{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T05:15:27Z","timestamp":1773465327308,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100009139","name":"Deutsches Zentrum f\u00fcr Infektionsforschung","doi-asserted-by":"publisher","award":["TTU 05.902"],"award-info":[{"award-number":["TTU 05.902"]}],"id":[{"id":"10.13039\/100009139","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.jhep.2017.05.027","type":"journal-article","created":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T17:45:25Z","timestamp":1497375925000},"page":"680-686","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Origin, prevalence and response to therapy of hepatitis C virus genotype 2k\/1b chimeras"],"prefix":"10.1016","volume":"67","author":[{"given":"Simone","family":"Susser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Dietz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Schlevogt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eli","family":"Zuckerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mira","family":"Barak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Piazzolla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Howe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Hinrichsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Passmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasha","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Cornberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Mangia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Zeuzem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Sarrazin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2017.05.027_b0005","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1056\/NEJM200107053450107","article-title":"Hepatitis C virus infection","volume":"345","author":"Lauer","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2017.05.027_b0010","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1016\/j.jhep.2014.07.027","article-title":"Global epidemiology and genotype distribution of the hepatitis C virus infection","volume":"61","author":"Gower","year":"2014","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2017.05.027_b0015","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Lozano","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2017.05.027_b0020","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/hep.26744","article-title":"Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: updated criteria and genotype assignment web resource","volume":"59","author":"Smith","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2017.05.027_b0025","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1099\/vir.0.80401-0","article-title":"Genetic diversity and evolution of hepatitis C virus\u201315 years on","volume":"85","author":"Simmonds","year":"2004","journal-title":"J Gen Virol"},{"key":"10.1016\/j.jhep.2017.05.027_b0030","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.1128\/JVI.76.8.4034-4043.2002","article-title":"A natural intergenotypic recombinant of hepatitis C virus identified in St. Petersburg","volume":"76","author":"Kalinina","year":"2002","journal-title":"J Virol"},{"key":"10.1016\/j.jhep.2017.05.027_b0035","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/hep.27361","article-title":"Characterization of hepatitis C virus intergenotypic recombinant strains and associated virological response to sofosbuvir\/ribavirin","volume":"61","author":"Hedskog","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2017.05.027_b0040","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1111\/hepr.12505","article-title":"High incidence of the hepatitis C virus recombinant 2k\/1b in Georgia: Recommendations for testing and treatment","volume":"45","author":"Karchava","year":"2015","journal-title":"Hepatol Res"},{"key":"10.1016\/j.jhep.2017.05.027_b0045","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1128\/JVI.06184-11","article-title":"Origin and evolution of the unique hepatitis C virus circulating recombinant form 2k\/1b","volume":"86","author":"Raghwani","year":"2012","journal-title":"J Virol"},{"key":"10.1016\/j.jhep.2017.05.027_b0050","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1186\/1743-422X-8-458","article-title":"Naturally occurring genotype 2b\/1a hepatitis C virus in the United States","volume":"8","author":"Bhattacharya","year":"2011","journal-title":"Virol J"},{"key":"10.1016\/j.jhep.2017.05.027_b0055","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1002\/jmv.20714","article-title":"A natural inter-genotypic (2b\/1b) recombinant of hepatitis C virus in the Philippines","volume":"78","author":"Kageyama","year":"2006","journal-title":"J Med Virol"},{"key":"10.1016\/j.jhep.2017.05.027_b0060","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1007\/s00705-011-1038-4","article-title":"Identification and characterization of a natural inter-genotypic (2b\/1b) recombinant hepatitis C virus in Japan","volume":"156","author":"Yokoyama","year":"2011","journal-title":"Arch Virol"},{"key":"10.1016\/j.jhep.2017.05.027_b0065","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1128\/JVI.02639-06","article-title":"New natural intergenotypic (2\/5) recombinant of hepatitis C virus","volume":"81","author":"Legrand-Abravanel","year":"2007","journal-title":"J Virol"},{"key":"10.1016\/j.jhep.2017.05.027_b0070","doi-asserted-by":"crossref","first-page":"7569","DOI":"10.1128\/JVI.00312-06","article-title":"Identification of a naturally occurring recombinant genotype 2\/6 hepatitis C virus","volume":"80","author":"Noppornpanth","year":"2006","journal-title":"J Virol"},{"key":"10.1016\/j.jhep.2017.05.027_b0075","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/jmv.21658","article-title":"Molecular epidemiology of HCV genotypes among injection drug users in Taiwan: Full-length sequences of two new subtype 6w strains and a recombinant form_2b6w","volume":"82","author":"Lee","year":"2010","journal-title":"J Med Virol"},{"key":"10.1016\/j.jhep.2017.05.027_b0080","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.tim.2014.02.005","article-title":"Comparative analysis of the molecular mechanisms of recombination in hepatitis C virus","volume":"22","author":"Galli","year":"2014","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.jhep.2017.05.027_b0085","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jhep.2015.03.025","article-title":"EASL Recommendations on Treatment of Hepatitis C 2015","volume":"63","year":"2015","journal-title":"J