{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T11:41:05Z","timestamp":1793446865897,"version":"4.5.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T00:00:00Z","timestamp":1563235200000},"content-version":"am","delay-in-days":349,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"publisher","award":["DK099558"],"award-info":[{"award-number":["DK099558"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["ERC-2014-AdG-671231"],"award-info":[{"award-number":["ERC-2014-AdG-671231"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journal-of-hepatology.eu","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.jhep.2018.03.011","type":"journal-article","created":{"date-parts":[[2018,3,20]],"date-time":"2018-03-20T22:47:08Z","timestamp":1521586028000},"page":"385-395","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":560,"title":["A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer"],"prefix":"10.1016","volume":"69","author":[{"given":"Takuma","family":"Tsuchida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngmin A.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Ybanez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiao","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Isabel","family":"Fiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Goossens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-I.","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujin","family":"Hoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott L.","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2018.03.011_b0005","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.cgh.2014.04.014","article-title":"Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies","volume":"13","author":"Singh","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2018.03.011_b0010","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.cld.2015.10.001","article-title":"Epidemiology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in the United States and the rest of the world","volume":"20","author":"Sayiner","year":"2016","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.jhep.2018.03.011_b0015","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2018.03.011_b0020","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1002\/hep.26986","article-title":"Nonalcoholic steatohepatitis is the most rapidly growing indication for liver transplantation in patients with hepatocellular carcinoma in the U.S.","volume":"59","author":"Wong","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2018.03.011_b0025","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1007\/s10620-015-3977-1","article-title":"Animal models of nonalcoholic steatohepatitis: eat, delete, and inflame","volume":"61","author":"Ibrahim","year":"2016","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jhep.2018.03.011_b0030","article-title":"Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease","volume":"10","author":"Machado","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jhep.2018.03.011_b0035","first-page":"2683","article-title":"Morphological and functional characterization of non-alcoholic fatty liver disease induced by a methionine-choline-deficient diet in C57BL\/6 mice","volume":"6","author":"Itagaki","year":"2013","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1016\/j.jhep.2018.03.011_b0040","doi-asserted-by":"crossref","first-page":"G825","DOI":"10.1152\/ajpgi.00145.2011","article-title":"Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition","volume":"301","author":"Charlton","year":"2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jhep.2018.03.011_b0045","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.jhep.2016.05.005","article-title":"A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer","volume":"65","author":"Asgharpour","year":"2016","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2018.03.011_b0050","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1177\/0023677215571192","article-title":"The carbon tetrachloride model in mice","volume":"49","author":"Scholten","year":"2015","journal-title":"Lab Anim"},{"key":"10.1016\/j.jhep.2018.03.011_b0055","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/1440-1681.12102","article-title":"A high-fat diet and multiple administration of carbon tetrachloride induces liver injury and pathological features associated with non-alcoholic steatohepatitis in mice","volume":"40","author":"Kubota","year":"2013","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.jhep.2018.03.011_b0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0097136","article-title":"HCC development is associated to peripheral insulin resistance in a mouse model of NASH","volume":"9","author":"De Minicis","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jhep.2018.03.011_b0065","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2018.03.011_b0070","doi-asserted-by":"crossref","first-page":"E261","DOI":"10.1152\/ajpendo.00676.2007","article-title":"Comparison between surrogate indexes of insulin sensitivity and resistance and hyperinsulinemic euglycemic clamp estimates in mice","volume":"294","author":"Lee","year":"2008","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jhep.2018.03.011_b0075","doi-asserted-by":"crossref","first-page":"G13","DOI":"10.1530\/JOE-14-0182","article-title":"Metabolic phenotyping guidelines: assessing glucose homeostasis in rodent models","volume":"222","author":"Bowe","year":"2014","journal-title":"J Endocrinol"},{"key":"10.1016\/j.jhep.2018.03.011_b0080","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/nmeth.2722","article-title":"Systematic evaluation of spliced alignment programs for RNA-seq data","volume":"10","author":"Engstrom","year":"2013","journal-title":"Nat