{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T05:38:27Z","timestamp":1793252307683,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.jhep.2018.12.014","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T22:26:59Z","timestamp":1545431219000},"page":"885-892","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":88,"title":["Association between physical activity and risk of hepatobiliary cancers: A multinational cohort study"],"prefix":"10.1016","volume":"70","author":[{"given":"Sebastian E.","family":"Baumeister","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4244-0832","authenticated-orcid":false,"given":"Sabrina","family":"Schlesinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krasimira","family":"Aleksandrova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Jochem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazda","family":"Jenab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc J.","family":"Gunter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Overvad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Tj\u00f8nneland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christine","family":"Boutron-Ruault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Carbonnel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Fournier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilman","family":"K\u00fchn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Kaaks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Pischon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiner","family":"Boeing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Trichopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Bamia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"La Vecchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Masala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Panico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Fasanelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Tumino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Grioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bas","family":"Bueno de Mesquita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roel","family":"Vermeulen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"May","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin B.","family":"Borch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunday O.","family":"Oyeyemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Ardanaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Rodr\u00edguez-Barranco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Dolores Chirlaque L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireia","family":"Felez-Nobrega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Sonestedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bodil","family":"Ohlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oskar","family":"Hemmingsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e5rten","family":"Werner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora","family":"Perez-Cornago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Stepien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"Freisling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos K.","family":"Tsilidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elio","family":"Riboli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabete","family":"Weiderpass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F.","family":"Leitzmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2018.12.014_b0005","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1001\/jamaoncol.2017.3055","article-title":"The burden of primary liver cancer and underlying etiologies from 1990 to 2015 at the global, regional, and national level: results from the Global Burden of Disease Study 2015","volume":"3","author":"Akinyemiju","year":"2017","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.jhep.2018.12.014_b0010","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.jhep.2012.12.005","article-title":"The burden of liver disease in Europe: a review of available epidemiological data","volume":"58","author":"Blachier","year":"2013","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2018.12.014_b0015","doi-asserted-by":"crossref","first-page":"3430","DOI":"10.1002\/cncr.30237","article-title":"Comparison of hepatocellular carcinoma in Eastern versus Western populations","volume":"122","author":"Choo","year":"2016","journal-title":"Cancer"},{"key":"10.1016\/j.jhep.2018.12.014_b0020","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1007\/s10620-016-4085-6","article-title":"Hepatocellular carcinoma in obesity, type 2 diabetes, and NAFLD","volume":"61","author":"Reeves","year":"2016","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jhep.2018.12.014_b0025","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jhep.2015.08.028","article-title":"Hepatocellular carcinoma and lifestyles","volume":"64","author":"Saran","year":"2016","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2018.12.014_b0030","article-title":"Incidence of hepatocellular carcinoma in all 50 United States, from 2000 through 2012","volume":"152","author":"White","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2018.12.014_b0035","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1158\/1055-9965.EPI-15-0578","article-title":"Global cancer incidence and mortality rates and trends\u2014an update","volume":"25","author":"Torre","year":"2016","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.jhep.2018.12.014_b0040","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1001\/jamainternmed.2016.1548","article-title":"Association of leisure-time physical activity with risk of 26 types of cancer in 1.44 million adults","volume":"176","author":"Moore","year":"2016","journal-title":"JAMA Int Med"},{"key":"10.1016\/j.jhep.2018.12.014_b0045","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1002\/cam4.1343","article-title":"Physical activity across the lifespan and liver cancer incidence in the NIH-AARP Diet and Health Study cohort","volume":"7","author":"Arem","year":"2018","journal-title":"Cancer Med"},{"key":"10.1016\/j.jhep.2018.12.014_b0050","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s10654-013-9767-1","article-title":"The association between frequency of vigorous physical activity and hepatobiliary cancers in the NIH-AARP Diet and Health Study","volume":"28","author":"Behrens","year":"2013","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.jhep.2018.12.014_b0055","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/S0140-6736(11)60749-6","article-title":"Minimum amount of physical activity for reduced mortality and extended life expectancy: a prospective cohort study","volume":"378","author":"Wen","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2018.12.014_b0060","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1186\/1471-2407-8-366","article-title":"Dietary preference, physical activity, and cancer risk in men: national health insurance corporation study","volume":"8","author":"Yun","year":"2008","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jhep.2018.12.014_b0065","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/aje\/kwn146","article-title":"Daily total physical activity level and total cancer risk in men and women: results from a large-scale population-based cohort study in Japan","volume":"168","author":"Inoue","year":"2008","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jhep.2018.12.014_b0070","unstructured":"World Cancer Research Fund International\/American Institute for Cancer Research. Diet, Nutrition, Physical Activity and Cancer: A Global Perspective (Continuous Update Project Expert Report 2018). Available from: dietandcancerreport.org"},{"key":"10.1016\/j.jhep.2018.12.014_b0075","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1136\/bjsports-2017-098391","article-title":"Physical activity and cancer: an