{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:12:09Z","timestamp":1792699929825,"version":"4.5.0"},"reference-count":156,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.jhep.2018.02.006","type":"journal-article","created":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T20:59:33Z","timestamp":1519073973000},"page":"1286-1300","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"title":["Paediatric fatty liver disease (PeFLD): All is not NAFLD \u2013 Pathophysiological insights and approach to management"],"prefix":"10.1016","volume":"68","author":[{"given":"Robert","family":"Hegarty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maesha","family":"Deheragoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emer","family":"Fitzpatrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Dhawan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2018.02.006_b0005","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S0025-6196(24)00530-5","article-title":"Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease","volume":"55","author":"Ludwig","year":"1980","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.jhep.2018.02.006_b0010","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1093\/alcalc\/agr074","article-title":"Alcoholic and non-alcoholic fatty liver in adolescents: a worrisome convergence","volume":"46","author":"Nobili","year":"2011","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.jhep.2018.02.006_b0015","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.jhep.2010.11.021","article-title":"Presence and significance of microvesicular steatosis in nonalcoholic fatty liver disease","volume":"55","author":"Tandra","year":"2011","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2018.02.006_b0020","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1097\/MPG.0000000000000632","article-title":"Liver biopsy in children: position paper of the ESPGHAN Hepatology Committee","volume":"60","author":"Dezs\u0151fi","year":"2015","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jhep.2018.02.006_b0025","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.jhep.2007.03.003","article-title":"Pediatric nonalcoholic fatty liver disease (NAFLD): a \u201cgrowing\u201d problem?","volume":"46","author":"Roberts","year":"2007","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2018.02.006_b0030","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.jpeds.2005.12.051","article-title":"Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group","volume":"148","author":"Squires","year":"2006","journal-title":"J Pediatr"},{"key":"10.1016\/j.jhep.2018.02.006_b0035","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.clinre.2012.03.022","article-title":"Acute liver failure in children and adolescents","volume":"36","author":"Dhawan","year":"2012","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"10.1016\/j.jhep.2018.02.006_b0040","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1023\/A:1007649815992","article-title":"Hepatotoxicity due to mitochondrial dysfunction","volume":"15","author":"Pessayre","year":"1999","journal-title":"Cell Biol Toxicol"},{"key":"10.1016\/j.jhep.2018.02.006_b0045","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/MPG.0b013e31829ef67a","article-title":"Evaluation of the child with suspected mitochondrial liver disease","volume":"57","author":"Molleston","year":"2013","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jhep.2018.02.006_b0050","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1097\/MPG.0b013e318048838f","article-title":"Liver failure in mitochondrial DNA depletion syndrome: the importance of serial neuroimaging in liver transplantation evaluation","volume":"45","author":"deBruyn","year":"2007","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jhep.2018.02.006_b0055","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/S0168-8278(99)80050-6","article-title":"Microvesicular steatosis, hemosiderosis and rapid development of liver cirrhosis in a patient with Pearson\u2019s syndrome","volume":"31","author":"Kr\u00e4henb\u00fchl","year":"1999","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2018.02.006_b0060","unstructured":"Cohen BH, Chinnery PF, Copeland WC. POLG-Related Disorders. In: Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJ, et al., editors. GeneReviews(\u00ae) [Internet]. Seattle (WA): University of Washington, Seattle; 1993 [cited 2016 Nov 14]. Available from: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK26471\/."},{"key":"10.1016\/j.jhep.2018.02.006_b0065","first-page":"2012","article-title":"Neonatal liver failure due to deoxyguanosine kinase deficiency","volume":"2","author":"Nobre","year":"2012","journal-title":"BMJ Case Rep"},{"key":"10.1016\/j.jhep.2018.02.006_b0070","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1002\/hep.21799","article-title":"Mutations in the MPV17 gene are responsible for rapidly progressive liver failure in infancy","volume":"46","author":"Wong","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2018.02.006_b0075","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ymgme.2012.04.017","article-title":"Identification of a mutation in LARS as a novel cause of infantile hepatopathy","volume":"106","author":"Casey","year":"2012","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.jhep.2018.02.006_b0080","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1056\/NEJM199812103392405","article-title":"A defect in the transport of long-chain fatty acids associated with acute liver failure","volume":"339","author":"Odaib","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2018.02.006_b0085","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1002\/hep.20680","article-title":"Acute liver failure in children: the role of defects in fatty acid oxidation","volume":"41","author":"Alonso","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2018.02.006_b0090","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1086\/519219","article-title":"A new genetic disorder in mitochondrial fatty acid \u03b2-oxidation: ACAD9 deficiency","volume":"81","author":"He","year":"2007","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jhep.2018.02.006_b0095","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/ajmg.c.30087","article-title":"Disorders