{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:47:05Z","timestamp":1791222425051,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NKFI","award":["108308"],"award-info":[{"award-number":["108308"]}]},{"name":"NKFI","award":["GINOP-2.3.2-15-2016-00006"],"award-info":[{"award-number":["GINOP-2.3.2-15-2016-00006"]}]}],"content-domain":{"domain":["journal-of-hepatology.eu","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.jhep.2016.10.023","type":"journal-article","created":{"date-parts":[[2016,10,29]],"date-time":"2016-10-29T00:47:58Z","timestamp":1477702078000},"page":"589-600","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":156,"title":["PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis"],"prefix":"10.1016","volume":"66","author":[{"given":"Partha","family":"Mukhopadhyay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9la","family":"Horv\u00e1th","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohanraj","family":"Rajesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n V.","family":"Varga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Gariani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongryeol","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongxian","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Holovac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ogyi","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Jiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz","family":"Godlewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janos","family":"Paloczi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balazs Tamas","family":"Nemeth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Persidsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Liaudet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gy\u00f6rgy","family":"Hask\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Hamid","family":"Boulares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Auwerx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pal","family":"Pacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2016.10.023_b0005","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1053\/j.gastro.2011.09.002","article-title":"Alcoholic liver disease: pathogenesis and new therapeutic targets","volume":"141","author":"Gao","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2016.10.023_b0010","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1053\/j.gastro.2016.02.035","article-title":"Linking pathogenic mechanisms of alcoholic liver disease with clinical phenotypes","volume":"150","author":"Nagy","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2016.10.023_b0015","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.bbrc.2008.03.005","article-title":"Effect of chronic alcohol consumption on Hepatic SIRT1 and PGC-1alpha in rats","volume":"370","author":"Lieber","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jhep.2016.10.023_b0020","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1053\/j.gastro.2014.10.042","article-title":"Gut-liver axis in alcoholic liver disease","volume":"148","author":"Szabo","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2016.10.023_b0025","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nrd1718","article-title":"Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors","volume":"4","author":"Jagtap","year":"2005","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jhep.2016.10.023_b0030","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.mam.2013.01.005","article-title":"PARP-1 and gene regulation: Progress and puzzles","volume":"34","author":"Kraus","year":"2013","journal-title":"Mol Aspects Med"},{"key":"10.1016\/j.jhep.2016.10.023_b0035","doi-asserted-by":"crossref","first-page":"4446","DOI":"10.1093\/emboj\/18.16.4446","article-title":"Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice","volume":"18","author":"Oliver","year":"1999","journal-title":"EMBO J"},{"key":"10.1016\/j.jhep.2016.10.023_b0040","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.tem.2014.11.003","article-title":"Poly(ADP-ribose) polymerases as modulators of mitochondrial activity","volume":"26","author":"Bai","year":"2015","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.jhep.2016.10.023_b0045","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1152\/physrev.00029.2006","article-title":"Nitric oxide and peroxynitrite in health and disease","volume":"87","author":"Pacher","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jhep.2016.10.023_b0050","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.mam.2013.01.006","article-title":"Therapeutic applications of PARP inhibitors: anticancer therapy and beyond","volume":"34","author":"Curtin","year":"2013","journal-title":"Mol Aspects Med"},{"key":"10.1016\/j.jhep.2016.10.023_b0055","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1002\/hep.26763","article-title":"Poly (ADP-ribose) polymerase-1 is a key mediator of liver inflammation and fibrosis","volume":"59","author":"Mukhopadhyay","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.10.023_b0060","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nprot.2013.032","article-title":"Mouse model of chronic and binge ethanol feeding (the NIAAA model)","volume":"8","author":"Bertola","year":"2013","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jhep.2016.10.023_b0065","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.cmet.2012.04.022","article-title":"The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity","volume":"15","author":"Canto","year":"2012","journal-title":"Cell Metab"},{"key":"10.1016\/j.jhep.2016.10.023_b0070","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1002\/hep.26419","article-title":"Chronic plus binge ethanol feeding synergistically induces neutrophil infiltration and liver injury in mice: a critical role for