{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:43:41Z","timestamp":1785876221707,"version":"3.56.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["journal-of-hepatology.eu","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.jhep.2016.10.032","type":"journal-article","created":{"date-parts":[[2016,11,5]],"date-time":"2016-11-05T16:45:25Z","timestamp":1478364325000},"page":"571-580","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["Adenylyl cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in polycystic liver disease"],"prefix":"10.1016","volume":"66","author":[{"given":"Carlo","family":"Spirli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Mariotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambra","family":"Villani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Fabris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Fiorotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Strazzabosco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2016.10.032_b0005","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ki.2015.59","article-title":"Autosomal-dominant polycystic kidney disease (ADPKD): executive summary from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference","volume":"88","author":"Chapman","year":"2015","journal-title":"Kidney Int"},{"key":"10.1016\/j.jhep.2016.10.032_b0010","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1053\/j.gastro.2011.04.030","article-title":"Polycystic liver diseases: congenital disorders of cholangiocyte signaling","volume":"140","author":"Strazzabosco","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2016.10.032_b0015","doi-asserted-by":"crossref","first-page":"S90","DOI":"10.1097\/01.mcg.0000155549.29643.ad","article-title":"Pathophysiology of cholangiopathies","volume":"39","author":"Strazzabosco","year":"2005","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.jhep.2016.10.032_b0020","doi-asserted-by":"crossref","first-page":"687","DOI":"10.3390\/cells4040687","article-title":"Role of the polycystins in cell migration, polarity, and tissue morphogenesis","volume":"4","author":"Nigro","year":"2015","journal-title":"Cells"},{"key":"10.1016\/j.jhep.2016.10.032_b0025","doi-asserted-by":"crossref","first-page":"6454","DOI":"10.1073\/pnas.0610324104","article-title":"Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2","volume":"104","author":"Anyatonwu","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2016.10.032_b0030","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.pharmthera.2011.03.005","article-title":"TRP channels: emerging targets for respiratory disease","volume":"130","author":"Banner","year":"2011","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jhep.2016.10.032_b0035","doi-asserted-by":"crossref","first-page":"15920","DOI":"10.1073\/pnas.0805062105","article-title":"Syntaxin 5 regulates the endoplasmic reticulum channel-release properties of polycystin-2","volume":"105","author":"Geng","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2016.10.032_b0040","doi-asserted-by":"crossref","first-page":"530","DOI":"10.4161\/cib.3.6.12751","article-title":"Unraveling the role of polycystin-2\/inositol 1,4,5-trisphosphate receptor interaction in Ca signaling","volume":"3","author":"Sammels","year":"2010","journal-title":"Commun Integr Biol"},{"key":"10.1016\/j.jhep.2016.10.032_b0045","doi-asserted-by":"crossref","first-page":"e367","DOI":"10.1053\/j.gastro.2009.09.005","article-title":"ERK1\/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice","volume":"138","author":"Spirli","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2016.10.032_b0050","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1002\/hep.23511","article-title":"Mammalian target of rapamycin regulates vascular endothelial growth factor-dependent liver cyst growth in polycystin-2-defective mice","volume":"51","author":"Spirli","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.10.032_b0055","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1002\/hep.28138","article-title":"Posttranslational regulation of polycystin-2 protein expression as a novel mechanism of cholangiocyte reaction and repair from biliary damage","volume":"62","author":"Spirli","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.10.032_b0060","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1002\/hep.24723","article-title":"Altered store operated calcium entry increases cyclic 3\u2019,5\u2019-adenosine monophosphate production and extracellular signal-regulated kinases 1 and 2 phosphorylation in polycystin-2-defective cholangiocytes","volume":"55","author":"Spirli","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.10.032_b0065","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1002\/hep.25872","article-title":"Cyclic AMP\/PKA-dependent paradoxical activation of Raf\/MEK\/ERK signaling in polycystin-2 defective mice treated with sorafenib","volume":"56","author":"Spirli","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.10.032_b0070","doi-asserted-by":"crossref","first-page":"20661","DOI":"10.1074\/jbc.C600126200","article-title":"Orai1 and STIM reconstitute store-operated calcium channel function","volume":"281","author":"Soboloff","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2016.10.032_b0075","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1242\/jcs.03462","article-title":"New molecular players in capacitative Ca2+ entry","volume":"120","author":"Putney","year":"2007","journal-title":"J Cell Sci"},{"key":"10.1016\/j.jhep.2016.10.032_b0080","doi-asserted-by":"crossref","first-page":"pe42","DOI":"10.1126\/scisignal.3148pe42","article-title":"Calcium signaling by STIM and Orai: intimate coupling details revealed","volume":"3","author":"Wang","year":"2010","journal-title":"Sci Signal"},{"key":"10.1016\/j.jhep.2016.10.032_b0085","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.ceca.2015.04.004","article-title":"Store-operated Ca(2)(+)-entry and adenylyl cyclase","volume":"58","author":"Cooper","year":"2015","journal-title":"Cell Calcium"},{"key":"10.1016\/j.jhep.2016.10.032_b0090","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/ncb1850","article-title":"Store-operated cyclic AMP signalling mediated by STIM1","volume":"11","author":"Lefkimmiatis","year":"2009","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jhep.2016.10.032_b0095","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/hep.22926","article-title":"Differentially expressed adenylyl cyclase isoforms mediate secretory functions in cholangiocyte subpopulation","volume":"50","author":"Strazzabosco","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.10.032_b0100","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1161\/CIRCULATIONAHA.107.730069","article-title":"Adenylyl cyclase type 6 deletion decreases left ventricular function via impaired calcium handling","volume":"117","author":"Tang","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jhep.2016.10.032_b0105","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1002\/lt.22359","article-title":"Cyclic adenosine 3\u2019,5\u2019-monophosphate in rat steatotic liver