver","volume":"70","author":"Nobili","year":"2015","journal-title":"Thorax"},{"key":"10.1016\/j.jhep.2016.04.010_b0240","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1183\/09031936.06.00067605","article-title":"Antioxidant status in patients with sleep apnoea and impact of continuous positive airway pressure treatment","volume":"27","author":"Barcelo","year":"2006","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jhep.2016.04.010_b0245","first-page":"123","article-title":"Evidence for lipid peroxidation in obstructive sleep apnea","volume":"27","author":"Lavie","year":"2004","journal-title":"Sleep"},{"key":"10.1016\/j.jhep.2016.04.010_b0250","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.atherosclerosis.2005.04.024","article-title":"HDL dysfunction in obstructive sleep apnea","volume":"184","author":"Tan","year":"2006","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jhep.2016.04.010_b0255","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s11325-011-0536-7","article-title":"The association of oxidative stress with central obesity in obstructive sleep apnea","volume":"16","author":"Lee","year":"2012","journal-title":"Sleep Breath"},{"key":"10.1016\/j.jhep.2016.04.010_b0260","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1093\/eurheartj\/ehi440","article-title":"Oxidative stress in obstructive sleep apnoea","volume":"26","author":"Svatikova","year":"2005","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jhep.2016.04.010_b0265","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1111\/j.1651-2227.2008.00927.x","article-title":"Correlation of 8-isoprostane, interleukin-6 and cardiac functions with clinical score in childhood obstructive sleep apnoea","volume":"97","author":"Biltagi","year":"2008","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.jhep.2016.04.010_b0270","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s11325-011-0560-7","article-title":"Oxidative stress and inflammatory markers in the exhaled breath condensate of children with OSA","volume":"16","author":"Malakasioti","year":"2012","journal-title":"Sleep Breath"},{"key":"10.1016\/j.jhep.2016.04.010_b0275","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s11325-006-0079-5","article-title":"Urinary F2-isoprostane metabolite levels in children with sleep-disordered breathing","volume":"10","author":"Montgomery-Downs","year":"2006","journal-title":"Sleep Breath"},{"key":"10.1016\/j.jhep.2016.04.010_b0280","doi-asserted-by":"crossref","first-page":"677","DOI":"10.5664\/jcsm.3800","article-title":"Oxidative stress in children with obstructive sleep apnea syndrome","volume":"10","author":"Tauman","year":"2014","journal-title":"J Clin Sleep Med"},{"key":"10.1016\/j.jhep.2016.04.010_b0285","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s11695-013-1087-8","article-title":"Association between liver vitamin A reserves and severity of nonalcoholic fatty liver disease in the class III obese following bariatric surgery","volume":"24","author":"Chaves","year":"2014","journal-title":"Obes Surg"},{"key":"10.1016\/j.jhep.2016.04.010_b0290","first-page":"727","article-title":"Prevalence of abnormal serum aminotransferase values in overweight and obese adolescents","volume":"136","author":"Strauss","year":"2000","journal-title":"J Pediatr"},{"key":"10.1016\/j.jhep.2016.04.010_b0295","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3945\/jn.113.183137","article-title":"Low serum concentrations of carotenoids and vitamin E are associated with high adiposity in Mexican-American children","volume":"144","author":"Gunanti","year":"2014","journal-title":"J Nutr"},{"key":"10.1016\/j.jhep.2016.04.010_b0300","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1056\/NEJMoa0907929","article-title":"Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis","volume":"362","author":"Sanyal","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2016.04.010_b0305","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1001\/jama.2011.520","article-title":"Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial","volume":"305","author":"Lavine","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.jhep.2016.04.010_b0310","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S1389-9457(02)00253-8","article-title":"Antioxidant capacity in obstructive sleep apnea patients","volume":"4","author":"Christou","year":"2003","journal-title":"Sleep Med"},{"key":"10.1016\/j.jhep.2016.04.010_b0315","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s11325-010-0456-y","article-title":"Total antioxidant status in patients with obstructive sleep apnea without comorbidities: the role of the severity of the disease","volume":"15","author":"Katsoulis","year":"2011","journal-title":"Sleep Breath"},{"key":"10.1016\/j.jhep.2016.04.010_b0320","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1001\/jama.2014.732","article-title":"Prevalence of childhood and adult obesity in the United States, 2011\u20132012","volume":"311","author":"Ogden","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.jhep.2016.04.010_b0325","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1046\/j.1365-2796.2003.01177.x","article-title":"Metabolic disturbances in obesity versus sleep apnoea: the importance of visceral obesity and insulin resistance","volume":"254","author":"Vgontzas","year":"2003","journal-title":"J Intern Med"},{"key":"10.1016\/j.jhep.2016.04.010_b0330","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.jhep.2012.03.013","article-title":"Visceral adiposity index is not a predictor of liver histology in patients with non-alcoholic fatty liver disease","volume":"57","author":"Vongsuvanh","year":"2012","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2016.04.010_b0335","doi-asserted-by":"crossref","first-page":"e931","DOI":"10.1016\/j.jpeds.2014.12.030","article-title":"Adolescent and young adult female determinants of visceral adipose tissue at ages 26\u201328 years","volume":"166","author":"Glueck","year":"2015","journal-title":"J Pediatr"},{"key":"10.1016\/j.jhep.2016.04.010_b0340","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0114112","article-title":"Surrogate markers of visceral adiposity in young adults: waist circumference and body mass index are more accurate than waist hip ratio, model of adipose distribution and visceral adiposity index","volume":"9","author":"Borruel","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jhep.2016.04.010_b0345","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1056\/NEJM200011163432007","article-title":"Cytokines in alcoholic and nonalcoholic steatohepatitis","volume":"343","author":"Tilg","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2016.04.010_b0350","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0168-8278(00)80414-6","article-title":"Mechanisms of liver cell injury","volume":"32","author":"Kaplowitz","year":"2000","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2016.04.010_b0355","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev.iy.12.040194.001041","article-title":"Function and activation of NF-kappa B in the immune system","volume":"12","author":"Baeuerle","year":"1994","journal-title":"Annu Rev Immunol"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827816301416?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827816301416?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T11:09:09Z","timestamp":1692443349000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827816301416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":71,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S0168827816301416"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2016.04.010","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nocturnal hypoxia-induced oxidative stress promotes progression of pediatric non-alcoholic fatty liver disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2016.04.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}