{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T11:15:42Z","timestamp":1793186142014,"version":"4.5.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.jhep.2017.02.001","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T18:02:19Z","timestamp":1486749739000},"page":"1251-1264","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["\u03b27-Integrin and MAdCAM-1 play opposing roles during the development of non-alcoholic steatohepatitis"],"prefix":"10.1016","volume":"66","author":[{"given":"Hannah K.","family":"Drescher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Schippers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Clahsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hacer","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Noels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Hornef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Trautwein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad L.","family":"Streetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela C.","family":"Kroy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2017.02.001_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cld.2007.02.009","article-title":"Epidemiology and natural history of NAFLD and NASH","volume":"11","author":"Ong","year":"2007","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.jhep.2017.02.001_b0010","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1002\/hep.21655","article-title":"Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis","volume":"45","author":"Yamaguchi","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2017.02.001_b0015","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1136\/gut.50.5.585","article-title":"Non-alcoholic steatohepatitis (NASH): where are we now and where are we going?","volume":"50","author":"Day","year":"2002","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2017.02.001_b0020","first-page":"S5","article-title":"The epidemiology of nonalcoholic fatty liver disease in adults","volume":"40","author":"Clark","year":"2006","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.jhep.2017.02.001_b0025","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1172\/JCI200422422","article-title":"Molecular mediators of hepatic steatosis and liver injury","volume":"114","author":"Browning","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2017.02.001_b0030","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1002\/hep.26986","article-title":"Nonalcoholic steatohepatitis is the most rapidly growing indication for liver transplantation in patients with hepatocellular carcinoma in the U.S","volume":"59","author":"Wong","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2017.02.001_b0035","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1111\/j.1365-2036.2007.03246.x","article-title":"GI epidemiology: nonalcoholic fatty liver disease","volume":"25","author":"Angulo","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jhep.2017.02.001_b0040","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1097\/SLA.0b013e31826b4b7e","article-title":"Liver transplantation for nonalcoholic steatohepatitis: the new epidemic","volume":"256","author":"Agopian","year":"2012","journal-title":"Ann Surg"},{"key":"10.1016\/j.jhep.2017.02.001_b0045","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/MOL.0b013e3282ff5e55","article-title":"Hepatic triglyceride synthesis and nonalcoholic fatty liver disease","volume":"19","author":"Choi","year":"2008","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.jhep.2017.02.001_b0050","doi-asserted-by":"crossref","first-page":"S99","DOI":"10.1002\/hep.20973","article-title":"Nonalcoholic fatty liver disease: from steatosis to cirrhosis","volume":"43","author":"Farrell","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2017.02.001_b0055","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.bbadis.2012.10.005","article-title":"Integrin-mediated regulation of TGFbeta in fibrosis","volume":"1832","author":"Henderson","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jhep.2017.02.001_b0060","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1038\/labinvest.3780164","article-title":"VCAM-1, but not ICAM-1 or MAdCAM-1, immunoblockade ameliorates DSS-induced colitis in mice","volume":"80","author":"Soriano","year":"2000","journal-title":"Lab Invest"},{"key":"10.1016\/j.jhep.2017.02.001_b0065","doi-asserted-by":"crossref","first-page":"3832","DOI":"10.1002\/(SICI)1521-4141(199811)28:11<3832::AID-IMMU3832>3.0.CO;2-J","article-title":"L-selectin and beta7 integrin synergistically mediate lymphocyte migration to mesenteric lymph nodes","volume":"28","author":"Wagner","year":"1998","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jhep.2017.02.001_b0070","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s00467-011-1890-1","article-title":"Integrins in renal development","volume":"27","author":"Mathew","year":"2012","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.jhep.2017.02.001_b0075","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1002\/eji.1830250216","article-title":"Alpha