{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:22:08Z","timestamp":1791897728808,"version":"4.3.4"},"reference-count":45,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["journal-of-hepatology.eu","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.jhep.2016.12.018","type":"journal-article","created":{"date-parts":[[2016,12,24]],"date-time":"2016-12-24T12:48:07Z","timestamp":1482583687000},"page":"693-702","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":335,"title":["HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1\u03b2 production via suppressing the NF-\u03baB pathway and ROS production"],"prefix":"10.1016","volume":"66","author":[{"given":"Xin","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peixiang","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuben","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuju","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenwei","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2016.12.018_b0005","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1136\/gutjnl-2011-301073","article-title":"Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection","volume":"61","author":"Bertoletti","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2016.12.018_b0010","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/cmi.2014.112","article-title":"Contribution of Toll-like receptors to the control of hepatitis B virus infection by initiating antiviral innate responses and promoting specific adaptive immune responses","volume":"12","author":"Ma","year":"2015","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.jhep.2016.12.018_b0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000986","article-title":"Hepatitis B virus polymerase blocks pattern recognition receptor signaling via interaction with DDX3: implications for immune evasion","volume":"6","author":"Wang","year":"2010","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jhep.2016.12.018_b0020","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1128\/JVI.02760-14","article-title":"Hepatitis B virus polymerase disrupts K63-linked ubiquitination of STING to block innate cytosolic DNA-sensing pathways","volume":"89","author":"Liu","year":"2015","journal-title":"J Virol"},{"key":"10.1016\/j.jhep.2016.12.018_b0025","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1128\/JVI.01825-10","article-title":"Hepatitis B virus regulatory HBx protein binds to adaptor protein IPS-1 and inhibits the activation of beta interferon","volume":"85","author":"Kumar","year":"2011","journal-title":"J Virol"},{"key":"10.1016\/j.jhep.2016.12.018_b0030","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.4049\/jimmunol.0903874","article-title":"The hepatitis B virus X protein disrupts innate immunity by downregulating mitochondrial antiviral signaling protein","volume":"185","author":"Wei","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.jhep.2016.12.018_b0035","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1002\/hep.22751","article-title":"Hepatitis B virus suppresses toll-like receptor-mediated innate immune responses in murine parenchymal and nonparenchymal liver cells","volume":"49","author":"Wu","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.12.018_b0040","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.jhep.2014.11.035","article-title":"Human hepatitis B virus surface and e antigens inhibit major vault protein signaling in interferon induction pathways","volume":"62","author":"Liu","year":"2015","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2016.12.018_b0045","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev.immunol.021908.132715","article-title":"The inflammasomes: Guardians of the body","volume":"27","author":"Martinon","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jhep.2016.12.018_b0050","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/ni.2231","article-title":"Sensing and reacting to microbes through the inflammasomes","volume":"13","author":"Franchi","year":"2012","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jhep.2016.12.018_b0055","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1182\/blood.V91.2.577","article-title":"Lipopolysaccharide activates caspase-1 (interleukin-1-converting enzyme) in cultured monocytic and endothelial cells","volume":"91","author":"Schumann","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.jhep.2016.12.018_b0060","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s13238-013-3905-0","article-title":"The NLRP3 inflammasome activation in human or mouse cells, sensitivity causes puzzle","volume":"4","author":"Wang","year":"2013","journal-title":"Protein Cell"},{"key":"10.1016\/j.jhep.2016.12.018_b0065","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1182\/blood-2010-07-273417","article-title":"Interleukin-1 in the pathogenesis and treatment of inflammatory diseases","volume":"117","author":"Dinarello","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jhep.2016.12.018_b0070","doi-asserted-by":"crossref","first-page":"5493","DOI":"10.1128\/JVI.77.9.5493-5498.2003","article-title":"Interleukin-1 