{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:23:44Z","timestamp":1782962624733,"version":"3.54.5"},"reference-count":39,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["journal-of-hepatology.eu","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.jhep.2017.05.024","type":"journal-article","created":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T21:15:18Z","timestamp":1500066918000},"page":"791-800","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Crosstalk between type II NKT cells and T cells leads to spontaneous chronic inflammatory liver disease"],"prefix":"10.1016","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2625-2137","authenticated-orcid":false,"given":"Xiufang","family":"Weng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavanya","family":"Visvabharathy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Min","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosheng","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun","family":"Balakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chyung-Ru","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2017.05.024_b0005","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1002\/hep.27254","article-title":"Immune tolerance in liver disease","volume":"60","author":"Crispe","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2017.05.024_b0010","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s00535-008-2276-4","article-title":"Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection","volume":"44","author":"Koike","year":"2009","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.jhep.2017.05.024_b0015","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/bs.apha.2015.04.001","article-title":"Xenobiotic and endobiotic mediated interactions between the cytochrome P450 system and the inflammatory response in the liver","volume":"74","author":"Woolbright","year":"2015","journal-title":"Adv Pharmacol"},{"key":"10.1016\/j.jhep.2017.05.024_b0020","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s00281-014-0439-3","article-title":"Mechanisms of tissue injury in autoimmune liver diseases","volume":"36","author":"Liaskou","year":"2014","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.jhep.2017.05.024_b0025","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nri981","article-title":"Hepatic T cells and liver tolerance","volume":"3","author":"Crispe","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jhep.2017.05.024_b0030","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/hep.22034","article-title":"Liver: An organ with predominant innate immunity","volume":"47","author":"Gao","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2017.05.024_b0035","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.4049\/jimmunol.173.3.2159","article-title":"Hepatic CD1d expression in hepatitis C virus infection and recognition by resident proinflammatory CD1d-reactive T cells","volume":"173","author":"Durante-Mangoni","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.jhep.2017.05.024_b0040","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3389\/fimmu.2011.00036","article-title":"CD161-expressing human T cells","volume":"2","author":"Fergusson","year":"2011","journal-title":"Front Immunol"},{"key":"10.1016\/j.jhep.2017.05.024_b0045","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1084\/jem.189.12.1907","article-title":"An invariant T cell receptor alpha chain defines a novel TAP-independent major histocompatibility complex class Ib-restricted alpha\/beta T cell subpopulation in mammals","volume":"189","author":"Tilloy","year":"1999","journal-title":"J Exp Med"},{"key":"10.1016\/j.jhep.2017.05.024_b0050","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/eji.200535487","article-title":"HIV-1 down-regulates the expression of CD1d via Nef","volume":"36","author":"Chen","year":"2006","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jhep.2017.05.024_b0055","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/ni1364","article-title":"Herpes simplex virus evades natural killer T cell recognition by suppressing CD1d recycling","volume":"7","author":"Yuan","year":"2006","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jhep.2017.05.024_b0060","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0165-5728(00)00450-1","article-title":"CD1 expression is differentially regulated by microglia, macrophages and T cells in the central nervous system upon inflammation and demyelination","volume":"113","author":"Busshoff","year":"2001","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.jhep.2017.05.024_b0065","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.4049\/jimmunol.168.4.1519","article-title":"Cutting edge: Compartmentalization of Th1-like noninvariant CD1d-reactive T cells in hepatitis C virus-infected liver","volume":"168","author":"Exley","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.jhep.2017.05.024_b0070","doi-asserted-by":"crossref","first-page":"4105","DOI":"10.4049\/jimmunol.171.8.4105","article-title":"Expression of CD1d under the control of a MHC class Ia promoter skews the development of NKT cells, but not CD8+ T cells","volume":"171","author":"Xu","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.jhep.2017.05.024_b0075","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1084\/jem.20050413","article-title":"Expansion and long-range differentiation of the NKT cell lineage in mice expressing CD1d exclusively on cortical thymocytes","volume":"202","author":"Wei","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.jhep.2017.05.024_b0080","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.4049\/jimmunol.176.3.1421","article-title":"A cell-type specific CD1d expression program modulates invariant NKT cell development and function","volume":"176","author":"Zimmer","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.jhep.2017.05.024_b0085","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.4049\/jimmunol.171.8.4096","article-title":"T cell development in mice expressing CD1d directed by a classical MHC class II promoter","volume":"171","author":"Forestier","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.jhep.2017.05.024_b0090","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1189\/jlb.69.2.207","article-title":"Activation-induced expression of CD1d antigen on mature T cells","volume":"69","author":"Salamone","year":"2001","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jhep.2017.05.024_b0095","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1084\/jem.20021366","article-title":"CD1d-expressing dendritic cells but not thymic epithelial cells can mediate negative selection of NKT