E-selectin","volume":"58","author":"Bertola","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.10.023_b0075","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1002\/hep.27921","article-title":"Short- or long-term high-fat diet feeding plus acute ethanol binge synergistically induce acute liver injury in mice: an important role for CXCL1","volume":"62","author":"Chang","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.10.023_b0080","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1046\/j.1440-1746.2001.02378.x","article-title":"Enhanced polyadenosine diphosphate-ribosylation in cirrhotic liver and carcinoma tissues in patients with hepatocellular carcinoma","volume":"16","author":"Shiobara","year":"2001","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2016.10.023_b0085","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1002\/hep.28245","article-title":"Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice","volume":"63","author":"Gariani","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.10.023_b0090","doi-asserted-by":"crossref","first-page":"35S","DOI":"10.1111\/j.1530-0277.2001.tb02415.x","article-title":"Effects of chronic alcohol consumption on hepatic poly-ADP-ribosylation in the rat","volume":"25","author":"Nomura","year":"2001","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.jhep.2016.10.023_b0095","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0165-7992(89)90067-5","article-title":"Acetaldehyde activation of poly(ADP-ribose)polymerase in hepatocytes of mice treated in vivo","volume":"227","author":"Clerici","year":"1989","journal-title":"Mutat Res"},{"key":"10.1016\/j.jhep.2016.10.023_b0100","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/hep.1840150320","article-title":"Ethanol enhances ADP-ribosylation of protein in rat hepatocytes","volume":"15","author":"Akinshola","year":"1992","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.10.023_b0105","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jhep.2016.08.024","article-title":"Inhibiting poly-ADP ribosylation increases fatty acid oxidation and protects against fatty liver disease","volume":"66","author":"Gariani","year":"2017","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2016.10.023_b0110","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0168-8278(87)80003-X","article-title":"Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess","volume":"4","author":"Bode","year":"1987","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2016.10.023_b0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0096864","article-title":"Acute binge drinking increases serum endotoxin and bacterial DNA levels in healthy individuals","volume":"9","author":"Bala","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jhep.2016.10.023_b0120","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/oxfordjournals.alcalc.a044987","article-title":"The effects of chronic ethanol consumption on hepatic mitochondrial energy metabolism","volume":"25","author":"Cunningham","year":"1990","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.jhep.2016.10.023_b0125","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0891-5849(01)00769-9","article-title":"Contribution of mitochondria to oxidative stress associated with alcoholic liver disease","volume":"32","author":"Bailey","year":"2002","journal-title":"Free Radical Biol Med"},{"key":"10.1016\/j.jhep.2016.10.023_b0130","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1002\/hep.21372","article-title":"Inactivation of oxidized and S-nitrosylated mitochondrial proteins in alcoholic fatty liver of rats","volume":"44","author":"Moon","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.10.023_b0135","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.bbrc.2008.06.006","article-title":"Alcohol alters hepatic FoxO1, p53, and mitochondrial SIRT5 deacetylation function","volume":"373","author":"Lieber","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jhep.2016.10.023_b0140","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1146\/annurev.pathol.4.110807.092250","article-title":"Mammalian sirtuins: biological insights and disease relevance","volume":"5","author":"Haigis","year":"2010","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.jhep.2016.10.023_b0145","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1083\/jcb.201207019","article-title":"Exploring the therapeutic space around NAD+","volume":"199","author":"Houtkooper","year":"2012","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jhep.2016.10.023_b0150","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1096\/fj.13-243568","article-title":"The SIRT1 deacetylase protects mice against the symptoms of metabolic syndrome","volume":"28","author":"Caron","year":"2014","journal-title":"FASEB J"},{"key":"10.1016\/j.jhep.2016.10.023_b0155","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1053\/j.gastro.2013.11.008","article-title":"Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver","volume":"146","author":"Yin","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2016.10.023_b0160","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1210\/en.2009-1013","article-title":"Lack of SIRT1 (Mammalian Sirtuin 1) activity leads to liver steatosis in the SIRT1+\/- mice: a role of lipid mobilization and inflammation","volume":"151","author":"Xu","year":"2010","journal-title":"Endocrinology"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827816306171?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827816306171?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T16:41:01Z","timestamp":1530117661000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827816306171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S0168827816306171"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2016.10.023","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2016.10.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V. on behalf of European Association for the Study of the Liver.","name":"copyright","label":"Copyright"}]}}