inhibits hepatitis C virus subgenomic RNA replication by activation of extracellular regulated kinase pathway","volume":"77","author":"Zhu","year":"2003","journal-title":"J Virol"},{"key":"10.1016\/j.jhep.2016.12.018_b0075","doi-asserted-by":"crossref","first-page":"31715","DOI":"10.1074\/jbc.M113.501122","article-title":"Interleukin-1 and tumor necrosis factor-alpha trigger restriction of hepatitis B virus infection via a cytidine deaminase activation-induced cytidine deaminase (AID)","volume":"288","author":"Watashi","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2016.12.018_b0080","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.chom.2010.06.005","article-title":"Inflammasome inhibition as a pathogenic stealth mechanism","volume":"8","author":"Taxman","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jhep.2016.12.018_b0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003330","article-title":"IL-1\u03b2 production through the NLRP3 inflammasome by hepatic macrophages links hepatitis C virus infection with liver inflammation and disease","volume":"9","author":"Negash","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jhep.2016.12.018_b0090","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1099\/vir.0.034033-0","article-title":"Hepatitis C virus activates interleukin-1beta via caspase-1-inflammasome complex","volume":"93","author":"Burdette","year":"2012","journal-title":"J Gen Virol"},{"key":"10.1016\/j.jhep.2016.12.018_b0095","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.26339","article-title":"Therapeutic recovery of hepatitis B virus (HBV)-induced hepatocyte-intrinsic immune defect reverses systemic adaptive immune tolerance","volume":"58","author":"Lan","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.12.018_b0100","doi-asserted-by":"crossref","first-page":"4772","DOI":"10.3748\/wjg.v17.i43.4772","article-title":"Lipopolysaccharide induces and activates the Nalp3 inflammasome in the liver","volume":"17","author":"Ganz","year":"2011","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jhep.2016.12.018_b0105","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.jhep.2012.03.035","article-title":"Inflammasomes in liver diseases","volume":"57","author":"Szabo","year":"2012","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2016.12.018_b0110","doi-asserted-by":"crossref","first-page":"34525","DOI":"10.1074\/jbc.M510981200","article-title":"Human hepatitis B viral e antigen interacts with cellular interleukin-1 receptor accessory protein and triggers interleukin-1 response","volume":"281","author":"Yang","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2016.12.018_b0115","doi-asserted-by":"crossref","first-page":"9340","DOI":"10.1073\/pnas.1004762107","article-title":"Hepatitis B virus core antigen determines viral persistence in a C57BL\/6 mouse model","volume":"107","author":"Lin","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2016.12.018_b0120","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1093\/bioinformatics\/btu097","article-title":"ZDOCK server: interactive docking prediction of protein-protein complexes and symmetric multimers","volume":"30","author":"Pierce","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jhep.2016.12.018_b0125","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.jhep.2010.12.042","article-title":"The hepatitis B e antigen (HBeAg) targets and suppresses activation of the toll-like receptor signaling pathway","volume":"55","author":"Lang","year":"2011","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2016.12.018_b0130","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/cmi.2015.95","article-title":"Molecular mechanisms regulating NLRP3 inflammasome activation","volume":"13","author":"Jo","year":"2016","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.jhep.2016.12.018_b0135","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/cmi.2014.89","article-title":"NADPH oxidases: an overview from structure to innate immunity-associated pathologies","volume":"12","author":"Panday","year":"2015","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.jhep.2016.12.018_b0140","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3858\/emm.2009.41.4.058","article-title":"P47phox, the phagocyte NADPH oxidase\/NOX2 organizer: structure, phosphorylation and implication in diseases","volume":"41","author":"El-Benna","year":"2009","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.jhep.2016.12.018_b0145","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fmicb.2011.00085","article-title":"Salmonella and caspase-1: A complex interplay of detection and evasion","volume":"2","author":"Miao","year":"2011","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jhep.2016.12.018_b0150","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s12250-014-3412-3","article-title":"Interplay between hepatitis B virus and the innate immune responses: implications for new therapeutic strategies","volume":"29","author":"Chen","year":"2014","journal-title":"Virol Sin"},{"key":"10.1016\/j.jhep.2016.12.018_b0155","first-page":"163","article-title":"Natural