{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:11:01Z","timestamp":1790115061443,"version":"4.0.1"},"reference-count":10,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research","doi-asserted-by":"publisher","award":["01ZZ9603"],"award-info":[{"award-number":["01ZZ9603"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research","doi-asserted-by":"publisher","award":["01ZZ0103"],"award-info":[{"award-number":["01ZZ0103"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research","doi-asserted-by":"publisher","award":["01ZZ0403"],"award-info":[{"award-number":["01ZZ0403"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Cultural Affairs, the Ministry of Social Affairs of the Federal State of Mecklenburg-West Pomerania"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.jhep.2017.11.038","type":"journal-article","created":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T02:41:55Z","timestamp":1512960115000},"page":"858-860","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["The PNPLA3 SNP rs738409:G allele is associated with increased liver disease-associated mortality but reduced overall mortality in a population-based cohort"],"prefix":"10.1016","volume":"68","author":[{"given":"Peter J.","family":"Meffert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja D.","family":"Repp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"V\u00f6lzke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Ulrich","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Homuth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens P.","family":"K\u00fchn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus M.","family":"Lerch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali A.","family":"Aghdassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2017.11.038_b0005","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jhep.2017.01.018","article-title":"Homozygosity for rs738409: G in PNPLA3 is associated with increased mortality following an episode of severe alcoholic hepatitis","volume":"67","author":"Atkinson","year":"2017","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2017.11.038_b0010","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/hep.24017","article-title":"Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians","volume":"53","author":"Stickel","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2017.11.038_b0015","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1038\/ng.3417","article-title":"A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis","volume":"47","author":"Buch","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.jhep.2017.11.038_b0020","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12913-016-1289-6","article-title":"Association of PNPLA3 rs738409 and TM6SF2 rs58542926 with health services utilization in a population-based study","volume":"16","author":"Kopp","year":"2016","journal-title":"BMC Health Serv Res"},{"key":"10.1016\/j.jhep.2017.11.038_b0025","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.ejim.2014.05.012","article-title":"Non-alcoholic fatty liver disease, metabolic syndrome and patatin-like phospholipase domain-containing protein3 gene variants","volume":"25","author":"Del Ben","year":"2014","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.jhep.2017.11.038_b0030","doi-asserted-by":"crossref","first-page":"E430","DOI":"10.1210\/jc.2010-0814","article-title":"Specifically PNPLA3-mediated accumulation of liver fat in obese patients with type 2 diabetes","volume":"95","author":"Petit","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jhep.2017.11.038_b0035","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1093\/ije\/dyp394","article-title":"Cohort profile: the study of health in Pomerania","volume":"40","author":"Volzke","year":"2011","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jhep.2017.11.038_b0040","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1210\/jc.2011-2768","article-title":"Serum thyroid-stimulating hormone levels are associated with blood pressure in children and adolescents","volume":"97","author":"Ittermann","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jhep.2017.11.038_b0045","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.bbalip.2013.12.006","article-title":"Recombinant PNPLA3 protein shows triglyceride hydrolase activity and its I148M mutation results in loss of function","volume":"1841","author":"Pingitore","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jhep.2017.11.038_b0050","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1161\/01.STR.0000038422.57919.7F","article-title":"Association between behavior-dependent cardiovascular risk factors and asymptomatic carotid atherosclerosis in a general population","volume":"33","author":"Luedemann","year":"2002","journal-title":"Stroke"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827817324832?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827817324832?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T19:33:36Z","timestamp":1759174416000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827817324832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S0168827817324832"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2017.11.038","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The PNPLA3 SNP rs738409:G allele is associated with increased liver disease-associated mortality but reduced overall mortality in a population-based cohort","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2017.11.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2017.01.018","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}