{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T13:57:30Z","timestamp":1788357450899,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001411","name":"ICMR","doi-asserted-by":"publisher","award":["5\/4\/3-12\/2011\/NCD-II"],"award-info":[{"award-number":["5\/4\/3-12\/2011\/NCD-II"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journal-of-hepatology.eu","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.jhep.2016.10.026","type":"journal-article","created":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T21:01:13Z","timestamp":1478034073000},"page":"528-536","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Minimal hepatic encephalopathy in children with chronic liver disease: Prevalence, pathogenesis and magnetic resonance-based diagnosis"],"prefix":"10.1016","volume":"66","author":[{"given":"Anshu","family":"Srivastava","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh","family":"Chaturvedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh Kumar","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrita","family":"Mathias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naranamangalam R.","family":"Jagannathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandra Mani","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surender Kumar","family":"Yachha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram Kishor Singh","family":"Rathore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2016.10.026_b0005","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1053\/jhep.2002.31250","article-title":"Hepatic encephalopathy-definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998","volume":"35","author":"Ferenci","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.10.026_b0010","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1111\/j.1440-1746.2010.06318.x","article-title":"Minimal Hepatic encephalopathy: consensus statement of a working party of the Indian National Association for study of the liver","volume":"25","author":"Dhiman","year":"2010","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2016.10.026_b0015","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1016\/j.jceh.2014.11.006","article-title":"Minimal hepatic encephalopathy impairs quality of life","volume":"5","author":"Agrawal","year":"2015","journal-title":"J Clin Exp Hepatol"},{"key":"10.1016\/j.jhep.2016.10.026_b0020","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s00234-014-1409-0","article-title":"Minimal hepatic encephalopathy in children with liver cirrhosis: diffusion-weighted MR imaging and proton MR spectroscopyof the brain","volume":"56","author":"Razek","year":"2014","journal-title":"Neuroradiology"},{"key":"10.1016\/j.jhep.2016.10.026_b0025","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/j.1478-3231.2009.02009.x","article-title":"Neuropsychological assessment of hepatic encephalopathy: ISHEN practice guidelines","volume":"29","author":"Randolph","year":"2009","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2016.10.026_b0030","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/ncpgasthep0999","article-title":"Minimal hepatic encephalopathy","volume":"4","author":"Stewart","year":"2007","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2016.10.026_b0035","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/hep.21114","article-title":"Demonstration of interstitial cerebral edema with diffusion tensor MR imaging in type C hepatic encephalopathy","volume":"43","author":"Kale","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.10.026_b0040","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1111\/j.1572-0241.2008.01788.x","article-title":"Value of the apparent diffusion coefficient for quantification of low-grade hepatic encephalopathy","volume":"103","author":"Sugimoto","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2016.10.026_b0045","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1002\/jmri.21342","article-title":"Voxel-based diffusion tensor magnetic resonance imaging evaluation of low-grade hepatic encephalopathy","volume":"27","author":"Kumar","year":"2008","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.jhep.2016.10.026_b0050","first-page":"683","article-title":"Encephalopathy assessment in children with extra-hepatic portal vein obstruction with MR, psychometry and critical flicker frequency","volume":"216","author":"Yadav","year":"2010","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2016.10.026_b0055","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/hep.21533","article-title":"Lactulose improves cognitive functions and health-related quality of life in patients with cirrhosis who have minimal hepatic encephalopathy","volume":"45","author":"Prasad","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.10.026_b0060","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1111\/j.1572-0241.2001.04130.x","article-title":"Subclinical hepatic encephalopathy predicts the development of overt hepatic