of carnitine transport and the carnitine cycle","volume":"142C","author":"Longo","year":"2006","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"10.1016\/j.jhep.2018.02.006_b0100","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1203\/00006450-198809000-00006","article-title":"Hepatic and muscular presentations of carnitine palmitoyl transferase deficiency: two distinct entities","volume":"24","author":"Demaugre","year":"1988","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jhep.2018.02.006_b0105","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ymgme.2013.01.017","article-title":"Dihydrolipoamide dehydrogenase deficiency: a still overlooked cause of recurrent acute liver failure and Reye-like syndrome","volume":"109","author":"Brassier","year":"2013","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.jhep.2018.02.006_b0110","first-page":"717","article-title":"Neonatal congenital lactic acidosis with pyruvate carboxylase deficiency in two siblings","volume":"65","author":"Saudubray","year":"1976","journal-title":"Acta Paediatr Scand"},{"key":"10.1016\/j.jhep.2018.02.006_b0115","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.ymgme.2010.02.010","article-title":"Current concepts in the pathogenesis of urea cycle disorders","volume":"100","author":"Braissant","year":"2010","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.jhep.2018.02.006_b0120","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.jpeds.2013.12.024","article-title":"Significant hepatic involvement in patients with ornithine transcarbamylase deficiency","volume":"164","author":"Gallagher","year":"2014","journal-title":"J Pediatr"},{"key":"10.1016\/j.jhep.2018.02.006_b0125","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1097\/MPG.0b013e318227b02d","article-title":"Early-onset hepatic fibrosis in lysinuric protein intolerance","volume":"53","author":"Shinawi","year":"2011","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jhep.2018.02.006_b0130","first-page":"84","article-title":"Oxidative stress contributes to outcome severity in a Drosophila melanogaster model of classic galactosemia","volume":"6","author":"Jumbo-Lucioni","year":"2013","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.jhep.2018.02.006_b0135","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1824-7288-38-64","article-title":"Fatty liver disease and hypertransaminasemia hiding the association of clinically silent Duchenne muscular dystrophy and hereditary fructose intolerance","volume":"31","author":"Paolella","year":"2012","journal-title":"Ital J Pediatr"},{"key":"10.1016\/j.jhep.2018.02.006_b0140","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1750-1172-5-29","article-title":"Wolcott-Rallison syndrome","volume":"4","author":"Julier","year":"2010","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.jhep.2018.02.006_b0145","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10545-015-9896-7","article-title":"Recurrent acute liver failure due to NBAS deficiency: phenotypic spectrum, disease mechanisms, and therapeutic concepts","volume":"39","author":"Staufner","year":"2016","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.jhep.2018.02.006_b0150","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/ncb3461","article-title":"Circadian- and UPR-dependent control of CPEB4 mediates a translational response to counteract hepatic steatosis under ER stress","volume":"19","author":"Maillo","year":"2017","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jhep.2018.02.006_b0155","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ajhg.2015.05.009","article-title":"Biallelic mutations in NBAS cause recurrent acute liver failure with onset in infancy","volume":"97","author":"Haack","year":"2015","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jhep.2018.02.006_b0160","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2016-0550","article-title":"Acute liver failure meets SOPH syndrome: a case report on an intermediate phenotype","volume":"139","author":"Kort\u00fcm","year":"2017","journal-title":"Pediatrics"},{"key":"10.1016\/j.jhep.2018.02.006_b0165","doi-asserted-by":"crossref","unstructured":"Li J-Q, Qiu Y-L, Gong J-Y, Dou L-M, Lu Y, Knisely AS, et al. Novel NBAS mutations and fever-related recurrent acute liver failure in Chinese children: a retrospective study. BMC Gastroenterol [Internet]. 2017 Jun 19 [cited 2017 Oct 22];17. Available from: https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5477288\/.","DOI":"10.1186\/s12876-017-0636-3"},{"key":"10.1016\/j.jhep.2018.02.006_b0170","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S1665-2681(19)30890-7","article-title":"Tyrosinemia type I: clinical and biochemical analysis of patients in Mexico","volume":"13","author":"Fern\u00e1ndez-Lainez","year":"2014","journal-title":"Ann Hepatol"},{"key":"10.1016\/j.jhep.2018.02.006_b0175","doi-asserted-by":"crossref","first-page":"1556S","DOI":"10.1093\/jn\/137.6.1556S","article-title":"Animal models of tyrosinemia","volume":"137","author":"Nakamura","year":"2007","journal-title":"J Nutr"},{"key":"10.1016\/j.jhep.2018.02.006_b0180","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1007\/BF01003441","article-title":"Liver findings in Niemann-Pick disease type C","volume":"16","author":"Elleder","year":"1984","journal-title":"Histochem J"},{"key":"10.1016\/j.jhep.2018.02.006_b0185","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1097\/PAS.0b013e31825793ff","article-title":"Liver and skin histopathology in adults with acid sphingomyelinase deficiency (Niemann-Pick disease type B)","volume":"36","author":"Thurberg","year":"2012","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.jhep.2018.02.006_b0190","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1002\/hep.1840040526","article-title":"Ultrastructural liver pathology in patients with minimal liver disease and alpha 1-antitrypsin deficiency: a comparison between heterozygous and homozygous patients","volume":"4","author":"Hultcrantz","year":"1984","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2018.02.006_b0195","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1586\/17474124.2014.943187","article-title":"Alpha-1 