{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:13:12Z","timestamp":1790806392525,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["journal-of-hepatology.eu","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.jhep.2017.01.005","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T14:46:14Z","timestamp":1484145974000},"page":"1205-1213","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"title":["RIPK1 protects hepatocytes from Kupffer cells-mediated TNF-induced apoptosis in mouse models of PAMP-induced hepatitis"],"prefix":"10.1016","volume":"66","author":[{"given":"Aveline","family":"Filliol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Piquet-Pellorce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Ragu\u00e9n\u00e8s-Nicol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Dion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Farooq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Lucas-Clerc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Vandenabeele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu J.M.","family":"Bertrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Le Seyec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Samson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2017.01.005_b0005","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/hep.20632","article-title":"Bacterial translocation (BT) in cirrhosis","volume":"41","author":"Wiest","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2017.01.005_b0010","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1146\/annurev.immunol.021908.132629","article-title":"The liver as a lymphoid organ","volume":"27","author":"Crispe","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jhep.2017.01.005_b0015","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nrgastro.2015.35","article-title":"Alcoholic liver disease: mechanisms of injury and targeted treatment","volume":"12","author":"Louvet","year":"2015","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2017.01.005_b0020","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.3748\/wjg.v18.i21.2609","article-title":"Leaky gut and the liver: a role for bacterial translocation in nonalcoholic steatohepatitis","volume":"18","author":"Ilan","year":"2012","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jhep.2017.01.005_b0025","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1136\/gut.2008.156307","article-title":"Toll-like receptors as targets in chronic liver diseases","volume":"58","author":"Mencin","year":"2009","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2017.01.005_b0030","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.jhep.2014.01.024","article-title":"Bacterial infections in cirrhosis: a position statement based on the EASL Special Conference 2013","volume":"60","author":"Jalan","year":"2014","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2017.01.005_b0035","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nrgastro.2015.219","article-title":"Acute-on-chronic liver failure: terminology, mechanisms and management","volume":"13","author":"Sarin","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2017.01.005_b0040","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrgastro.2015.200","article-title":"Immunology in the liver \u2013 from homeostasis to disease","volume":"13","author":"Heymann","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2017.01.005_b0045","first-page":"319","article-title":"The role of the liver in the response to LPS: experimental and clinical findings","volume":"8","author":"Jirillo","year":"2002","journal-title":"J Endotoxin Res"},{"key":"10.1016\/j.jhep.2017.01.005_b0050","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jhep.2007.04.019","article-title":"Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis","volume":"47","author":"Rivera","year":"2007","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2017.01.005_b0055","first-page":"1509","article-title":"Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice","volume":"35","author":"Inokuchi","year":"2011","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.jhep.2017.01.005_b0060","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1097\/MEG.0b013e32834a75dc","article-title":"Endotoxin and tumor necrosis factor-receptor levels in portal and hepatic vein of patients with alcoholic liver cirrhosis receiving elective transjugular intrahepatic portosystemic shunt","volume":"23","author":"Trebicka","year":"2011","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2017.01.005_b0065","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jhep.2004.04.028","article-title":"Soluble TNF-R1, but not tumor necrosis factor alpha, predicts the 3-month mortality in patients with alcoholic hepatitis","volume":"41","author":"Spahr","year":"2004","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2017.01.005_b0070","doi-asserted-by":"crossref","first-page":"5939","DOI":"10.1073\/pnas.76.11.5939","article-title":"Galactosamine-induced sensitization to the lethal effects of endotoxin","volume":"76","author":"Galanos","year":"1979","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2017.01.005_b0075","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jhep.2009.02.032","article-title":"Lipopolysaccharide triggered TNF-alpha-induced hepatocyte apoptosis in a murine non-alcoholic steatohepatitis model","volume":"51","author":"Kudo","year":"2009","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2017.01.005_b0080","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/0006-2952(89)90208-6","article-title":"Tumor necrosis factor is a terminal mediator in galactosamine\/endotoxin-induced hepatitis in mice","volume":"38","author":"Tiegs","year":"1989","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jhep.2017.01.005_b0085","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/BFb0027661","article-title":"Galactosamine hepatitis: key role of the nucleotide deficiency period in the pathogenesis of cell injury and cell death","author":"Decker","year":"1974","journal-title":"Rev Physiol Biochem Pharmacol"},{"key":"10.1016\/j.jhep.2017.01.005_b0090","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.4049\/jimmunol.153.4.1778","article-title":"Murine hepatocyte apoptosis induced in vitro and in vivo by TNF-alpha requires transcriptional arrest","volume":"153","author":"Leist","year":"1994","journal-title":"J Immunol"},{"key":"10.1016\/j.jhep.2017.01.005_b0095","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1053\/j.gastro.2007.03.033","article-title":"Genetic inactivation of RelA\/p65 sensitizes adult mouse hepatocytes to TNF-induced apoptosis in vivo and in vitro","volume":"132","author":"Geisler","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2017.01.005_b0100","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1002\/hep.20206","article-title":"A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis","volume":"39","author":"Naveau","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2017.01.005_b0105","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1053\/j.gastro.2008.08.057","article-title":"A randomized, double-blinded, placebo-controlled multicenter trial of etanercept in the treatment of alcoholic hepatitis","volume":"135","author":"Boetticher","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2017.01.005_b0110","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nature14191","article-title":"Necroptosis and its role in