umbrella review of the literature including 22 major anatomical sites and 770 000 cancer cases","volume":"52","author":"Rezende","year":"2018","journal-title":"Br J Sports Med"},{"key":"10.1016\/j.jhep.2018.12.014_b0080","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1079\/PHN2002394","article-title":"European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection","volume":"5","author":"Riboli","year":"2002","journal-title":"Public Health Nutr"},{"key":"10.1016\/j.jhep.2018.12.014_b0085","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1093\/jnci\/djr395","article-title":"Hepatocellular carcinoma risk factors and disease burden in a European cohort: a nested case-control study","volume":"103","author":"Trichopoulos","year":"2011","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.jhep.2018.12.014_b0090","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1079\/PHN2002397","article-title":"Physical activity of subjects aged 50\u201364 years involved in the European Prospective Investigation into Cancer and Nutrition (EPIC)","volume":"5","author":"Haftenberger","year":"2002","journal-title":"Public Health Nutr"},{"key":"10.1016\/j.jhep.2018.12.014_b0095","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s10654-011-9625-y","article-title":"Validity of a short questionnaire to assess physical activity in 10 European countries","volume":"27","author":"Peters","year":"2012","journal-title":"Eur J Epidemiol"},{"issue":"Suppl. 1","key":"10.1016\/j.jhep.2018.12.014_b0100","doi-asserted-by":"crossref","first-page":"S181","DOI":"10.1093\/ije\/26.suppl_1.S181","article-title":"Estimation of reproducibility and relative validity of the questions included in the EPIC Physical Activity Questionnaire","volume":"26","author":"Pols","year":"1997","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jhep.2018.12.014_b0105","series-title":"An Update on How to Treat Physical Activity Data in the Epic Study","author":"Benjaminsen Borch","year":"2015"},{"key":"10.1016\/j.jhep.2018.12.014_b0110","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1079\/PHN2002439","article-title":"Validity and repeatability of a simple index derived from the short Physical Activity Questionnaire used in the European Prospective Investigation into Cancer and Nutrition (EPIC) study","volume":"6","author":"Wareham","year":"2003","journal-title":"Public Health Nutr"},{"key":"10.1016\/j.jhep.2018.12.014_b0115","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1479-5868-9-2","article-title":"Criterion validity of a 10-category scale for ranking physical activity in Norwegian women","volume":"9","author":"Borch","year":"2012","journal-title":"Int J Behav Nutr Phys Act"},{"key":"10.1016\/j.jhep.2018.12.014_b0120","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s10654-016-0119-9","article-title":"Physical activity and risk of amyotrophic lateral sclerosis in a prospective cohort study","volume":"31","author":"Gallo","year":"2016","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.jhep.2018.12.014_b0125","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1177\/0962280214521348","article-title":"Multiple imputation of covariates by fully conditional specification: accommodating the substantive model","volume":"24","author":"Bartlett","year":"2015","journal-title":"Stat Methods Med Res"},{"key":"10.1016\/j.jhep.2018.12.014_b0130","doi-asserted-by":"crossref","first-page":"4695","DOI":"10.1002\/sim.6308","article-title":"Interaction of treatment with a continuous variable: simulation study of power for several methods of analysis","volume":"33","author":"Royston","year":"2014","journal-title":"Stat Med"},{"key":"10.1016\/j.jhep.2018.12.014_b0135","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/978-3-319-42542-9_10","article-title":"Obesity and liver cancer","volume":"208","author":"Aleksandrova","year":"2016","journal-title":"Recent Results Cancer Res"},{"key":"10.1016\/j.jhep.2018.12.014_b0140","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1001\/jamaoncol.2016.1035","article-title":"Physical activity and digestive system cancer risk: still chasing the promise","volume":"2","author":"Greenlee","year":"2016","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.jhep.2018.12.014_b0145","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1097\/EDE.0000000000000253","article-title":"SAS macro for causal mediation analysis with survival data","volume":"26","author":"Valeri","year":"2015","journal-title":"Epidemiology"},{"key":"10.1016\/j.jhep.2018.12.014_b0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v059.i05","article-title":"Mediation: R package for causal mediation analysis","volume":"59","author":"Tingley","year":"2014","journal-title":"J Stat Softw"},{"key":"10.1016\/j.jhep.2018.12.014_b0155","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1136\/bjsports-2017-098995","article-title":"Physical activity and longevity: how to move closer to causal inference","volume":"52","author":"Wade","year":"2018","journal-title":"Br J Sports Med"},{"key":"10.1016\/j.jhep.2018.12.014_b0160","doi-asserted-by":"crossref","first-page":"268","DOI":"10.7326\/M16-2607","article-title":"Sensitivity analysis in observational research: introducing the E-value","volume":"167","author":"VanderWeele","year":"2017","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jhep.2018.12.014_b0165","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.trecan.2017.04.007","article-title":"Exercise and the hallmarks of cancer","volume":"3","author":"Ruiz-Casado","year":"2017","journal-title":"Trends Cancer"},{"key":"10.1016\/j.jhep.2018.12.014_b0170","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1056\/NEJMcibr1606456","article-title":"Muscling in on cancer","volume":"375","author":"Lucia","year":"2016","journal-title":"New Engl J Med"},{"key":"10.1016\/j.jhep.2018.12.014_b0175","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1042\/BST20160466","article-title":"Exercise protects from cancer through regulation of immune function and inflammation","volume":"15","author":"Hojman","year":"2017","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.jhep.2018.12.014_b0180","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1002\/hep.28132","article-title":"Physical activity and liver diseases","volume":"63","author":"Berzigotti","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2018.12.014_b0185","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1001\/jamaoncol.2016.0740","article-title":"Association of physical activity by type and intensity with digestive system cancer risk","volume":"2","author":"Keum","year":"2016","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.jhep.2018.12.014_b0190","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1093\/jnci\/djy091","article-title":"An integrative approach for deciphering the causal associations of physical activity and cancer risk: the role of adiposity","volume":"110","author":"Giovannucci","year":"2018","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.jhep.2018.12.014_b0195","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s12029-017-9959-0","article-title":"Global epidemiology of hepatocellular carcinoma (HCC epidemiology)","volume":"48","author":"Ozakyol","year":"2017","journal-title":"J Gastrointest Cancer"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827818326333?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827818326333?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T19:36:22Z","timestamp":1759174582000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827818326333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S0168827818326333"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2018.12.014","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between physical activity and risk of hepatobiliary cancers: A multinational cohort study","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2018.12.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}