encephalopathy","volume":"96","author":"Romero-Gomez","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2016.10.026_b0065","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1053\/j.gastro.2015.07.067","article-title":"Minimal hepatic encephalopathy and critical flicker frequency are associated with survival of patients with cirrhosis","volume":"149","author":"Ampuero","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2016.10.026_b0070","doi-asserted-by":"crossref","first-page":"e405","DOI":"10.1542\/peds.2005-1177","article-title":"Surgically restoring portal blood flow to the liver in children with primary extrahepatic portal vein thrombosis improves fluid neurocognitive ability","volume":"117","author":"Mack","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.jhep.2016.10.026_b0075","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1746-6342.2006.03215.x","article-title":"Review article: the burden of hepatic encephalopathy","volume":"25","author":"Poordad","year":"2007","journal-title":"Alimentary Pharmacol Ther"},{"key":"10.1016\/j.jhep.2016.10.026_b0080","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/MPG.0b013e318228d7da","article-title":"Acute on chronic liver disease in children from the developing world: recognition and prognosis","volume":"54","author":"Jagadisan","year":"2012","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jhep.2016.10.026_b0085","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1046\/j.1440-1746.2001.02487.x","article-title":"Prevalence and natural history of subclinical hepatic encephalopathy in cirrhosis","volume":"16","author":"Das","year":"2001","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2016.10.026_b0090","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1002\/hep.510290619","article-title":"Clinical features and survival of cirrhotic patients with subclinical cognitive alterations detected by the number connection test and computerized psychometric tests","volume":"29","author":"Amodio","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.10.026_b0095","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0009-8981(84)90054-8","article-title":"A simple and rapid microdiffusion method for blood ammonia using a reflectance meter and a reagent plate, and its clinical evaluation for liver diseases","volume":"144","author":"Murawaki","year":"1984","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jhep.2016.10.026_b0100","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.clnu.2011.11.018","article-title":"Thiamine deficiency related microstructural brain changes in acute and acute-on-chronic liver failure of non-alcoholic etiology","volume":"31","author":"Gupta","year":"2012","journal-title":"Clin Nutr"},{"key":"10.1016\/j.jhep.2016.10.026_b0105","series-title":"Diffusion and perfusion magnetic resonance imaging: applications to functional MRI","year":"1995"},{"key":"10.1016\/j.jhep.2016.10.026_b0110","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/nbm.698","article-title":"Automatic quantitation of localized in vivo 1H spectra with LC Model","volume":"14","author":"Provencher","year":"2001","journal-title":"NMR Biomed"},{"key":"10.1016\/j.jhep.2016.10.026_b0115","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1111\/j.1572-0241.2000.02265.x","article-title":"The prognostic significance of subclinical hepatic encephalopathy","volume":"95","author":"Hartmann","year":"2000","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2016.10.026_b0120","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1007\/s10620-010-1249-7","article-title":"Diagnosis and prognostic significance of minimal hepatic encephalopathy in patients with cirrhosis of liver","volume":"55","author":"Dhiman","year":"2010","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jhep.2016.10.026_b0125","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1038\/ajg.2014.264","article-title":"Covert hepatic encephalopathy is independently associated with poor survival and increased risk of hospitalization","volume":"109","author":"Patidar","year":"2014","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2016.10.026_b0130","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1111\/jgh.12160","article-title":"Serum endotoxin, inflammatory mediators, and magnetic resonance spectroscopy before and after treatment in patients with minimal hepatic encephalopathy","volume":"28","author":"Jain","year":"2013","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2016.10.026_b0135","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.3174\/ajnr.A1652","article-title":"Minimal hepatic encephalopathy in children: evaluation with proton MR spectroscopy","volume":"30","author":"Foerster","year":"2009","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.jhep.2016.10.026_b0140","first-page":"513","article-title":"The BCAA\/AAA ratio of plasma amino acids in three different groups of cirrhotics","volume":"44","author":"Campollo","year":"1992","journal-title":"Rev Invest Clin"},{"key":"10.1016\/j.jhep.2016.10.026_b0145","doi-asserted-by":"crossref","first-page":"1579S","DOI":"10.1093\/jn\/137.6.1579S","article-title":"Aromatic