history of HBeAg-negative chronic hepatitis B virus infection: A cohort study","volume":"12","author":"Moon","year":"2006","journal-title":"Korean J Hepatol"},{"key":"10.1016\/j.jhep.2016.12.018_b0160","doi-asserted-by":"crossref","first-page":"4186","DOI":"10.1073\/pnas.88.10.4186","article-title":"Wild-type and e antigen-minus hepatitis B viruses and course of chronic hepatitis","volume":"88","author":"Brunetto","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2016.12.018_b0165","doi-asserted-by":"crossref","first-page":"9369","DOI":"10.1128\/JVI.79.15.9369-9380.2005","article-title":"Stealth and cunning: hepatitis B and hepatitis C viruses","volume":"79","author":"Wieland","year":"2005","journal-title":"J Virol"},{"key":"10.1016\/j.jhep.2016.12.018_b0170","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.4049\/jimmunol.160.4.2013","article-title":"The secreted hepatitis B precore antigen can modulate the immune response to the nucleocapsid: A mechanism for persistence","volume":"160","author":"Milich","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.jhep.2016.12.018_b0175","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/hep.21482","article-title":"Regulation of Toll-like receptor-2 expression in chronic hepatitis B by the precore protein","volume":"45","author":"Visvanathan","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.12.018_b0180","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1053\/jhep.2001.27810","article-title":"Endothelial cell-mediated uptake of a hepatitis B virus: A new concept of liver targeting of hepatotropic microorganisms","volume":"34","author":"Breiner","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2016.12.018_b0185","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1146\/annurev.immunol.021908.132612","article-title":"Immunological and inflammatory functions of the interleukin-1 family","volume":"27","author":"Dinarello","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jhep.2016.12.018_b0190","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.immuni.2005.10.003","article-title":"A poxvirus-encoded pyrin domain protein interacts with ASC-1 to inhibit host inflammatory and apoptotic responses to infection","volume":"23","author":"Johnston","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.jhep.2016.12.018_b0195","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1126\/science.1199478","article-title":"Discovery of a viral NLR homolog that inhibits the inflammasome","volume":"331","author":"Gregory","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.jhep.2016.12.018_b0200","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1093\/clinids\/18.2.194","article-title":"Serum levels of interleukin-1 alpha, interleukin-1 beta, interleukin-6, and tumor necrosis factor in patients with acute viral hepatitis","volume":"18","author":"Torre","year":"1994","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jhep.2016.12.018_b0205","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1084\/jem.20061287","article-title":"Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage","volume":"204","author":"Dunn","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.jhep.2016.12.018_b0210","doi-asserted-by":"crossref","first-page":"3925","DOI":"10.4049\/jimmunol.1103139","article-title":"IL-10-producing regulatory B cells in the pathogenesis of chronic hepatitis B virus infection","volume":"189","author":"Das","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.jhep.2016.12.018_b0215","doi-asserted-by":"crossref","first-page":"4844","DOI":"10.4049\/jimmunol.1100998","article-title":"Hepatitis B virus induces a novel inflammation network involving three inflammatory factors, IL-29, IL-8, and cyclooxygenase-2","volume":"187","author":"Yu","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.jhep.2016.12.018_b0220","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1038\/mi.2014.1","article-title":"Inflammasome activation has an important role in the development of spontaneous colitis","volume":"7","author":"Zhang","year":"2014","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jhep.2016.12.018_b0225","doi-asserted-by":"crossref","first-page":"5472","DOI":"10.4049\/jimmunol.1401343","article-title":"Prostaglandin E2 inhibits NLRP3 inflammasome activation through EP4 receptor and intracellular cyclic AMP in human macrophages","volume":"194","author":"Sokolowska","year":"2015","journal-title":"J Immunol"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827816307516?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827816307516?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T07:51:18Z","timestamp":1718956278000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827816307516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S0168827816307516"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2016.12.018","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1\u03b2 production via suppressing the NF-\u03baB pathway and ROS production","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2016.12.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}