antitrypsin and liver disease: mechanisms of injury and novel interventions","volume":"9","author":"Teckman","year":"2015","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2018.02.006_b0200","doi-asserted-by":"crossref","first-page":"G851","DOI":"10.1152\/ajpgi.00175.2003","article-title":"Mitochondrial autophagy and injury in the liver in alpha 1-antitrypsin deficiency","volume":"286","author":"Teckman","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jhep.2018.02.006_b0205","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1136\/gut.52.10.1494","article-title":"Mutations in SRD5B1 (AKR1D1), the gene encoding delta(4)-3-oxosteroid 5beta-reductase, in hepatitis and liver failure in infancy","volume":"52","author":"Lemonde","year":"2003","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2018.02.006_b0210","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s10545-010-9259-3","article-title":"Disorders of bile acid synthesis","volume":"34","author":"Clayton","year":"2011","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.jhep.2018.02.006_b0215","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jhep.2005.08.024","article-title":"Adult onset type II citrullinemia as a cause of non-alcoholic steatohepatitis","volume":"44","author":"Takagi","year":"2006","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2018.02.006_b0220","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.jhep.2008.05.016","article-title":"Citrin deficiency as a cause of chronic liver disorder mimicking non-alcoholic fatty liver disease","volume":"49","author":"Komatsu","year":"2008","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2018.02.006_b0225","first-page":"244","article-title":"A case of adult-onset type II citrullinemia having a liver histology of nonalcoholic steatohepatitis (NASH)","volume":"105","author":"Fukumoto","year":"2008","journal-title":"Nihon Shokakibyo Gakkai Zasshi"},{"key":"10.1016\/j.jhep.2018.02.006_b0230","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.humpath.2011.07.008","article-title":"Total parenteral nutrition therapy and liver injury: a histopathologic study with clinical correlation","volume":"43","author":"Naini","year":"2012","journal-title":"Hum Pathol Phila"},{"key":"10.1016\/j.jhep.2018.02.006_b0235","unstructured":"Adolph M, Heller AR, Koch T, Koletzko B, Kreymann KG, Krohn K, et al. Lipid emulsions \u2013 Guidelines on Parenteral Nutrition, Chapter 6. GMS Ger Med Sci [Internet]. 2009 Nov 18 [cited 2017 Oct 25];7. Available from: https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2795378\/."},{"key":"10.1016\/j.jhep.2018.02.006_b0240","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1002\/(SICI)1099-081X(199712)18:9<803::AID-BDD65>3.0.CO;2-S","article-title":"Effects of intravenous lipid as a source of energy in parenteral nutrition associated hepatic dysfunction and lidocaine elimination: a study using isolated rat liver perfusion","volume":"18","author":"Zaman","year":"1997","journal-title":"Biopharm Drug Dispos"},{"key":"10.1016\/j.jhep.2018.02.006_b0245","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/0022-4804(88)90095-9","article-title":"Increasing dextrose concentrations in total parenteral nutrition (TPN) causes alterations in hepatic morphology and plasma levels of insulin and glucagon in rats","volume":"44","author":"Li","year":"1988","journal-title":"J Surg Res"},{"key":"10.1016\/j.jhep.2018.02.006_b0250","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1007\/BF01709340","article-title":"Lipid deposition in Kupffer cells after parenteral fat nutrition in rats: a biochemical and ultrastructural study","volume":"22","author":"Roth","year":"1996","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jhep.2018.02.006_b0255","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/MPG.0000000000000586","article-title":"Intestinal failure-associated liver disease: a position paper of the ESPGHAN Working Group of Intestinal Failure and Intestinal Transplantation","volume":"60","author":"Lacaille","year":"2015","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jhep.2018.02.006_b0260","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1097\/GIM.0b013e3181e655b6","article-title":"Glycogen storage disease type III diagnosis and management guidelines","volume":"12","author":"Kishnani","year":"2010","journal-title":"Genet Med"},{"key":"10.1016\/j.jhep.2018.02.006_b0265","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s10545-015-9811-2","article-title":"Lipids in hepatic glycogen storage diseases: pathophysiology, monitoring of dietary management and future directions","volume":"38","author":"Derks","year":"2015","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.jhep.2018.02.006_b0270","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1172\/JCI63967","article-title":"Malonyl-CoA: the regulator of fatty acid synthesis and oxidation","volume":"122","author":"Foster","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2018.02.006_b0275","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/S0168-8278(01)00132-5","article-title":"Liver glycogen storage associated with uncontrolled type 1 diabetes mellitus","volume":"35","author":"Torres","year":"2001","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2018.02.006_b0280","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1097\/00000478-200604000-00012","article-title":"Glycogenic hepatopathy: an underrecognized hepatic complication of diabetes mellitus","volume":"30","author":"Torbenson","year":"2006","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.jhep.2018.02.006_b0285","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1136\/archdischild-2013-304426","article-title":"Hepatopathy of Mauriac syndrome: a retrospective review from a tertiary liver centre","volume":"99","author":"Fitzpatrick","year":"2014","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jhep.2018.02.006_b0290","doi-asserted-by":"crossref","first-page":"S481","DOI":"10.1007\/s10545-010-9246-8","article-title":"Novel ETF dehydrogenase mutations in a patient with mild glutaric aciduria type