{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:05:01Z","timestamp":1793156701996,"version":"4.5.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100012352","name":"Universit\u00e0 degli Studi di Milano","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012352","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["RBSI1465UH"],"award-info":[{"award-number":["RBSI1465UH"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["14360"],"award-info":[{"award-number":["14360"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.jhep.2017.03.011","type":"journal-article","created":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T13:05:13Z","timestamp":1490101513000},"page":"302-309","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":509,"title":["Global trends and predictions in hepatocellular carcinoma mortality"],"prefix":"10.1016","volume":"67","author":[{"given":"Paola","family":"Bertuccio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Turati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Carioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"La Vecchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Malvezzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Negri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2017.03.011_b0005","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1093\/annonc\/mdw027","article-title":"The global decrease in cancer mortality: trends and disparities","volume":"27","author":"Hashim","year":"2016","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jhep.2017.03.011_b0010","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S0959-8049(00)00052-6","article-title":"Trends in mortality from primary liver cancer in Europe","volume":"36","author":"La Vecchia","year":"2000","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jhep.2017.03.011_b0015","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.bpg.2014.08.007","article-title":"Hepatocellular carcinoma epidemiology","volume":"28","author":"Bosetti","year":"2014","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1016\/j.jhep.2017.03.011_b0020","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1093\/annonc\/mdt301","article-title":"Cancer mortality in Europe, 2005\u20132009, and an overview of trends since 1980","volume":"24","author":"Bosetti","year":"2013","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jhep.2017.03.011_b0025","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/hep.22312","article-title":"Trends in mortality from hepatocellular carcinoma in Europe, 1980\u20132004","volume":"48","author":"Bosetti","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2017.03.011_b0030","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/S0140-6736(16)30579-7","article-title":"The global burden of viral hepatitis from 1990 to 2013: findings from the Global Burden of Disease Study 2013","volume":"388","author":"Stanaway","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2017.03.011_b0035","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1093\/annonc\/mdu020","article-title":"Alcohol and liver cancer: a systematic review and meta-analysis of prospective studies","volume":"25","author":"Turati","year":"2014","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jhep.2017.03.011_b0040","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.canlet.2008.10.040","article-title":"Liver cancer: descriptive epidemiology and risk factors other than HBV and HCV infection","volume":"286","author":"Chuang","year":"2009","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jhep.2017.03.011_b0045","article-title":"Coffee and the risk of hepatocellular carcinoma and chronic liver disease: a systematic review and meta-analysis of prospective studies","author":"Bravi","year":"2016","journal-title":"Eur J Cancer Prev"},{"key":"10.1016\/j.jhep.2017.03.011_b0050","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1016\/j.ejca.2007.07.012","article-title":"Nutrient intake and the risk of hepatocellular carcinoma in Italy","volume":"43","author":"Polesel","year":"2007","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jhep.2017.03.011_b0055","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1017\/S0007114515004419","article-title":"Inflammatory potential of diet and risk for hepatocellular cancer in a case-control study from Italy","volume":"115","author":"Shivappa","year":"2016","journal-title":"Br J Nutr"},{"key":"10.1016\/j.jhep.2017.03.011_b0060","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.jhep.2013.10.034","article-title":"Mediterranean diet and hepatocellular carcinoma","volume":"60","author":"Turati","year":"2014","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2017.03.011_b0065","unstructured":"World Health Organization Statistical Information System. WHO mortality database. Geneva: World Health Organization, 2014. [Internet]. [Cited 2016 Sep 20]. Available from: http:\/\/www.who.int\/healthinfo\/statistics\/mortality_rawdata\/en\/index.html."},{"key":"10.1016\/j.jhep.2017.03.011_b0070","series-title":"International Classification of Disease: 9th revision","author":"World Health Organization","year":"1977"},{"key":"10.1016\/j.jhep.2017.03.011_b0075","series-title":"International Statistical Classification of Disease and related Health Problems: 10th revision","author":"World Health Organization","year":"1992"},{"key":"10.1016\/j.jhep.2017.03.011_b0080","unstructured":"Pan American Health Organization (PAHO). Health Statistics from the Americas, 2006 Edition, Chapter VI, 2-20. [Internet]. [Cited 2016 Sep 20]. Available from: http:\/\/www.paho.org\/English\/DD\/AIS\/HSA2006.htm."