cells","volume":"197","author":"Chun","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.jhep.2017.05.024_b0100","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1126\/science.278.5343.1626","article-title":"CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides","volume":"278","author":"Kawano","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.jhep.2017.05.024_b0105","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S1074-7613(01)00186-8","article-title":"Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter","volume":"15","author":"Mohrs","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.jhep.2017.05.024_b0110","doi-asserted-by":"crossref","first-page":"168","DOI":"10.4049\/jimmunol.165.1.168","article-title":"CD1d-specific NK1.1+ T cells with a transgenic variant TCR","volume":"165","author":"Skold","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.jhep.2017.05.024_b0115","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1073\/pnas.1323845111","article-title":"Polyclonal type II natural killer T cells require PLZF and SAP for their development and contribute to CpG-mediated antitumor response","volume":"111","author":"Zhao","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2017.05.024_b0120","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1084\/jem.20090898","article-title":"CD1-restricted adaptive immune responses to Mycobacteria in human group 1 CD1 transgenic mice","volume":"206","author":"Felio","year":"2009","journal-title":"J Exp Med"},{"key":"10.1016\/j.jhep.2017.05.024_b0125","doi-asserted-by":"crossref","first-page":"3870","DOI":"10.1182\/blood-2011-03-341941","article-title":"Autoreactive CD1b-restricted T cells: a new innate-like T-cell population that contributes to immunity against infection","volume":"118","author":"Li","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jhep.2017.05.024_b0130","doi-asserted-by":"crossref","first-page":"4817","DOI":"10.3748\/wjg.v21.i16.4817","article-title":"Murine study of portal hypertension associated endothelin-1 hypo-response","volume":"21","author":"Theodorakis","year":"2015","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jhep.2017.05.024_b0135","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1084\/jem.20022227","article-title":"Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumor immunosurveillance: abrogation prevents tumor recurrence","volume":"198","author":"Terabe","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.jhep.2017.05.024_b0140","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1146\/annurev-immunol-032712-095937","article-title":"The immunology of fibrosis","volume":"31","author":"Wick","year":"2013","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jhep.2017.05.024_b0145","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.4049\/jimmunol.138.10.3185","article-title":"Mechanisms of T and B cell collaboration in the in vitro production of anti-DNA antibodies in the NZB\/NZW F1 murine SLE model","volume":"138","author":"Ando","year":"1987","journal-title":"J Immunol"},{"key":"10.1016\/j.jhep.2017.05.024_b0150","doi-asserted-by":"crossref","first-page":"4984","DOI":"10.4049\/jimmunol.1000466","article-title":"B Cell and BAFF dependence of IFN-alpha-exaggerated disease in systemic lupus erythematosus-prone NZM 2328 mice","volume":"186","author":"Jacob","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.jhep.2017.05.024_b0155","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/ni.2347","article-title":"Lower TCR repertoire diversity in Traj18-deficient mice","volume":"13","author":"Bedel","year":"2012","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jhep.2017.05.024_b0160","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1172\/JCI31602","article-title":"Type II NKT cell-mediated anergy induction in type I NKT cells prevents inflammatory liver disease","volume":"117","author":"Halder","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2017.05.024_b0165","doi-asserted-by":"crossref","first-page":"4580","DOI":"10.4049\/jimmunol.1400699","article-title":"Recognition of lysophosphatidylcholine by type II NKT cells and protection from an inflammatory liver disease","volume":"193","author":"Maricic","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.jhep.2017.05.024_b0170","article-title":"Autoimmune hepatitis: progress from global immunosuppression to personalised regulatory T cell therapy","volume":"2016","author":"Than","year":"2016","journal-title":"Can J Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2017.05.024_b0175","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1586\/17474124.1.1.113","article-title":"Autoimmune hepatitis. Part A: pathogenesis","volume":"1","author":"Czaja","year":"2007","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2017.05.024_b0180","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/hep.27884","article-title":"In autoimmune hepatitis type 1 or the autoimmune hepatitis-sclerosing cholangitis variant defective regulatory T-cell responsiveness to IL-2 results in low IL-10 production and impaired suppression","volume":"62","author":"Liberal","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2017.05.024_b0185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143715","article-title":"The role of regulatory CD4 T cells in maintaining tolerance in a mouse model of autoimmune hepatitis","volume":"10","author":"An Haack","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jhep.2017.05.024_b0190","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S1074-7613(02)00274-1","article-title":"Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation","volume":"16","author":"Mizoguchi","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.jhep.2017.05.024_b0195","doi-asserted-by":"crossref","first-page":"7841","DOI":"10.4049\/jimmunol.177.11.7841","article-title":"IFN-beta-mediated up-regulation of CD1d in bacteria-infected APCs","volume":"177","author":"Raghuraman","year":"2006","journal-title":"J Immunol"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827817320639?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827817320639?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T10:20:08Z","timestamp":1719310808000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827817320639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S0168827817320639"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2017.05.024","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727697900.793536335","asserted-by":"object"}]},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Crosstalk between type II NKT cells and T cells leads to spontaneous chronic inflammatory liver disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2017.05.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}