II and complex II-III deficiency in liver and muscle","volume":"33","author":"Wolfe","year":"2010","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.jhep.2018.02.006_b0295","first-page":"221","article-title":"Early speech delay and hepatitis as presenting signs of homocystinuria","volume":"33","author":"Mack","year":"2001","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jhep.2018.02.006_b0300","doi-asserted-by":"crossref","first-page":"e49346","DOI":"10.1371\/journal.pone.0049346","article-title":"Exploration of lipid metabolism in relation with plasma membrane properties of Duchenne muscular dystrophy cells: influence of L-carnitine","volume":"7","author":"Le Borgne","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jhep.2018.02.006_b0305","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/MPG.0b013e318217f5d9","article-title":"Duchenne and Becker muscular dystrophy presenting as nonalcoholic fatty liver disease","volume":"53","author":"Veropalumbo","year":"2011","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jhep.2018.02.006_b0310","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13395-015-0056-4","article-title":"Congenital muscular dystrophy with fatty liver and infantile-onset cataract caused by TRAPPC11 mutations: broadening of the phenotype","volume":"5","author":"Liang","year":"2015","journal-title":"Skelet Muscle"},{"key":"10.1016\/j.jhep.2018.02.006_b0315","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/0140-6736(90)93426-P","article-title":"Secondary metabolic defects in spinal muscular atrophy type II","volume":"336","author":"Harpey","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2018.02.006_b0320","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.ejpn.2012.01.004","article-title":"Abnormal fatty acid metabolism in spinal muscular atrophy may predispose to perioperative risks","volume":"16","author":"Zolkipli","year":"2012","journal-title":"Eur J Paediatr Neurol"},{"key":"10.1016\/j.jhep.2018.02.006_b0325","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/8904_2011_107","article-title":"Infantile progressive hepatoencephalomyopathy with combined OXPHOS deficiency due to mutations in the mitochondrial translation elongation factor gene GFM1","volume":"5","author":"Balasubramaniam","year":"2012","journal-title":"JIMD Rep"},{"key":"10.1016\/j.jhep.2018.02.006_b0330","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1750-1172-9-52","article-title":"A multicenter study on Leigh syndrome: disease course and predictors of survival","volume":"15","author":"Sofou","year":"2014","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.jhep.2018.02.006_b0335","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/8904_2012_199","article-title":"MNGIE syndrome: liver cirrhosis should be ruled out prior to bone marrow transplantation","volume":"10","author":"Finkenstedt","year":"2013","journal-title":"JIMD Rep"},{"key":"10.1016\/j.jhep.2018.02.006_b0340","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1097\/00004836-200310000-00014","article-title":"Is hypothyroidism a risk factor for non-alcoholic steatohepatitis?","volume":"37","author":"Liangpunsakul","year":"2003","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.jhep.2018.02.006_b0345","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.jhep.2012.05.025","article-title":"Impact of subclinical hypothyroidism on the development of non-alcoholic fatty liver disease: a prospective case-control study","volume":"57","author":"Xu","year":"2012","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2018.02.006_b0350","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1097\/MED.0b013e32833d6d46","article-title":"New insights into regulation of lipid metabolism by thyroid hormone","volume":"17","author":"Zhu","year":"2010","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"10.1016\/j.jhep.2018.02.006_b0355","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.jacl.2017.08.015","article-title":"Association between thyroid function and lipid profiles, apolipoproteins, and high-density lipoprotein function","volume":"11","author":"Jung","year":"2017","journal-title":"J Clin Lipidol"},{"key":"10.1016\/j.jhep.2018.02.006_b0360","first-page":"488","article-title":"Metabolic syndrome prevalence in subclinic and overt hypothyroid patients and the relation among metabolic syndrome parameters","volume":"34","author":"Erdogan","year":"2011","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.jhep.2018.02.006_b0365","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jhep.2012.02.027","article-title":"Non-alcoholic fatty liver disease across the spectrum of hypothyroidism","volume":"57","author":"Chung","year":"2012","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2018.02.006_b0370","doi-asserted-by":"crossref","unstructured":"Demir \u015e, \u00dcn\u00fcbol M, Aypak S\u00dc, \u0130pek E, Akta\u015f S, Ekren GS, et al. Histopathologic Evaluation of Nonalcoholic Fatty Liver Disease in Hypothyroidism-Induced Rats [Internet]. International Journal of Endocrinology. 2016 [cited 2018 Jan 13]. Available from: https:\/\/www.hindawi.com\/journals\/ije\/2016\/5083746\/.","DOI":"10.1155\/2016\/5083746"},{"key":"10.1016\/j.jhep.2018.02.006_b0375","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.bbalip.2007.05.001","article-title":"Activation of the hepatic LDL receptor promoter by thyroid hormone","volume":"1771","author":"Lopez","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jhep.2018.02.006_b0380","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1432-1033.1976.tb10827.x","article-title":"Effects of thyroid hormone deficiency on the distribution of hepatic metabolites and control of pathways of carbohydrate metabolism in liver and adipose tissue of the rat","volume":"68","author":"Baquer","year":"1976","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.jhep.2018.02.006_b0385","first-page":"183","article-title":"Hypothyroidism induces a moderate steatohepatitis accompanied by liver regeneration, mast cells infiltration, and changes in the expression of the farnesoid X