},{"key":"10.1016\/j.jhep.2017.03.011_b0085","unstructured":"Pan American Health Organization (PAHO). Regional Core Health Data Initiative. Table Generator System. [Internet]. [Cited 2016 Sep 20]. Available from: http:\/\/www.paho.org\/English\/SHA\/coredata\/tabulator\/newTabulator.htm."},{"key":"10.1016\/j.jhep.2017.03.011_b0090","series-title":"Cancer incidence in five continents","first-page":"671","article-title":"Comparison between registries: age-standardized rates. Vol. IV. IARC Sci Publ No. 42.","author":"Doll","year":"1982"},{"key":"10.1016\/j.jhep.2017.03.011_b0095","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/(SICI)1097-0258(20000215)19:3<335::AID-SIM336>3.0.CO;2-Z","article-title":"Permutation tests for joinpoint regression with applications to cancer rates. (Erratum. In: Stat Med 2001;20: 655)","volume":"19","author":"Kim","year":"2000","journal-title":"Stat Med"},{"key":"10.1016\/j.jhep.2017.03.011_b0100","unstructured":"National Cancer Institute. Joinpoint Regression Program, version 4.1. [Internet]. [Cited 2015 Mar 10]. Available from: http:\/\/srab.cancer.gov\/joinpoint\/."},{"key":"10.1016\/j.jhep.2017.03.011_b0105","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1002\/sim.3733","article-title":"Estimating average annual per cent change in trend analysis","volume":"28","author":"Clegg","year":"2009","journal-title":"Stat Med"},{"key":"10.1016\/j.jhep.2017.03.011_b0110","volume":"Vol. 63.","author":"Faraway","year":"2005"},{"key":"10.1016\/j.jhep.2017.03.011_b0115","unstructured":"US Census Bureau. 2014 National Population Projections. [Internet]. [Cited 2016 Oct 15]. Available from: http:\/\/www.census.gov\/population\/projections\/data\/national\/2014.html."},{"key":"10.1016\/j.jhep.2017.03.011_b0120","unstructured":"European Commission. Eurostat population database. [Internet]. [Cited 2016 Oct 15]. Available from: http:\/\/epp.eurostat.ec.europa.eu\/portal\/page\/portal\/population\/data\/database."},{"key":"10.1016\/j.jhep.2017.03.011_b0125","unstructured":"Research NIoPaSS. Japanese National Institute of Population and Social Security Research. [Internet]. [Cited 2016 Oct 15]. Available from: http:\/\/www.ipss.go.jp\/index-e.asp."},{"key":"10.1016\/j.jhep.2017.03.011_b0130","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1002\/cncr.29936","article-title":"Annual Report to the Nation on the Status of Cancer, 1975\u20132012, featuring the increasing incidence of liver cancer","volume":"122","author":"Ryerson","year":"2016","journal-title":"Cancer"},{"key":"10.1016\/j.jhep.2017.03.011_b0135","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3322\/caac.21338","article-title":"Cancer statistics in China, 2015","volume":"66","author":"Chen","year":"2016","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jhep.2017.03.011_b0140","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/bjc.2012.492","article-title":"Metabolic syndrome and hepatocellular carcinoma risk","volume":"108","author":"Turati","year":"2013","journal-title":"Br J Cancer"},{"key":"10.1016\/j.jhep.2017.03.011_b0145","doi-asserted-by":"crossref","first-page":"3430","DOI":"10.1002\/cncr.30237","article-title":"Comparison of hepatocellular carcinoma in Eastern vs. Western populations","volume":"122","author":"Choo","year":"2016","journal-title":"Cancer"},{"key":"10.1016\/j.jhep.2017.03.011_b0150","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1093\/jnci\/djh334","article-title":"Cigarette smoking, alcohol drinking, hepatitis B, and risk for hepatocellular carcinoma in Korea","volume":"96","author":"Jee","year":"2004","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.jhep.2017.03.011_b0155","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0959-8049(96)00500-X","article-title":"Attributable risks for hepatocellular carcinoma in northern Italy","volume":"33","author":"Braga","year":"1997","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jhep.2017.03.011_b0160","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1158\/1055-9965.EPI-05-0702","article-title":"Hepatitis viruses, alcohol, and tobacco in the etiology of hepatocellular carcinoma in Italy","volume":"15","author":"Franceschi","year":"2006","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.jhep.2017.03.011_b0165","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1038\/ajg.2013.160","article-title":"Population-attributable fractions of risk factors for hepatocellular carcinoma in the United States","volume":"108","author":"Welzel","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2017.03.011_b0170","doi-asserted-by":"crossref","first-page":"7251","DOI":"10.7314\/APJCP.2013.14.12.7251","article-title":"Attributable causes of liver cancer mortality and incidence in china","volume":"14","author":"Fan","year":"2013","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1016\/j.jhep.2017.03.011_b0175","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1093\/carcin\/bgt007","article-title":"Dramatic reduction of liver cancer incidence in young adults: 28 year follow-up of etiological interventions in an endemic area of China","volume":"34","author":"Sun","year":"2013","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jhep.2017.03.011_b0180","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2131\/jts.23.SupplementII_143","article-title":"Primary liver cancer: natural toxins and prevention in China","volume":"23","author":"Yu","year":"1998","journal-title":"J Toxicol Sci"},{"key":"10.1016\/j.jhep.2017.03.011_b0185","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1016\/j.ejca.2012.02.009","article-title":"Population