Hepatol"},{"issue":"4","key":"10.1016\/j.jhep.2017.05.027_b9000","doi-asserted-by":"crossref","first-page":"e0122082","DOI":"10.1371\/journal.pone.0122082","article-title":"HCV genotyping from NGS short reads and its application in genotype detection from HCV mixed infected plasma","volume":"10","author":"Qiu","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jhep.2017.05.027_b0090","doi-asserted-by":"crossref","first-page":"e0134395","DOI":"10.1371\/journal.pone.0134395","article-title":"Consideration of viral resistance for optimization of direct antiviral therapy of hepatitis C virus genotype 1-infected patients","volume":"10","author":"Dietz","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jhep.2017.05.027_b0095","doi-asserted-by":"crossref","first-page":"W5","DOI":"10.1093\/nar\/gkn201","article-title":"NCBI BLAST: a better web interface","volume":"36","author":"Johnson","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jhep.2017.05.027_b0100","doi-asserted-by":"crossref","first-page":"vev003","DOI":"10.1093\/ve\/vev003","article-title":"RDP4: Detection and analysis of recombination patterns in virus genomes","volume":"1","author":"Martin","year":"2015","journal-title":"Virus Evol"},{"key":"10.1016\/j.jhep.2017.05.027_b0105","doi-asserted-by":"crossref","first-page":"W580","DOI":"10.1093\/nar\/gkv279","article-title":"The EMBL-EBI bioinformatics web and programmatic tools framework","volume":"43","author":"Li","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jhep.2017.05.027_b0110","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1093\/molbev\/msw054","article-title":"MEGA7: molecular evolutionary genetics analysis version 7.0 for bigger datasets","volume":"33","author":"Kumar","year":"2016","journal-title":"Mol Biol Evol"},{"key":"10.1016\/j.jhep.2017.05.027_b0115","unstructured":"Tolts M. Post-Soviet Aliyah and Jewish Demographic Transformation. 15th World Congress of Jewish Studies. Jerusalem; 2009."},{"key":"10.1016\/j.jhep.2017.05.027_b0120","unstructured":"Denisenko M. Historical and Current Trends in Emigration from Russia. 2013. http:\/\/russiancouncil.ru\/en\/inner\/?id_4=2292 - top-content (accessed 05. September 2013)."},{"key":"10.1016\/j.jhep.2017.05.027_b0125","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.jcv.2010.01.011","article-title":"Emergence of a genomic variant of the recombinant 2k\/1b strain during a mixed Hepatitis C infection: a case report","volume":"47","author":"Morel","year":"2010","journal-title":"J Clin Virol"},{"key":"10.1016\/j.jhep.2017.05.027_b0130","doi-asserted-by":"crossref","first-page":"710438","DOI":"10.1155\/2011\/710438","article-title":"Near-full genome characterisation of two natural intergenotypic 2k\/1b recombinant hepatitis C virus isolates","volume":"2011","author":"Demetriou","year":"2011","journal-title":"Adv Virol"},{"key":"10.1016\/j.jhep.2017.05.027_b0135","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/infdis\/jis679","article-title":"Whole genome pyrosequencing of rare hepatitis C virus genotypes enhances subtype classification and identification of naturally occurring drug resistance variants","volume":"208","author":"Newman","year":"2013","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jhep.2017.05.027_b0140","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1111\/j.1365-2893.2010.01342.x","article-title":"Evidence for separation of HCV subtype 1a into two distinct clades","volume":"18","author":"Pickett","year":"2011","journal-title":"J Viral Hepat"},{"key":"10.1016\/j.jhep.2017.05.027_b0145","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1002\/jmv.23545","article-title":"Hepatitis C virus subtyping based on sequencing of the C\/E1 and NS5B genomic regions in comparison to a commercially available line probe assay","volume":"85","author":"Avo","year":"2013","journal-title":"J Med Virol"},{"key":"10.1016\/j.jhep.2017.05.027_b0150","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.diagmicrobio.2015.04.001","article-title":"Potential risk of misclassification HCV 2k\/1b strains as HCV 2a\/2c using VERSANT HCV Genotype 2.0 assay","volume":"82","author":"De Keukeleire","year":"2015","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.jhep.2017.05.027_b0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijid.2015.10.010","article-title":"Diagnosis of hepatitis C virus genotype 2k\/1b needs NS5B sequencing","volume":"41","author":"De Keukeleire","year":"2015","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.jhep.2017.05.027_b0160","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17091384","article-title":"Heads or tails: genotyping of hepatitis C virus concerning the 2k\/1b circulating recombinant form","volume":"17","author":"Schuermans","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jhep.2017.05.027_b0165","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1001\/jama.1936.02770120029009","article-title":"Transfusion of cadaver blood","volume":"106","author":"Yudin","year":"1936","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.jhep.2017.05.027_b0170","first-page":"406","article-title":"The neighbor-joining method: a new method for reconstructing phylogenetic trees","volume":"4","author":"Saitou","year":"1987","journal-title":"Mol Biol Evol"},{"key":"10.1016\/j.jhep.2017.05.027_b0175","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.1558-5646.1985.tb00420.x","article-title":"Confidence limits on phylogenies: an approach using the bootstrap","volume":"39","author":"Felsenstein","year":"1985","journal-title":"Evolution"},{"key":"10.1016\/j.jhep.2017.05.027_b0180","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/BF01731581","article-title":"A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences","volume":"16","author":"Kimura","year":"1980","journal-title":"J Mol Evol"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016882781732069X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016882781732069X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T12:25:50Z","timestamp":1656246350000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016882781732069X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S016882781732069X"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2017.05.027","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Origin, prevalence and response to therapy of hepatitis C virus genotype 2k\/1b chimeras","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2017.05.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}