amino acid metabolism during liver failure","volume":"137","author":"Dejong","year":"2007","journal-title":"J Nutr"},{"key":"10.1016\/j.jhep.2016.10.026_b0150","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/hep.21126","article-title":"Noncirrhotic portal vein thrombosis exhibits neuropsychological and MR changes consistent with minimal hepatic encephalopathy","volume":"43","author":"M\u00ednguez","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.10.026_b0155","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/nbm.1940080707","article-title":"Inferring microstructural features and the physiological state of tissues from diffusion-weighted images","volume":"8","author":"Basser","year":"1995","journal-title":"NMR Biomed"},{"key":"10.1016\/j.jhep.2016.10.026_b0160","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/MCG.0b013e31815e7f58","article-title":"IL-6 and IL-18 in blood may discriminate cirrhotic patients with and without minimal hepatic encephalopathy","volume":"43","author":"Montoliu","year":"2009","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.jhep.2016.10.026_b0165","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s11011-006-9042-1","article-title":"Role of ammonia and inflammation in minimal hepatic encephalopathy","volume":"22","author":"Shawcross","year":"2007","journal-title":"Metab Brain Dis"},{"key":"10.1016\/j.jhep.2016.10.026_b0170","doi-asserted-by":"crossref","DOI":"10.1038\/ctg.2015.38","article-title":"Reversal of low-grade cerebral edema after lactulose\/rifaximin therapy in patients with cirrhosis and minimal hepatic encephalopathy","volume":"6","author":"Rai","year":"2015","journal-title":"Clin Transl Gastroenterol"},{"key":"10.1016\/j.jhep.2016.10.026_b0175","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/jmri.20291","article-title":"Adding another spectral dimension to 1H MR Spectroscopy of hepatic encephalopathy","volume":"21","author":"Binesh","year":"2005","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.jhep.2016.10.026_b0180","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/jmri.22216","article-title":"Two-dimensional MR spectroscopy of minimal hepatic encephalopathy and neuropsychological correlates in vivo","volume":"32","author":"Singhal","year":"2010","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.jhep.2016.10.026_b0185","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/BF02098881","article-title":"Regional variations in cerebral proton spectroscopy in patients with chronic hepatic encephalopathy","volume":"9","author":"Taylor-Robinson","year":"1994","journal-title":"Metab Brain Dis"},{"key":"10.1016\/j.jhep.2016.10.026_b0190","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.neuroscience.2005.07.003","article-title":"Prefrontal cortex and working memory processes","volume":"139","author":"Funahashi","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.jhep.2016.10.026_b0195","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1016\/S0016-5085(97)70043-X","article-title":"Proton magnetic resonance spectroscopic studies of the brain in symptomatic and asymptomatic patients with liver cirrhosis","volume":"112","author":"Laubenberger","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2016.10.026_b0200","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.jhep.2010.12.008","article-title":"Cerebral magnetic resonance imaging reveals marked abnormalities of brain tissue density in patients with cirrhosis without overt hepatic encephalopathy","volume":"55","author":"Guevara","year":"2011","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2016.10.026_b0205","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/ajg.2010.455","article-title":"Rifaximin improves psychometric performance and health-related quality of life in patients with minimal hepatic encephalopathy (The RIME Trial)","volume":"106","author":"Sidhu","year":"2011","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2016.10.026_b0210","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.cld.2015.04.002","article-title":"Should we treat minimal\/covert hepatic encephalopathy, and with what?","volume":"19","author":"Henderson","year":"2015","journal-title":"Clin Liver Dis"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827816306201?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827816306201?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T21:59:42Z","timestamp":1536271182000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827816306201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S0168827816306201"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2016.10.026","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726930286.793529735","asserted-by":"object"}]},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Minimal hepatic encephalopathy in children with chronic liver disease: Prevalence, pathogenesis and magnetic resonance-based diagnosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2016.10.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}