Methods"},{"key":"10.1016\/j.jhep.2018.03.011_b0085","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2010-11-3-r25","article-title":"A scaling normalization method for differential expression analysis of RNA-seq data","volume":"11","author":"Robinson","year":"2010","journal-title":"Genome Biol"},{"key":"10.1016\/j.jhep.2018.03.011_b0090","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2018.03.011_b0095","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell systems"},{"key":"10.1016\/j.jhep.2018.03.011_b0100","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/hep.26661","article-title":"Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease","volume":"59","author":"Moylan","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2018.03.011_b0105","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.cmet.2013.07.004","article-title":"DNA methylation analysis in nonalcoholic fatty liver disease suggests distinct disease-specific and remodeling signatures after bariatric surgery","volume":"18","author":"Ahrens","year":"2013","journal-title":"Cell Metab"},{"key":"10.1016\/j.jhep.2018.03.011_b0110","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.ccell.2016.11.004","article-title":"Molecular liver cancer prevention in cirrhosis by organ transcriptome analysis and lysophosphatidic acid pathway inhibition","volume":"30","author":"Nakagawa","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jhep.2018.03.011_b0115","doi-asserted-by":"crossref","first-page":"7385","DOI":"10.1158\/0008-5472.CAN-09-1089","article-title":"Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma","volume":"69","author":"Hoshida","year":"2009","journal-title":"Cancer Res"},{"key":"10.1016\/j.jhep.2018.03.011_b0120","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1038\/ncomms3823","article-title":"Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology","volume":"4","author":"Mederacke","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhep.2018.03.011_b0125","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1053\/j.gastro.2007.05.012","article-title":"Progressive fibrosis in nonalcoholic steatohepatitis: association with altered regeneration and a ductular reaction","volume":"133","author":"Richardson","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2018.03.011_b0130","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1002\/hep.26937","article-title":"The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease","volume":"59","author":"Gadd","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2018.03.011_b0135","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.cell.2005.04.014","article-title":"IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis","volume":"121","author":"Maeda","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2018.03.011_b0140","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1097\/PAS.0b013e3181f31caa","article-title":"Steatohepatitic hepatocellular carcinoma (SH-HCC): a distinctive histological variant of HCC in hepatitis C virus-related cirrhosis with associated NAFLD\/NASH","volume":"34","author":"Salomao","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.jhep.2018.03.011_b0145","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1053\/j.gastro.2016.05.051","article-title":"Comparison of gene expression patterns between mouse models of nonalcoholic fatty liver disease and liver tissues from patients","volume":"151","author":"Teufel","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2018.03.011_b0150","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/mnfr.201000392","article-title":"Chronic dietary intake of quercetin alleviates hepatic fat accumulation associated with consumption of a Western-style diet in C57\/BL6J mice","volume":"55","author":"Kobori","year":"2011","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.jhep.2018.03.011_b0155","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/labinvest.2014.3","article-title":"Increased expression of c-Jun in nonalcoholic fatty liver disease","volume":"94","author":"Dorn","year":"2014","journal-title":"Lab Invest"},{"key":"10.1016\/j.jhep.2018.03.011_b0160","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1002\/hep.26699","article-title":"All-trans-retinoic acid ameliorates hepatic steatosis in mice by a novel transcriptional cascade","volume":"59","author":"Kim","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2018.03.011_b0165","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1186\/1471-2164-13-450","article-title":"Time-course microarrays reveal early activation of the immune transcriptome and adipokine dysregulation leads to fibrosis in visceral adipose depots during diet-induced obesity","volume":"13","author":"Kwon","year":"2012","journal-title":"BMC Genomics"},{"key":"10.1016\/j.jhep.2018.03.011_b0170","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.biocel.2015.04.016","article-title":"Downregulation of microRNA-451 in non-alcoholic steatohepatitis inhibits fatty acid-induced proinflammatory cytokine production through the AMPK\/AKT pathway","volume":"64","author":"Hur","year":"2015","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.jhep.2018.03.011_b0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0043056","article-title":"Metformin prevents and reverses inflammation in a non-diabetic mouse model of nonalcoholic steatohepatitis","volume":"7","author":"Kita","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jhep.2018.03.011_b0180","doi-asserted-by":"crossref","first-page":"4592","DOI":"10.1096\/fj.12-209569","article-title":"Interstrain differences in the severity of liver injury induced by a choline- and