receptor","volume":"125","author":"Rodr\u00edguez-Castel\u00e1n","year":"2017","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"10.1016\/j.jhep.2018.02.006_b0390","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1097\/MPG.0000000000000444","article-title":"The liver in pediatric gastrointestinal disease","volume":"59","author":"Vo","year":"2014","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jhep.2018.02.006_b0395","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1002\/hep.22848","article-title":"Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease","volume":"49","author":"Miele","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2018.02.006_b0400","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2147\/CEG.S7556","article-title":"Hepatic manifestations of celiac disease","volume":"3","author":"Freeman","year":"2010","journal-title":"Clin Exp Gastroenterol"},{"key":"10.1016\/j.jhep.2018.02.006_b0405","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1097\/MIB.0000000000000832","article-title":"Incidence and predictors of nonalcoholic fatty liver disease by serum biomarkers in patients with inflammatory bowel disease","volume":"22","author":"Bessissow","year":"2016","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jhep.2018.02.006_b0410","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1002\/ibd.21585","article-title":"The prevalence and epidemiology of overweight and obesity in children with inflammatory bowel disease","volume":"17","author":"Long","year":"2011","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jhep.2018.02.006_b0415","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/ibd.21669","article-title":"The changing shape of disease: non-alcoholic fatty liver disease in crohn\u2019s disease a case series and review of the literature","volume":"18","author":"McGowan","year":"2012","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jhep.2018.02.006_b0420","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1007\/s10620-017-4495-0","article-title":"Intestinal inflammation does not predict nonalcoholic fatty liver disease severity in inflammatory bowel disease patients","volume":"62","author":"Carr","year":"2017","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jhep.2018.02.006_b0425","doi-asserted-by":"crossref","first-page":"e279","DOI":"10.1016\/j.crohns.2012.10.015","article-title":"Risk factors of non-alcoholic fatty liver disease in patients with inflammatory bowel disease","volume":"7","author":"Sourianarayanane","year":"2013","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.jhep.2018.02.006_b0430","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/j.jhep.2013.02.014","article-title":"Cholesteryl ester storage disease: review of the findings in 135 reported patients with an underdiagnosed disease","volume":"58","author":"Bernstein","year":"2013","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2018.02.006_b0435","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1111\/j.1365-2559.2011.04164.x","article-title":"Distinctive histopathological features that support a diagnosis of cholesterol ester storage disease in liver biopsy specimens","volume":"60","author":"H\u016flkov\u00e1","year":"2012","journal-title":"Histopathology"},{"key":"10.1016\/j.jhep.2018.02.006_b0440","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2016-0214","article-title":"Lysosomal acid lipase deficiency unmasked in two children with nonalcoholic fatty liver disease","volume":"138","author":"Himes","year":"2016","journal-title":"Pediatrics"},{"key":"10.1016\/j.jhep.2018.02.006_b0445","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1097\/MPG.0000000000000935","article-title":"Clinical features of lysosomal acid lipase deficiency","volume":"61","author":"Burton","year":"2015","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jhep.2018.02.006_b0450","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s10545-013-9665-4","article-title":"Abetalipoproteinemia and homozygous hypobetalipoproteinemia: a framework for diagnosis and management","volume":"37","author":"Lee","year":"2014","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.jhep.2018.02.006_b0455","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.jhep.2014.05.023","article-title":"Homozygous MTTP and APOB mutations may lead to hepatic steatosis and fibrosis despite metabolic differences in congenital hypocholesterolemia","volume":"61","author":"Di Filippo","year":"2014","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2018.02.006_b0460","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1750-1172-3-19","article-title":"Abetalipoproteinemia: two case reports and literature review","volume":"8","author":"Zamel","year":"2008","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.jhep.2018.02.006_b0465","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/0016-5085(89)90651-3","article-title":"Hepatic peroxisomal abnormalities in abetalipoproteinemia","volume":"97","author":"Collins","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2018.02.006_b0470","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/0016-5085(91)90033-H","article-title":"Intestinal and hepatic apolipoprotein B gene expression in abetalipoproteinemia","volume":"101","author":"Black","year":"1991","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2018.02.006_b0475","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev.genom.7.080505.115715","article-title":"Genetic disorders of adipose tissue development, differentiation, and death","volume":"7","author":"Agarwal","year":"2006","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"10.1016\/j.jhep.2018.02.006_b0480","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/ng880","article-title":"AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34","volume":"31","author":"Agarwal","year":"2002","journal-title":"Nat Genet"},{"key":"10.1016\/j.jhep.2018.02.006_b0485","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1210\/jc.2002-021506","article-title":"A new clinical condition linked to a novel mutation in lamins A and C with generalized lipoatrophy, insulin-resistant diabetes, disseminated leukomelanodermic papules, liver steatosis, and