attributable risk of aflatoxin-related liver cancer: systematic review and meta-analysis","volume":"48","author":"Liu","year":"2012","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jhep.2017.03.011_b0190","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.bpg.2015.09.007","article-title":"Changing epidemiology of hepatocellular carcinoma in Asia","volume":"29","author":"Goh","year":"2015","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1016\/j.jhep.2017.03.011_b0195","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s00535-008-2251-0","article-title":"Epidemiology of hepatocellular carcinoma in Japan","volume":"44","author":"Umemura","year":"2009","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.jhep.2017.03.011_b0200","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/hep.27388","article-title":"Emerging trends in hepatocellular carcinoma incidence and mortality","volume":"61","author":"Njei","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2017.03.011_b0205","article-title":"Incidence of hepatocellular carcinoma in all 50 United States, from 2000 through 2012","author":"White","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2017.03.011_b0210","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1053\/j.gastro.2004.09.013","article-title":"Hepatocellular carcinoma: recent trends in the United States","volume":"127","author":"El-Serag","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2017.03.011_b0215","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/CEJ.0b013e32836562f1","article-title":"Trends in alcohol consumption in Europe and their impact on major alcohol-related cancers","volume":"23","author":"La Vecchia","year":"2014","journal-title":"Eur J Cancer Prev"},{"key":"10.1016\/j.jhep.2017.03.011_b0220","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/CEJ.0b013e328354d2d7","article-title":"Cancer prevention in Europe: the Mediterranean diet as a protective choice","volume":"22","author":"Giacosa","year":"2013","journal-title":"Eur J Cancer Prev"},{"key":"10.1016\/j.jhep.2017.03.011_b0225","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1056\/NEJM199109053251002","article-title":"Hepatocellular carcinoma in Italian patients with cirrhosis","volume":"325","author":"Colombo","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2017.03.011_b0230","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1097\/00008469-199808000-00007","article-title":"Liver cirrhosis and the risk of primary liver cancer","volume":"7","author":"La Vecchia","year":"1998","journal-title":"Eur J Cancer Prev"},{"key":"10.1016\/j.jhep.2017.03.011_b0235","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1093\/annonc\/mdi266","article-title":"History of cirrhosis and risk of digestive tract neoplasms","volume":"16","author":"Randi","year":"2005","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jhep.2017.03.011_b0240","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000317248","article-title":"Liver cirrhosis mortality in Europe, with special attention to Central and Eastern Europe","volume":"16","author":"Zatonski","year":"2010","journal-title":"Eur Addict Res"},{"key":"10.1016\/j.jhep.2017.03.011_b0245","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.jhep.2007.01.025","article-title":"Worldwide mortality from cirrhosis: an update to 2002","volume":"46","author":"Bosetti","year":"2007","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2017.03.011_b0250","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1053\/j.gastro.2003.12.049","article-title":"Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance","volume":"126","author":"Sangiovanni","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2017.03.011_b0255","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s00394-014-0746-4","article-title":"Overweight and obesity in 16 European countries","volume":"54","author":"Gallus","year":"2015","journal-title":"Eur J Nutr"},{"key":"10.1016\/j.jhep.2017.03.011_b0260","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1053\/j.gastro.2012.05.054","article-title":"Predicted effects of treatment for HCV infection vary among European countries","volume":"143","author":"Deuffic-Burban","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2017.03.011_b0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejca.2015.07.034","article-title":"Survival in patients with primary liver cancer, gallbladder and extrahepatic biliary tract cancer and pancreatic cancer in Europe 1999\u20132007: Results of EUROCARE-5","author":"Lepage","year":"2015","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jhep.2017.03.011_b0270","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1056\/NEJMe1403619","article-title":"Therapy of hepatitis C- back to the future","volume":"370","author":"Liang","year":"2014","journal-title":"N Engl J Med"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827817301459?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827817301459?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,19]],"date-time":"2022-06-19T16:19:52Z","timestamp":1655655592000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827817301459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":54,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["S0168827817301459"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2017.03.011","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Global trends and predictions in hepatocellular carcinoma mortality","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2017.03.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}