folate-deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism","volume":"26","author":"Tryndyak","year":"2012","journal-title":"FASEB J"},{"key":"10.1016\/j.jhep.2018.03.011_b0185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0124544","article-title":"Integrative genomic signatures of hepatocellular carcinoma derived from nonalcoholic Fatty liver disease","volume":"10","author":"Frades","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jhep.2018.03.011_b0190","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1172\/JCI63455","article-title":"MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis","volume":"122","author":"Tsai","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2018.03.011_b0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013858","article-title":"Changes in hepatic gene expression upon oral administration of taurine-conjugated ursodeoxycholic acid in ob\/ob mice","volume":"5","author":"Yang","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jhep.2018.03.011_b0200","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nature16969","article-title":"NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis","volume":"531","author":"Ma","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2018.03.011_b0205","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1055\/s-0035-1550060","article-title":"Emerging and disease-specific mechanisms of hepatic stellate cell activation","volume":"35","author":"Wallace","year":"2015","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jhep.2018.03.011_b0210","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1136\/gutjnl-2014-306842","article-title":"Pathobiology of liver fibrosis: a translational success story","volume":"64","author":"Lee","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2018.03.011_b0215","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.jhep.2015.05.031","article-title":"Accumulation of duct cells with activated YAP parallels fibrosis progression in NonAlcoholic Fatty Liver Disease","volume":"63","author":"Machado","year":"2015","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2018.03.011_b0220","doi-asserted-by":"crossref","first-page":"G483","DOI":"10.1152\/ajpgi.00079.2013","article-title":"Diet-induced mouse model of fatty liver disease and nonalcoholic steatohepatitis reflecting clinical disease progression and methods of assessment","volume":"305","author":"Clapper","year":"2013","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jhep.2018.03.011_b0225","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/j.ajpath.2014.01.034","article-title":"Development of hepatocellular carcinoma in a murine model of nonalcoholic steatohepatitis induced by use of a high-fat\/fructose diet and sedentary lifestyle","volume":"184","author":"Dowman","year":"2014","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jhep.2018.03.011_b0230","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.cld.2015.10.011","article-title":"Histology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in adults and children","volume":"20","author":"Kleiner","year":"2016","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.jhep.2018.03.011_b0235","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/hep.24701","article-title":"Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin alpha(V)beta(3) engagement and PI3K\/pAkt\/NFkappaB signaling","volume":"55","author":"Urtasun","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2018.03.011_b0240","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/hep.25789","article-title":"Synergistic interaction of dietary cholesterol and dietary fat in inducing experimental steatohepatitis","volume":"57","author":"Savard","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2018.03.011_b0245","first-page":"G751","article-title":"Cholic acid aids absorption, biliary secretion, and phase transitions of cholesterol in murine cholelithogenesis","volume":"276","author":"Wang","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jhep.2018.03.011_b0250","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1002\/hep.21763","article-title":"A lipidomic analysis of nonalcoholic fatty liver disease","volume":"46","author":"Puri","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2018.03.011_b0255","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.jhep.2008.12.016","article-title":"Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH","volume":"50","author":"Caballero","year":"2009","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2018.03.011_b0260","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.cmet.2016.09.016","article-title":"Hepatocyte TAZ\/WWTR1 promotes inflammation and fibrosis in nonalcoholic steatohepatitis","volume":"24","author":"Wang","year":"2016","journal-title":"Cell Metab"},{"key":"10.1016\/j.jhep.2018.03.011_b0265","doi-asserted-by":"crossref","first-page":"673","DOI":"10.4254\/wjh.v8.i16.673","article-title":"Obese diet-induced mouse models of nonalcoholic steatohepatitis-tracking disease by liver biopsy","volume":"8","author":"Kristiansen","year":"2016","journal-title":"World J Hepatol"}],"updated-by":[{"DOI":"10.1016\/j.jhep.2018.07.010","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000}}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827818301752?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827818301752?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T20:55:22Z","timestamp":1618260922000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827818301752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S0168827818301752"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2018.03.011","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2018.03.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}