cardiomyopathy","volume":"88","author":"Caux","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jhep.2018.02.006_b0490","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.bbalip.2008.12.014","article-title":"Lipodystrophies: disorders of adipose tissue biology","volume":"1791","author":"Garg","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jhep.2018.02.006_b0495","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.ecl.2004.03.003","article-title":"Lipodystrophies: rare disorders causing metabolic syndrome","volume":"33","author":"Garg","year":"2004","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.1016\/j.jhep.2018.02.006_b0500","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1146\/annurev.genom.8.080706.092327","article-title":"Congenital disorders of glycosylation: a rapidly expanding disease family","volume":"8","author":"Jaeken","year":"2007","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"10.1016\/j.jhep.2018.02.006_b0505","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s10545-016-0012-4","article-title":"Liver involvement in congenital disorders of glycosylation (CDG). A systematic review of the literature","volume":"40","author":"Marques-da-Silva","year":"2017","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.jhep.2018.02.006_b0510","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1056\/NEJMoa1206605","article-title":"Multiple phenotypes in phosphoglucomutase 1 deficiency","volume":"370","author":"Tegtmeyer","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2018.02.006_b0515","article-title":"Clinical, laboratory and molecular findings and long-term follow-up data in 96 French patients with PMM2-CDG (phosphomannomutase 2-congenital disorder of glycosylation) and review of the literature","volume":"27","author":"Schiff","year":"2017","journal-title":"J Med Genet"},{"key":"10.1016\/j.jhep.2018.02.006_b0520","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s13023-016-0543-7","article-title":"Ataxia telangiectasia: a review","volume":"25","author":"Rothblum-Oviatt","year":"2016","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.jhep.2018.02.006_b0525","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.4161\/cc.20259","article-title":"The DNA damage checkpoint protein ATM promotes hepatocellular apoptosis and fibrosis in a mouse model of non-alcoholic fatty liver disease","volume":"11","author":"Daugherity","year":"2012","journal-title":"Cell Cycle"},{"key":"10.1016\/j.jhep.2018.02.006_b0530","doi-asserted-by":"crossref","unstructured":"Caballero T, Caba-Molina M, Salmer\u00f3n J, G\u00f3mez-Morales M. Nonalcoholic Steatohepatitis in a Patient with Ataxia-Telangiectasia [Internet]. Case Reports in Hepatology. 2014 [cited 2017 Oct 30]. Available from: https:\/\/www.hindawi.com\/journals\/crihep\/2014\/761250\/.","DOI":"10.1155\/2014\/761250"},{"key":"10.1016\/j.jhep.2018.02.006_b0535","doi-asserted-by":"crossref","first-page":"E70","DOI":"10.1152\/ajpendo.00259.2006","article-title":"Impaired insulin secretion in a mouse model of ataxia telangiectasia","volume":"293","author":"Miles","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jhep.2018.02.006_b0540","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/stem.2235","article-title":"Ataxia telangiectasia mutated dysregulation results in diabetic retinopathy","volume":"34","author":"Bhatwadekar","year":"2016","journal-title":"Stem Cells Dayt Ohio"},{"key":"10.1016\/j.jhep.2018.02.006_b0545","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1542\/peds.2006-1212","article-title":"Prevalence of fatty liver in children and adolescents","volume":"118","author":"Schwimmer","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.jhep.2018.02.006_b0550","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1111\/apt.12518","article-title":"Paediatric gastroenterology evaluation of overweight and obese children referred from primary care for suspected non-alcoholic fatty liver disease","volume":"38","author":"Schwimmer","year":"2013","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jhep.2018.02.006_b0555","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1471-2431-13-40","article-title":"Pediatric non alcoholic fatty liver disease: old and new concepts on development, progression, metabolic insight and potential treatment targets","volume":"25","author":"Giorgio","year":"2013","journal-title":"BMC Pediatr"},{"key":"10.1016\/j.jhep.2018.02.006_b0560","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jpeds.2017.08.004","article-title":"Genome-wide associations related to hepatic histology in nonalcoholic fatty liver disease in hispanic boys","volume":"190","author":"Wattacheril","year":"2017","journal-title":"J Pediatr"},{"key":"10.1016\/j.jhep.2018.02.006_b0565","doi-asserted-by":"crossref","first-page":"9721","DOI":"10.3390\/nu7125494","article-title":"Assessment of diet and physical activity in paediatric non-alcoholic fatty liver disease patients: a united kingdom case control study","volume":"7","author":"Gibson","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/j.jhep.2018.02.006_b0570","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1053\/j.gastro.2014.07.056","article-title":"Pathological features of fatty liver disease","volume":"147","author":"Yeh","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2018.02.006_b0575","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1055\/s-2004-823098","article-title":"Nonalcoholic steatohepatitis","volume":"24","author":"Brunt","year":"2004","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jhep.2018.02.006_b0580","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1053\/j.gastro.2016.03.009","article-title":"Comparison of the phenotype and approach to pediatric vs. adult patients with nonalcoholic fatty liver disease","volume":"150","author":"Nobili","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2018.02.006_b0585","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/hep.20842","article-title":"Histopathology of pediatric nonalcoholic fatty liver disease","volume":"42","author":"Schwimmer","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2018.02.006_b0590","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1002\/hep.23133","article-title":"Nonalcoholic steatohepatitis