transplantation","volume":"17","author":"Jimenez-Castro","year":"2011","journal-title":"Liver Transpl"},{"key":"10.1016\/j.jhep.2016.10.032_b0110","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1053\/j.gastro.2011.06.052","article-title":"Loss of CFTR affects biliary epithelium innate immunity and causes TLR4-NF-kappaB-mediated inflammatory response in mice","volume":"141","author":"Fiorotto","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2016.10.032_b0115","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1002\/hep.21143","article-title":"Effects of angiogenic factor overexpression by human and rodent cholangiocytes in polycystic liver diseases","volume":"43","author":"Fabris","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.10.032_b0120","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1002\/hep.28000","article-title":"Stimulation of nuclear receptor peroxisome proliferator-activated receptor-gamma limits NF-kappaB-dependent inflammation in mouse cystic fibrosis biliary epithelium","volume":"62","author":"Scirpo","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.10.032_b0125","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.cell.2014.11.050","article-title":"Long-term culture of genome-stable bipotent stem cells from adult human liver","volume":"160","author":"Huch","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2016.10.032_b0130","doi-asserted-by":"crossref","first-page":"24452","DOI":"10.1038\/srep24452","article-title":"Dynamic interaction of SARAF with STIM1 and Orai1 to modulate store-operated calcium entry","volume":"6","author":"Albarran","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jhep.2016.10.032_b0135","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1152\/physrev.00049.2006","article-title":"Organization and Ca2+ regulation of adenylyl cyclases in cAMP microdomains","volume":"87","author":"Willoughby","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jhep.2016.10.032_b0140","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s00210-015-1197-z","article-title":"Inhibitors of membranous adenylyl cyclases with affinity for adenosine receptors","volume":"389","author":"Klotz","year":"2016","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.jhep.2016.10.032_b0145","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1021\/bi802122k","article-title":"Structural basis for inhibition of mammalian adenylyl cyclase by calcium","volume":"48","author":"Mou","year":"2009","journal-title":"Biochemistry"},{"key":"10.1016\/j.jhep.2016.10.032_b0150","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/hep.27165","article-title":"Generation of functional cholangiocyte-like cells from human pluripotent stem cells and HepaRG cells","volume":"60","author":"Dianat","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.10.032_b0155","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nbt.3275","article-title":"Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation","volume":"33","author":"Sampaziotis","year":"2015","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jhep.2016.10.032_b0160","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1053\/j.gastro.2006.12.039","article-title":"Octreotide inhibits hepatic cystogenesis in a rodent model of polycystic liver disease by reducing cholangiocyte adenosine 3\u2019,5\u2019-cyclic monophosphate","volume":"132","author":"Masyuk","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2016.10.032_b0165","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1681\/ASN.2009121302","article-title":"Sirolimus therapy to halt the progression of ADPKD","volume":"21","author":"Perico","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.jhep.2016.10.032_b0170","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1136\/gut.2008.155721","article-title":"Somatostatin analogues reduce liver volume in polycystic liver disease","volume":"57","author":"van Keimpema","year":"2008","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2016.10.032_b0175","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1053\/j.gastro.2006.07.003","article-title":"Cholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular Ca2+ and cAMP signaling","volume":"131","author":"Masyuk","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2016.10.032_b0180","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/hep.28550","article-title":"Soluble adenylyl cyclase regulates bile salt-induced apoptosis in human cholangiocytes","volume":"64","author":"Chang","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.10.032_b0185","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1042\/BST0340480","article-title":"Layers of organization of cAMP microdomains in a simple cell","volume":"34","author":"Martin","year":"2006","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.jhep.2016.10.032_b0190","doi-asserted-by":"crossref","first-page":"10679","DOI":"10.1073\/pnas.1016214108","article-title":"Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases","volume":"108","author":"Choi","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2016.10.032_b0195","doi-asserted-by":"crossref","first-page":"H1","DOI":"10.1152\/ajpheart.00080.2013","article-title":"Adenylyl cyclase type 5 in cardiac disease, metabolism, and aging","volume":"305","author":"Vatner","year":"2013","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jhep.2016.10.032_b0200","doi-asserted-by":"crossref","first-page":"F400","DOI":"10.1152\/ajprenal.2000.279.3.F400","article-title":"Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase","volume":"279","author":"Defer","year":"2000","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.jhep.2016.10.032_b0205","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1038\/ncb3245","article-title":"STIMATE reveals a STIM1 transitional state","volume":"17","author":"Hooper","year":"2015","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jhep.2016.10.032_b0210","doi-asserted-by":"crossref","first-page":"ra29","DOI":"10.1126\/scisignal.2002299","article-title":"Direct binding between Orai1 and AC8 mediates dynamic interplay between Ca2+ and cAMP signaling","volume":"5","author":"Willoughby","year":"2012","journal-title":"Sci Signal"},{"key":"10.1016\/j.jhep.2016.10.032_b0215","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/ncb0409-381","article-title":"SOC: now also store-operated cyclase","volume":"11","author":"Putney","year":"2009","journal-title":"Nat Cell Biol"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827816306432?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827816306432?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T01:02:13Z","timestamp":1749690133000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827816306432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S0168827816306432"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2016.10.032","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adenylyl cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in polycystic liver disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2016.10.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}