E beta 7 and alpha 4 beta 7 integrins associated with intraepithelial and mucosal homing, are expressed on macrophages","volume":"25","author":"Tiisala","year":"1995","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jhep.2017.02.001_b0080","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1046\/j.1365-2249.2002.01892.x","article-title":"Beta7 Integrin expression is not required for the localization of T cells to the intestine and colitis pathogenesis","volume":"129","author":"Sydora","year":"2002","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jhep.2017.02.001_b0085","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/382366a0","article-title":"Critical role for beta7 integrins in formation of the gut-associated lymphoid tissue","volume":"382","author":"Wagner","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2017.02.001_b0090","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0165-5728(99)00245-3","article-title":"Beta7 integrins contribute to demyelinating disease of the central nervous system","volume":"103","author":"Kanwar","year":"2000","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.jhep.2017.02.001_b0095","doi-asserted-by":"crossref","first-page":"836","DOI":"10.2174\/156652409789105525","article-title":"Role of beta7 integrins in intestinal lymphocyte homing and retention","volume":"9","author":"Gorfu","year":"2009","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.jhep.2017.02.001_b0100","doi-asserted-by":"crossref","first-page":"140","DOI":"10.14310\/horm.2002.1340","article-title":"Intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1 in children. Do they play a role in the progression of atherosclerosis?","volume":"11","author":"Fotis","year":"2012","journal-title":"Hormones (Athens)"},{"key":"10.1016\/j.jhep.2017.02.001_b0105","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1182\/blood.V88.9.3259.bloodjournal8893259","article-title":"Selectins and their ligands: current concepts and controversies","volume":"88","author":"Kansas","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.jhep.2017.02.001_b0110","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/366695a0","article-title":"L-selectin-mediated lymphocyte rolling on MAdCAM-1","volume":"366","author":"Berg","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2017.02.001_b0115","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1472-6793-7-10","article-title":"Inflammatory cytokines induce MAdCAM-1 in murine hepatic endothelial cells and mediate alpha-4 beta-7 integrin dependent lymphocyte endothelial adhesion in vitro","volume":"7","author":"Ando","year":"2007","journal-title":"BMC Physiol"},{"key":"10.1016\/j.jhep.2017.02.001_b0120","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/jlb.65.3.349","article-title":"Expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in acute and chronic inflammation","volume":"65","author":"Connor","year":"1999","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jhep.2017.02.001_b0125","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1007\/s10620-013-2755-1","article-title":"Mucosal addressin cell adhesion molecule (MAdCAM-1) expression is upregulated in the cirrhotic liver and immunolocalises to the peribiliary plexus and lymphoid aggregates","volume":"58","author":"Ala","year":"2013","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jhep.2017.02.001_b0130","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/BF02786396","article-title":"Mucosal addressin cell adhesion molecule-1 (MAdCAM-1). Its binding motif for alpha 4 beta 7 and role in experimental colitis","volume":"16","author":"Fong","year":"1997","journal-title":"Immunol Res"},{"key":"10.1016\/j.jhep.2017.02.001_b0135","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1053\/jhep.2001.24231","article-title":"MAdCAM-1 expressed in chronic inflammatory liver disease supports mucosal lymphocyte adhesion to hepatic endothelium (MAdCAM-1 in chronic inflammatory liver disease)","volume":"33","author":"Grant","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2017.02.001_b0140","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1478-3231.1999.tb00084.x","article-title":"Expression of the mucosal vascular addressin, MAdCAM-1, in inflammatory liver disease","volume":"19","author":"Hillan","year":"1999","journal-title":"Liver"},{"key":"10.1016\/j.jhep.2017.02.001_b0145","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1053\/j.gastro.2009.05.039","article-title":"Mucosal addressin cell-adhesion molecule-1 controls plasma-cell migration and function in the small intestine of mice","volume":"137","author":"Schippers","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2017.02.001_b0150","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/1074-7613(94)90076-0","article-title":"Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice","volume":"1","author":"Arbones","year":"1994","journal-title":"Immunity"},{"key":"10.1016\/j.jhep.2017.02.001_b0155","doi-asserted-by":"crossref","first-page":"20858","DOI":"10.1074\/jbc.M101198200","article-title":"Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation","volume":"276","author":"He","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2017.02.001_b0160","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.4049\/jimmunol.172.7.3983","article-title":"IL-2, regulatory