in children: a multicenter clinicopathological study","volume":"50","author":"Carter-Kent","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2018.02.006_b0595","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.cgh.2012.01.020","article-title":"Association between puberty and features of nonalcoholic fatty liver disease","volume":"10","author":"Suzuki","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2018.02.006_b0600","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1097\/MPG.0b013e3181fb47d3","article-title":"Relations of steatosis type, grade, and zonality to histological features in pediatric nonalcoholic fatty liver disease","volume":"52","author":"Carter-Kent","year":"2011","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jhep.2018.02.006_b0605","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1111\/j.1440-1746.2006.04640.x","article-title":"Role of mitochondria in non-alcoholic fatty liver disease","volume":"22","author":"Pessayre","year":"2007","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2018.02.006_b0610","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1159\/000358570","article-title":"Is non-alcoholic fatty liver disease less frequent among women with Prader-Willi syndrome?","volume":"7","author":"Bedogni","year":"2014","journal-title":"Obes Facts"},{"key":"10.1016\/j.jhep.2018.02.006_b0615","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1111\/liv.13163","article-title":"Advanced non-alcoholic fatty liver disease and adipose tissue fibrosis in patients with Alstr\u00f6m syndrome","volume":"36","author":"Gathercole","year":"2016","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2018.02.006_b0620","article-title":"Liver anomalies as a phenotype parameter of Bardet-Biedl syndrome","author":"Branfield Day","year":"2015","journal-title":"Clin Genet"},{"key":"10.1016\/j.jhep.2018.02.006_b0625","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/ijpo.12052","article-title":"Non-alcoholic fatty liver disease (NAFLD) in children and adolescents with Prader-Willi Syndrome (PWS)","volume":"11","author":"Fintini","year":"2016","journal-title":"Pediatr Obes"},{"key":"10.1016\/j.jhep.2018.02.006_b0630","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1038\/s41598-017-03538-7","article-title":"Circulating angiopoietin-like 8 (ANGPTL8) is a marker of liver steatosis and is negatively regulated by Prader-Willi Syndrome","volume":"7","author":"Mele","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jhep.2018.02.006_b0635","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1210\/jc.2003-031118","article-title":"Elevated fasting plasma ghrelin in prader-willi syndrome adults is not solely explained by their reduced visceral adiposity and insulin resistance","volume":"89","author":"Goldstone","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jhep.2018.02.006_b0640","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1093\/ajcp\/102.4.443","article-title":"The liver biopsy diagnosis of Wilson\u2019s disease. Methods in pathology","volume":"102","author":"Ludwig","year":"1994","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.jhep.2018.02.006_b0645","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1016\/0016-5085(93)91080-2","article-title":"Alterations in hepatocyte lysosomes in experimental hepatic copper overload in rats","volume":"105","author":"Myers","year":"1993","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2018.02.006_b0650","first-page":"1782","article-title":"An array of mitochondrial alterations in the hepatocytes of Long-Evans Cinnamon rats","volume":"22","author":"Sternlieb","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2018.02.006_b0655","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1172\/JCI45401","article-title":"Liver mitochondrial membrane crosslinking and destruction in a rat model of Wilson disease","volume":"121","author":"Zischka","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2018.02.006_b0660","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.clinre.2012.03.038","article-title":"The relationship between copper and steatosis in Wilson\u2019s disease","volume":"37","author":"Liggi","year":"2013","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"10.1016\/j.jhep.2018.02.006_b0665","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jhep.2015.01.034","article-title":"Hepatic steatosis in Wilson disease\u2013Role of copper and PNPLA3 mutations","volume":"63","author":"St\u00e4ttermayer","year":"2015","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2018.02.006_b0670","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1111\/j.1440-1746.2011.06801.x","article-title":"Hepatic steatosis in hepatitis B virus infected patients: meta-analysis of risk factors and comparison with hepatitis C infected patients","volume":"26","author":"Machado","year":"2011","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2018.02.006_b0675","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1002\/hep.1840060613","article-title":"A histological study of hepatitis delta virus liver disease","volume":"6","author":"Verme","year":"1986","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2018.02.006_b0680","doi-asserted-by":"crossref","first-page":"e5832","DOI":"10.1097\/MD.0000000000005832","article-title":"Liver steatosis in children with chronic hepatitis B and C: Prevalence, predictors, and impact on disease progression","volume":"96","author":"Pokorska-\u015apiewak","year":"2017","journal-title":"Medicine"},{"key":"10.1016\/j.jhep.2018.02.006_b0685","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S0168-8278(98)80004-4","article-title":"Host- and disease-specific factors affecting steatosis in chronic hepatitis C","volume":"29","author":"Czaja","year":"1998","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2018.02.006_b0690","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.jhep.2006.03.010","article-title":"Is HCV infection associated with liver steatosis also in children?","volume":"45","author":"Giannattasio","year":"2006","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2018.02.006_b0695","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1136\/gut.2005.069757","article-title":"Steatosis