{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T21:59:41Z","timestamp":1648504781992},"reference-count":18,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["journal-of-hepatology.eu","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.jhep.2017.04.001","type":"journal-article","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T11:17:03Z","timestamp":1492082223000},"page":"12-14","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evidence for a role of genetics in alcoholic hepatitis: Data from the STOPAH randomized controlled trial"],"prefix":"10.1016","volume":"67","author":[{"given":"Alexandre","family":"Louvet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Peck-Radosavljevic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2017.04.001_b0005","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1002\/hep.21607","article-title":"The Lille model: a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids","volume":"45","author":"Louvet","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2017.04.001_b0010","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1053\/jhep.2003.09038","article-title":"Early change in bilirubin levels is an important prognostic factor in severe alcoholic hepatitis treated with prednisolone","volume":"38","author":"Mathurin","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2017.04.001_b0015","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1136\/gut.2010.224097","article-title":"Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis: meta-analysis of individual patient data","volume":"60","author":"Mathurin","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2017.04.001_b0020","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.jhep.2014.05.014","article-title":"Pentoxifylline vs. corticosteroid to treat severe alcoholic hepatitis: a randomised, non-inferiority, open trial","volume":"61","author":"Park","year":"2014","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2017.04.001_b0025","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1111\/j.1365-2036.2008.03685.x","article-title":"Systematic review: glucocorticosteroids for alcoholic hepatitis\u2013a Cochrane Hepato-Biliary Group systematic review with meta-analyses and trial sequential analyses of randomized clinical trials","volume":"27","author":"Rambaldi","year":"2008","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jhep.2017.04.001_b0030","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1056\/NEJMoa1412278","article-title":"Prednisolone or pentoxifylline for alcoholic hepatitis","volume":"372","author":"Thursz","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2017.04.001_b0035","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jhep.2017.01.018","article-title":"Homozygosity for rs738409: G in PNPLA3 is associated with increased mortality following an episode of severe alcoholic hepatitis","volume":"67","author":"Atkinson","year":"2017","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2017.04.001_b0040","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nrgastro.2015.35","article-title":"Alcoholic liver disease: mechanisms of injury and targeted treatment","volume":"12","author":"Louvet","year":"2015","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2017.04.001_b0045","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1056\/NEJMra0805786","article-title":"Alcoholic hepatitis","volume":"360","author":"Lucey","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2017.04.001_b0050","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1001\/jama.2013.276300","article-title":"Prednisolone with vs. without pentoxifylline and survival of patients with severe alcoholic hepatitis: a randomized clinical trial","volume":"310","author":"Mathurin","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.jhep.2017.04.001_b0055","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1038\/ng.3417","article-title":"A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis","volume":"47","author":"Buch","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.jhep.2017.04.001_b0060","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jhep.2016.08.011","article-title":"The genetics of alcohol dependence and alcohol-related liver disease","volume":"66","author":"Stickel","year":"2017","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2017.04.001_b0065","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jhep.2012.04.004","article-title":"EASL clinical practical guidelines: management of alcoholic liver disease","volume":"57","year":"2012","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2017.04.001_b0070","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1053\/j.gastro.2016.02.042","article-title":"Standard definitions and common data elements for clinical trials in patients with alcoholic hepatitis: recommendation from the NIAAA alcoholic hepatitis consortia","volume":"150","author":"Crabb","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2017.04.001_b0075","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/hep.24017","article-title":"Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians","volume":"53","author":"Stickel","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2017.04.001_b0080","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/ng.488","article-title":"Variant in PNPLA3 is associated with alcoholic liver disease","volume":"42","author":"Tian","year":"2010","journal-title":"Nat Genet"},{"key":"10.1016\/j.jhep.2017.04.001_b0085","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.jhep.2011.01.028","article-title":"Common polymorphism in the PNPLA3\/adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease","volume":"55","author":"Trepo","year":"2011","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2017.04.001_b0090","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1002\/hep.25518","article-title":"PNPLA3 (rs738409 C>G) is a common risk variant associated with hepatocellular carcinoma in alcoholic cirrhosis","volume":"55","author":"Trepo","year":"2012","journal-title":"Hepatology"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827817302106?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827817302106?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T07:15:56Z","timestamp":1536304556000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827817302106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S0168827817302106"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2017.04.001","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evidence for a role of genetics in alcoholic hepatitis: Data from the STOPAH randomized controlled trial","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2017.04.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2017.01.018","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}