T cells, and tolerance","volume":"172","author":"Nelson","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.jhep.2017.02.001_b0165","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1038\/cdd.2012.7","article-title":"Mutual antagonism of TGF-beta and Interleukin-2 in cell survival and lineage commitment of induced regulatory T cells","volume":"19","author":"Tischner","year":"2012","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jhep.2017.02.001_b0170","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1182\/blood-2006-02-004747","article-title":"IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo","volume":"108","author":"Zorn","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.jhep.2017.02.001_b0175","doi-asserted-by":"crossref","first-page":"19846","DOI":"10.3390\/ijms141019846","article-title":"Development of nonalcoholic hepatopathy: contributions of oxidative stress and advanced glycation end products","volume":"14","author":"Santos","year":"2013","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jhep.2017.02.001_b0180","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.4049\/jimmunol.158.5.2099","article-title":"Monoclonal antibodies specific for beta 7 integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) reduce inflammation in the colon of scid mice reconstituted with CD45RBhigh CD4+ T cells","volume":"158","author":"Picarella","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.jhep.2017.02.001_b0185","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1182\/blood-2005-08-3445","article-title":"Absence of beta7 integrin results in less graft-versus-host disease because of decreased homing of alloreactive T cells to intestine","volume":"107","author":"Waldman","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.jhep.2017.02.001_b0190","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1183\/09031936.96.09040673","article-title":"Integrin alpha E beta 7 expression on BAL CD4+, CD8+, and gamma delta T-cells in bleomycin-induced lung fibrosis in mouse","volume":"9","author":"Braun","year":"1996","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jhep.2017.02.001_b0195","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1172\/JCI116575","article-title":"Attenuation of colitis in the cotton-top tamarin by anti-alpha 4 integrin monoclonal antibody","volume":"92","author":"Podolsky","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2017.02.001_b0200","doi-asserted-by":"crossref","first-page":"4975","DOI":"10.4049\/jimmunol.162.8.4975","article-title":"Administration of mAb against alpha E beta 7 prevents and ameliorates immunization-induced colitis in IL-2-\/- mice","volume":"162","author":"Ludviksson","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.jhep.2017.02.001_b0205","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1053\/gast.1996.v111.pm8898653","article-title":"Rapid resolution of chronic colitis in the cotton-top tamarin with an antibody to a gut-homing integrin alpha 4 beta 7","volume":"111","author":"Hesterberg","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2017.02.001_b0210","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1046\/j.1365-2036.2002.01205.x","article-title":"A pilot study of treatment of active ulcerative colitis with natalizumab, a humanized monoclonal antibody to alpha-4 integrin","volume":"16","author":"Gordon","year":"2002","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jhep.2017.02.001_b0215","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1056\/NEJMoa042982","article-title":"Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin","volume":"352","author":"Feagan","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2017.02.001_b0220","doi-asserted-by":"crossref","first-page":"G425","DOI":"10.1152\/ajpgi.00050.2011","article-title":"Role of integrins in fibrosing liver diseases","volume":"301","author":"Patsenker","year":"2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jhep.2017.02.001_b0225","doi-asserted-by":"crossref","first-page":"13031","DOI":"10.1073\/pnas.192162899","article-title":"Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells","volume":"99","author":"Lehmann","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2017.02.001_b0230","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.freeradbiomed.2015.12.014","article-title":"Hepatocyte-specific Keap1 deletion reduces liver steatosis but not inflammation during non-alcoholic steatohepatitis development","volume":"91","author":"Ramadori","year":"2016","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jhep.2017.02.001_b0235","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1002\/hep.21874","article-title":"Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet","volume":"46","author":"Matsuzawa","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2017.02.001_b0240","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.5754\/hge10501","article-title":"Upregulation