in chronic hepatitis C: why does it really matter?","volume":"55","author":"Asselah","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2018.02.006_b0700","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1016\/S0168-8278(12)60007-5","article-title":"The interaction of metabolic factors with HCV infection: does it matter?","volume":"56","author":"Bugianesi","year":"2012","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2018.02.006_b0705","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/hep.25990","article-title":"Elevated lipogenesis and diminished cholesterol synthesis in patients with hepatitis C viral infection compared to healthy humans","volume":"57","author":"Lambert","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2018.02.006_b0710","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1053\/gast.2002.30983","article-title":"Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein","volume":"122","author":"Okuda","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2018.02.006_b0715","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1365-2893.2005.00662.x","article-title":"Hepatic iron, liver steatosis and viral genotypes in patients with chronic hepatitis C","volume":"13","author":"Sebastiani","year":"2006","journal-title":"J Viral Hepat"},{"key":"10.1016\/j.jhep.2018.02.006_b0720","doi-asserted-by":"crossref","first-page":"39802","DOI":"10.1074\/jbc.M510391200","article-title":"Hepatitis C virus nonstructural proteins inhibit apolipoprotein B100 secretion","volume":"280","author":"Domitrovich","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2018.02.006_b0725","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.jhep.2004.12.034","article-title":"An in vitro model of hepatitis C virus genotype 3a-associated triglycerides accumulation","volume":"42","author":"Abid","year":"2005","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2018.02.006_b0730","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1136\/gut.2006.108647","article-title":"The genotype 3-specific hepatitis C virus core protein residue phenylalanine 164 increases steatosis in an in vitro cellular model","volume":"56","author":"Hourioux","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2018.02.006_b0735","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1086\/648094","article-title":"Domain 3 of hepatitis C core protein is sufficient for intracellular lipid accumulation","volume":"200","author":"Jhaveri","year":"2009","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jhep.2018.02.006_b0740","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1053\/jhep.2001.24432","article-title":"Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity","volume":"33","author":"Adinolfi","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2018.02.006_b0745","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/j.1365-2893.2009.01098.x","article-title":"The impact of hepatic steatosis on the natural history of chronic hepatitis C infection","volume":"16","author":"Cross","year":"2009","journal-title":"J Viral Hepat"},{"key":"10.1016\/j.jhep.2018.02.006_b0750","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.1002\/cncr.11427","article-title":"Hepatic steatosis is a risk factor for hepatocellular carcinoma in patients with chronic hepatitis C virus infection","volume":"97","author":"Ohata","year":"2003","journal-title":"Cancer"},{"key":"10.1016\/j.jhep.2018.02.006_b0755","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.jhep.2010.11.006","article-title":"Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver","volume":"54","author":"Begriche","year":"2011","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2018.02.006_b0760","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1002\/hep.23891","article-title":"Polymerase \u03b3 gene POLG determines the risk of sodium valproate-induced liver toxicity","volume":"52","author":"Stewart","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2018.02.006_b0765","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1002\/hep.1840080513","article-title":"Inhibition of the mitochondrial oxidation of fatty acids by tetracycline in mice and in man: Possible role in microvesicular steatosis induced by this antibiotic","volume":"8","author":"Fr\u00e9neaux","year":"1988","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2018.02.006_b0770","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1055\/s-0032-1329896","article-title":"Congenital portosystemic shunts in children: recognition, evaluation, and management","volume":"32","author":"Bernard","year":"2012","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jhep.2018.02.006_b0775","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1053\/gast.1996.v110.pm8964424","article-title":"Three brothers with progressive hepatic dysfunction and severe hepatic steatosis due to a patent ductus venosus","volume":"110","author":"Uchino","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2018.02.006_b0780","unstructured":"Hepatic steatosis due to congenital absence of the portal VE...\u202f: J Pediatr Gastroenterol Nutr [Internet]. LWW. [cited 2016 Nov 14]. Available from: http:\/\/journals.lww.com\/jpgn\/Fulltext\/1997\/10000\/HEPATIC_STEATOSIS_DUE_TO_CONGENITAL_ABSENCE_OF_THE.147.aspx."}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827818301235?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827818301235?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T18:28:55Z","timestamp":1751394535000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827818301235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":156,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S0168827818301235"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2018.02.006","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Paediatric fatty liver disease (PeFLD): All is not NAFLD \u2013 Pathophysiological insights and approach to management","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2018.02.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V. on behalf of European Association for the Study of the Liver.","name":"copyright","label":"Copyright"}]}}