inflammation","volume":"517","author":"Pasparakis","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2017.01.005_b0115","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/nature13706","article-title":"RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis","volume":"513","author":"Takahashi","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2017.01.005_b0120","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.362","article-title":"RIPK1 protects from TNF-\u03b1 mediated liver damage during hepatitis","volume":"7","author":"Filliol","year":"2016","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jhep.2017.01.005_b0125","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0022-1759(94)90012-4","article-title":"Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications","volume":"174","author":"Van Rooijen","year":"1994","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.jhep.2017.01.005_b0130","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1002\/jlb.62.6.702","article-title":"Elimination, blocking, and activation of macrophages: three of a kind?","volume":"62","author":"van Rooijen","year":"1997","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jhep.2017.01.005_b0135","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1002\/eji.1830111013","article-title":"F4\/80, a monoclonal antibody directed specifically against the mouse macrophage","volume":"11","author":"Austyn","year":"1981","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jhep.2017.01.005_b0140","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S1074-7613(00)80535-X","article-title":"The death domain kinase RIP mediates the TNF-induced NF-kappaB signal","volume":"8","author":"Kelliher","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.jhep.2017.01.005_b0145","doi-asserted-by":"crossref","first-page":"13282","DOI":"10.1074\/jbc.M110.216226","article-title":"In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8","volume":"286","author":"Gentle","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2017.01.005_b0150","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/jlb.55.3.321","article-title":"Elimination of macrophages by liposome-encapsulated dichloromethylene diphosphonate suppresses the endotoxin-induced priming of Kupffer cells","volume":"55","author":"Bautista","year":"1994","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jhep.2017.01.005_b0155","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/hep.1840190229","article-title":"Endotoxin-induced cytokine gene expression and excretion in the liver","volume":"19","author":"Luster","year":"1994","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2017.01.005_b0160","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1053\/j.gastro.2014.07.018","article-title":"Cell death and cell death responses in liver disease: mechanisms and clinical relevance","volume":"147","author":"Luedde","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2017.01.005_b0165","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.ccell.2015.10.001","article-title":"NEMO prevents steatohepatitis and hepatocellular carcinoma by inhibiting ripk1 kinase activity-mediated hepatocyte apoptosis","volume":"28","author":"Kondylis","year":"2015","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jhep.2017.01.005_b0170","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.ccr.2010.03.021","article-title":"TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer","volume":"17","author":"Bettermann","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jhep.2017.01.005_b0175","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/0016-5085(95)90450-6","article-title":"Risk factors for intrahepatic recurrence in human small hepatocellular carcinoma","volume":"108","author":"Adachi","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2017.01.005_b0180","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000337585","article-title":"Reduced hepatic injury in Toll-like receptor 4-deficient mice following D-galactosamine\/lipopolysaccharide-induced fulminant hepatic failure","volume":"29","author":"Ben Ari","year":"2012","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.jhep.2017.01.005_b0185","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1002\/hep.23122","article-title":"Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice","volume":"50","author":"Spruss","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2017.01.005_b0190","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1053\/jhep.2001.25350","article-title":"Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice","volume":"34","author":"Uesugi","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2017.01.005_b0195","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/ni1061","article-title":"RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation","volume":"5","author":"Meylan","year":"2004","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jhep.2017.01.005_b0200","doi-asserted-by":"crossref","first-page":"G1310","DOI":"10.1152\/ajpgi.00365.2011","article-title":"Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2","volume":"302","author":"Miura","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jhep.2017.01.005_b0205","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.jhep.2010.05.029","article-title":"Soluble TNF, but not membrane TNF, is critical in LPS-induced hepatitis","volume":"53","author":"Olleros","year":"2010","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2017.01.005_b0210","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00441-015-2252-2","article-title":"Kupffer-cell-expressed transmembrane TNF-alpha is a major contributor to lipopolysaccharide and D-galactosamine-induced liver injury","volume":"363","author":"Yang","year":"2016","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.jhep.2017.01.005_b0215","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.pharmthera.2007.10.001","article-title":"Tumor necrosis factor antagonist mechanisms of action: a comprehensive review","volume":"117","author":"Tracey","year":"2008","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jhep.2017.01.005_b0220","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.ejcb.2011.10.001","article-title":"The role of TNF and Fas dependent signaling in animal models of inflammatory liver injury and liver cancer","volume":"91","author":"Liedtke","year":"2012","journal-title":"Eur J Cell Biol"},{"key":"10.1016\/j.jhep.2017.01.005_b0225","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/hep.28551","article-title":"Opposing role of tumor necrosis factor receptor 1 signaling in T cell-mediated hepatitis and bacterial infection in mice","volume":"64","author":"Wroblewski","year":"2016","journal-title":"Hepatology"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827817300090?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827817300090?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T14:06:22Z","timestamp":1692626782000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827817300090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S0168827817300090"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2017.01.005","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RIPK1 protects hepatocytes from Kupffer cells-mediated TNF-induced apoptosis in mouse models of PAMP-induced hepatitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2017.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}