of Nrf2 expression in non-alcoholic fatty liver and steatohepatitis","volume":"58","author":"Xu","year":"2011","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.jhep.2017.02.001_b0245","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/jbt.20177","article-title":"Genes of the antioxidant response undergo upregulation in a rodent model of nonalcoholic steatohepatitis","volume":"21","author":"Lickteig","year":"2007","journal-title":"J Biochem Mol Toxicol"},{"key":"10.1016\/j.jhep.2017.02.001_b0250","doi-asserted-by":"crossref","first-page":"517","DOI":"10.4049\/jimmunol.153.2.517","article-title":"Expression and function of the MAdCAM-1 receptor, integrin alpha 4 beta 7, on human leukocytes","volume":"153","author":"Erle","year":"1994","journal-title":"J Immunol"},{"key":"10.1016\/j.jhep.2017.02.001_b0255","doi-asserted-by":"crossref","first-page":"7487","DOI":"10.4049\/jimmunol.174.12.7487","article-title":"Cutting edge: CD4+CD25+ regulatory T cells impaired for intestinal homing can prevent colitis","volume":"174","author":"Denning","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.jhep.2017.02.001_b0260","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.bbrc.2004.12.106","article-title":"Critical role of heme oxygenase-1 in Foxp3-mediated immune suppression","volume":"327","author":"Choi","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jhep.2017.02.001_b0265","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1002\/hep.21823","article-title":"A high-fat diet and regulatory T cells influence susceptibility to endotoxin-induced liver injury","volume":"46","author":"Ma","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2017.02.001_b0270","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.1038\/ncomms4862","article-title":"Knockdown and knockout of beta1-integrin in hepatocytes impairs liver regeneration through inhibition of growth factor signalling","volume":"5","author":"Speicher","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhep.2017.02.001_b0275","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1182\/blood-2009-04-216085","article-title":"Evidence for a cross-talk between human neutrophils and Th17 cells","volume":"115","author":"Pelletier","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jhep.2017.02.001_b0280","doi-asserted-by":"crossref","first-page":"345803","DOI":"10.1155\/2011\/345803","article-title":"Role of IL-17 and Th17 cells in liver diseases","volume":"2011","author":"Hammerich","year":"2011","journal-title":"Clin Dev Immunol"},{"key":"10.1016\/j.jhep.2017.02.001_b0285","first-page":"G1","article-title":"Cell adhesion and migration. IV. Lymphocyte trafficking in the intestine and liver","volume":"274","author":"Salmi","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jhep.2017.02.001_b0290","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1136\/gut.2007.122168","article-title":"Immunology of the gut and liver: a love\/hate relationship","volume":"57","author":"Adams","year":"2008","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2017.02.001_b0295","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1002\/hep.26093","article-title":"Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: a connection between endogenous alcohol and NASH","volume":"57","author":"Zhu","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2017.02.001_b0300","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nrg3182","article-title":"The human microbiome: at the interface of health and disease","volume":"13","author":"Cho","year":"2012","journal-title":"Nat Rev Genetics"},{"key":"10.1016\/j.jhep.2017.02.001_b0305","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1002\/hep.27982","article-title":"CX3CR1 is a gatekeeper for intestinal barrier integrity in mice: Limiting steatohepatitis by maintaining intestinal homeostasis","volume":"62","author":"Schneider","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2017.02.001_b0310","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1210\/en.2008-0971","article-title":"Estrogens protect against high-fat diet-induced insulin resistance and glucose intolerance in mice","volume":"150","author":"Riant","year":"2009","journal-title":"Endocrinology"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016882781730065X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016882781730065X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T05:33:50Z","timestamp":1692682430000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016882781730065X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":62,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S016882781730065X"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2017.02.001","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u03b27-Integrin and MAdCAM-1 play opposing roles during the development of non-alcoholic steatohepatitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2017.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}